Detailed information for compound 767705

Basic information

Technical information
  • TDR Targets ID: 767705
  • Name: (5Z)-5-[[5-(2-bromo-4-nitrophenyl)furan-2-yl] methylidene]-4-methyl-2,6-dioxopyridine-3-car bonitrile
  • MW: 428.193 | Formula: C18H10BrN3O5
  • H donors: 1 H acceptors: 5 LogP: 2.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(C)C(=Cc2ccc(o2)c2ccc(cc2Br)[N+](=O)[O-])C(=O)NC1=O
  • InChi: 1S/C18H10BrN3O5/c1-9-13(17(23)21-18(24)14(9)8-20)7-11-3-5-16(27-11)12-4-2-10(22(25)26)6-15(12)19/h2-7H,1H3,(H,21,23,24)/b13-7-
  • InChiKey: OGXHTJHESZHGNV-QPEQYQDCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[[5-(2-bromo-4-nitro-phenyl)-2-furyl]methylene]-4-methyl-2,6-dioxo-pyridine-3-carbonitrile
  • (5Z)-5-[[5-(2-bromo-4-nitrophenyl)-2-furyl]methylene]-4-methyl-2,6-dioxo-3-pyridinecarbonitrile
  • (5Z)-5-[[5-(2-bromo-4-nitro-phenyl)-2-furyl]methylene]-2,6-diketo-4-methyl-nicotinonitrile
  • (5Z)-5-[[5-(2-bromo-4-nitro-phenyl)furan-2-yl]methylidene]-4-methyl-2,6-dioxo-pyridine-3-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0525 0.051
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1327 0.6267
Loa Loa (eye worm) hypothetical protein 0.0105 0.2092 0.9926
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0145 0.0338
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0404 0.1021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0145 0.038
Schistosoma mansoni glucose transport protein 0.0105 0.2107 0.5507
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Loa Loa (eye worm) hypothetical protein 0.0032 0.0419 0.199
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0404 0.0617
Entamoeba histolytica protein kinase, putative 0.0032 0.0419 0.0479
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Leishmania major glucose transporter, lmgt3 0.0033 0.0429 0.8107
Echinococcus multilocularis lamin dm0 0.0029 0.0349 0.0915
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0145 0.038
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3606 0.3595
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0349 0.1656
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0404 0.106
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0017 0.0079
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0218 0.057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0145 0.038
Echinococcus multilocularis solute carrier family 22 0.0015 0.0017 0.0043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0123 0.0584
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0036 0.017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0145 0.0613
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.042 0.0617
Echinococcus granulosus tar DNA binding protein 0.0069 0.1259 0.3301
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0091 0.0196
Brugia malayi Sugar transporter family protein 0.0105 0.2107 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0373 0.0979
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0145 0.0613
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0419 0.0641
Echinococcus multilocularis tar DNA binding protein 0.0069 0.1259 0.3301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0091 0.0196
Leishmania major hypothetical protein, conserved 0.0016 0.0048 0.0621
Plasmodium falciparum protein kinase 7 0.0298 0.6548 0.6542
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0145 0.0613
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Schistosoma mansoni hypothetical protein 0.0179 0.3813 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0048 0.0621
Leishmania major protein kinase, putative 0.0032 0.0419 0.7919
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0145 0.0613
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0091 0.0239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0145 0.038
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1259 0.3272
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0218 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0145 0.0613
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0429 0.8107
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0404 0.0967
Brugia malayi TAR-binding protein 0.0069 0.1259 0.5942
Echinococcus granulosus solute carrier family 22 0.0015 0.0017 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0087 0.1383
Loa Loa (eye worm) RNA binding protein 0.0069 0.1259 0.5974
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1866 0.4892
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2107 0.3201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0218 0.0694
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0218 0.032
Loa Loa (eye worm) sugar transporter 0.0015 0.0017 0.0079
Schistosoma mansoni protein kinase 0.0032 0.0419 0.1061
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0419 0.199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0552 0.1448
Schistosoma mansoni glucose transport protein 0.0105 0.2107 0.5507
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0145 0.0613
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0136 0.0411
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0439 0.2022
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.1113
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0017 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0123 0.2094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.2092 0.9925
Loa Loa (eye worm) hypothetical protein 0.0075 0.1402 0.6653
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0439 0.1152
Schistosoma mansoni hypothetical protein 0.0105 0.2107 0.5507
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0145 0.038
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0136 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0145 0.0613
Brugia malayi intermediate filament protein 0.0029 0.0349 0.159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0145 0.0613
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0145 0.038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0036 0.0092
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0429 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.042 0.0617
Plasmodium vivax CDK-related protein kinase 6, putative 0.0447 1 1
Echinococcus multilocularis lamin 0.0029 0.0349 0.0915
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Entamoeba histolytica hypothetical protein 0.0024 0.0218 0.0153
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0178 0.0847
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0145 0.0338
Echinococcus granulosus lamin 0.0029 0.0349 0.0915
Echinococcus multilocularis General substrate transporter 0.0091 0.1765 0.4629
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Echinococcus granulosus General substrate transporter 0.0091 0.1765 0.4629
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0145 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0145 0.0613
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0552 0.1448
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1259 0.3272
Trypanosoma cruzi ISWI complex protein 0.0016 0.0048 0.0621
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.1259 0.5942
Schistosoma mansoni coup transcription factor 0.002 0.0145 0.0338
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0145 0.0338
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Echinococcus multilocularis zinc finger protein 0.0021 0.0153 0.04
Echinococcus granulosus geminin 0.0179 0.3813 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0123 0.0169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0281
Schistosoma mansoni lamin 0.0029 0.0349 0.0876
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0123 0.0323
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.042 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0404 0.1855
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0218 0.5
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0017 0.0043
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0091 0.0239
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0218 0.0529
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.1113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0218 0.395
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0017 0.0079
Echinococcus granulosus solute carrier family 22 0.0015 0.0017 0.0043
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0349 0.1656
Brugia malayi Bromodomain containing protein 0.0041 0.061 0.2838
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0225 0.059
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0145 0.3858
Brugia malayi steroid hormone receptor 0.002 0.0145 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0145 0.0613
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.1919
Brugia malayi RNA binding protein 0.0069 0.1259 0.5942
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0404 0.1855
Trypanosoma cruzi hexose transporter 0.0033 0.0429 0.8107
Plasmodium vivax hexose transporter 0.0105 0.2107 0.2094
Loa Loa (eye worm) hypothetical protein 0.0024 0.0218 0.1032
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0525 1
Schistosoma mansoni protein kinase 0.0032 0.0419 0.1061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0145 0.038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0716 0.3399
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1133 0.297
Echinococcus granulosus GPCR family 2 0.0033 0.0439 0.1152
Loa Loa (eye worm) hypothetical protein 0.0043 0.067 0.3177
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0145 0.0338
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0218 0.0308
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0349 0.159
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.042 0.0404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.1379 0.3616
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0429 0.8107
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0145 0.0338
Schistosoma mansoni lamin 0.0029 0.0349 0.0876
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Brugia malayi Bromodomain containing protein 0.0079 0.1506 0.7126
Brugia malayi Cam kinase protein 1 0.0032 0.0419 0.1927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1866 0.487
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.042 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1866 0.487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0145 0.038
Echinococcus multilocularis solute carrier family 22 0.0015 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Leishmania major glucose transporter, lmgt1 0.0033 0.0429 0.8107
Onchocerca volvulus 0.0029 0.0349 1
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0429 0.0656
Schistosoma mansoni hypothetical protein 0.0016 0.0048 0.0083
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0225 0.0549
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0123 0.2094
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0123 0.0323
Echinococcus multilocularis musashi 0.0029 0.0349 0.0915
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0349 0.1656
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1866 0.8844
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0107
Toxoplasma gondii protein kinase, putative 0.0298 0.6548 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0145 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0091 0.0196
Schistosoma mansoni zinc finger protein 0.0016 0.0048 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0145 0.038
Brugia malayi ecdysteroid receptor 0.002 0.0145 0.0613
Loa Loa (eye worm) hypothetical protein 0.0029 0.0337 0.1598
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2107 0.3325
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.2092 0.9926
Echinococcus granulosus FTZ F1 alpha 0.002 0.0145 0.038
Brugia malayi hypothetical protein 0.0074 0.1379 0.6516
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3606 0.5495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.6305 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0145 0.038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0123 0.0368
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0419 0.11
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0225 0.059
Brugia malayi nuclear receptor NHR-88 0.002 0.0145 0.0613
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0429 0.8107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.2092 0.9925
Echinococcus granulosus solute carrier family 22 0.0015 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.6305 1
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.1113
Trypanosoma brucei ISWI complex protein 0.0016 0.0048 0.0621
Entamoeba histolytica hypothetical protein 0.0074 0.1379 0.2032
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0525 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0017 0.0043
Schistosoma mansoni hypothetical protein 0.0074 0.1379 0.3588
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0419 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0145 0.0687
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0429 0.8107
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.6305 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0429 0.8107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.1379 0.3616
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0373 0.0979
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0218 0.0201
Schistosoma mansoni protein kinase 0.0032 0.0419 0.1061
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0218 0.032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.1259 0.5974
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0145 0.0687
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0439 0.1152
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.042 0.0404
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0218 0.0201
Echinococcus granulosus zinc finger protein 0.0021 0.0153 0.04
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1259 0.3272
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.6305 1
Entamoeba histolytica hypothetical protein 0.0074 0.1379 0.2032
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0123 0.0169
Echinococcus multilocularis solute carrier family 22 0.0015 0.0017 0.0043
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0017 0.0043
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0525 1
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.6305 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0145 0.0613
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.042 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0145 0.0613
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0145 0.038
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0439 0.1152
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0145 0.0613
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0145 0.3858
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0404 0.1021
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0091 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0145 0.0687
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0145 0.0687
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3606 0.3595
Toxoplasma gondii exonuclease III APE 0.0019 0.0123 0.0163
Schistosoma mansoni hypothetical protein 0.0179 0.3813 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1866 0.4892
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0404 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0429 0.0656
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0281
Schistosoma mansoni hypothetical protein 0.0072 0.1327 0.3451
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0123 0.2094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0612 0.2903
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0432
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1133 0.297
Schistosoma mansoni thyroid hormone receptor 0.002 0.0145 0.0338
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0091 0.0196
Schistosoma mansoni glucose transport protein 0.0105 0.2107 0.5507
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0218 0.0694
Schistosoma mansoni zinc finger protein 0.0021 0.0153 0.0358
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0429 0.0656
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.1379 0.3588
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0429 0.8107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0525 0.0779
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1259 0.3272
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0145 0.0338
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Trypanosoma brucei glucose transporter 2A 0.0033 0.0429 0.8107
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0525 0.051
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0218 0.0295
Loa Loa (eye worm) sugar transporter 0.0105 0.2107 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0145 0.038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.2085
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0017 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0145 0.0338
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0123 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0145 0.038
Onchocerca volvulus 0.002 0.0145 0.3858
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0429 0.0656
Onchocerca volvulus 0.0029 0.0349 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1327 0.6296
Entamoeba histolytica hypothetical protein 0.0074 0.1379 0.2032
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0429 0.0656
Plasmodium falciparum hexose transporter 0.0105 0.2107 0.2094
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.042 0.0404
Schistosoma mansoni intermediate filament proteins 0.0029 0.0349 0.0876
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0123 0.2094
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Brugia malayi nuclear hormone receptor 0.002 0.0145 0.0613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0145 0.0687
Echinococcus granulosus solute carrier family 22 0.0015 0.0017 0.0043
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.2913 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2107 0.5526
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0429 0.0656
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0145 0.0338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1866 0.4892
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.042 0.0404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1866 0.4892
Loa Loa (eye worm) hypothetical protein 0.0026 0.0267 0.1269
Leishmania major glucose transporter, lmgt2 0.0033 0.0429 0.8107
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0404 0.106
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0218 0.0961
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1259 0.3272
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0419 0.199
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0091 0.0239
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0145 0.038
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.042 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0145 0.0613
Schistosoma mansoni nuclear hormone receptor 0.002 0.0145 0.0338
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0439 0.1152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1866 0.8853
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0145 0.0613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0145 0.0687
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.042 0.0404
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0151 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1866 0.487
Schistosoma mansoni thyroid hormone receptor 0.002 0.0145 0.0338
Brugia malayi PHD-finger family protein 0.0026 0.0283 0.1274
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0145 0.3858
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0145 0.0338
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0123 0.0368
Echinococcus multilocularis GPCR, family 2 0.0033 0.0439 0.1152
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0218 0.395
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0145 0.0687
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0123 0.051
Trypanosoma brucei glucose transporter 1E 0.0033 0.0429 0.8107
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0439 0.2022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0079
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0525 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0419 0.1927
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.1113
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0429 0.0656
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0439 0.2085
Schistosoma mansoni bromodomain containing protein 0.0067 0.122 0.317
Loa Loa (eye worm) TAR-binding protein 0.0069 0.1259 0.5974
Echinococcus multilocularis geminin 0.0179 0.3813 1
Schistosoma mansoni hypothetical protein 0.0022 0.0178 0.0426
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.1919
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0145 0.038
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0218 0.395
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0419 0.11
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.042 0.0404
Echinococcus granulosus intermediate filament protein 0.0029 0.0349 0.0915
Entamoeba histolytica protein kinase, putative 0.0032 0.0419 0.0479
Echinococcus granulosus lamin dm0 0.0029 0.0349 0.0915
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0218 0.057
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0145 0.038
Trypanosoma brucei glucose transporter, putative 0.0033 0.0429 0.8107
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0123 0.0169
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0106 0.0503
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0404 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0145 0.0687
Entamoeba histolytica hypothetical protein 0.0074 0.1379 0.2032
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2107 0.5526
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0419 0.7919
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0687

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.