TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.459 | Formula: C21H28N2O3
H donors: 1 H acceptors: 1 LogP: 5.67 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(COc1ccc(cc1)C(CC(C)(C)C)(C)C)N/N=C/c1ccco1
InChi: 1S/C21H28N2O3/c1-20(2,3)15-21(4,5)16-8-10-17(11-9-16)26-14-19(24)23-22-13-18-7-6-12-25-18/h6-13H,14-15H2,1-5H3,(H,23,24)/b22-13+
InChiKey: JFDWDHSWJIRQNF-LPYMAVHISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.0715	0.0701
Leishmania major	glucose transporter, lmgt1	0.0031	0.0621	0.7894
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0033	0.0041
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0217	0.5239
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0217	0.0956
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0333	0.1532
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.002	0.0016
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0217	0.0327
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.0198
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0612	0.0597
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0621	0.7894
Onchocerca volvulus		0.0014	0.0217	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0134	0.2978
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0195	0.2481
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.0033	0.0076
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0094	0.0347
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0094	0.0347
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0597	0.2102
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0198
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0799	0.348
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0333	0.1532
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0976	0.4268
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0217	0.2755
Onchocerca volvulus		0.0014	0.0217	0.0442
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0094	0.0187
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0786	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0566	0.2448
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	cGMP dependent protein kinase	0.0006	0.002	0.002
Brugia malayi	N-terminal motif family protein	0.0006	0.0033	0.0041
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0597	0.2583
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0097	0.2176	1
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0217	0.0728
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0006	0.002	0.0011
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0612	0.0597
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0414	0.0953
Onchocerca volvulus		0.0014	0.0217	0.0442
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0094	0.0347
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.2266	0.3424
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0621	0.274
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0611	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0611	0.2699
Schistosoma mansoni	hypothetical protein	0.0101	0.2266	0.814
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0195	0.2481
Giardia lamblia	Hexose transporter	0.0014	0.0217	0.346
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0195	0.2481
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0217	0.2755
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0195	0.0295
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0195	0.018
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0612	0.0925
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0414	0.1769
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0094	0.0187
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0786	0.0772
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0621	0.274
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0611	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0094	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0183	0.4193	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0094	0.0187
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0033	0.0062
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0597	0.2102
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0094	0.0283
Treponema pallidum	NADH oxidase	0.0013	0.0195	1
Brugia malayi	hypothetical protein	0.0009	0.0094	0.0187
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0217	0.0481
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0198
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0195	0.2481
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0414	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0414	0.6849
Trypanosoma cruzi	hypothetical protein	0.0006	0.0033	0.0417
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0621	0.7894
Schistosoma mansoni	protein kinase	0.0031	0.0611	0.2156
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0094	0.0283
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0134	0.6603
Onchocerca volvulus		0.0014	0.0217	0.0442
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0481
Onchocerca volvulus		0.0014	0.0217	0.0442
Brugia malayi	DIX domain containing protein	0.0009	0.0094	0.0187
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0006	0.002	0.002
Onchocerca volvulus		0.0014	0.0217	0.0442
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0033	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0786	0.1188
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0033	0.0041
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	glucose transport protein	0.0101	0.2266	0.814
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0728
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0429	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0097	0.2176	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Echinococcus granulosus	General substrate transporter	0.0087	0.193	0.851
Brugia malayi	Sugar transporter family protein	0.0014	0.0217	0.0481
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0217	0.0894
Echinococcus granulosus	son of sevenless 1	0.0006	0.0033	0.0076
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0094	0.0146
Entamoeba histolytica	protein kinase, putative	0.0031	0.0611	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0414	0.1901
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0414	0.1769
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0094	0.0347
Brugia malayi	RasGEF domain containing protein	0.0006	0.0033	0.0041
Leishmania major	glucose transporter, lmgt3	0.0031	0.0621	0.7894
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.1946	0.8941
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0481
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.1946	0.8941
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0786	0.0772
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0621	0.7894
Toxoplasma gondii	hypothetical protein	0.0009	0.0094	0.0142
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0072
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0612	0.0925
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Brugia malayi	major facilitator superfamily protein	0.0014	0.0217	0.0481
Brugia malayi	major facilitator superfamily protein	0.0014	0.0217	0.0481
Echinococcus multilocularis	son of sevenless 1	0.0006	0.0033	0.0076
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0195	0.0861
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0112	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.107
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0728
Schistosoma mansoni	dep domain containing protein	0.0009	0.0094	0.0283
Loa Loa (eye worm)	sugar transporter	0.0101	0.2266	0.5386
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.1946	0.8941
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0799	0.348
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0621	0.7894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Brugia malayi	N-terminal motif family protein	0.0183	0.4193	1
Plasmodium falciparum	glutathione reductase	0.0013	0.0195	0.018
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0333	0.1532
Echinococcus multilocularis	expressed conserved protein	0.0006	0.002	0.002
Brugia malayi	Cam kinase protein 1	0.0031	0.0611	0.1426
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0597	0.2583
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0611	0.1426
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.0798
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0286	0.3632
Schistosoma mansoni	glucose transporter	0.0014	0.0217	0.0728
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0112	0.023
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0195	0.2481
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0612	0.0597
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0195	0.3089
Plasmodium falciparum	protein kinase 7	0.0285	0.6617	0.6612
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0134	0.3243
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.003	0.0597	0.1391
Onchocerca volvulus		0.0014	0.0217	0.0442
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0006	0.002	0.002
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0377
Mycobacterium tuberculosis	Probable reductase	0.0087	0.1946	0.8941
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.0033	0.0076
Onchocerca volvulus		0.0014	0.0217	0.0442
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Schistosoma mansoni	glucose transport protein	0.0101	0.2266	0.814
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0195	0.018
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0414	0.0399
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0414	0.144
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Entamoeba histolytica	protein kinase, putative	0.0031	0.0611	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.0715	0.1081
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0217	0.2755
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0183	0.4193	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0097	0.2176	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Leishmania major	protein kinase, putative	0.0006	0.002	0.0256
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0217	0.2755
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0094	0.0347
Plasmodium falciparum	hexose transporter	0.0101	0.2266	0.2253
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0094	0.0347
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0597	0.2742
Schistosoma mansoni	dishevelled	0.0009	0.0094	0.0283
Schistosoma mansoni	dishevelled	0.0009	0.0094	0.0283
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0072
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0033	0.0145
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.2481
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0414	0.0625
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0566	0.2448
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0414	0.144
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Onchocerca volvulus		0.0014	0.0217	0.0442
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	RasGEF domain containing protein	0.0006	0.0033	0.0041
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.0033	0.0076
Schistosoma mansoni	protein kinase	0.0031	0.0611	0.2156
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0217	0.0327
Plasmodium falciparum	cGMP-dependent protein kinase	0.0006	0.002	0.0005
Leishmania major	hypothetical protein, conserved	0.0014	0.0217	0.2755
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0612	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5259
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0348	0.1536
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0976	0.4268
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0195	0.0896
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0414	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.0033	0.0076
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0715	0.9094
Brugia malayi	Egg laying defective protein 4	0.0006	0.002	0.0011
Plasmodium vivax	sugar transporter, putative	0.0014	0.0217	0.0201
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0611	0.2156
Brugia malayi	N-terminal motif family protein	0.0006	0.0033	0.0041
Trypanosoma cruzi	hypothetical protein	0.0006	0.0033	0.0417
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0217	0.0894
Trypanosoma cruzi	hexose transporter	0.0031	0.0621	0.7894
Leishmania major	glucose transporter, lmgt2	0.0031	0.0621	0.7894
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0006	0.002	0.003
Onchocerca volvulus		0.0009	0.0094	0.0146
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0033	0.0041
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0195	0.8925
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Schistosoma mansoni	protein kinase	0.0031	0.0611	0.2156
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0195	0.0295
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0025	0.0035
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0597	0.1391
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0597	0.2634
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0006	0.002	0.002
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0217	0.0996
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.0033	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0621	0.274
Leishmania major	protein kinase, putative	0.0006	0.002	0.0256
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0621	0.274
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.003	0.0597	0.1391
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5259
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0611	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0195	0.018
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.5259
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0414	0.0953
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Onchocerca volvulus		0.0014	0.0217	0.0442
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0195	0.4509
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0612	0.0597
Brugia malayi	glutathione reductase	0.0038	0.0786	0.1845
Onchocerca volvulus		0.0014	0.0217	0.0442
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0786	0.3614
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0094	0.0347
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0976	0.3474
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0195	0.018
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0217	0.2755
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0033	0.0062
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0217	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0217	0.5239
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0786	0.0772
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0377
Plasmodium falciparum	glutathione reductase	0.0038	0.0786	0.0772
Onchocerca volvulus		0.0014	0.0217	0.0442
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0728
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0621	0.7894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0217	0.0201
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Leishmania major	protein kinase, putative	0.0031	0.0611	0.7775
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0195	0.4717
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0094	0.0347
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.1946	0.8941
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0481
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0006	0.0033	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0976	0.3474
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Onchocerca volvulus		0.0014	0.0217	0.0442
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0195	0.8925
Onchocerca volvulus	Putative transporter	0.0014	0.0217	0.0442
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0715	0.9094
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	Thioredoxin reductase	0.0038	0.0786	0.1845
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0611	0.7775
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0217	0.0481
Onchocerca volvulus		0.0014	0.0217	0.0442
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0597	0.1391
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0094	0.0347
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.0033	0.0076
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0217	0.2755
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.1946	0.8941
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0217	0.5239
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0012	0.0175	0.0382
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.002	0.0016
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0621	0.274
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0195	0.018
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0621	0.274
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0715	0.9094
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0195	0.4717
Schistosoma mansoni	glucose transport protein	0.0101	0.2266	0.814
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0094	0.0187
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0612	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.0033	0.0076
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0621	0.7894
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0006	0.0033	0.0417
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0786	0.1845
Mycobacterium tuberculosis	Probable oxidoreductase	0.0097	0.2176	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0621	0.7894
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0006	0.002	0.002
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0612	0.0925
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Brugia malayi	Sugar transporter family protein	0.0014	0.0217	0.0481
Onchocerca volvulus		0.0014	0.0217	0.0442
Onchocerca volvulus		0.0014	0.0217	0.0442
Brugia malayi	RasGEF domain containing protein	0.0006	0.0033	0.0041
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0094	0.0187
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0094	0.0187
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0621	0.274
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0163	0.3734	0.5643
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0976	0.4268
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0414	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0976	0.2298
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0612	0.0597
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.2481
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0195	0.043
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0217	0.0327
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.2266	1
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0481
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Plasmodium vivax	hexose transporter	0.0101	0.2266	0.2253
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0033	0.0062
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Entamoeba histolytica	hypothetical protein	0.0006	0.0033	0.0288
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0195	0.0861
Giardia lamblia	Sugar-proton symporter	0.0014	0.0217	0.346
Brugia malayi	hypothetical protein	0.0009	0.0094	0.0187
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0611	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0612	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.0715	0.0701
Loa Loa (eye worm)	sugar transporter	0.0014	0.0217	0.0481
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0069
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0597	0.9752
Brugia malayi	Sugar transporter family protein	0.0101	0.2266	0.5386
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0145
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0414	0.1826
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0621	0.7894
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0033	0.0041
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0786	0.1845
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0198
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.0798
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0033	0.0062
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0033	0.0041
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0611	0.1426
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2266	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0715	0.9094
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0621	0.7894
Entamoeba histolytica	hypothetical protein	0.0023	0.0414	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Mycobacterium ulcerans	sugar transporter	0.0014	0.0217	0.5239
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0414	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0217	0.0996
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0612	0.0597
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.1946	0.8941
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0715	0.9094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0976	0.3474
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.4717
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0163	0.3734	0.3724
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0195	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0094	0.0283
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0033	0.0062
Trypanosoma brucei	trypanothione reductase	0.0038	0.0786	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0976	0.2298
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0195	0.2481
Toxoplasma gondii	protein kinase, putative	0.0285	0.6617	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0163	0.3734	0.3724
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0976	0.4268
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0195	0.2481
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2266	1
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0621	0.7894
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0094	0.0347
Leishmania major	trypanothione reductase	0.0038	0.0786	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0033	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0481
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0217	0.0894
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0597	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0094	0.0187
Echinococcus multilocularis	General substrate transporter	0.0087	0.193	0.851
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0195	0.2481
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0481
Echinococcus granulosus	Protein son of sevenless	0.0006	0.0033	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 786521