Detailed information for compound 784527

Basic information

Technical information
  • TDR Targets ID: 784527
  • Name: 4-(4-hydroxy-3-methoxyphenyl)-2-(2-methylprop -2-enylsulfanyl)-6-oxo-4,5-dihydro-1H-pyridin e-3-carbonitrile
  • MW: 330.401 | Formula: C17H18N2O3S
  • H donors: 2 H acceptors: 3 LogP: 2.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(SCC(=C)C)NC(=O)CC1c1ccc(c(c1)OC)O
  • InChi: 1S/C17H18N2O3S/c1-10(2)9-23-17-13(8-18)12(7-16(21)19-17)11-4-5-14(20)15(6-11)22-3/h4-6,12,20H,1,7,9H2,2-3H3,(H,19,21)
  • InChiKey: MPSUUKLRZQZSKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(4-hydroxy-3-methoxy-phenyl)-2-(2-methylprop-2-enylsulfanyl)-6-oxo-4,5-dihydro-1H-pyridine-3-carbonitrile
  • 4-(4-hydroxy-3-methoxyphenyl)-2-(2-methylprop-2-enylthio)-6-oxo-4,5-dihydro-1H-pyridine-3-carbonitrile
  • 4-(4-hydroxy-3-methoxy-phenyl)-6-keto-2-(2-methylprop-2-enylthio)-4,5-dihydro-1H-pyridine-3-carbonitrile
  • Oprea1_792902
  • Oprea1_139386
  • A2089/0087834

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0322 0.1608
Schistosoma mansoni hypothetical protein 0.0171 0.2004 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0096 0.0477
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0182 0.0907
Echinococcus multilocularis GPCR, family 2 0.0065 0.0694 0.0694
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0551 0.0551
Schistosoma mansoni single-minded 0.0016 0.0088 0.0441
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0199 0.0313
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0498 0.1994
Brugia malayi isocitrate dehydrogenase 0.0016 0.0088 0.0294
Schistosoma mansoni hypothetical protein 0.0065 0.0694 0.3466
Loa Loa (eye worm) hypothetical protein 0.014 0.1626 0.6692
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0096 0.0477
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.1434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0651 0.3248
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0627 0.0627
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0088 0.0545
Loa Loa (eye worm) hypothetical protein 0.0205 0.243 1
Brugia malayi PAS domain containing protein 0.0016 0.0088 0.0294
Brugia malayi beta-NAC-like protein 0.0035 0.0327 0.1285
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0322 0.0322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0498 0.2487
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0088 0.0547
Echinococcus multilocularis cpg binding protein 0.0032 0.0293 0.0293
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0354 0.1448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Onchocerca volvulus Protein cycle homolog 0.0037 0.0354 0.6345
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0199 0.0313
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0088 0.0545
Schistosoma mansoni zinc finger protein 0.0015 0.0075 0.0372
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0088 0.0547
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0498 0.2044
Schistosoma mansoni zinc finger protein 0.0021 0.0146 0.0729
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0088 0.27
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.27
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0086
Echinococcus granulosus geminin 0.0171 0.2004 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0327 0.4687
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Schistosoma mansoni transcription factor btf3 0.0035 0.0327 0.1633
Loa Loa (eye worm) hypothetical protein 0.0065 0.0694 0.2852
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0017
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0086
Brugia malayi hypothetical protein 0.0037 0.035 0.138
Leishmania major hypothetical protein, conserved 0.0025 0.0199 0.4936
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.27
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0372
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0088 0.0547
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0199 0.4936
Schistosoma mansoni hypothetical protein 0.0171 0.2004 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0088 0.0545
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0182 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0088 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0327 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0017
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0088 0.0294
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0199 0.2177
Schistosoma mansoni hypothetical protein 0.0035 0.0322 0.1608
Loa Loa (eye worm) hypothetical protein 0.0025 0.0199 0.0812
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0354 0.1394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1626 0.6671
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0017
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0088 0.0545
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0551 0.2748
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0327 1
Echinococcus granulosus transcription factor btf3 0.0035 0.0327 0.1633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.2487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.2487
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0088 0.27
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0086
Schistosoma mansoni hypothetical protein 0.0065 0.0694 0.3466
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0092 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Schistosoma mansoni cpg binding protein 0.0032 0.0293 0.146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0379 0.1553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0086
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0302 0.363 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0199 0.4936
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0327 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Echinococcus multilocularis zinc finger protein 0.0021 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0351 0.1436
Mycobacterium leprae Possible regulatory protein 0.0016 0.0088 0.0243
Schistosoma mansoni hypothetical protein 0.0065 0.0694 0.3466
Schistosoma mansoni bromodomain containing protein 0.0063 0.0669 0.3341
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0355
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.1434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0088 0.0088
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0088 0.0547
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.243 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0302 0.363 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0249 0.0962
Leishmania major protein kinase, putative 0.0016 0.0088 0.0547
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.243 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0088 0.27
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0088 0.27
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.1434
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.243 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0029 0.0147
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0016 0.0088 0.5
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0086
Onchocerca volvulus 0.0029 0.0249 0.4378
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0086
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0086
Schistosoma mansoni hypothetical protein 0.002 0.0138 0.0691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0498 0.2487
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0017
Brugia malayi Bromodomain containing protein 0.0074 0.081 0.3285
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0088 0.27
Echinococcus multilocularis transcription factor btf3 0.0035 0.0327 0.0327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0086
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0088 0.27
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0088 0.0545
Loa Loa (eye worm) hypothetical protein 0.0043 0.0422 0.1731
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0694 0.3466
Echinococcus multilocularis geminin 0.0171 0.2004 0.2004
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0327 0.0675
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0694 0.2852
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.035 0.138
Brugia malayi hypothetical protein 0.0025 0.0199 0.0754
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0322 0.1605
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0063
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0088 0.0547
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0354 0.1765
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0182 0.0907
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0551 0.2259
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0417
Brugia malayi hypothetical protein 0.0016 0.009 0.0302
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0063
Echinococcus granulosus GPCR family 2 0.0065 0.0694 0.3466
Schistosoma mansoni hypothetical protein 0.0011 0.0029 0.0147
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0354 0.1394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0516
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0694 0.2807
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0694 0.3466
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0249 0.1019
Entamoeba histolytica hypothetical protein 0.0035 0.0327 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0138 0.0561
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0103 0.0516
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0086
Brugia malayi hypothetical protein 0.0037 0.0354 0.1394
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0103 0.0103
Brugia malayi PHD-finger family protein 0.0026 0.021 0.0799
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0327 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.27
Brugia malayi hypothetical protein 0.0053 0.0547 0.2197
Schistosoma mansoni cpg binding protein 0.0029 0.0249 0.1244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0322 0.1608
Schistosoma mansoni cpg binding protein 0.0032 0.0293 0.146
Onchocerca volvulus 0.0053 0.0547 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0498 0.2487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0086
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.2246
Brugia malayi hypothetical protein 0.0035 0.0322 0.1264
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0322 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0498 0.0498
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0017
Brugia malayi Bromodomain containing protein 0.0037 0.035 0.1379
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0516
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0327 0.1339
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0088 0.0088
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0088 0.0243
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0017
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0088 0.0547
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0068 0.0738 0.3032
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.1434
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0199 0.4936
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0063
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0327 0.0675
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0088 0.27
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0694 0.0694
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0088 0.0441
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0627 0.3127
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0086
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0092 0.0457
Schistosoma mansoni hypothetical protein 0.014 0.1626 0.8117
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0096 0.0477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0063
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0088 0.0441
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0029 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0086
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0327 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0086
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0302 0.363 1
Leishmania major basic transcription factor 3a, putative 0.0035 0.0327 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0065 0.0694 0.3466
Treponema pallidum hypothetical protein 0.0302 0.363 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0086
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0302 0.363 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0088 0.0355
Leishmania major protein kinase, putative 0.0016 0.0088 0.0547
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0302 0.363 1
Echinococcus granulosus cpg binding protein 0.0032 0.0293 0.146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0694 0.0694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0498 0.0498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0088 0.0088
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0103 0.0415
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0598 1
Echinococcus granulosus zinc finger protein 0.0021 0.0146 0.0729
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0694 0.2807
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0199 0.0313
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0088 0.27
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0092 0.0457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.