Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipD | 0.0192 | 0.1165 | 0.0133 |
Onchocerca volvulus | 0.005 | 0.0203 | 0.1737 | |
Echinococcus multilocularis | tumor protein p63 | 0.0345 | 0.2209 | 0.2208 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0524 | 0.3431 | 0.6519 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.006 | 0.0158 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.004 | 0.0129 | 0.0375 |
Mycobacterium ulcerans | beta-lactamase | 0.0192 | 0.1165 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.023 | 0.1612 |
Schistosoma mansoni | bromodomain containing protein | 0.0134 | 0.0774 | 0.0773 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.005 | 0.0198 | 0.0702 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.004 | 0.0129 | 0.0598 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0129 | 0.0773 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.0989 | 0.0989 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0127 | 0.0722 | 0.0721 |
Brugia malayi | beta-lactamase family protein | 0.0192 | 0.1165 | 0.2213 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0989 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0414 | 0.0784 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0198 | 0.1391 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0792 | 0.5263 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0036 | 0.0106 | 0.0105 |
Brugia malayi | PHD-finger family protein | 0.0053 | 0.0219 | 0.0415 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0106 | 0.0105 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0036 | 0.0106 | 0.0105 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0042 | 0.0002 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0792 | 0.5263 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0399 | 0.0756 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0192 | 0.1165 | 0.1164 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0192 | 0.1165 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0192 | 0.1165 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0044 | 0.0157 | 0.0297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0792 | 0.5263 | 0.5262 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.1624 | 0.1623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0042 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0106 | 0.0105 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.0717 | 0.1361 |
Trichomonas vaginalis | esterase, putative | 0.0192 | 0.1165 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0399 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0041 | 0.0142 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0989 | 0.0989 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0358 | 0.2301 | 0.4371 |
Echinococcus multilocularis | tar DNA binding protein | 0.0792 | 0.5263 | 0.5262 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0192 | 0.1165 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.005 | 0.0198 | 0.4246 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0176 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.005 | 0.0198 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0448 | 0.0849 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0192 | 0.1165 | 0.0133 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0399 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.005 | 0.0198 | 0.0375 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.0717 | 0.1361 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0192 | 0.1165 | 0.0133 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.0399 | 0.0398 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0337 | 0.2158 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0345 | 0.2209 | 0.2208 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.005 | 0.0198 | 0.0197 |
Loa Loa (eye worm) | TAR-binding protein | 0.0792 | 0.5263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1165 | 1 |
Onchocerca volvulus | 0.0192 | 0.1165 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.006 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 0.2301 | 0.23 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0192 | 0.1165 | 0.1164 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0192 | 0.1165 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0024 | 0.002 | 0.009 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.0989 | 0.0989 |
Echinococcus granulosus | flap endonuclease 1 | 0.0028 | 0.005 | 0.0049 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0106 | 0.0105 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0192 | 0.1165 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0881 | 0.1673 |
Echinococcus granulosus | GPCR family 2 | 0.0166 | 0.0989 | 0.0989 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.008 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0989 | 0.1879 |
Echinococcus granulosus | tar DNA binding protein | 0.0792 | 0.5263 | 0.5262 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Mycobacterium tuberculosis | Conserved protein | 0.0192 | 0.1165 | 0.0133 |
Loa Loa (eye worm) | RNA binding protein | 0.0792 | 0.5263 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.0399 | 0.0398 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.005 | 0.0232 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.004 | 0.0129 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.2301 | 0.4371 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0106 | 0.0199 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0166 | 0.0989 | 0.1879 |
Schistosoma mansoni | zinc finger protein | 0.0041 | 0.0142 | 0.0141 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.005 | 0.0198 | 0.4246 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1487 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0192 | 0.1165 | 0.1164 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.005 | 0.0198 | 0.0702 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.005 | 0.0198 | 0.0918 |
Echinococcus multilocularis | zinc finger protein | 0.0041 | 0.0142 | 0.0141 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0378 | 0.0378 |
Mycobacterium tuberculosis | Conserved protein | 0.0192 | 0.1165 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0399 | 0.0398 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.0149 | 0.095 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0399 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0413 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0203 | 0.0384 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0192 | 0.1165 | 0.0133 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.0032 | 0.0031 |
Schistosoma mansoni | thyroid hormone receptor | 0.028 | 0.1765 | 0.1765 |
Trypanosoma brucei | ISWI complex protein | 0.0032 | 0.008 | 0.0372 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0182 | 0.0627 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.0182 | 0.0845 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0042 | 0.0002 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.0182 | 0.0627 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.005 | 0.0198 | 0.0375 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0166 | 0.0989 | 0.0989 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.005 | 0.0198 | 0.0702 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0192 | 0.1165 | 0.0133 |
Plasmodium falciparum | flap endonuclease 1 | 0.0028 | 0.005 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0032 | 0.008 | 0.0143 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0337 | 0.2158 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0032 | 0.008 | 0.0143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0524 | 0.3431 | 0.6519 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0166 | 0.0989 | 0.0989 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0106 | 0.0105 |
Leishmania major | hypothetical protein, conserved | 0.0192 | 0.1165 | 0.529 |
Plasmodium vivax | hypothetical protein, conserved | 0.0192 | 0.1165 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0037 | 0.0111 | 0.0549 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0166 | 0.0989 | 0.1879 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0129 | 0.0773 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0079 | 0.0332 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0127 | 0.0722 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0198 | 0.1391 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.0399 | 0.0398 |
Onchocerca volvulus | 0.0192 | 0.1165 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.1223 | 0.8202 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0048 | 0.0185 | 0.0184 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0192 | 0.1165 | 0.0133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0524 | 0.3431 | 0.6519 |
Brugia malayi | RNA binding protein | 0.0792 | 0.5263 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0192 | 0.1165 | 0.2213 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.005 | 0.0198 | 0.0918 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0337 | 0.2158 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0166 | 0.0989 | 0.0989 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.028 | 0.1765 | 0.1765 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1487 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0106 | 0.0105 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0048 | 0.0185 | 0.0184 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0042 | 0.0002 |
Onchocerca volvulus | 0.0192 | 0.1165 | 1 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.016 | 0.0947 | 0.4389 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0182 | 0.0627 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Giardia lamblia | GTOR | 0.005 | 0.0198 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0028 | 0.005 | 0.0049 |
Loa Loa (eye worm) | beta-lactamase | 0.0192 | 0.1165 | 0.2213 |
Toxoplasma gondii | ABC1 family protein | 0.0192 | 0.1165 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0028 | 0.005 | 0.0094 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0259 | 0.1624 | 0.1623 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.0253 | 0.0963 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0166 | 0.0989 | 0.1879 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0337 | 0.2158 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0192 | 0.1165 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0192 | 0.1165 | 0.5399 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.016 | 0.0947 | 0.4255 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.0717 | 0.1361 |
Schistosoma mansoni | tar DNA-binding protein | 0.0792 | 0.5263 | 0.5262 |
Brugia malayi | beta-lactamase family protein | 0.0192 | 0.1165 | 0.2213 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.016 | 0.0947 | 0.4255 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0192 | 0.1165 | 0.529 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0106 | 0.0105 |
Mycobacterium ulcerans | lipase LipD | 0.0192 | 0.1165 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0192 | 0.1165 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0192 | 0.1165 | 0.2213 |
Leishmania major | hypothetical protein, conserved | 0.0032 | 0.008 | 0.0143 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.005 | 0.0198 | 0.0702 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0192 | 0.1165 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0792 | 0.5263 | 0.5262 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0378 | 0.0378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0792 | 0.5263 | 0.5262 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.005 | 0.0198 | 0.0197 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0176 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0087 | 0.0397 |
Mycobacterium tuberculosis | Conserved protein | 0.0192 | 0.1165 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0157 | 0.0157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0129 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.3431 | 0.6519 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0129 | 0.0773 |
Brugia malayi | Bromodomain containing protein | 0.0159 | 0.0943 | 0.179 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0048 | 0.0185 | 0.0184 |
Brugia malayi | beta-lactamase | 0.0192 | 0.1165 | 0.2213 |
Schistosoma mansoni | thyroid hormone receptor | 0.028 | 0.1765 | 0.1765 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0475 | 0.0902 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0989 | 0.0989 |
Mycobacterium leprae | conserved hypothetical protein | 0.0192 | 0.1165 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0129 | 0.0773 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0037 | 0.0114 | 0.0216 |
Brugia malayi | TAR-binding protein | 0.0792 | 0.5263 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0192 | 0.1165 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0259 | 0.1624 | 0.1623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0111 | 0.0618 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0198 | 0.1391 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0399 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0176 |
Schistosoma mansoni | tar DNA-binding protein | 0.0792 | 0.5263 | 0.5262 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0028 | 0.005 | 0.0094 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0192 | 0.1165 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1165 | 0.2213 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0203 | 0.0202 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0028 | 0.005 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0989 | 0.0989 |
Schistosoma mansoni | zinc finger protein | 0.0032 | 0.008 | 0.0079 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0192 | 0.1165 | 0.529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.