Detailed information for compound 784443

Basic information

Technical information
  • TDR Targets ID: 784443
  • Name: 5-(2-phenylethyl)-2H-[1,2,4]triazino[5,6-b]in dole-3-thione
  • MW: 306.385 | Formula: C17H14N4S
  • H donors: 0 H acceptors: 3 LogP: 3.41 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Sc1nnc2c(n1)n(CCc1ccccc1)c1c2cccc1
  • InChi: 1S/C17H14N4S/c22-17-18-16-15(19-20-17)13-8-4-5-9-14(13)21(16)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,18,20,22)
  • InChiKey: JZMKJONDRDUVGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-188659
  • EU-0085516
  • ChemDivAM_001098
  • ZINC00080593
  • ZERO/001434
  • 1,2,4-Triazino[5,6-b]indole-3-thiol, 5-(2-phenylethyl)-
  • 5-(2-Phenylethyl)-5H-[1,2,4]triazino[5,6-b]indol-3-yl hydrosulfide
  • 3H-1,2,4-Triazino[5,6-b]indole-3-thione, 2,5-dihydro-5-(2-phenylethyl)-
  • AG-205/12646071
  • AIDS188659
  • 9-Phenethyl-9H-1,3,4,9-tetraaza-fluorene-2-thiol
  • BAS 08330030
  • ChemDiv1_025826

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0012 0.0062 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0291 0.4106
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0447 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0062 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0062 0.0031
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Brugia malayi PHD-finger family protein 0.0011 0.0041 0.0116
Brugia malayi hypothetical protein 0.0014 0.0109 0.0307
Plasmodium falciparum protein kinase 6 0.0437 0.882 1
Echinococcus granulosus cpg binding protein 0.0037 0.0566 0.0537
Brugia malayi Sugar transporter family protein 0.0014 0.0109 0.0307
Schistosoma mansoni glucose transporter 0.0014 0.0109 0.0109
Echinococcus multilocularis GPCR, family 2 0.0016 0.0149 0.0118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.095
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0284 0.0284
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0461 0.0475
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0213 0.0408
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Schistosoma mansoni hypothetical protein 0.0028 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0062 0.0031
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Brugia malayi nuclear hormone receptor 0.0012 0.0062 0.0175
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.046 0.1303
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0279 0.0248
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0062 0.0031
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0109 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0468 0.0651
Onchocerca volvulus 0.0014 0.0109 0.1007
Entamoeba histolytica hypothetical protein 0.0028 0.0393 0.0213
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0284 0.095
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0447 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.0921
Loa Loa (eye worm) hypothetical protein 0.018 0.3532 0.47
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0291 0.4106
Echinococcus multilocularis snurportin 1 0.0372 0.7479 0.7471
Brugia malayi jmjC domain containing protein 0.0036 0.0554 0.1569
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0447 0.096
Echinococcus multilocularis geminin 0.0344 0.6906 0.6897
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Schistosoma mansoni hypothetical protein 0.0016 0.0149 0.0149
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0461 0.0793
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.5635 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0077
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0109 0.0187
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0062 0.0031
Trypanosoma brucei glucose transporter 2A 0.0032 0.0468 0.8479
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.046 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0468 0.0651
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.2656 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.2656 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.1713 0.1687
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0468 0.8107
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0391 0.0673
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Onchocerca volvulus 0.0014 0.0109 0.1007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0062 0.0031
Echinococcus granulosus dna polymerase kappa 0.0023 0.0291 0.026
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.324 0.5579
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0284 0.0292
Onchocerca volvulus 0.0014 0.0109 0.1007
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0553 0.0951
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.0921
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0461 0.0793
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.046 0.043
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0284 0.395
Brugia malayi Sugar transporter family protein 0.0103 0.1933 0.5474
Schistosoma mansoni glucose transport protein 0.0103 0.1933 0.1933
Echinococcus multilocularis cpg binding protein 0.0037 0.0566 0.0537
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0391 0.0391
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0077
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 0.882 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0307
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0468 0.8479
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Onchocerca volvulus 0.0014 0.0109 0.1007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0284 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0062 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.088 0.1139
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0291 0.0291
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0284 0.5139
Toxoplasma gondii sugar transporter ST3 0.0014 0.0109 0.0187
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0062 0.0031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0279 0.383
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Onchocerca volvulus 0.0014 0.0109 0.1007
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0284 0.0274
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0109 0.0281
Onchocerca volvulus 0.0014 0.0109 0.1007
Trypanosoma brucei unspecified product 0.0016 0.0142 0.2564
Leishmania major glucose transporter, lmgt3 0.0032 0.0468 0.8107
Leishmania major glucose transporter, lmgt2 0.0032 0.0468 0.8107
Echinococcus granulosus peregrin 0.0028 0.0391 0.0361
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0062 0.0175
Onchocerca volvulus 0.0014 0.0109 0.1007
Echinococcus granulosus snurportin 1 0.0372 0.7479 0.7471
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0291 0.0716
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0062 0.0031
Schistosoma mansoni protein kinase 0.0032 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Leishmania major protein kinase, putative 0.0032 0.046 0.7919
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0178 0.0178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.088 0.2492
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0291 0.026
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0553 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0109 0.0077
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0619 0.0589
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0279 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Brugia malayi jmjC domain containing protein 0.0092 0.1713 0.4851
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Schistosoma mansoni hypothetical protein 0.0016 0.0149 0.0149
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0447 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Schistosoma mansoni hypothetical protein 0.0016 0.0149 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0291 0.4106
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0291 0.5264
Entamoeba histolytica hypothetical protein 0.0023 0.0284 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0062 0.0175
Schistosoma mansoni hypothetical protein 0.0344 0.6906 0.6906
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0284 0.0317
Brugia malayi hypothetical protein 0.0014 0.0109 0.0307
Loa Loa (eye worm) hypothetical protein 0.018 0.3532 0.47
Plasmodium falciparum phd finger protein, putative 0.0028 0.0391 0.0396
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0279 0.0435
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0461 0.0793
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0038 0.0007
Brugia malayi hypothetical protein 0.0014 0.0109 0.0307
Leishmania major importin beta-1 subunit, putative 0.0028 0.0393 0.6397
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.5635 1
Brugia malayi RNA, U transporter 1 0.0099 0.1853 0.5247
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0109 0.1965
Onchocerca volvulus 0.0014 0.0109 0.1007
Schistosoma mansoni hypothetical protein 0.0344 0.6906 0.6906
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0291 0.4106
Onchocerca volvulus 0.0014 0.0109 0.1007
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0284 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0062 0.0041
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0391 0.0673
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0279 0.0789
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0291 0.4106
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0109 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0542 0.0685
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0062 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0468 0.0651
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1933 0.3328
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0468 0.8107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0291 0.0348
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Onchocerca volvulus 0.0014 0.0109 0.1007
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0447 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0468 0.0651
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.1713 0.1687
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0391 0.0361
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0284 0.0284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0149 0.0118
Brugia malayi Importin beta-1 subunit 0.0035 0.0528 0.1496
Brugia malayi Bromodomain containing protein 0.0028 0.0391 0.1108
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0109 0.0077
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0284 0.0489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0062 0.0041
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0109 0.0104
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0062 0.0062
Toxoplasma gondii sugar transporter ST2 0.0014 0.0109 0.0187
Onchocerca volvulus 0.0014 0.0109 0.1007
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0077
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0279 0.0668
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0553 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0542 0.1533
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0062 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0062 0.0041
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0461 0.0475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0062 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0062 0.0041
Trypanosoma brucei unspecified product 0.0023 0.0291 0.5264
Echinococcus multilocularis peregrin 0.0028 0.0391 0.0361
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0461 0.0475
Loa Loa (eye worm) hypothetical protein 0.0025 0.0328 0.0398
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0554 0.0524
Brugia malayi CXXC zinc finger family protein 0.0035 0.0526 0.1488
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0554 0.0554
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0554 0.0554
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0461 0.0475
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0291 0.0824
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0037 0.0566 0.0566
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0447 0.1266
Brugia malayi Cam kinase protein 1 0.0032 0.046 0.1303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0062 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0279 0.0308
Brugia malayi Muscleblind-like protein 0.018 0.3532 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0284 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Onchocerca volvulus 0.0014 0.0109 0.1007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0393 0.0514
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0553 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0062 0.0062
Brugia malayi steroid hormone receptor 0.0012 0.0062 0.0175
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0062 0.0031
Echinococcus multilocularis muscleblind protein 0.018 0.3532 0.3511
Entamoeba histolytica protein kinase, putative 0.0032 0.046 0.0339
Leishmania major glucose transporter, lmgt1 0.0032 0.0468 0.8107
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0291 0.0291
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0284 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Loa Loa (eye worm) hypothetical protein 0.0052 0.088 0.1139
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Brugia malayi PHD-finger family protein 0.0028 0.0391 0.1108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0062 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0062 0.0031
Loa Loa (eye worm) sugar transporter 0.0014 0.0109 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0062 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.0921
Toxoplasma gondii protein kinase, putative 0.0291 0.5808 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0291 0.0716
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0461 0.0475
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Echinococcus multilocularis General substrate transporter 0.0088 0.1634 0.1608
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0553 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Brugia malayi major facilitator superfamily protein 0.0014 0.0109 0.0307
Trypanosoma cruzi hexose transporter 0.0032 0.0468 0.8107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.095
Echinococcus granulosus calcium dependent protein kinase 0.003 0.042 0.039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0279 0.0268
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0062 0.0175
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0038 0.0007
Schistosoma mansoni protein kinase 0.0032 0.046 0.046
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0062 0.0062
Entamoeba histolytica protein kinase, putative 0.0032 0.046 0.0339
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.324 0.3642
Onchocerca volvulus 0.0014 0.0109 0.1007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0291 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0291 0.5264
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0149 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0062 0.0041
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0447 0.1266
Schistosoma mansoni jumonji domain containing protein 0.0073 0.1322 0.1322
Onchocerca volvulus 0.0014 0.0109 0.1007
Onchocerca volvulus 0.0035 0.0526 1
Plasmodium falciparum protein kinase 7 0.0291 0.5808 0.6568
Trypanosoma brucei sugar transporter, putative 0.0014 0.0109 0.1965
Giardia lamblia DINP protein human, muc B family 0.0023 0.0291 0.033
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.7479 1
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0062 0.0041
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Plasmodium vivax hexose transporter 0.0103 0.1933 0.2153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0062 0.0031
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0307
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0062 0.0031
Schistosoma mansoni glucose transport protein 0.0103 0.1933 0.1933
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0393 0.0514
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0077
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0393 0.6397
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1933 0.3301
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0142 0.2564
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.101 0.1314
Echinococcus granulosus geminin 0.0344 0.6906 0.6897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0142 0.2564
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0062 0.0062
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.2656 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0291 0.0976
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.042 0.039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0284 0.095
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0062 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0149 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0062 0.0175
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0528 0.9564
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.088 0.2492
Schistosoma mansoni hypothetical protein 0.0035 0.0542 0.0542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1328 0.1328
Echinococcus granulosus muscleblind protein 0.018 0.3532 0.3511
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0526 0.0663
Loa Loa (eye worm) hypothetical protein 0.0035 0.0528 0.0667
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0553 0.058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Brugia malayi Sugar transporter family protein 0.0014 0.0109 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0554 0.0702
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0553 0.058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0062 0.0062
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0109 0.0281
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.095 0.1233
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0149 0.0421
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.5635 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0072 0.0054
Onchocerca volvulus 0.0014 0.0109 0.1007
Loa Loa (eye worm) hypothetical protein 0.0032 0.046 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0062 0.0175
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0291 0.033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0558
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0284 0.395
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0391 0.0361
Echinococcus multilocularis muscleblind protein 1 0.018 0.3532 0.3511
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0109 0.0281
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0109 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0291 0.5264
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0447 0.0417
Onchocerca volvulus Putative transporter 0.0014 0.0109 0.1007
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0109 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0062 0.0062
Schistosoma mansoni ap endonuclease 0.0023 0.0279 0.0279
Plasmodium falciparum importin beta, putative 0.0035 0.0528 0.0552
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Schistosoma mansoni hypothetical protein 0.0016 0.0149 0.0149
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1933 0.1908
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0461 0.0475
Schistosoma mansoni protein kinase 0.0032 0.046 0.046
Echinococcus granulosus GPCR family 2 0.0016 0.0149 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0142 0.2564
Echinococcus granulosus dna polymerase eta 0.0023 0.0291 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0279 0.0332
Echinococcus multilocularis dna polymerase eta 0.0023 0.0291 0.026
Schistosoma mansoni hypothetical protein 0.0372 0.7479 0.7479
Schistosoma mansoni hypothetical protein 0.0103 0.1933 0.1933
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0528 0.091
Plasmodium vivax sugar transporter, putative 0.0014 0.0109 0.0074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0279 0.5043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0062 0.0062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0279 0.383
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0468 0.8107
Toxoplasma gondii exonuclease III APE 0.0023 0.0279 0.048
Loa Loa (eye worm) sugar transporter 0.0103 0.1933 0.2553
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0279 0.0308
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0279 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0468 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0461 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0013
Schistosoma mansoni coup transcription factor 0.0012 0.0062 0.0062
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0062 0.0062
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0291 0.026
Onchocerca volvulus Alhambra homolog 0.0028 0.0391 0.7101
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0219 0.0619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0284 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0062 0.0175
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0279 0.0308
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0461 0.0475
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0447 0.0417
Plasmodium falciparum hexose transporter 0.0103 0.1933 0.2153
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0149 0.0118
Plasmodium vivax importin-beta 2, putative 0.0035 0.0528 0.0552
Schistosoma mansoni glucose transport protein 0.0103 0.1933 0.1933
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Onchocerca volvulus 0.0014 0.0109 0.1007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.5635 1
Mycobacterium ulcerans sugar transporter 0.0014 0.0109 0.0281
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0468 0.8479
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0468 0.8479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0062 0.0175
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0291 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0468 0.0651
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Leishmania major DNA polymerase eta, putative 0.0023 0.0291 0.4106
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0619 0.0589
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0062 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0391 0.0396
Echinococcus granulosus General substrate transporter 0.0088 0.1634 0.1608
Giardia lamblia PHD finger protein 15 0.0028 0.0391 0.0511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.095 0.2689
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0513 0.0483
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0291 0.4106
Schistosoma mansoni ap endonuclease 0.0023 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0284 0.0317
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0558
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0391 0.0483
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0279 0.0929
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.324 0.3642
Schistosoma mansoni DNA polymerase eta 0.0023 0.0291 0.0291
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0291 0.0976
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0291 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.046 0.046
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0077
Trypanosoma brucei unspecified product 0.0016 0.0142 0.2564
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0062 0.0175
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.046 0.0576
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0528 0.9564
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0062 0.0041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0279 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0291 0.5264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0391 0.0483
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0279 0.383
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1933 0.1908
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0291 0.033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1166 0.2007
Brugia malayi ecdysteroid receptor 0.0012 0.0062 0.0175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0149 0.0118
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0077
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0226 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.046 0.8328
Schistosoma mansoni cpg binding protein 0.0037 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0048 0.0806 0.104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5635 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0447 0.0612
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0062 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0062 0.0175
Trypanosoma brucei glucose transporter 1E 0.0032 0.0468 0.8479
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0468 0.0651
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0284 0.0253
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0393 0.0514
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0213 0.0408
Schistosoma mansoni cpg binding protein 0.0035 0.0526 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.5264
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0528 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0062 0.0175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0553 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0468 0.8107
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0062 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0041
Echinococcus granulosus importin subunit beta 1 0.0035 0.0528 0.0499
Trypanosoma brucei glucose transporter, putative 0.0032 0.0468 0.8479
Leishmania major DNA polymerase kappa, putative 0.0023 0.0291 0.4106
Schistosoma mansoni importin beta-1 0.0035 0.0528 0.0528
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0291 0.0023
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0461 0.0475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0149 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0062 0.0031
Trypanosoma cruzi hexose transporter, putative 0.0017 0.017 0.1383
Toxoplasma gondii sugar transporter ST1 0.0014 0.0109 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.046 0.0636
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.046 0.043
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0062 0.0031
Brugia malayi major facilitator superfamily protein 0.0014 0.0109 0.0307
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0062 0.0031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0104

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 33.8078 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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