Detailed information for compound 737832

Basic information

Technical information
  • TDR Targets ID: 737832
  • Name: N-(furan-2-ylmethyl)-4-[(3-methoxyphenyl)meth yl]piperazine-1-carbothioamide
  • MW: 345.459 | Formula: C18H23N3O2S
  • H donors: 1 H acceptors: 0 LogP: 2.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCN(CC1)C(=S)NCc1ccco1
  • InChi: 1S/C18H23N3O2S/c1-22-16-5-2-4-15(12-16)14-20-7-9-21(10-8-20)18(24)19-13-17-6-3-11-23-17/h2-6,11-12H,7-10,13-14H2,1H3,(H,19,24)
  • InChiKey: BKBXOEYNFRBCHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-4-[(3-methoxyphenyl)methyl]piperazine-1-carbothioamide
  • N-(2-furylmethyl)-4-[(3-methoxyphenyl)methyl]-1-piperazinecarbothioamide
  • N-(2-furylmethyl)-4-(3-methoxybenzyl)piperazine-1-carbothioamide
  • CBKinase1_019312
  • IVK/1238443
  • CBKinase1_006912

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Trypanosoma cruzi sugar transporter, putative 0.0062 0.0184 0.1009
Entamoeba histolytica hypothetical protein 0.0099 0.0382 0.4238
Loa Loa (eye worm) hypothetical protein 0.0048 0.0108 0.0484
Schistosoma mansoni hypothetical protein 0.005 0.012 0.0155
Brugia malayi major facilitator superfamily protein 0.0062 0.0184 0.0823
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.0706 0.3154
Brugia malayi hypothetical protein 0.0072 0.0236 0.1053
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Brugia malayi Pre-SET motif family protein 0.003 0.001 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Plasmodium vivax sugar transporter, putative 0.0062 0.0184 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Entamoeba histolytica protein kinase, putative 0.0136 0.0581 1
Onchocerca volvulus 0.0062 0.0184 0.1627
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0382 0.0494
Onchocerca volvulus 0.0062 0.0184 0.1627
Loa Loa (eye worm) hypothetical protein 0.0099 0.0382 0.1705
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0087 0.0316 0.1233
Onchocerca volvulus 0.0062 0.0184 0.1627
Trypanosoma cruzi hexose transporter, putative 0.0138 0.059 0.3956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Trichomonas vaginalis glucose transporter, putative 0.0138 0.059 0.248
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.0184 0.1009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Chlamydia trachomatis lysine--tRNA ligase 0.0099 0.0382 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0136 0.0581 0.0581
Echinococcus multilocularis chromobox protein 1 0.0067 0.0211 0.0273
Plasmodium falciparum calcium-dependent protein kinase 2 0.0136 0.0581 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0045
Echinococcus granulosus GPCR family 2 0.005 0.012 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0133 0.0566 0.0731
Echinococcus multilocularis calcium dependent protein kinase 0.0127 0.0535 0.0692
Loa Loa (eye worm) hypothetical protein 0.0109 0.0435 0.1941
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.012 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Brugia malayi Sugar transporter family protein 0.0062 0.0184 0.0823
Echinococcus multilocularis solute carrier family 22 0.0062 0.0184 0.0238
Entamoeba histolytica protein kinase, putative 0.0136 0.0581 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0677 0.593
Echinococcus granulosus chromobox protein 1 0.0067 0.0211 0.0273
Onchocerca volvulus 0.0062 0.0184 0.1627
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0184 0.0823
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0184 0.0633
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0133 0.0566 0.2526
Brugia malayi major facilitator superfamily protein 0.0062 0.0184 0.0823
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0184 0.0823
Echinococcus multilocularis chromobox protein 1 0.0067 0.0211 0.0273
Brugia malayi hypothetical protein 0.0062 0.0184 0.0823
Plasmodium vivax proline--tRNA ligase, putative 0.0155 0.0685 0.0685
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.0184 0.0238
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.0184 0.0238
Echinococcus granulosus solute carrier family 22 0.0062 0.0184 0.0238
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0047 0.0102 0.0887
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0302 0.492
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0254 0.1512
Trichomonas vaginalis sugar transporter, putative 0.0138 0.059 0.248
Echinococcus multilocularis solute carrier family 22 0.0062 0.0184 0.0238
Brugia malayi lysyl-tRNA synthetase 0.0099 0.0382 0.1705
Echinococcus granulosus calcium dependent protein kinase 0.0127 0.0535 0.0692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.0706 0.3154
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0444 0.224 0.2896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0046 0.0059
Plasmodium falciparum proline--tRNA ligase 0.0155 0.0685 0.0685
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0155 0.0685 0.1036
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0136 0.0581 0.0879
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0184 0.0823
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.012 0.0534
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Brugia malayi Pre-SET motif family protein 0.0209 0.0977 0.4364
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0136 0.0581 0.2592
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Leishmania major hypothetical protein, conserved 0.0062 0.0184 0.1009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0004 0.0005
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0136 0.0581 0.0879
Trypanosoma brucei glucose transporter 2A 0.0138 0.059 0.3956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.059 0.3956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0133 0.0566 0.0731
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.0184 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0184 0.0633
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0133 0.0566 0.0731
Onchocerca volvulus 0.0048 0.0107 0.0944
Schistosoma mansoni sugar transporter 0.0062 0.0184 0.0238
Onchocerca volvulus Putative transporter 0.0062 0.0184 0.1627
Onchocerca volvulus 0.0238 0.1133 1
Trichomonas vaginalis CAMK family protein kinase 0.0136 0.0581 0.2438
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0032 0.0041
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0136 0.0581 0.3888
Plasmodium falciparum calcium-dependent protein kinase 1 0.0136 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0136 0.0581 0.2592
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.059 0.248
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0136 0.0581 0.0879
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1421 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.059 0.3956
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0162 0.0722
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0069 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1421 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.0184 0.1304
Echinococcus multilocularis lysyl tRNA synthetase 0.0099 0.0382 0.0494
Loa Loa (eye worm) beta-lactamase 0.0037 0.0046 0.0204
Echinococcus granulosus chromobox protein 1 0.0067 0.0211 0.0273
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Brugia malayi beta-lactamase family protein 0.0037 0.0046 0.0204
Loa Loa (eye worm) sugar transporter 0.0444 0.224 1
Trypanosoma cruzi hexose transporter, putative 0.0138 0.059 0.3956
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.012 0.0155
Trichomonas vaginalis glucose transporter, putative 0.0138 0.059 0.248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0069 0.0172
Leishmania major protein kinase, putative 0.0136 0.0581 0.3888
Brugia malayi Sugar transporter family protein 0.0444 0.224 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.012 0.0534
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Brugia malayi Latrophilin receptor protein 2 0.005 0.012 0.0534
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0136 0.0581 0.0581
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0346 0.0447
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0685 0.4645
Schistosoma mansoni protein kinase 0.0136 0.0581 0.075
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0133 0.0566 0.237
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0067 0.0097
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0032 0.0041
Schistosoma mansoni chromobox protein 0.0067 0.0211 0.0273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.001 0.0015
Trypanosoma cruzi glucose transporter, putative 0.0062 0.0184 0.1009
Onchocerca volvulus 0.0062 0.0184 0.1627
Brugia malayi Heterochromatin protein 1 0.0067 0.0211 0.0942
Brugia malayi Sugar transporter family protein 0.0062 0.0184 0.0823
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.0184 0.1009
Loa Loa (eye worm) hypothetical protein 0.0159 0.0706 0.3154
Plasmodium falciparum mitogen-activated protein kinase 2 0.0717 0.3713 0.3713
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Echinococcus granulosus solute carrier family 22 0.0062 0.0184 0.0238
Trypanosoma brucei glucose transporter 1E 0.0138 0.059 0.3956
Trichomonas vaginalis conserved hypothetical protein 0.0444 0.224 1
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.012 0.0155
Trypanosoma cruzi hexose transporter 0.0138 0.059 0.3956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Giardia lamblia Lysyl-tRNA synthetase 0.0099 0.0382 0.6753
Loa Loa (eye worm) sugar transporter 0.0062 0.0184 0.0823
Echinococcus multilocularis solute carrier family 22 0.0062 0.0184 0.0238
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0184 0.0823
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0099 0.0382 0.2445
Plasmodium vivax calcium-dependent protein kinase, putative 0.0136 0.0581 0.0581
Schistosoma mansoni glucose transport protein 0.0444 0.224 0.2896
Toxoplasma gondii lysine-tRNA ligase 0.0099 0.0382 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Leishmania major glucose transporter/membrane transporter D2, putative 0.0138 0.059 0.3956
Giardia lamblia Prolyl-tRNA synthetase 0.0133 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0034
Trypanosoma cruzi hexose transporter, putative 0.0138 0.059 0.3956
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0136 0.0581 0.2592
Brugia malayi hypothetical protein 0.0062 0.0184 0.0823
Plasmodium vivax SET domain protein, putative 0.003 0.001 0.001
Plasmodium falciparum lysine--tRNA ligase 0.0099 0.0382 0.0382
Echinococcus granulosus solute carrier family 22 0.0062 0.0184 0.0238
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0593 0.3976
Brugia malayi chromobox protein homolog 3 0.0038 0.0052 0.023
Plasmodium falciparum calcium-dependent protein kinase 5 0.0136 0.0581 0.0581
Plasmodium vivax hexose transporter 0.0444 0.224 0.224
Onchocerca volvulus 0.0062 0.0184 0.1627
Schistosoma mansoni glucose transporter 0.0062 0.0184 0.0238
Schistosoma mansoni hypothetical protein 0.005 0.012 0.0155
Onchocerca volvulus 0.0037 0.0046 0.0403
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1133 0.4957
Loa Loa (eye worm) hypothetical protein 0.0108 0.0431 0.1925
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0184 0.1009
Echinococcus multilocularis solute carrier family 22 0.0062 0.0184 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0052 0.0027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0069 0.0172
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0062 0.0184 0.0184
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0717 0.3713 0.5621
Plasmodium falciparum hexose transporter 0.0444 0.224 0.224
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0977 0.4364
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0184 0.0633
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1117 0.1444
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0184 0.0823
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0055 0.0143 0.0637
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0155 0.0685 0.4645
Echinococcus granulosus microtubule associated protein 2 0.1463 0.7736 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0717 0.3713 0.3713
Schistosoma mansoni survival motor neuron protein 0.0048 0.0107 0.0138
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.0706 0.3154
Mycobacterium ulcerans hypothetical protein 0.0154 0.0677 1
Leishmania major lysyl-tRNA synthetase, putative 0.0099 0.0382 0.2445
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0046 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0052 0.0027
Loa Loa (eye worm) hypothetical protein 0.005 0.012 0.0534
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0069 0.0172
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0099 0.0382 0.1533
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.0184 0.0633
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0032 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0685 0.4645
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0236 0.0305
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0685 0.4645
Schistosoma mansoni hypothetical protein 0.0072 0.0236 0.0305
Onchocerca volvulus 0.0062 0.0184 0.1627
Onchocerca volvulus 0.0062 0.0184 0.1627
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0133 0.0566 0.2526
Leishmania major glucose transporter, lmgt3 0.0138 0.059 0.3956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0136 0.0581 0.075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.001 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0211 0.0754
Brugia malayi Cam kinase protein 1 0.0136 0.0581 0.2592
Schistosoma mansoni protein kinase 0.0136 0.0581 0.075
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0581 0.075
Schistosoma mansoni protein kinase 0.0136 0.0581 0.075
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Echinococcus multilocularis General substrate transporter 0.0381 0.1904 0.2461
Schistosoma mansoni hypothetical protein 0.0109 0.0435 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Onchocerca volvulus 0.0062 0.0184 0.1627
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0136 0.0581 0.0581
Brugia malayi beta-lactamase family protein 0.0037 0.0046 0.0204
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0236 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0138 0.059 0.248
Onchocerca volvulus 0.0062 0.0184 0.1627
Schistosoma mansoni sugar transporter 0.0062 0.0184 0.0238
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0099 0.0382 0.6468
Onchocerca volvulus 0.0037 0.0046 0.0403
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Plasmodium falciparum protein kinase 7 0.1253 0.6606 0.6606
Brugia malayi jmjC domain containing protein 0.0092 0.0346 0.1543
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0099 0.0382 0.2445
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0118 0.0524
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.007 0.009
Onchocerca volvulus 0.0037 0.0046 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0046 0.0046
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.0184 0.2199
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0211 0.0754
Schistosoma mansoni hypothetical protein 0.005 0.012 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.012 0.0155
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Trichomonas vaginalis sugar transporter, putative 0.0138 0.059 0.248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.023
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0136 0.0581 0.2592
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.0184 0.0238
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0032 0.0143
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0084 0.0302 0.2404
Leishmania major glucose transporter, lmgt2 0.0138 0.059 0.3956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Leishmania major glucose transporter, lmgt1 0.0138 0.059 0.3956
Onchocerca volvulus 0.0062 0.0184 0.1627
Onchocerca volvulus 0.003 0.0008 0.0067
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.0184 0.2199
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Echinococcus granulosus General substrate transporter 0.0381 0.1904 0.2461
Plasmodium vivax CDK-related protein kinase 6, putative 0.1883 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0211 0.0942
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.0184 0.1304
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Schistosoma mansoni glucose transport protein 0.0444 0.224 0.2896
Onchocerca volvulus 0.0062 0.0184 0.1627
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0133 0.0566 0.957
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.001 0.0013
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.0184 0.0238
Onchocerca volvulus 0.0062 0.0184 0.1627
Brugia malayi beta-lactamase 0.0037 0.0046 0.0204
Onchocerca volvulus 0.0062 0.0184 0.1627
Toxoplasma gondii sugar transporter ST2 0.0062 0.0184 0.0279
Schistosoma mansoni sugar transporter 0.0062 0.0184 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0059 0.0077
Schistosoma mansoni glucose transport protein 0.0444 0.224 0.2896
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Brugia malayi hypothetical protein 0.0235 0.1117 0.4988
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1117 0.1444
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0133 0.0566 0.0731
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0046 0.0204
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0581 0.075
Loa Loa (eye worm) hypothetical protein 0.0133 0.0566 0.2526
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0107 0.0478
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0136 0.0581 0.0581
Toxoplasma gondii ABC1 family protein 0.0037 0.0046 0.0069
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.001 0.0013
Toxoplasma gondii sugar transporter ST1 0.0062 0.0184 0.0279
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1421 1
Onchocerca volvulus 0.0062 0.0184 0.1627
Brugia malayi jmjC domain containing protein 0.0034 0.0032 0.0143
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0243 0.0315
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0346 0.0447
Treponema pallidum prolyl-tRNA synthetase 0.0047 0.0102 0.5
Schistosoma mansoni microtubule-associated protein tau 0.1463 0.7736 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0593 0.3976
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0155 0.0685 0.4645
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.111 1
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0435 0.1941
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.0184 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0593 0.3976
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0236 0.0305
Brugia malayi hypothetical protein 0.0062 0.0184 0.0823
Toxoplasma gondii hypothetical protein 0.0047 0.0102 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Mycobacterium ulcerans sugar transporter 0.0062 0.0184 0.2199
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0046 0.0059
Echinococcus granulosus solute carrier family 22 0.0062 0.0184 0.0238
Echinococcus granulosus lysyl tRNA synthetase 0.0099 0.0382 0.0494
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0059 0.0077
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0067 0.0097
Echinococcus multilocularis microtubule associated protein 2 0.1463 0.7736 1
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.059 0.248
Onchocerca volvulus 0.0041 0.007 0.0613
Loa Loa (eye worm) hypothetical protein 0.0235 0.1117 0.4988
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0382 0.5329
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.0184 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0184 0.0633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0013
Schistosoma mansoni chromobox protein 0.0067 0.0211 0.0273
Schistosoma mansoni sugar transporter 0.0062 0.0184 0.0238
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0067 0.0591
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.059 0.3956
Echinococcus multilocularis GPCR, family 2 0.005 0.012 0.0155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0052 0.0455
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0046 0.0059
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0382 0.5329
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0046 0.0204
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.224 0.2896
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0184 0.0633
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0032 0.0041
Giardia lamblia Sugar-proton symporter 0.0062 0.0184 0.326
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.0184 0.2199
Loa Loa (eye worm) hypothetical protein 0.0133 0.0566 0.2526
Plasmodium vivax lysine--tRNA ligase, putative 0.0099 0.0382 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0184 0.0633
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0133 0.0566 1
Trypanosoma brucei sugar transporter, putative 0.0062 0.0184 0.1009
Schistosoma mansoni hypothetical protein 0.005 0.012 0.0155
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0302 0.2404
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0382 0.0494
Toxoplasma gondii facilitative glucose transporter GT1 0.0444 0.224 0.3391
Onchocerca volvulus 0.0062 0.0184 0.1627
Schistosoma mansoni hypothetical protein 0.0444 0.224 0.2896
Toxoplasma gondii protein kinase, putative 0.1253 0.6606 1
Trypanosoma brucei glucose transporter, putative 0.0138 0.059 0.3956
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1421 1
Giardia lamblia Hexose transporter 0.0062 0.0184 0.326
Plasmodium falciparum calcium-dependent protein kinase 4 0.0136 0.0581 0.0581
Toxoplasma gondii sugar transporter ST3 0.0062 0.0184 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0823

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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