Detailed information for compound 74108

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 477.393 | Formula: C20H26Cl2N10--
  • H donors: 4 H acceptors: 0 LogP: 1.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1=NC(N(C(=N1)N)c1cccc2c1cccc2N1C(=NC(=NC1(C)C)N)N)(C)C.[Cl-].[Cl-]
  • InChi: 1S/C20H26N10.2ClH/c1-19(2)27-15(21)25-17(23)29(19)13-9-5-8-12-11(13)7-6-10-14(12)30-18(24)26-16(22)28-20(30,3)4;;/h5-10H,1-4H3,(H4,21,23,25,27)(H4,22,24,26,28);2*1H/p-2
  • InChiKey: DCABCCOTZBDKFJ-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0455 0.3023
Schistosoma mansoni coup transcription factor 0.001 0.001 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0077 0.028
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.049
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni ran 0.0021 0.0065 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.007 0.0069
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.001 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.003 0.0072
Schistosoma mansoni glutaminase 0.028 0.1395 0.6968
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0022 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0534
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0455 0.1681
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.007 0.0256
Toxoplasma gondii RNA-directed DNA polymerase 0.0534 0.2699 1
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0098 0.0097
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Loa Loa (eye worm) helicase 0.0023 0.0077 0.0503
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0093 0.0613
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.028 0.1392
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.007 0.0496
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0455 0.0626
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0161 0.3529
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0204 0.1456
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0678
Plasmodium falciparum telomerase reverse transcriptase 0.0534 0.2699 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0424
Loa Loa (eye worm) steroid hormone receptor 0.001 0.001 0.0059
Plasmodium vivax telomerase reverse transcriptase, putative 0.0534 0.2699 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trypanosoma brucei unspecified product 0.0024 0.008 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma brucei unspecified product 0.0027 0.0098 0.036
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0077 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0152 0.0559
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0103 0.0377
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0152 0.0753
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0645
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus granulosus FTZ F1 alpha 0.001 0.001 0.0045
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0016 0.0037
Echinococcus granulosus muscleblind protein 0.0149 0.0722 0.3603
Leishmania major metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Plasmodium falciparum importin beta, putative 0.0028 0.0103 0.0377
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0077 0.0187
Onchocerca volvulus 0.0011 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.1082
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0161 0.0221
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0098 0.049
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1501 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.1989
Leishmania major ribonuclease H1, putative 0.0022 0.007 0.0256
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0152 0.1005
Brugia malayi Importin beta-1 subunit 0.0028 0.0103 0.014
Echinococcus multilocularis caspase 0.0027 0.0098 0.024
Loa Loa (eye worm) carboxylesterase 0.0066 0.03 0.1989
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.001 0.0052
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0093 0.0466
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0022 0.0075
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0077 0.0104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0245 0.175
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0161 0.0806
Mycobacterium tuberculosis Probable oxidoreductase 0.0306 0.1529 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0793
Loa Loa (eye worm) glutaminase 2 0.028 0.1395 0.9289
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0077 0.0377
Loa Loa (eye worm) carboxylesterase 0.0011 0.0016 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0012
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0359
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.0024 0.1777
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0152 1
Brugia malayi Telomerase reverse transcriptase 0.142 0.725 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0127 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0098 0.049
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.4036 1
Trichomonas vaginalis hypothetical protein 0.0023 0.0077 0.0542
Onchocerca volvulus 0.001 0.001 0.0009
Echinococcus granulosus Chromo domain 0.0023 0.0077 0.0377
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0098 0.0359
Giardia lamblia DINP protein human, muc B family 0.0039 0.0161 0.0593
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0065 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0127 0.082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0112 0.0793
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0161 0.1149
Loa Loa (eye worm) hypothetical protein 0.0066 0.0295 0.1959
Loa Loa (eye worm) hypothetical protein 0.0149 0.0722 0.4806
Schistosoma mansoni hypothetical protein 0.0333 0.1666 0.8323
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Echinococcus multilocularis FTZ F1 alpha 0.001 0.001 0.0022
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0022 0.0075
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.03 0.1989
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Echinococcus granulosus caspase 8 0.0027 0.0098 0.0483
Schistosoma mansoni cpg binding protein 0.0059 0.0263 0.1316
Schistosoma mansoni kinase 0.0049 0.0211 0.1053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0142 0.101
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.003 0.0072
Echinococcus multilocularis caspase 8 0.0027 0.0098 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.049
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.001 0.0052
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0455 0.1681
Brugia malayi SET domain containing protein 0.0024 0.0083 0.0113
Echinococcus granulosus chromobox protein 2 0.0023 0.0077 0.0377
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0016 0.0074
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0236
Echinococcus multilocularis cpg binding protein 0.0059 0.0263 0.0649
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.03 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Echinococcus granulosus chromobox protein 1 0.0141 0.0681 0.3396
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.1989
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0152 0.0559
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0681 0.4876
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0645
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0093 0.0228
Loa Loa (eye worm) heterochromatin protein 1 0.0141 0.0681 0.4529
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0016 0.0107
Echinococcus granulosus caspase 0.0027 0.0098 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0359
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0146 0.3196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0048 0.0232
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0016 0.0074
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni chromobox protein 0.0023 0.0077 0.0384
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0001 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.001 0.0022
Brugia malayi polk-prov protein 0.0012 0.0022 0.0028
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0722 0.1787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0077 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.001 0.0045
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0077 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0245 0.175
Trypanosoma brucei Metacaspase-4 0.0027 0.0098 0.0359
Trypanosoma brucei unspecified product 0.0027 0.0098 0.036
Schistosoma mansoni hypothetical protein 0.0398 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0363 0.2414
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0022 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Schistosoma mansoni chromobox protein 0.0141 0.0681 0.3401
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0077 0.028
Echinococcus multilocularis snurportin 1 0.03 0.1501 0.3718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.007 0.4583
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trypanosoma brucei ribonuclease H1 0.0022 0.007 0.0256
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0161 0.0806
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Entamoeba histolytica hypothetical protein 0.0023 0.0076 0.1641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.003 0.0144
Giardia lamblia Kinase, PLK 0.0097 0.0455 0.1681
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0077 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0155 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0012
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0161 0.1149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0152 0.0374
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0048 0.0115
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0731
Trichomonas vaginalis helicase, putative 0.0013 0.0024 0.0162
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0016 0.0074
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0077 0.028
Echinococcus granulosus neuroligin 0.0011 0.0016 0.0074
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0161 0.0397
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Echinococcus granulosus importin subunit beta 1 0.0028 0.0103 0.0509
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0247 0.1637
Echinococcus multilocularis chromobox protein 1 0.0141 0.0681 0.1684
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.001 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.001 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0295 0.0405
Plasmodium falciparum metacaspase-like protein 0.0027 0.0098 0.0359
Onchocerca volvulus 0.0011 0.0016 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0152 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Loa Loa (eye worm) hypothetical protein 0.0062 0.0276 0.1831
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.028 0.1398
Brugia malayi hypothetical protein 0.0011 0.0016 0.0021
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.0052
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0022 0.0075
Brugia malayi CHD4 protein 0.0026 0.0093 0.0127
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0001 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0161 0.08
Leishmania major importin beta-1 subunit, putative 0.0023 0.0076 0.0276
Echinococcus multilocularis Chromo domain 0.0023 0.0077 0.0187
Leishmania major DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus multilocularis caspase 2 0.0027 0.0098 0.024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0559
Plasmodium vivax importin-beta 2, putative 0.0028 0.0103 0.0377
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0012
Trypanosoma brucei telomerase reverse transcriptase 0.0534 0.2699 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0022 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.008 0.0291
Echinococcus granulosus dna polymerase eta 0.0066 0.0295 0.1469
Schistosoma mansoni chromobox protein 0.0141 0.0681 0.3401
Mycobacterium ulcerans glutaminase 0.028 0.1395 0.9123
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0065 0.0236
Echinococcus multilocularis acetylcholinesterase 0.0066 0.03 0.074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0306 0.1529 1
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0077 0.028
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Leishmania major DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0045
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.076
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0152 0.0208
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0016 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.0377
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.076
Echinococcus multilocularis chromobox protein 2 0.0023 0.0077 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.001 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Onchocerca volvulus 0.0023 0.0077 0.0075
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0016 0.0098
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Brugia malayi Protein cec-1. 0.0023 0.0077 0.0104
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Plasmodium vivax metacaspase 1, putative 0.0027 0.0098 0.0359
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Echinococcus multilocularis neuroligin 0.0011 0.0016 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0077 0.028
Echinococcus granulosus acetylcholinesterase 0.0066 0.03 0.1492
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0045
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0077 0.0542
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0022 0.0075
Loa Loa (eye worm) carboxylesterase 0.0011 0.0016 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.001 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0083 0.0415
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0161 0.1048
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.1082
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0103 0.0252
Brugia malayi Inositol-1 0.0037 0.0146 0.02
Schistosoma mansoni hypothetical protein 0.0333 0.1666 0.8323
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0455 0.1124
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0394 0.2819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.001 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.001 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Schistosoma mansoni chromobox protein 0.0023 0.0077 0.0384
Brugia malayi Carboxylesterase family protein 0.0066 0.03 0.0412
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Brugia malayi steroid hormone receptor 0.001 0.001 0.0012
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0001 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.065 0.1607
Brugia malayi hypothetical protein 0.0023 0.0077 0.0104
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Giardia lamblia DNA damage repair protein 0.0012 0.0022 0.0075
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0022 0.0075
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0295 0.109
Schistosoma mansoni gliotactin 0.0011 0.0016 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.0377
Schistosoma mansoni hypothetical protein 0.03 0.1501 0.75
Onchocerca volvulus Bile acid receptor homolog 0.001 0.001 0.0009
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0098 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0455 0.1681
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0152 0.0559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0022
Echinococcus multilocularis acetylcholinesterase 0.0066 0.03 0.074
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0161 0.1048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0534
Brugia malayi Cell death protein 3 precursor 0.0027 0.0098 0.0133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0505 0.1867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.001 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Echinococcus granulosus Chromobox protein 3 0.0023 0.0077 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.001 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.001 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.001 0.0059
Leishmania major telomerase reverse transcriptase, putative 0.0534 0.2699 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0161 0.1048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.001 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Brugia malayi CXXC zinc finger family protein 0.0056 0.0247 0.0339
Echinococcus multilocularis ribonuclease H1 0.0022 0.007 0.0171
Echinococcus multilocularis geminin 0.0333 0.1666 0.4126
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.001 0.0052
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0146 0.0537
Trypanosoma brucei metacaspase MCA3 0.0027 0.0098 0.0359
Echinococcus multilocularis muscleblind protein 0.0149 0.0722 0.1787
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0048 0.031
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.001 0.0022
Giardia lamblia Telomerase catalytic subunit 0.0534 0.2699 1
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0022 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0022 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.065 0.1607
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.03 0.1498
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0161 0.1067
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Brugia malayi RNA, U transporter 1 0.008 0.037 0.0508
Echinococcus multilocularis dna polymerase eta 0.0066 0.0295 0.0728
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.001 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.001 0.0059
Brugia malayi Carboxylesterase family protein 0.0066 0.03 0.0412
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2002 0.4959
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0142 0.101
Schistosoma mansoni hypothetical protein 0.0082 0.0378 0.1888
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0077 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0107 0.0759
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0455 1
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.008 0.0291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.001 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0204 0.1456
Schistosoma mansoni ran 0.0021 0.0065 0.0325
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0016 0.0098
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0455 0.2267
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0016 0.0037
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0024 0.0146
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0155 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.001 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.001 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.065 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Trypanosoma brucei RNA helicase, putative 0.0082 0.0378 0.1396
Echinococcus granulosus ribonuclease H1 0.0022 0.007 0.0345
Schistosoma mansoni hypothetical protein 0.0023 0.0077 0.0384
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0146 0.0725
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0152 0.0987
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0016 0.0037
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0455 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0363 0.2598
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Toxoplasma gondii ribonuclease HI protein 0.0022 0.007 0.0256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0022
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0022 0.0075
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.003 0.0144
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Trypanosoma brucei metacaspase 0.0027 0.0098 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Schistosoma mansoni cpg binding protein 0.0056 0.0247 0.1234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Onchocerca volvulus 0.0011 0.0016 0.0015
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0016 0.0081
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0076 0.0534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.065 0.4321
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.0052
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0016 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.028 0.1824
Echinococcus multilocularis chromobox protein 1 0.0141 0.0681 0.1684
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0065 0.0236
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0146 0.0359
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Brugia malayi ecdysteroid receptor 0.001 0.001 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0152 0.0987
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0559
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0158 0.077 0.5029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0016 0.0098
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0098 0.024
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0394 0.0393
Schistosoma mansoni importin beta-1 0.0028 0.0103 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0077 0.028
Echinococcus granulosus acetylcholinesterase 0.0066 0.03 0.1492
Onchocerca volvulus 0.0023 0.0077 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Onchocerca volvulus 0.0062 0.0276 0.0275
Plasmodium falciparum metacaspase 1 0.0027 0.0098 0.0359
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0455 0.2272
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.065 0.324
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.001 0.0059
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0681 0.4876
Schistosoma mansoni DNA polymerase eta 0.0066 0.0295 0.1475
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Leishmania major DNA polymerase eta, putative 0.0066 0.0295 0.109
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.008 0.0291
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.007 0.0256
Loa Loa (eye worm) inositol-1 0.0037 0.0146 0.0966
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.003 0.0151
Trypanosoma brucei polo-like protein kinase 0.0097 0.0455 0.1681
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.0024 0.0146
Echinococcus granulosus chromobox protein 1 0.0141 0.0681 0.3396
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0161 0.0593
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0077 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.001 0.0012
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.008 0.0291
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0731
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0146 0.9617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.001 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.001 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.001 0.0012
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.001 0.0045
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0534 0.2699 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.0542
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Leishmania major GTP-binding protein, putative 0.0021 0.0065 0.0236
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0295 0.109
Brugia malayi glutaminase DH11.1 0.028 0.1395 0.1922
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0077 0.0384
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0065 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.065 0.324
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0001 0.0007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0236
Onchocerca volvulus 0.0024 0.0083 0.0082
Trichomonas vaginalis ran, putative 0.0021 0.0065 0.0457
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0077 0.028
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0022 0.0108
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0076 0.0276
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus granulosus dna polymerase kappa 0.0039 0.0161 0.08
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0363 0.0362
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0146 0.104
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0047 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0045
Trypanosoma brucei metacaspase MCA2 0.0027 0.0098 0.0359
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.028 0.1033
Onchocerca volvulus 0.0011 0.0016 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0559
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0012
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Schistosoma mansoni acetylcholinesterase 0.0011 0.0016 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0559
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0394 0.2819
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.028 0.1398
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0016 0.0098
Toxoplasma gondii exonuclease III APE 0.0038 0.0152 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0363 0.2598
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Brugia malayi chromobox protein homolog 3 0.0079 0.0363 0.05
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0022 0.0075
Trypanosoma brucei unspecified product 0.0039 0.0161 0.0593
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.0542
Brugia malayi Muscleblind-like protein 0.0149 0.0722 0.0994
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.001 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Echinococcus granulosus geminin 0.0333 0.1666 0.8322
Schistosoma mansoni cpg binding protein 0.0059 0.0263 0.1316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Leishmania major DNA damage repair protein, putative 0.0012 0.0022 0.0075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.104
Loa Loa (eye worm) glutaminase 0.028 0.1395 0.9289
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0161 0.0397
Echinococcus granulosus caspase 2 0.0027 0.0098 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0534 0.2699 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.001 0.001 0.0012
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0077 0.028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0152 0.3323
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.028 0.069
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0098 0.0359
Brugia malayi Heterochromatin protein 1 0.0141 0.0681 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Mycobacterium ulcerans hypothetical protein 0.0012 0.0022 0.0132
Echinococcus granulosus snurportin 1 0.03 0.1501 0.7498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Leishmania major DNA polymerase eta, putative 0.0038 0.0155 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.028 0.1033
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.001 0.0022
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0077 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Onchocerca volvulus 0.0011 0.0016 0.0015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Echinococcus granulosus carboxylesterase 5A 0.0066 0.03 0.1492
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Mycobacterium ulcerans epoxide hydrolase EphA 0.0158 0.077 0.5029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.057 0.2848
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0093 0.0459
Entamoeba histolytica Ran family GTPase 0.0021 0.0065 0.1403
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0022 0.0075
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0146 0.0949
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Echinococcus granulosus cpg binding protein 0.0059 0.0263 0.131
Trichomonas vaginalis glutaminase, putative 0.028 0.1395 1
Giardia lamblia Ribonuclease H 0.0022 0.007 0.0256
Loa Loa (eye worm) hypothetical protein 0.0149 0.0722 0.4806
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0098 0.0483
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Onchocerca volvulus 0.0056 0.0247 0.0246
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0161 0.1048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0088

Activities

Activity type Activity value Assay description Source Reference
Delta MST (functional) = -0.3 day Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 424 mg/kg,administered subcutaneously ChEMBL. 4067999
Delta MST (functional) = 0 day Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 106 mg/kg administered subcutaneously ChEMBL. 4067999
Delta MST (functional) = 0 day Anti-trypanosomal activity against Trypanosoma rhodesiense infections in mice, 26 mg/kg administered subcutaneously ChEMBL. 4067999
Toxic (functional) = 3 Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 424 mg/kg,administered subcutaneously;Toxic ChEMBL. 4067999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.