Detailed information for compound 755563

Basic information

Technical information
  • TDR Targets ID: 755563
  • Name: ethyl 4-[[3-[4-(trifluoromethyl)phenyl]-1,2,4 -oxadiazol-5-yl]methyl]piperazine-1-carboxyla te
  • MW: 384.353 | Formula: C17H19F3N4O3
  • H donors: 0 H acceptors: 3 LogP: 2.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCN(CC1)Cc1onc(n1)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C17H19F3N4O3/c1-2-26-16(25)24-9-7-23(8-10-24)11-14-21-15(22-27-14)12-3-5-13(6-4-12)17(18,19)20/h3-6H,2,7-11H2,1H3
  • InChiKey: KZQBLKVEZYQDPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinecarboxylic acid ethyl ester
  • 4-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]piperazine-1-carboxylic acid ethyl ester
  • BAS 15443606

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0141 0.054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Echinococcus granulosus cpg binding protein 0.0031 0.0185 0.0707
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0337 0.2128
Echinococcus granulosus snurportin 1 0.0318 0.2301 0.8795
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0163 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0346 0.1505
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0346 0.1505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.1287
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0346 0.2189
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.002 0.0077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0346 0.1323
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Brugia malayi hypothetical protein 0.0025 0.0141 0.0894
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0346 0.1323
Trichomonas vaginalis helicase, putative 0.0007 0.0007 0.0039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0346 0.1323
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0346 0.2189
Leishmania major importin beta-1 subunit, putative 0.0024 0.0136 0.9235
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0163 0.071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0346 0.1323
Schistosoma mansoni hypothetical protein 0.0048 0.0314 0.12
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.108
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1022 0.6463
Brugia malayi steroid hormone receptor 0.0053 0.0346 0.2189
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0314 0.1364
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1582 0.6874
Brugia malayi conserved hypotetical protein 0.0025 0.0141 0.0894
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0032 0.0205
Loa Loa (eye worm) DR-78 0.0025 0.0141 0.0614
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.071
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0271 0.1037
Loa Loa (eye worm) hypothetical protein 0.0104 0.0726 0.3157
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.071
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0141 0.054
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0141 0.054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0141 0.054
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0163 0.0624
Trichomonas vaginalis ran, putative 0.0022 0.012 0.0665
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1364 1 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1082 0.4702
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0346 0.1323
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0141 0.054
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.014 0.0536
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0346 0.1323
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1022 0.3908
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.012 0.0459
Plasmodium falciparum importin beta, putative 0.003 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.014 0.0536
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.071
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.014 0.014
Schistosoma mansoni importin beta-1 0.003 0.0178 0.068
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0141 0.0894
Onchocerca volvulus 0.0032 0.0195 0.0324
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.0521
Leishmania major GTP-binding protein, putative 0.0022 0.012 0.8123
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0141 0.054
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.012 0.012
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.012 0.6744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0346 0.1323
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0033 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0337 0.1287
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0141 0.054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0314 0.1985
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0992 0.3794
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.014 0.3516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0346 0.2189
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0271 0.1503
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1364 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0346 0.1505
Entamoeba histolytica hypothetical protein 0.0108 0.0752 0.5953
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0346 0.1323
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.014 0.0886
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0346 0.1323
Brugia malayi ecdysone receptor 0.0025 0.0141 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0346 0.2189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0195 0.0849
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0141 0.0614
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0141 0.0894
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0346 0.1231
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0163 0.1032
Echinococcus granulosus tumor protein p63 0.0357 0.2586 0.9886
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0178 1
Trichomonas vaginalis chaperonin, putative 0.0025 0.014 0.0777
Brugia malayi nuclear receptor RXR 0.0028 0.0163 0.1032
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0141 0.0614
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0182 0.0696
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Plasmodium vivax importin-beta 2, putative 0.003 0.0178 0.0178
Loa Loa (eye worm) T-complex protein 1 0.0025 0.014 0.0609
Schistosoma mansoni hypothetical protein 0.0048 0.0314 0.12
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0195 0.0747
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Schistosoma mansoni nuclear receptor 0.0025 0.0141 0.054
Echinococcus multilocularis geminin 0.0361 0.2616 1
Echinococcus multilocularis snurportin 1 0.0318 0.2301 0.8795
Echinococcus multilocularis GPCR, family 2 0.0048 0.0314 0.12
Brugia malayi Pre-SET motif family protein 0.0221 0.1582 1
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0141 0.0614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0314 0.12
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0346 0.1323
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0346 0.1231
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0346 0.1323
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0399 1
Entamoeba histolytica hypothetical protein 0.0108 0.0752 0.5953
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0726 0.4592
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.2301 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0346 0.2189
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0195 0.4898
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0141 0.054
Onchocerca volvulus 0.0251 0.1805 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.002 0.0077
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.014 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0195 0.0747
Entamoeba histolytica fatty acid elongase, putative 0.0177 0.1263 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0421 0.161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.1287
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0346 0.2189
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.012 0.3009
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.014 0.014
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0195 0.0747
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0314 0.1985
Leishmania major hypothetical protein, conserved 0.0026 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0642
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0163 0.0624
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0346 0.1323
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0346 0.1323
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0346 0.1323
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0141 0.054
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0346 0.1323
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0173 0.075
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0136 0.0756
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.014 0.0777
Brugia malayi CXXC zinc finger family protein 0.0029 0.0173 0.1091
Echinococcus granulosus importin subunit beta 1 0.003 0.0178 0.068
Schistosoma mansoni cpg binding protein 0.0031 0.0185 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0195 0.0747
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0141 0.054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Brugia malayi nuclear receptor NHR-88 0.0053 0.0346 0.2189
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0141 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0007 0.0039
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0346 0.1323
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0346 0.1323
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.1082 0.6839
Entamoeba histolytica Ran family GTPase 0.0022 0.012 0.095
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0178 0.4461
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0346 0.1323
Entamoeba histolytica fatty acid elongase, putative 0.0177 0.1263 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1364 1 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0043 0.0166
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0752 0.2873
Brugia malayi Importin beta-1 subunit 0.003 0.0178 0.1125
Echinococcus multilocularis cpg binding protein 0.0031 0.0185 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0346 0.2189
Loa Loa (eye worm) histone methyltransferase 0.001 0.0033 0.0145
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0271 0.0271
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0166
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0271 0.6804
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0337 0.1287
Schistosoma mansoni hypothetical protein 0.0108 0.0752 0.2873
Onchocerca volvulus 0.0053 0.0346 0.1231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0141 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Brugia malayi hypothetical protein 0.0028 0.0163 0.1032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.1082 0.6839
Brugia malayi Pre-SET motif family protein 0.0032 0.0195 0.1235
Entamoeba histolytica hypothetical protein 0.0108 0.0752 0.5953
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0346 0.1323
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0346 0.1323
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0346 0.1323
Brugia malayi hypothetical protein 0.0028 0.0163 0.1032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0346 0.1505
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.002 0.0077
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.014 0.0886
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0346 0.1323
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0346 0.1323
Brugia malayi ecdysteroid receptor 0.0053 0.0346 0.2189
Brugia malayi hypothetical protein 0.0108 0.0752 0.4752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Brugia malayi tailless protein 0.0025 0.0141 0.0894
Loa Loa (eye worm) hypothetical protein 0.0052 0.0343 0.1491
Loa Loa (eye worm) hypothetical protein 0.003 0.0178 0.0773
Schistosoma mansoni hypothetical protein 0.0048 0.0314 0.12
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0346 0.2189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0245 0.1943
Schistosoma mansoni hypothetical protein 0.0361 0.2616 1
Brugia malayi hypothetical protein 0.0025 0.0141 0.0894
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0314 0.12
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0141 0.054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0337 0.1287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0136 0.0756
Schistosoma mansoni ran 0.0022 0.012 0.0459
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0148 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.002 0.0077
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.014 0.7881
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0178 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0346 0.1505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Echinococcus granulosus GPCR family 2 0.0048 0.0314 0.12
Schistosoma mansoni coup transcription factor 0.0053 0.0346 0.1323
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0314 0.12
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0343 0.1312
Schistosoma mansoni nuclear receptor 0.0025 0.0141 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.014 0.1111
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0136 0.5926
Onchocerca volvulus 0.0029 0.0173 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0271 0.1503
Brugia malayi hypothetical protein 0.0017 0.0081 0.051
Schistosoma mansoni cpg binding protein 0.0031 0.0185 0.0707
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0141 0.054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0346 0.2189
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.014 0.9492
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.071
Brugia malayi RNA, U transporter 1 0.0085 0.0582 0.3682
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0141 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0346 0.2189
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0346 0.1323
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.012 0.0759
Brugia malayi nuclear receptor NHR-88 0.0025 0.0141 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0346 0.2189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0346 0.2189
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0346 0.1231
Echinococcus multilocularis tumor protein p63 0.0357 0.2586 0.9886
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.1082 0.4702
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0141 0.054
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.014 0.0536
Schistosoma mansoni zinc finger protein 0.0025 0.0141 0.054
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0141 0.0894
Schistosoma mansoni hypothetical protein 0.0048 0.0314 0.12
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.014 0.1614
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1022 0.3908
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.012 0.0459
Brugia malayi nuclear hormone receptor 0.0025 0.0141 0.0894
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0043 0.0166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.002 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0314 0.12
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.1287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Plasmodium vivax SET domain protein, putative 0.0032 0.0195 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0346 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0346 0.2189
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1364 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0346 0.1323
Loa Loa (eye worm) hypothetical protein 0.0048 0.0314 0.1364
Schistosoma mansoni cpg binding protein 0.0029 0.0173 0.066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0346 0.1323
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1364 1 0.5
Entamoeba histolytica fatty acid elongase, putative 0.0177 0.1263 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0752 0.2873
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0245 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0346 0.1323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0195 0.0747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0141 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0195 0.0747
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0148 0.3704
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0346 0.1505
Entamoeba histolytica fatty acid elongase, putative 0.0177 0.1263 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0346 0.1505
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.071
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.014 0.0536
Schistosoma mansoni ran 0.0022 0.012 0.0459
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0136 0.0756
Loa Loa (eye worm) hypothetical protein 0.0053 0.0346 0.1505
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0346 0.2189
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0346 0.2189
Schistosoma mansoni hypothetical protein 0.0361 0.2616 1
Brugia malayi nuclear hormone receptor 0.0053 0.0346 0.2189
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0163 0.1032
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1364 1 0.5
Entamoeba histolytica fatty acid elongase, putative 0.0177 0.1263 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0337 0.1287
Brugia malayi nuclear receptor NHR-67 0.0025 0.0141 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0141 0.054
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.0148
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0752 0.2873
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0007 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1805 1
Echinococcus granulosus geminin 0.0361 0.2616 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 1
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.014 0.7294
Onchocerca volvulus 0.0052 0.0343 0.1212
Echinococcus multilocularis importin subunit beta 1 0.003 0.0178 0.068
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0141 0.0894
Entamoeba histolytica hypothetical protein 0.0108 0.0752 0.5953
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0033 0.0127
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0141 0.054
Schistosoma mansoni hypothetical protein 0.0318 0.2301 0.8795
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0346 0.2189
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0007 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0346 0.1323
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0346 0.1323
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0163 0.0624
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0337 0.1463
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0148 0.8302
Schistosoma mansoni hypothetical protein 0.0104 0.0726 0.2777
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0195 0.0747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0271 0.6804
Brugia malayi hypothetical protein 0.0026 0.0148 0.0934
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0614
Loa Loa (eye worm) acetyltransferase 0.0145 0.1022 0.4443
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0039
Brugia malayi nuclear receptor RXR 0.0025 0.0141 0.0894
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1364 1 0.5
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0346 0.1323

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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