TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.269 | Formula: C19H18BrN3O3
H donors: 3 H acceptors: 5 LogP: 3.45 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cccc(c1)C1C2=C(O)CC(CC2=Nc2c1c(O)nc(n2)O)(C)C
InChi: 1S/C19H18BrN3O3/c1-19(2)7-11-14(12(24)8-19)13(9-4-3-5-10(20)6-9)15-16(21-11)22-18(26)23-17(15)25/h3-6,13,24H,7-8H2,1-2H3,(H2,22,23,25,26)
InChiKey: PLJFGSVBOFVQGO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0559	0.229
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0086	0.1767	0.8108
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0484	0.0617
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	0.6424
Brugia malayi	Cam kinase protein 1	0.0032	0.0484	0.0874
Trypanosoma cruzi	hypothetical protein, conserved	0.0214	0.4772	0.7198
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.0657
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.003	0.0441	0.036
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0025	0.0323	0.0367
Plasmodium vivax	thioredoxin reductase, putative	0.0086	0.1755	0.1686
Plasmodium vivax	SET domain protein, putative	0.003	0.0449	0.0369
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0484	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Echinococcus granulosus	histone lysine methyltransferase setb	0.0047	0.0836	0.3624
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0484	0.0404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0328
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0025	0.0323	0.0455
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.1098	0.4886
Trypanosoma brucei	hypothetical protein, conserved	0.0214	0.4772	0.7198
Brugia malayi	glutathione reductase	0.0086	0.1755	0.3651
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0441	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Echinococcus granulosus	thioredoxin glutathione reductase	0.0086	0.1767	0.8108
Schistosoma mansoni	glucose transport protein	0.0103	0.216	0.3412
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.5342	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0292	0.6596	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0248
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.003	0.0441	0.0549
Brugia malayi	Sugar transporter family protein	0.0103	0.216	0.4535
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.0256	0.0376
Plasmodium falciparum	hexose transporter	0.0103	0.216	0.2094
Loa Loa (eye worm)	glutathione reductase	0.0086	0.1755	0.3709
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0195	0.4332	0.8897
Onchocerca volvulus		0.0238	0.5342	1
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0212	0.0369
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.003	0.0441	0.172
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0025	0.0323	0.0963
Trypanosoma brucei	ISWI complex protein	0.0015	0.0091	0.0011
Leishmania major	glucose transporter, lmgt2	0.0032	0.0493	0.0629
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.2987	0.4458
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.0436
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0217	0.4844	1
Brugia malayi	Thioredoxin reductase	0.0086	0.1755	0.3651
Brugia malayi	Bromodomain containing protein	0.0072	0.1446	0.2974
Mycobacterium tuberculosis	Probable dehydrogenase	0.0195	0.4332	0.8924
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0668	0.1356
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0084	0.025
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.2987	0.4458
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0025	0.0323	0.0963
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.0629
Loa Loa (eye worm)	thioredoxin reductase	0.0086	0.1755	0.3709
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.3353	0.6868
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0484	0.0957
Entamoeba histolytica	protein kinase, putative	0.0032	0.0484	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0047	0.0836	0.3624
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0559	0.229
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0484	0.0657
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.0779
Plasmodium falciparum	protein kinase 7	0.0291	0.6571	0.6542
Schistosoma mansoni	glucose transport protein	0.0103	0.216	0.3412
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0255	0.0827
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.0201
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0145	0.0223
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0195	0.4332	0.8924
Mycobacterium ulcerans	sugar transporter	0.0014	0.0084	0.025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Brugia malayi	Pre-SET motif family protein	0.0209	0.4663	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0484	0.0404
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0493	0.0629
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0195	0.4332	0.8924
Schistosoma mansoni	glucose transport protein	0.0103	0.216	0.3412
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Echinococcus granulosus	General substrate transporter	0.0088	0.1821	0.8364
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.003	0.0441	0.1315
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.216	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.003	0.0441	0.0587
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Trypanosoma cruzi	hexose transporter	0.0032	0.0493	0.0629
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0323	0.0963
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0707	0.0958
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.0925
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.0256	0.0376
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0131	0.0077
Plasmodium falciparum	thioredoxin reductase	0.003	0.0441	0.036
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.038
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0484	0.0957
Echinococcus multilocularis	General substrate transporter	0.0088	0.1821	0.8364
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.5182
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0255	0.0827
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0323	0.0502
Plasmodium falciparum	glutathione reductase	0.003	0.0441	0.036
Trypanosoma cruzi	trypanothione reductase, putative	0.0086	0.1755	0.2567
Brugia malayi	Pre-SET motif family protein	0.003	0.0449	0.0799
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.0131	0.0227
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0423	0.1636
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0253
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0493	0.0629
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0084	0.025
Echinococcus multilocularis	zinc finger protein	0.0019	0.0188	0.0503
Entamoeba histolytica	protein kinase, putative	0.0032	0.0484	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.003	0.0441	0.9276
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1348	0.2828
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0086	0.1755	0.3512
Loa Loa (eye worm)	sugar transporter	0.0103	0.216	0.4585
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0484	0.0957
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0449	0.0601
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.003	0.0441	0.075
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.0961
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0308
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0091	0.0011
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0707	0.0958
Trypanosoma cruzi	hypothetical protein, conserved	0.0214	0.4772	0.7198
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0836	0.1236
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0025	0.0323	0.0502
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0469	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.0629
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0025	0.0323	0.0963
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.0629
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0441	0.0549
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.003	0.0441	0.0549
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0441	0.0549
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0441	1
Schistosoma mansoni	hypothetical protein	0.002	0.0212	0.0211
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0484	0.0404
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0484	0.0617
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0255	0.0282
Leishmania major	trypanothione reductase	0.0086	0.1755	0.2567
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.1855
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0306
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0484	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.0779
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0025	0.0323	0.1152
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0306
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.0779
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0589	0.0776
Trichomonas vaginalis	glutathione reductase, putative	0.003	0.0441	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0484	0.0761
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0484	0.0874
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.0779
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.1855
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.0131	0.0227
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0918	0.1281
Plasmodium vivax	hexose transporter	0.0103	0.216	0.2094
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.003	0.0441	0.1315
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.0845
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0493	0.0629
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0707	0.0958
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.6596	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Mycobacterium ulcerans	hypothetical protein	0.0154	0.3353	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.6596	1
Schistosoma mansoni	bromodomain containing protein	0.0061	0.118	0.18
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0154	0.0107
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.003	0.0441	0.1315
Mycobacterium tuberculosis	Probable reductase	0.0195	0.4332	0.8924
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.0733
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0484	0.0614
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.003	0.0441	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0217	0.4844	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0484	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0449	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0195	0.4332	0.8924
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.003	0.0441	0.036
Leishmania major	glucose transporter, lmgt3	0.0032	0.0493	0.0629
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0441	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0633
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0441	0.0549
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0484	0.0404
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0589	0.0776
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.2987	0.4458
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0091
Echinococcus granulosus	zinc finger protein	0.0019	0.0188	0.0503
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.0629
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Toxoplasma gondii	thioredoxin reductase	0.0086	0.1755	0.2577
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.0779
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.216	0.3949
Loa Loa (eye worm)	sugar transporter	0.0014	0.0084	0.0091
Schistosoma mansoni	hypothetical protein	0.0015	0.0091	0.0012
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.4663	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.0629
Leishmania major	hypothetical protein, conserved	0.0015	0.0091	0.0011
Schistosoma mansoni	zinc finger protein	0.0015	0.0091	0.0012
Toxoplasma gondii	hypothetical protein	0.0047	0.0849	0.118
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0449	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.0523
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0484	0.0617
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0469	0.0575
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.1098	0.4886
Leishmania major	mitochondrial DNA polymerase beta	0.0292	0.6596	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0707	0.0958
Schistosoma mansoni	hypothetical protein	0.0103	0.216	0.3412
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.003	0.0441	0.078
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.0961
Plasmodium vivax	glutathione reductase, putative	0.0086	0.1755	0.1686
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0589	0.051
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0091	0.0011
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0836	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0836	0.172
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.0925
Brugia malayi	PHD-finger family protein	0.0024	0.0309	0.0492
Leishmania major	hypothetical protein, conserved	0.0214	0.4772	0.7198
Onchocerca volvulus		0.003	0.0449	0.0696
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.003	0.0441	0.0551
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0484	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.0629
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.003	0.0441	0.036
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0323	0.0963
Leishmania major	protein kinase, putative	0.0032	0.0484	0.0614
Toxoplasma gondii	protein kinase, putative	0.0291	0.6571	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0333	0.0631
Schistosoma mansoni	zinc finger protein	0.0019	0.0188	0.0171
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0306
Toxoplasma gondii	NADPH-glutathione reductase	0.003	0.0441	0.0551
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0328
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0248
Mycobacterium tuberculosis	Probable oxidoreductase	0.0217	0.4844	1
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.0657
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0484	0.1927
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.003	0.0441	0.036
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0437	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3649	0.5495
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0438	0.1707
Echinococcus granulosus	citrate lyase subunit beta protein	0.0025	0.0323	0.1152
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0217	0.4844	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0201
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0084	0.025
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0195	0.4332	0.8924
Plasmodium falciparum	glutathione reductase	0.0086	0.1755	0.1686
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0589	0.0779
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0025	0.0323	0.0367
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0449	0.1761
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.9253
Plasmodium falciparum	thioredoxin reductase	0.0086	0.1755	0.1686
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.0779
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.003	0.0441	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trypanosoma brucei	trypanothione reductase	0.0086	0.1755	0.2567
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0438	0.1707
Leishmania major	glucose transporter, lmgt1	0.0032	0.0493	0.0629
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.216	0.3201
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.0841
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.216	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0441	0.0549
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0484	0.0404
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0025	0.0323	0.0367
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.003	0.0441	0.0549
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0589	0.051
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.003	0.0441	0.172
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3649	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.0845
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0131	0.0077
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0712	0.145
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0441	0.0549
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.0629
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3649	0.3595
Treponema pallidum	NADH oxidase	0.003	0.0441	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	0.0776
Trichomonas vaginalis	mercuric reductase, putative	0.003	0.0441	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0614	0.124
Brugia malayi	Bromodomain containing protein	0.0037	0.0613	0.1156
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.1927

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 792597