Detailed information for compound 766757

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.289 | Formula: C14H16N2O2
  • H donors: 2 H acceptors: 2 LogP: 1.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CN=C(C(=O)N1)C=C(c1ccc(cc1)C)O
  • InChi: 1S/C14H16N2O2/c1-9-3-5-11(6-4-9)13(17)7-12-14(18)16-10(2)8-15-12/h3-7,10,17H,8H2,1-2H3,(H,16,18)
  • InChiKey: FGDQBHPBLLRSDR-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0036 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0194 0.0552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0375 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.0021 0.0124 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.3505 1
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1075 0.1075
Leishmania major hypothetical protein, conserved 0.0375 0.3505 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0194 0.183
Schistosoma mansoni zinc finger protein 0.0375 0.3505 0.3505
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0036 0.0036
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0408 0.0408
Trichomonas vaginalis ankyrin, putative 0.0019 0.0102 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0194 1
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0036 0.0036
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Brugia malayi RING finger protein 20 0.0019 0.0102 0.0102
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1546 0.1546
Trichomonas vaginalis hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0102 0.0102
Brugia malayi nuclear hormone receptor 0.0012 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0375 0.3505 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0375 0.3505 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1057 0.1057
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0019 0.0102 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Schistosoma mansoni mind bomb 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Schistosoma mansoni brg-1 associated factor 0.1053 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0036 0.0036
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0019 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0194 0.0552
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.0408 0.0408
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1053 1 1
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0019 0.0102 0.0102
Plasmodium vivax DNA repair protein RAD5, putative 0.0019 0.0102 0.0102
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0375 0.3505 0.3505
Trypanosoma cruzi hypothetical protein 0.0019 0.0102 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0194 1
Trichomonas vaginalis ankyrin, putative 0.0019 0.0102 0.0102
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0019 0.0102 0.0102
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1053 1 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0194 1
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0102 0.0291
Brugia malayi Neuralized family protein 0.0019 0.0102 0.0102
Leishmania major DNA repair protein-like protein 0.0019 0.0102 0.0291
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0019 0.0102 0.0102
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0194 0.183
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0194
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Schistosoma mansoni hypothetical protein 0.1053 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1053 1 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0019 0.0102 0.0102
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0019 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.0375 0.3505 1
Schistosoma mansoni RNA binding protein 0.0375 0.3505 0.3505
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.0102 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.018 0.1646 0.1646
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.0102 0.0102
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0019 0.0102 0.0291
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0113 0.5844
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Schistosoma mansoni ring finger protein 151 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Entamoeba histolytica hypothetical protein 0.0019 0.0102 0.0965
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Mycobacterium ulcerans hypothetical protein 0.0029 0.0194 1
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Plasmodium vivax zinc finger protein, putative 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Leishmania major hypothetical protein 0.0019 0.0102 0.0291
Trypanosoma cruzi hypothetical protein 0.0019 0.0102 0.0291
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Loa Loa (eye worm) hypothetical protein 0.0021 0.0124 0.0124
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0194 1
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.3505 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.3505 0.3505
Schistosoma mansoni patched 1 0.0051 0.0408 0.0408
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0194 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1057 0.1057
Giardia lamblia Zinc finger domain 0.0019 0.0102 0.5
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0375 0.3505 0.3505
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0375 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1057 0.1057
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Toxoplasma gondii hypothetical protein 0.0019 0.0102 0.0102
Plasmodium vivax trophozoite exported protein 1, putative 0.0019 0.0102 0.0102
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0408 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0036 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0036 0.0036
Echinococcus multilocularis muscleblind protein 0.018 0.1646 0.1646
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0375 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Onchocerca volvulus Protein neuralized homolog 0.0019 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0375 0.3505 0.3505
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Onchocerca volvulus Putative RING finger protein 207 0.0019 0.0102 0.0102
Schistosoma mansoni rnf5 0.0019 0.0102 0.0102
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0496 0.0496
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0036 0.0036
Brugia malayi Zinc finger protein 183 homolog 0.0019 0.0103 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0036 0.0036
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0375 0.3505 0.3505
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0036 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0036 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1546 0.1546
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0019 0.0102 0.0102
Toxoplasma gondii RING zinc finger protein 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0102 0.0102
Plasmodium falciparum zinc finger protein, putative 0.0019 0.0102 0.0102
Brugia malayi brahma associated protein 60 kDa 0.1053 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0036 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Brugia malayi ecdysteroid receptor 0.0012 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0019 0.0102 0.0965
Onchocerca volvulus RING finger protein 141 homolog 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Onchocerca volvulus 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0375 0.3505 0.3505
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0194 0.183
Loa Loa (eye worm) brahma associated protein 0.1053 1 1
Brugia malayi RING zinc finger protein 0.0019 0.0102 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0113 0.5844
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0019 0.0102 0.0102
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1057 0.1057
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0036 0.0036
Onchocerca volvulus 0.0029 0.0194 0.0194
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.0102 0.0102
Trichomonas vaginalis ion channel nompc, putative 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0036 0.0036
Plasmodium falciparum trophozoite exported protein 1 0.0019 0.0102 0.0102
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Schistosoma mansoni hypothetical protein 0.0049 0.039 0.039
Leishmania major hypothetical protein, conserved 0.0375 0.3505 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0036 0.0036
Onchocerca volvulus 0.0375 0.3505 0.3505
Giardia lamblia Kinase, NEK 0.0019 0.0102 0.5
Toxoplasma gondii helicase, putative 0.0019 0.0102 0.0102
Echinococcus granulosus GPCR family 2 0.0019 0.0102 0.0102
Echinococcus multilocularis GPCR, family 2 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0375 0.3505 0.3505
Trypanosoma brucei hypothetical protein, conserved 0.0375 0.3505 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0036 0.0036
Loa Loa (eye worm) RiNg Finger protein family member 0.0019 0.0103 0.0103
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0375 0.3505 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1053 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1053 1 1
Echinococcus granulosus zinc finger protein Ran binding 0.0375 0.3505 0.3505
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0019 0.0102 0.0102
Echinococcus granulosus ring finger protein 170 0.0019 0.0102 0.0102
Trypanosoma brucei predicted zinc finger protein 0.0019 0.0102 0.0291
Loa Loa (eye worm) hypothetical protein 0.0021 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0496 0.0496
Schistosoma mansoni TRABID protein (C64 family) 0.0375 0.3505 0.3505
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0375 0.3505 0.3505
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0019 0.0102 0.0102
Giardia lamblia Ribonuclease 0.0019 0.0102 0.5
Echinococcus granulosus cell growth regulator with ring finger domain 0.0019 0.0102 0.0102
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0375 0.3505 0.3505
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0019 0.0102 0.0102
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0375 0.3505 0.3505
Echinococcus multilocularis 0.0019 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0019 0.0102 0.0102
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Toxoplasma gondii hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0103
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0019 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.1053 1 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1053 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0036 0.0036
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Schistosoma mansoni peter pan-related 0.0019 0.0102 0.0102
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0036 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0124 0.0124
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0036 0.0036
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Echinococcus multilocularis ring and YY1 binding protein 0.0375 0.3505 0.3505
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0019 0.0102 0.0102
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi CHE-14 protein 0.0051 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0049 0.039 0.039
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0036 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Plasmodium falciparum RING zinc finger protein, putative 0.0019 0.0102 0.0102
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0036 0.0036
Trypanosoma cruzi WLM domain containing protein, putative 0.0375 0.3505 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0194 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0375 0.3505 0.3505
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0375 0.3505 1
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0036 0.0036
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi WLM domain containing protein, putative 0.0375 0.3505 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1053 1 1
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Plasmodium vivax RING zinc finger protein, putative 0.0019 0.0102 0.0102
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0124 0.6421
Schistosoma mansoni peter pan-related 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus ring and YY1 binding protein 0.0375 0.3505 0.3505
Echinococcus multilocularis protein dispatched 1 0.0058 0.0477 0.0477
Schistosoma mansoni hypothetical protein 0.0041 0.0313 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.006 0.0496 0.0496
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0375 0.3505 0.3505
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0036 0.0036
Loa Loa (eye worm) RING finger protein 20 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0113 0.5844
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus RING finger protein 185 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0194
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0036 0.0036
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0375 0.3505 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0036 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0313 0.0313
Brugia malayi Muscleblind-like protein 0.018 0.1646 0.1646
Schistosoma mansoni zinc finger protein 0.0019 0.0102 0.0102
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9292 0.9292
Brugia malayi SWIB/MDM2 domain containing protein 0.1053 1 1
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0019 0.0102 0.0102
Giardia lamblia Zinc finger domain 0.0019 0.0102 0.5
Onchocerca volvulus 0.0019 0.0102 0.0102
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0019 0.0102 0.5
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0036 0.0036
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0036 0.0036
Echinococcus granulosus muscleblind protein 0.018 0.1646 0.1646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0113 0.5844
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.1053 1 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0036 0.0036
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1053 1 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0408 0.0408
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1053 1 1
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Echinococcus multilocularis ring finger protein 113a 0.0019 0.0103 0.0103
Brugia malayi B-box zinc finger family protein 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0375 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.018 0.1646 0.1646
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Onchocerca volvulus 0.1053 1 1
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Chlamydia trachomatis SWIB complex protein 0.1053 1 1
Giardia lamblia Kinase, NEK 0.0019 0.0102 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Toxoplasma gondii hypothetical protein 0.0019 0.0102 0.0102
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0036 0.0036
Schistosoma mansoni coup transcription factor 0.0012 0.0036 0.0036
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0375 0.3505 0.3505
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0019 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0049 0.039 0.039
Toxoplasma gondii hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0124 0.0124
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0036 0.0036
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0375 0.3505 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0019 0.0102 0.0102
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0036 0.0036
Echinococcus multilocularis ring finger protein 170 0.0019 0.0102 0.0102
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0019 0.0102 0.0102
Echinococcus granulosus SWI:SNF matrix associated 0.1053 1 1
Trypanosoma brucei ring finger containing protein 0.0019 0.0102 0.0291
Brugia malayi steroid hormone receptor 0.0012 0.0036 0.0036
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0036 0.0036
Entamoeba histolytica SPRY domain protein 0.0019 0.0102 0.0965
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.0102 0.0965
Onchocerca volvulus 0.0375 0.3505 0.3505
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0375 0.3505 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0375 0.3505 1
Giardia lamblia Ser/Thr protein kinase 0.0019 0.0102 0.5
Trichomonas vaginalis ankyrin, putative 0.0019 0.0102 0.0102
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0019 0.0102 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0194 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1053 1 1
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Echinococcus multilocularis zinc finger protein Ran binding 0.0375 0.3505 0.3505
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0408 0.0408
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0019 0.0102 0.0102
Echinococcus multilocularis muscleblind protein 1 0.018 0.1646 0.1646
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0194 0.0194
Echinococcus multilocularis RING finger protein 185 0.0019 0.0102 0.0102
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0194 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0124 0.0124
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0124 0.6421
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0194 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0019 0.0102 0.0291
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0194 0.0194
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1053 1 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0988 0.0988
Schistosoma mansoni hypothetical protein 0.0049 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0102 0.0102
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0375 0.3505 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0194 1
Leishmania major hypothetical protein, unknown function 0.0019 0.0102 0.0291
Toxoplasma gondii ran binding protein 0.0375 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0036 0.0036
Brugia malayi nuclear receptor NHR-88 0.0012 0.0036 0.0036
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.0102 0.0102
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0019 0.0102 0.0102
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0375 0.3505 0.3505
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0102 0.0291
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0036 0.0036
Echinococcus granulosus ring finger protein 113a 0.0019 0.0103 0.0103
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Echinococcus multilocularis protein patched 0.0051 0.0408 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Giardia lamblia Kinase 0.0019 0.0102 0.5
Onchocerca volvulus 0.0019 0.0102 0.0102
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0019 0.0102 0.0291
Schistosoma mansoni fusion 0.0375 0.3505 0.3505
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0375 0.3505 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0036 0.0036
Echinococcus granulosus expressed conserved protein 0.0112 0.0988 0.0988
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.3505 1
Giardia lamblia Protein 21.1 0.0019 0.0102 0.5
Onchocerca volvulus 0.0012 0.0036 0.0036
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0019 0.0102 0.0291
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0019 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.1053 1 1
Giardia lamblia Hypothetical protein 0.0019 0.0102 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0036 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0194 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0194 0.0552
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0036
Brugia malayi YY1-associated factor 2 0.0375 0.3505 0.3505
Chlamydia trachomatis DNA topoisomerase I 0.1053 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0102 0.0102
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.1053 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0036 0.0036
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.0102 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0019 0.0102 0.0102
Onchocerca volvulus 0.0375 0.3505 0.3505

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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