TDR Targets

Basic information

Technical information

TDR Targets ID: 736695
Name: 2-(2,8-dimethyl-4-oxoquinolin-1-yl)-N-(2-meth oxyphenyl)acetamide
MW: 336.384 | Formula: C20H20N2O3
H donors: 1 H acceptors: 2 LogP: 3.31 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)Cn1c(C)cc(=O)c2c1c(C)ccc2
InChi: 1S/C20H20N2O3/c1-13-7-6-8-15-17(23)11-14(2)22(20(13)15)12-19(24)21-16-9-4-5-10-18(16)25-3/h4-11H,12H2,1-3H3,(H,21,24)
InChiKey: UPJDMUFKNOBRRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,8-dimethyl-4-oxo-1-quinolyl)-N-(2-methoxyphenyl)acetamide
2-(4-keto-2,8-dimethyl-1-quinolyl)-N-(2-methoxyphenyl)acetamide
2-(2,8-dimethyl-4-oxo-quinolin-1-yl)-N-(2-methoxyphenyl)ethanamide
ZINC00460394
STOCK3S-08597

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0048	0.0226	0.0307
Mycobacterium leprae	cell division protein FtsZ	0.0461	0.4493	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0058	0.0331	0.015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Plasmodium vivax	thioredoxin reductase, putative	0.0167	0.1454	1
Echinococcus multilocularis	peregrin	0.0069	0.0445	0.061
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0048	0.0226	0.0752
Schistosoma mansoni	hypothetical protein	0.0077	0.0533	0.0436
Schistosoma mansoni	hypothetical protein	0.0066	0.042	0.0276
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.018	0.1595	0.1947
Trichomonas vaginalis	mercuric reductase, putative	0.0058	0.0331	0.0331
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0426	0.0285
Schistosoma mansoni	hypothetical protein	0.0061	0.0367	0.02
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0058	0.0331	0.1546
Loa Loa (eye worm)	jmjC domain-containing protein	0.008	0.0563	0.0637
Trypanosoma cruzi	ISWI complex protein	0.0049	0.0243	0.0882
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0058	0.0331	0.1546
Brugia malayi	Cell division protein ftsZ	0.0221	0.2018	0.2301
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0533	0.073
Trypanosoma brucei	trypanothione reductase	0.0167	0.1454	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0031	0.0053	0.0054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0126	0.0126
Echinococcus multilocularis	zinc finger protein	0.0063	0.0385	0.0527
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0058	0.0331	0.0453
Echinococcus granulosus	PHD finger protein rhinoceros	0.0061	0.0367	0.0501
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0426	0.0285
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Treponema pallidum	cell division protein FtsZ	0.0461	0.4493	1
Echinococcus multilocularis	jumonji domain containing protein	0.0085	0.0614	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1086	0.1236
Toxoplasma gondii	NADPH-glutathione reductase	0.0058	0.0331	0.1706
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0126	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0226	0.0226
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0058	0.0331	0.7488
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0426	0.0285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0154	0.0154
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0072	0.0483	0.0662
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0461	0.4493	1
Entamoeba histolytica	hypothetical protein	0.0077	0.0533	1
Brugia malayi	PHD-finger family protein	0.008	0.0562	0.0636
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0054	0.0054
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0226	0.0252
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0125	0.1029	0.6864
Loa Loa (eye worm)	PHD-finger family protein	0.0066	0.042	0.0474
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0192	0.1715	0.236
Plasmodium falciparum	phd finger protein, putative	0.0061	0.0367	0.0315
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0426	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0227	0.208	0.2372
Echinococcus granulosus	peregrin	0.0069	0.0445	0.061
Mycobacterium tuberculosis	Probable oxidoreductase	0.0423	0.4092	0.9037
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0423	0.4092	0.9037
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0167	0.1454	0.2698
Schistosoma mansoni	zinc finger protein	0.0063	0.0385	0.0226
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0048	0.0226	0.0752
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.02	0.1802	0.2479
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0426	0.0285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Trichomonas vaginalis	glutathione reductase, putative	0.0058	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0137	0.115	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0795	0.0902
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0226	0.0252
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0058	0.0331	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0817	0.0928
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0426	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0126	0.0126
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Schistosoma mansoni	jumonji/arid domain-containing protein	0.008	0.0563	0.0479
Echinococcus multilocularis	lysine specific demethylase 5A	0.0074	0.0499	0.0684
Loa Loa (eye worm)	hypothetical protein	0.018	0.1595	0.1817
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0226	0.0226
Trypanosoma cruzi	ISWI complex protein	0.0049	0.0243	0.0882
Trypanosoma cruzi	trypanothione reductase, putative	0.0058	0.0331	0.1546
Schistosoma mansoni	hypothetical protein	0.0049	0.0243	0.0025
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0072	0.0483	0.0366
Echinococcus granulosus	lysine specific demethylase 5A	0.008	0.0563	0.0772
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0426	0.0481
Echinococcus granulosus	thioredoxin glutathione reductase	0.0168	0.147	0.2023
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Onchocerca volvulus		0.0103	0.0795	0.0445
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0058	0.0331	0.1546
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0426	0.0481
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Entamoeba histolytica	hypothetical protein	0.0077	0.0533	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0192	0.1715	0.236
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0058	0.0331	0.1546
Plasmodium falciparum	glutathione reductase	0.0167	0.1454	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0029	0.0029
Schistosoma mansoni	jumonji domain containing protein	0.0159	0.1377	0.1637
Schistosoma mansoni	cellular tumor antigen P53	0.0103	0.0795	0.0809
Echinococcus granulosus	tumor protein p63	0.0702	0.6971	0.9604
Brugia malayi	RNA binding protein	0.0067	0.0426	0.0481
Brugia malayi	TAR-binding protein	0.0067	0.0426	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0029	0.0029
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0423	0.4092	0.5219
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0058	0.0331	0.1706
Leishmania major	trypanothione reductase	0.0167	0.1454	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0042	0.0173	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1008	0.1146
Toxoplasma gondii	PHD-finger domain-containing protein	0.0061	0.0367	0.1968
Loa Loa (eye worm)	jmjC domain-containing protein	0.0126	0.1038	0.1181
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0125	0.1029	0.1143
Onchocerca volvulus		0.0125	0.1029	0.0688
Echinococcus multilocularis	microtubule associated protein 2	0.073	0.7258	1
Brugia malayi	PHD-finger family protein	0.0061	0.0367	0.0413
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0058	0.0331	0.5
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0042	0.0173	0.0192
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0058	0.0331	0.1546
Loa Loa (eye worm)	bromodomain containing protein	0.0057	0.0322	0.0361
Trichomonas vaginalis	set domain proteins, putative	0.0996	1	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0055	0.0301	0.0107
Plasmodium vivax	SET domain protein, putative	0.0125	0.1029	0.6219
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.038	0.3655	0.7986
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0058	0.0331	0.1546
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.038	0.3655	0.7986
Toxoplasma gondii	thioredoxin reductase	0.0167	0.1454	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0121	0.0982	0.1349
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0168	0.147	0.2023
Brugia malayi	Bromodomain containing protein	0.0123	0.1006	0.1143
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.038	0.3655	0.7986
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0058	0.0331	0.0372
Loa Loa (eye worm)	thioredoxin reductase	0.0167	0.1454	0.1656
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0048	0.0226	0.0752
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0116	0.0927	0.1274
Trypanosoma cruzi	trypanothione reductase, putative	0.0167	0.1454	1
Mycobacterium tuberculosis	Probable reductase	0.038	0.3655	0.7986
Brugia malayi	Thioredoxin reductase	0.0167	0.1454	0.1656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0126	0.0126
Echinococcus granulosus	jumonji domain containing protein	0.0085	0.0614	0.0842
Brugia malayi	Bromodomain containing protein	0.0069	0.0445	0.0503
Giardia lamblia	PHD finger protein 15	0.0061	0.0367	1
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0533	0.0436
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0226	0.0226
Echinococcus granulosus	zinc finger protein	0.0063	0.0385	0.0527
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.02	0.1802	0.2479
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0061	0.0367	0.02
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0426	0.0285
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.018	0.1595	0.1947
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0055	0.0301	0.0107
Plasmodium vivax	hypothetical protein, conserved	0.0061	0.0367	0.0315
Brugia malayi	jmjC domain containing protein	0.008	0.0563	0.0637
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0116	0.0927	0.1274
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0058	0.0331	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0026
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0461	0.4493	1
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0426	0.0584
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0061	0.0367	0.0501
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Schistosoma mansoni	zinc finger protein	0.0049	0.0243	0.0025
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0423	0.4092	0.9037
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0048	0.0226	0.0752
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0125	0.1029	0.1415
Echinococcus granulosus	microtubule associated protein 2	0.073	0.7258	1
Brugia malayi	Pre-SET motif family protein	0.0875	0.8754	1
Echinococcus multilocularis	tumor protein p63	0.0702	0.6971	0.9604
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0367	0.0413
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0533	0.073
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0048	0.0226	0.0307
Brugia malayi	jmjC domain containing protein	0.02	0.1802	0.2053
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0125	0.1029	0.1143
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0055	0.0301	0.0411
Plasmodium vivax	glutathione reductase, putative	0.0167	0.1454	1
Brugia malayi	Bromodomain containing protein	0.0241	0.2222	0.2534
Echinococcus granulosus	histone lysine methyltransferase setb	0.018	0.1595	0.2194
Entamoeba histolytica	hypothetical protein	0.0077	0.0533	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0875	0.8754	1
Entamoeba histolytica	hypothetical protein	0.0077	0.0533	1
Schistosoma mansoni	microtubule-associated protein tau	0.073	0.7258	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.018	0.1595	0.2194
Brugia malayi	glutathione reductase	0.0167	0.1454	0.1656
Brugia malayi	Pre-SET motif family protein	0.0125	0.1029	0.117
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0426	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Schistosoma mansoni	bromodomain containing protein	0.0203	0.1834	0.2286
Mycobacterium ulcerans	cell division protein FtsZ	0.0461	0.4493	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0058	0.0331	0.1546
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0048	0.0226	0.0752
Mycobacterium tuberculosis	Probable dehydrogenase	0.038	0.3655	0.7986
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.038	0.3655	0.7986
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0055	0.0301	0.0411
Brugia malayi	hypothetical protein	0.0077	0.0533	0.0603
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0058	0.0331	0.1546
Schistosoma mansoni	jumonji/arid domain-containing protein	0.008	0.0563	0.0479
Loa Loa (eye worm)	glutathione reductase	0.0167	0.1454	0.1656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0126	0.0126
Toxoplasma gondii	PHD-finger domain-containing protein	0.0061	0.0367	0.1968
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0048	0.0226	0.0752
Loa Loa (eye worm)	PHD-finger family protein	0.0061	0.0367	0.0413
Brugia malayi	Cell division protein ftsZ	0.0228	0.2084	0.2376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Trypanosoma brucei	ISWI complex protein	0.0049	0.0243	0.0882
Leishmania major	hypothetical protein, conserved	0.0049	0.0243	0.0882
Plasmodium falciparum	thioredoxin reductase	0.0167	0.1454	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0029	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.01	0.01
Echinococcus granulosus	fetal alzheimer antigen falz	0.0072	0.0483	0.0662

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 736695