Detailed information for compound 785820

Basic information

Technical information
  • TDR Targets ID: 785820
  • Name: 8-(4-ethoxy-3-methoxyphenyl)-3-(2-methylpheny l)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3, 5]thiadiazine-9-carbonitrile
  • MW: 435.539 | Formula: C24H25N3O3S
  • H donors: 0 H acceptors: 2 LogP: 4.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C1CC(=O)N2C(=C1C#N)SCN(C2)c1ccccc1C
  • InChi: 1S/C24H25N3O3S/c1-4-30-21-10-9-17(11-22(21)29-3)18-12-23(28)27-14-26(15-31-24(27)19(18)13-25)20-8-6-5-7-16(20)2/h5-11,18H,4,12,14-15H2,1-3H3
  • InChiKey: FVYYPAHRRDPEJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(4-ethoxy-3-methoxy-phenyl)-3-(2-methylphenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile
  • 8-(4-ethoxy-3-methoxy-phenyl)-6-keto-3-(2-methylphenyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0016 0.034 0.0194
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0174 0.7132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Onchocerca volvulus Cathepsin L homolog 0.0016 0.034 0.0251
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.091 1
Brugia malayi Pre-SET motif family protein 0.003 0.0931 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4346 0.4391
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0094 0.0131
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4346 0.4969
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2268 0.4981
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.034 0.0477
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Leishmania major cathepsin L-like protease 0.0016 0.034 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0094 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0094 0.0108
Leishmania major cathepsin L-like protease 0.0016 0.034 0.0194
Brugia malayi 6-phosphofructokinase 0.0109 0.4346 0.5023
Brugia malayi beta-lactamase family protein 0.0038 0.126 0.1457
Echinococcus granulosus cathepsin l1 0.0016 0.034 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Onchocerca volvulus 0.0016 0.034 0.0251
Brugia malayi beta-lactamase family protein 0.0038 0.126 0.1457
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0094 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0474 0.0445
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.1706 0.7275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0094 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0215 0.0494
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.034 0.0783
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.126 0.1273
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.2268 0.2106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.1277 0.7483
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0108 0.0249
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0094 0.0131
Plasmodium vivax vivapain-2 0.0016 0.034 0.1994
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.034 0.0344
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.1277 0.2938
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Onchocerca volvulus 0.003 0.0931 0.0854
Schistosoma mansoni hypothetical protein 0.0171 0.6978 0.9784
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0206 0.0474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.126 0.1273
Loa Loa (eye worm) hypothetical protein 0.0011 0.0108 0.0017
Mycobacterium ulcerans beta-lactamase 0.0038 0.126 0.2546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Brugia malayi cathepsin L-like precursor 0.0011 0.0108 0.0125
Schistosoma mansoni DNA polymerase eta 0.0019 0.0474 0.0665
Brugia malayi Thioredoxin reductase 0.0038 0.1277 0.1476
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.1277 0.1382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.162 0.2271
Toxoplasma gondii cathepsin CPL 0.0016 0.034 0.065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0094 0.0108
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.126 0.1767
Entamoeba histolytica cysteine protease, putative 0.0016 0.034 0.0783
Giardia lamblia DINP protein human, muc B family 0.0019 0.0474 0.3808
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.126 0.2546
Leishmania major cathepsin L-like protease 0.0016 0.034 0.0194
Brugia malayi TAR-binding protein 0.0066 0.2492 0.288
Onchocerca volvulus 0.0016 0.034 0.0251
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.091 0.1701
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.034 0.0477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0931 0.1306
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.3376 0.3236
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.4346 0.6094
Brugia malayi Pre-SET motif family protein 0.0209 0.8653 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.208 0.4787
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0094 0.0131
Echinococcus multilocularis cysteine protease 0.0016 0.034 0.0477
Trypanosoma brucei unspecified product 0.0019 0.0474 0.1091
Brugia malayi RNA binding protein 0.0066 0.2492 0.288
Trichomonas vaginalis set domain proteins, putative 0.0238 0.9898 1
Loa Loa (eye worm) ctsf protein 0.0016 0.034 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0108 0.0109
Loa Loa (eye worm) beta-lactamase 0.0038 0.126 0.1363
Mycobacterium tuberculosis Conserved protein 0.0038 0.126 0.1076
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.2268 0.2978
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.4346 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.162 0.2271
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.4346 0.5978
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Plasmodium falciparum thioredoxin reductase 0.0013 0.0206 0.1209
Leishmania major cathepsin L-like protease 0.0062 0.2312 0.3041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Brugia malayi steroid hormone receptor 0.0011 0.0094 0.0108
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4346 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0094 0.0131
Onchocerca volvulus Cathepsin F homolog 0.0016 0.034 0.0251
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0206 0.0238
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0931 0.1306
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0474 0.0445
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0474 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0215 0.0494
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.3376 0.3236
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0094 0.0131
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Leishmania major DNA polymerase eta, putative 0.0019 0.0474 0.0387
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0094 0.0131
Echinococcus multilocularis tar DNA binding protein 0.0066 0.2492 0.3494
Trichomonas vaginalis esterase, putative 0.0038 0.126 0.1273
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.126 0.29
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.162 0.1872
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.3376 0.3236
Echinococcus multilocularis cysteine protease 0.0016 0.034 0.0477
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.126 0.1363
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0206 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4346 0.4391
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0094 0.0131
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0474 0.1091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0094 0.0131
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0206 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0094 0.0108
Onchocerca volvulus 0.0038 0.126 0.119
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0094 0.0131
Onchocerca volvulus 0.0016 0.034 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0094 0.0131
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0206 0.0474
Onchocerca volvulus 0.0016 0.034 0.0251
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0474 0.0479
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.126 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.126 0.29
Onchocerca volvulus 0.0238 0.9898 1
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.4346 0.6094
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0474 0.0648
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.3793 0.3662
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.126 0.1076
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.2268 0.3181
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0206 0.0474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.3376 0.3236
Mycobacterium tuberculosis Conserved protein 0.0038 0.126 0.1076
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.126 0.1273
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.8653 1
Leishmania major hypothetical protein, unknown function 0.0174 0.7132 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.126 0.1076
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.091 0.5335
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0474 0.0648
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4346 0.4391
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0094 0.0131
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0474 0.0274
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0094 0.0131
Brugia malayi Cathepsin L-like precursor 0.0011 0.0108 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Leishmania major cathepsin L-like protease 0.0062 0.2312 0.3041
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2492 0.3494
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0094 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.4809 0.551
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4346 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.091 0.3415
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0215 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2492 0.3494
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0094 0.0131
Schistosoma mansoni coup transcription factor 0.0011 0.0094 0.0131
Echinococcus granulosus dna polymerase kappa 0.0019 0.0474 0.0665
Mycobacterium ulcerans lipase LipD 0.0038 0.126 0.2546
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.4346 0.4227
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.034 0.0783
Plasmodium falciparum glutathione reductase 0.0013 0.0206 0.1209
Loa Loa (eye worm) hypothetical protein 0.0011 0.0108 0.0017
Echinococcus multilocularis geminin 0.0171 0.6978 0.9784
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.091 0.3415
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0474 0.1091
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0206 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Echinococcus granulosus tar DNA binding protein 0.0066 0.2492 0.3494
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Brugia malayi Cathepsin L-like precursor 0.0011 0.0108 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Onchocerca volvulus 0.0038 0.126 0.119
Trypanosoma brucei unspecified product 0.0013 0.0215 0.0494
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0474 0.0665
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.1706 0.1972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.1277 0.1093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.126 0.1767
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.162 0.1783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.034 0.0783
Plasmodium falciparum glutathione reductase 0.0038 0.1277 0.7483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.162 0.2271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.126 0.1767
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.3376 0.3236
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.126 0.1076
Brugia malayi phosphofructokinase 0.0109 0.4346 0.5023
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.126 0.1273
Echinococcus granulosus dna polymerase eta 0.0019 0.0474 0.0665
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0094 0.0131
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0474 0.0665
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0094 0.0131
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2312 0.532
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0474 0.1091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.034 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0474 0.1091
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2492 0.3494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Brugia malayi NG,NG-dimethylarginine dimethylaminohydrolase 1, putative 0.0174 0.7132 0.8242
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0094 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.126 0.1273
Loa Loa (eye worm) glutathione reductase 0.0038 0.1277 0.1382
Plasmodium falciparum thioredoxin reductase 0.0038 0.1277 0.7483
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.3793 0.8206
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0094 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0931 0.1306
Loa Loa (eye worm) hypothetical protein 0.003 0.0931 0.0979
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.4346 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.1706 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0206 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.2312 0.532
Brugia malayi 6-phosphofructokinase 0.0109 0.4346 0.5023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.034 0.0477
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2312 0.532
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0474 0.0665
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.174 0.4004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0206 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Schistosoma mansoni hypothetical protein 0.0171 0.6978 0.9784
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0474 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0474 0.1091
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.034 0.0477
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.2492 0.2802
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0094 0.0108
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.091 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0094 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.1706 0.2393
Echinococcus granulosus cathepsin l1 0.0011 0.0108 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0094 0.0108
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0474 0.0548
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.126 0.1076
Loa Loa (eye worm) RNA binding protein 0.0066 0.2492 0.2802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0174 0.7132 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0206 0.0474
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.126 0.2546
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.1299 0.1821
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0056 0.0064
Onchocerca volvulus 0.0174 0.7132 0.7178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.162 0.2271
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0094 0.0131
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.2492 0.288
Loa Loa (eye worm) TAR-binding protein 0.0066 0.2492 0.2802
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0094 0.0108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0474 0.0274
Leishmania major hypothetical protein, conserved 0.0038 0.126 0.1522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0094 0.0108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0094 0.0131
Echinococcus granulosus expressed protein 0.0048 0.1706 0.2393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.162 0.2271
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2268 0.3181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0094 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Brugia malayi glutathione reductase 0.0038 0.1277 0.1476
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0931 0.1306
Leishmania major hypothetical protein, unknown function 0.0174 0.7132 1
Plasmodium vivax glutathione reductase, putative 0.0038 0.1277 0.7483
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.034 0.1994
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.3793 0.3662
Loa Loa (eye worm) fibroinase 0.0016 0.034 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0474 0.0548
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4346 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.126 0.7386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2492 0.3494
Onchocerca volvulus 0.0038 0.126 0.119
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0474 0.0665
Toxoplasma gondii thioredoxin reductase 0.0038 0.1277 0.5192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.162 0.2271
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0474 0.1091
Brugia malayi nuclear hormone receptor 0.0011 0.0094 0.0108
Leishmania major cathepsin L-like protease 0.0062 0.2312 0.3041
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.034 0.0344
Echinococcus multilocularis expressed protein 0.0048 0.1706 0.2393
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.1299 0.1821
Brugia malayi nuclear receptor NHR-88 0.0011 0.0094 0.0108
Loa Loa (eye worm) hypothetical protein 0.0174 0.7132 0.8223
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0108 0.0125
Onchocerca volvulus 0.0016 0.034 0.0251
Mycobacterium ulcerans hypothetical protein 0.0038 0.126 0.2546
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0094 0.0108
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0931 0.1306
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4346 0.4969
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.4346 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.034 0.0251
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.1706 0.1884
Plasmodium vivax SET domain protein, putative 0.003 0.0931 0.5458
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.3793 0.3662
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2312 0.532
Echinococcus granulosus geminin 0.0171 0.6978 0.9784
Trypanosoma brucei trypanothione reductase 0.0038 0.1277 0.2938
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4346 0.6094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0094 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.2268 0.3181
Brugia malayi ecdysteroid receptor 0.0011 0.0094 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Onchocerca volvulus 0.0011 0.0108 0.0015
Plasmodium vivax vivapain-2 0.0016 0.034 0.1994
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0094 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Toxoplasma gondii ABC1 family protein 0.0038 0.126 0.5111
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0206 0.1209
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.126 0.29
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.034 0.1994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0108 0.0109
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.1706 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0056 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.126 0.1767
Leishmania major cysteine peptidase A (CPA) 0.0016 0.034 0.0194
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.091 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0474 0.1091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0094 0.0108
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4346 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0206 0.1209
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2268 0.3181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0094 0.0131
Loa Loa (eye worm) cysteine protease 0.0016 0.034 0.0288
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4346 0.6094
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0474 0.0665
Echinococcus multilocularis dna polymerase eta 0.0019 0.0474 0.0665
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0206 0.1209
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.034 0.1994
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.091 0.5335
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.1706 0.7275
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.091 0.092
Brugia malayi beta-lactamase 0.0038 0.126 0.1457
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4346 0.4391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0094 0.0131
Mycobacterium tuberculosis Conserved protein 0.0038 0.126 0.1076
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.126 0.1076
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0206 0.0474
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.4809 0.551
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.126 0.1076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0884 0.1239
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.034 0.0393
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.034 0.0477
Onchocerca volvulus 0.0016 0.034 0.0251
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Trypanosoma brucei unspecified product 0.0013 0.0215 0.0494
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0094 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0094 0.0108
Leishmania major cathepsin L-like protease 0.0016 0.034 0.0194
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0931 0.1306
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0931 0.3517
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.091 0.5335
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0094 0.0108
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0206 0.0289
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0094 0.0108
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.091 0.5335
Onchocerca volvulus 0.0016 0.034 0.0251
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.3376 0.6855
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0206 0.5
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.091 0.3415
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.034 0.0288
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.091 0.092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2268 0.4981
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0206 0.0208
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.034 0.0477
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0094 0.0131
Brugia malayi MH2 domain containing protein 0.012 0.4809 0.5558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.034 0.0344
Loa Loa (eye worm) phosphofructokinase 0.0109 0.4346 0.4969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Leishmania major DNA polymerase kappa, putative 0.0019 0.0474 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.2268 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.126 0.1457
Echinococcus multilocularis ng dimethylarginine dimethylaminohydrolase 0.0174 0.7132 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0108 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.034 0.0393
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0108 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0931 0.1306
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0206 0.0474
Loa Loa (eye worm) hypothetical protein 0.0038 0.126 0.1363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0206 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0094 0.0131
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0206 0.0289
Echinococcus granulosus ng dimethylarginine dimethylaminohydrolase 0.0174 0.7132 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.034 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0094 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.034 0.0344
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.091 0.2095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2312 0.532
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4346 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.162 0.2271
Mycobacterium tuberculosis Probable reductase 0.0087 0.3376 0.3236
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2268 0.4981
Leishmania major trypanothione reductase 0.0038 0.1277 0.1546
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.034 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2492 0.3494
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.034 0.0477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.