Detailed information for compound 770703

Basic information

Technical information
  • TDR Targets ID: 770703
  • Name: [2-(4-methylphenyl)-2-oxoethyl] 4-(di(phenyl) amino)-4-oxobutanoate
  • MW: 401.454 | Formula: C25H23NO4
  • H donors: 0 H acceptors: 3 LogP: 4.37 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OCC(=O)c1ccc(cc1)C)CCC(=O)N(c1ccccc1)c1ccccc1
  • InChi: 1S/C25H23NO4/c1-19-12-14-20(15-13-19)23(27)18-30-25(29)17-16-24(28)26(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15H,16-18H2,1H3
  • InChiKey: DPHWKKLXDNJRHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(4-methylphenyl)-2-oxo-ethyl] 4-(di(phenyl)amino)-4-oxo-butanoate
  • 4-(di(phenyl)amino)-4-oxobutanoic acid [2-(4-methylphenyl)-2-oxoethyl] ester
  • 4-(di(phenyl)amino)-4-keto-butyric acid [2-keto-2-(4-methylphenyl)ethyl] ester
  • ST009241
  • ZINC02068325
  • AK-918/11940338

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0025 0.0007 0.0191
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.0158 0.1578
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0586 1
Echinococcus granulosus tar DNA binding protein 0.0145 0.0242 0.2198
Brugia malayi hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Echinococcus multilocularis tar DNA binding protein 0.0145 0.0242 0.0242
Leishmania major importin beta-1 subunit, putative 0.0024 0.0005 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0053 0.0527
Onchocerca volvulus Protein patched homolog 0.0025 0.0007 0.0191
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0016 0.0279
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.0158 0.0158
Loa Loa (eye worm) GMP reductase 0.01 0.0155 0.1543
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0158 0.1578
Onchocerca volvulus 0.0109 0.0172 0.4931
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0642
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0064 0.1599
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0175 0.0301 0.2996
Mycobacterium ulcerans transcriptional regulator 0.1444 0.2787 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.01 0.1328
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0195
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0403 0.6885
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0031 0.0031
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0227 0.0403 0.1447
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Schistosoma mansoni hypothetical protein 0.0174 0.0299 0.2548
Echinococcus granulosus importin subunit beta 1 0.003 0.0016 0.0148
Echinococcus granulosus Niemann Pick C1 protein 0.0582 0.1099 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0227 0.0403 0.1447
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0005 0.0097
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.0158 0.0158
Echinococcus multilocularis snurportin 1 0.0316 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0228
Onchocerca volvulus 0.0102 0.0158 0.4553
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0242 0.2056
Loa Loa (eye worm) patched family protein 0.0025 0.0007 0.0066
Toxoplasma gondii hypothetical protein 0.0052 0.0059 0.1474
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0005 0.0097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0059 0.0211
Onchocerca volvulus 0.0025 0.0007 0.0191
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.01 0.0155 0.1543
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0227 0.0403 0.0403
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0031 0.0261
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0064 0.1599
Brugia malayi Patched related family protein 12 0.0025 0.0007 0.0066
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.01 0.036
Loa Loa (eye worm) hypothetical protein 0.0214 0.0378 0.3764
Echinococcus granulosus expressed conserved protein 0.0383 0.0708 0.6443
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.015 0.1492
Schistosoma mansoni hypothetical protein 0.0169 0.0288 0.2455
Plasmodium vivax patched family protein, putative 0.0025 0.0007 0.0165
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Entamoeba histolytica hypothetical protein 0.0037 0.0031 0.0406
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Leishmania major GTP-binding protein, putative 0.0022 0.0001 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0073 0.01 0.1
Brugia malayi protein C24B5.3 0.0025 0.0007 0.0066
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.01 0.1328
Brugia malayi Patched related family protein 4 0.0025 0.0007 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.01 0.036
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0127 0.0207 0.0741
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0064 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.0462 0.4598
Entamoeba histolytica hypothetical protein 0.0037 0.0031 0.0406
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0642
Loa Loa (eye worm) MBCTL1 0.0116 0.0186 0.1854
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.01 0.036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0017
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.0158 0.4553
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0403 0.0747 0.6797
Loa Loa (eye worm) RNA binding protein 0.0145 0.0242 0.2406
Echinococcus granulosus Protein patched homolog 1 0.0175 0.0301 0.2737
Echinococcus granulosus survival motor neuron protein 1 0.0534 0.1004 0.9135
Echinococcus multilocularis Niemann Pick C1 protein 0.0408 0.0756 0.0756
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0289 0.1036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0255 0.4357
Loa Loa (eye worm) hypothetical protein 0.0073 0.01 0.1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0053 0.0527
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.01 0.036
Echinococcus multilocularis sterol regulatory element binding protein 0.0175 0.0301 0.0301
Trichomonas vaginalis ran, putative 0.0022 0.0001 0.0018
Echinococcus multilocularis Niemann Pick C1 protein 0.0582 0.1099 0.1099
Schistosoma mansoni hypothetical protein 0.0169 0.0288 0.2455
Brugia malayi Cytochrome P450 family protein 0.0028 0.0014 0.0137
Toxoplasma gondii patched family protein 0.0025 0.0007 0.0165
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0014 0.0137
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0408 0.0756 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0016 0.0279
Brugia malayi AMP-binding enzyme family protein 0.0073 0.01 0.1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.01 0.036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Onchocerca volvulus 0.0025 0.0007 0.0191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0642
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0053 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1444 0.2787 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0227 0.0403 0.1447
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.0186 0.1854
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.0158 0.1441
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0242 0.2056
Loa Loa (eye worm) IMP dehydrogenase 1 0.0227 0.0403 0.4017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Onchocerca volvulus 0.0073 0.01 0.2887
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0001 0.0009
Echinococcus granulosus Niemann Pick C1 protein 0.0408 0.0756 0.6883
Brugia malayi RNA recognition motif domain containing protein 0.0145 0.0242 0.2406
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.0186 0.0186
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0227 0.0403 0.1447
Leishmania major inosine-5-monophosphate dehydrogenase 0.0227 0.0403 0.6885
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0642
Loa Loa (eye worm) patched family protein 0.0025 0.0007 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.0158 0.1441
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0408 0.0756 0.7535
Onchocerca volvulus 0.0025 0.0007 0.0191
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0227 0.0403 0.4017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0145 0.0242 0.2406
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0227 0.0403 0.3669
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0046 0.0794
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1444 0.2787 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0303 0.0552 0.5499
Loa Loa (eye worm) patched family protein 0.0025 0.0007 0.0066
Trypanosoma brucei GMP reductase 0.0227 0.0403 0.6885
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) patched family protein 0.0025 0.0007 0.0066
Mycobacterium ulcerans hypothetical protein 0.0169 0.0289 0.1036
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0001 0.0024
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0046 0.0794
Brugia malayi Importin beta-1 subunit 0.003 0.0016 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Schistosoma mansoni hypothetical protein 0.0174 0.0299 0.2548
Echinococcus multilocularis importin subunit beta 1 0.003 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0169 0.0288 0.2455
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0046 0.0794
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.0369 0.6681
Schistosoma mansoni hypothetical protein 0.0169 0.0288 0.2455
Brugia malayi TAR-binding protein 0.0145 0.0242 0.2406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.015 0.015
Echinococcus multilocularis geminin 0.0174 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0109 0.0172 0.146
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.0369 0.6681
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0023 0.0228
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0403 1
Schistosoma mansoni ran 0.0022 0.0001 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0001 0.0024
Echinococcus multilocularis survival motor neuron protein 1 0.0534 0.1004 0.1004
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0303 0.0552 0.5499
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.015 0.1492
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.0186 0.0186
Trypanosoma cruzi GMP reductase 0.0227 0.0403 0.6885
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0158 0.1348
Brugia malayi hypothetical protein 0.0534 0.1004 1
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0158 0.1348
Mycobacterium ulcerans TetR family transcriptional regulator 0.1444 0.2787 1
Schistosoma mansoni importin beta-1 0.003 0.0016 0.0139
Plasmodium falciparum importin beta, putative 0.003 0.0016 0.0405
Schistosoma mansoni hypothetical protein 0.0621 0.1175 1
Toxoplasma gondii patched family protein 0.0025 0.0007 0.0165
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Onchocerca volvulus 0.0025 0.0007 0.0191
Loa Loa (eye worm) hypothetical protein 0.0073 0.01 0.1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.015 0.1275
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi follicle stimulating hormone receptor 0.0257 0.0462 0.4598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0403 0.0747 0.0747
Loa Loa (eye worm) TAR-binding protein 0.0145 0.0242 0.2406
Trypanosoma cruzi GMP reductase 0.0227 0.0403 0.6885
Brugia malayi hypothetical protein 0.0025 0.0007 0.0066
Leishmania major mitochondrial DNA polymerase beta 0.032 0.0586 1
Brugia malayi AMP-binding enzyme family protein 0.0073 0.01 0.1
Brugia malayi GMP reductase 0.01 0.0155 0.1543
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0031 0.0279
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0046 0.0794
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0242 0.2056
Echinococcus multilocularis expressed conserved protein 0.0383 0.0708 0.0708
Brugia malayi RNA binding protein 0.0145 0.0242 0.2406
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.0586 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.0578 0.5758
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Onchocerca volvulus Glucosylceramidase homolog 0.0199 0.0348 1
Brugia malayi mbt repeat family protein 0.0102 0.0158 0.1578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.015 0.1363
Echinococcus multilocularis protein dispatched 1 0.02 0.0349 0.0349
Brugia malayi CHE-14 protein 0.0175 0.0301 0.2996
Brugia malayi Niemann-Pick C1 protein precursor 0.0408 0.0756 0.7535
Brugia malayi RNA, U transporter 1 0.0084 0.0123 0.1229
Entamoeba histolytica hypothetical protein 0.0037 0.0031 0.0406
Brugia malayi Patched related family protein 10 0.0025 0.0007 0.0066
Onchocerca volvulus Putative GMP reductase 0.01 0.0155 0.4451
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0016 0.0405
Onchocerca volvulus Protein patched homolog 0.0025 0.0007 0.0191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0059 0.0211
Brugia malayi hypothetical protein 0.0037 0.0031 0.0306
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.01 0.1328
Schistosoma mansoni hypothetical protein 0.0037 0.0031 0.0261
Echinococcus granulosus geminin 0.0174 0.0299 0.2725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.015 0.1363
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0227 0.0403 0.6885
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0403 0.6885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.015 0.1275
Brugia malayi Myosin head containing protein 0.0025 0.0007 0.0066
Echinococcus granulosus snurportin 1 0.0316 0.0578 0.526
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.01 0.0155 0.0556
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0005 0.0091
Plasmodium falciparum lipid/sterol:H+ symporter 0.0025 0.0007 0.0165
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0227 0.0403 0.3432
Toxoplasma gondii patched family protein 0.0025 0.0007 0.0165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0301 0.5448
Toxoplasma gondii IMP dehydrogenas 0.0227 0.0403 1
Toxoplasma gondii hypothetical protein 0.0025 0.0007 0.0165
Brugia malayi N-terminal motif family protein 0.0175 0.0301 0.2997
Entamoeba histolytica Ran family GTPase 0.0022 0.0001 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0059 0.0211
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.0186 0.1693
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0227 0.0403 0.5
Loa Loa (eye worm) patched family protein 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0116 0.0186 0.1854
Mycobacterium ulcerans hypothetical protein 0.0073 0.01 0.036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.015 0.015
Echinococcus granulosus sterol regulatory element binding protein 0.0175 0.0301 0.2737
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0172 0.1709
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0534 0.1004 1
Leishmania major guanosine monophosphate reductase 0.0227 0.0403 0.6885
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0175 0.0301 0.2997
Loa Loa (eye worm) hypothetical protein 0.0175 0.0301 0.2996
Plasmodium vivax importin-beta 2, putative 0.003 0.0016 0.0405
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.0186 0.1584
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0348 0.6301
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0242 0.2056
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.0158 0.1348
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0586 1
Echinococcus multilocularis protein patched 0.0175 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi mbt repeat family protein 0.0102 0.0158 0.1578
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0017
Onchocerca volvulus 0.0025 0.0007 0.0191
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0127 0.0207 0.0741
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.01 0.036
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0301 0.8649
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0064 0.0231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0053 0.0527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.01 0.036
Brugia malayi hypothetical protein 0.0025 0.0007 0.0066
Schistosoma mansoni ran 0.0022 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0242 0.2056
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0066 0.1123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.01 0.1715
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0642
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Brugia malayi protein C24B5.3 0.0025 0.0007 0.0066
Brugia malayi Patched protein homolog 1 0.0025 0.0007 0.0066
Brugia malayi Patched family protein 0.0025 0.0007 0.0066
Entamoeba histolytica hypothetical protein 0.0037 0.0031 0.0406
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0414 0.0769 0.6543
Toxoplasma gondii patched family protein 0.0025 0.0007 0.0165
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.01 0.0155 0.0556
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.01 0.1715
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.01 0.036
Onchocerca volvulus 0.0026 0.0008 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0552 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.01 0.036
Brugia malayi hypothetical protein 0.0025 0.0007 0.0066
Onchocerca volvulus 0.0025 0.0007 0.0191
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.0186 0.1693
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1444 0.2787 1
Schistosoma mansoni patched 1 0.0175 0.0301 0.256
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0064 0.0231
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.01 0.1715
Schistosoma mansoni survival motor neuron protein 0.0109 0.0172 0.146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0059 0.0211
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0255 0.4357
Entamoeba histolytica hypothetical protein 0.0024 0.0005 0.0071
Schistosoma mansoni hypothetical protein 0.0316 0.0578 0.492
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.01 0.036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.01 0.036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.015 0.1275
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0005 0.0097
Loa Loa (eye worm) hypothetical protein 0.0073 0.01 0.1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0255 0.4357
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0227 0.0403 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0403 0.6885
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.01 0.0155 0.1543

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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