Detailed information for compound 79502

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 173.214 | Formula: C10H11N3
  • H donors: 0 H acceptors: 2 LogP: 1.66 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc2c(c1)cncn2)C
  • InChi: 1S/C10H11N3/c1-13(2)9-3-4-10-8(5-9)6-11-7-12-10/h3-7H,1-2H3
  • InChiKey: YAERXMIGDADHGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase 0.0054 0.0907 0.1205
Onchocerca volvulus 0.0018 0.0217 0.0151
Schistosoma mansoni hypothetical protein 0.0054 0.0907 0.1205
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus carboxylesterase 5A 0.0081 0.1428 0.1907
Schistosoma mansoni glucose transport protein 0.0125 0.2266 0.3037
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0335 0.3697
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0043 0.0697 0.1054
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0217 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0546 0.6022
Brugia malayi Protein kinase domain containing protein 0.0058 0.0981 0.1925
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0332 0.3661
Schistosoma mansoni tyrosine kinase 0.018 0.3322 0.4461
Echinococcus multilocularis carbonic anhydrase II 0.0054 0.0907 0.1205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0332 0.3661
Schistosoma mansoni ran 0.0024 0.0335 0.0434
Leishmania major importin beta-1 subunit, putative 0.0026 0.0382 0.4206
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0335 0.0434
Trypanosoma brucei glucose transporter 1E 0.0039 0.0621 0.6844
Schistosoma mansoni tyrosine kinase 0.0097 0.173 0.2315
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Schistosoma mansoni cpg binding protein 0.0029 0.0442 0.0578
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.6844
Toxoplasma gondii sugar transporter ST3 0.0018 0.0217 0.0327
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0498 0.5491
Plasmodium vivax importin-beta 2, putative 0.0032 0.0498 0.0483
Echinococcus multilocularis snurportin 1 0.0345 0.6465 0.8698
Echinococcus multilocularis General substrate transporter 0.0107 0.193 0.2585
Onchocerca volvulus 0.0018 0.0217 0.0151
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.0143 0.0175
Onchocerca volvulus 0.0018 0.0217 0.0151
Brugia malayi Carboxylesterase family protein 0.0014 0.0143 0.0254
Schistosoma mansoni tyrosine kinase 0.0058 0.0981 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni tyrosine kinase 0.0058 0.0981 0.1305
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.0143 0.0175
Leishmania major protein kinase, putative 0.0038 0.0611 0.6741
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0697 0.1057
Brugia malayi polk-prov protein 0.0035 0.0546 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0143 0.0175
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0217 0.0327
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0191 0.2106
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Echinococcus granulosus neuroligin 0.0014 0.0143 0.0175
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0597 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0981 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0697 0.7687
Echinococcus multilocularis acetylcholinesterase 0.0081 0.1428 0.1907
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0191 0.024
Trypanosoma brucei carbonic anhydrase-like protein 0.0054 0.0907 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.0143 0.0175
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0172
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0335 0.3697
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.7885
Loa Loa (eye worm) hypothetical protein 0.003 0.0463 0.0693
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0217 0.0274
Loa Loa (eye worm) hypothetical protein 0.003 0.0458 0.0686
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0611 0.0807
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0611 0.0924
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Schistosoma mansoni hypothetical protein 0.0395 0.743 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.6465 1
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.173 0.2315
Loa Loa (eye worm) carboxylesterase 0.0081 0.1428 0.219
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0217 0.0274
Schistosoma mansoni tyrosine kinase 0.0097 0.173 0.2315
Echinococcus multilocularis musashi 0.003 0.0458 0.06
Echinococcus multilocularis acetylcholinesterase 0.0081 0.1428 0.1907
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0332 0.9961
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0043 0.0697 0.0922
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0458 0.0883
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0621 0.274
Loa Loa (eye worm) carboxylesterase 0.0014 0.0143 0.0197
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0612 0.0925
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0119 0.0179
Entamoeba histolytica protein kinase, putative 0.0038 0.0611 0.8741
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.0907 1
Onchocerca volvulus 0.003 0.0458 0.0646
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.0143 0.4282
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.016 0.0198
Entamoeba histolytica protein kinase, putative 0.0038 0.0611 0.8741
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0191 0.2106
Echinococcus granulosus geminin 0.019 0.3505 0.4709
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0907 0.1778
Entamoeba histolytica hypothetical protein 0.0026 0.0382 0.5368
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0274
Brugia malayi Carboxylesterase family protein 0.0014 0.0143 0.0254
Trypanosoma cruzi hexose transporter 0.0039 0.0621 0.6844
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0207
Onchocerca volvulus 0.0028 0.0411 0.055
Loa Loa (eye worm) hypothetical protein 0.0054 0.0907 0.1382
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0217 0.0956
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0217 0.2852
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0016 0.0205
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0348 0.1536
Toxoplasma gondii sugar transporter ST1 0.0018 0.0217 0.0327
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0335 0.032
Echinococcus granulosus intermediate filament protein 0.003 0.0458 0.06
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0597 0.0787
Leishmania major glucose transporter, lmgt3 0.0039 0.0621 0.6844
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0566 0.0746
Echinococcus granulosus acetylcholinesterase 0.0081 0.1428 0.1907
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0414 0.0794
Loa Loa (eye worm) carboxylesterase 0.0014 0.0143 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Schistosoma mansoni gliotactin 0.0014 0.0143 0.0175
Leishmania major glucose transporter, lmgt1 0.0039 0.0621 0.6844
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.019 0.0271
Brugia malayi CXXC zinc finger family protein 0.0028 0.0411 0.079
Schistosoma mansoni lamin 0.003 0.0458 0.06
Schistosoma mansoni tyrosine kinase 0.0096 0.171 0.2288
Brugia malayi hypothetical protein 0.0018 0.0217 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.2389
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Brugia malayi intermediate filament protein 0.003 0.0458 0.0883
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0597 1
Echinococcus granulosus carbonic anhydrase 0.0054 0.0907 0.1205
Leishmania major hypothetical protein, conserved 0.0018 0.0217 0.2389
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.3322 0.6595
Schistosoma mansoni tyrosine kinase 0.0096 0.171 0.2288
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0286 0.3149
Brugia malayi Importin beta-1 subunit 0.0032 0.0498 0.0963
Schistosoma mansoni glucose transport protein 0.0125 0.2266 0.3037
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0611 0.2699
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0546 0.6022
Echinococcus multilocularis dna polymerase kappa 0.0046 0.076 0.1007
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0981 0.1305
Trichomonas vaginalis ran, putative 0.0024 0.0335 0.148
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0217 0.0956
Mycobacterium ulcerans carboxylesterase, LipT 0.0014 0.0143 0.1879
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.076 0.8375
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.2602
Plasmodium falciparum hexose transporter 0.0125 0.2266 0.2253
Brugia malayi Sugar transporter family protein 0.0125 0.2266 0.4488
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0414 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.2602
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0907 0.1205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0016 0.0024
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0414 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0612 0.0597
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0134 0.1765
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0054 0.0907 0.1778
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0125 0.2266 0.3037
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Onchocerca volvulus 0.0018 0.0217 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0611 0.0807
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0191 0.024
Echinococcus granulosus dna polymerase eta 0.0016 0.0191 0.024
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0414 0.1826
Schistosoma mansoni hypothetical protein 0.019 0.3505 0.4709
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0043 0.0697 0.0922
Echinococcus granulosus dnaJ subfamily B 0.0395 0.743 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi Carboxylesterase family protein 0.0014 0.0143 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Giardia lamblia Sugar-proton symporter 0.0018 0.0217 0.346
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0498 0.0654
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Echinococcus multilocularis cpg binding protein 0.0029 0.0442 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0016 0.0262
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.0143 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0043 0.0055
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0335 0.0434
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.0143 0.4282
Trypanosoma brucei sugar transporter, putative 0.0018 0.0217 0.2389
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0697 0.0683
Echinococcus granulosus epidermal growth factor receptor 0.018 0.3322 0.4461
Onchocerca volvulus 0.0018 0.0217 0.0151
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0611 0.6741
Leishmania major DNA polymerase eta, putative 0.0016 0.0191 0.2106
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0043 0.0697 0.136
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.076 0.3353
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0274
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0043 0.0697 1
Brugia malayi hypothetical protein 0.0014 0.0143 0.0254
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0333 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.6844
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.0016 0.0003
Echinococcus multilocularis insulin receptor 0.0058 0.0981 0.1305
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Echinococcus granulosus cpg binding protein 0.0029 0.0442 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0217 0.2852
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.076 0.8375
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0611 0.0924
Onchocerca volvulus 0.0018 0.0217 0.0151
Brugia malayi Carboxylesterase family protein 0.0081 0.1428 0.2817
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0414 0.054
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0172
Schistosoma mansoni cpg binding protein 0.0028 0.0411 0.0537
Schistosoma mansoni tyrosine kinase 0.0096 0.171 0.2288
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0172
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi hypothetical protein 0.0018 0.0217 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0014 0.0143 0.063
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0907 0.1778
Echinococcus granulosus dna polymerase kappa 0.0046 0.076 0.1007
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0401
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0382 0.1684
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.0907 0.1205
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0907 0.1205
Echinococcus multilocularis neuroligin 0.0014 0.0143 0.0175
Schistosoma mansoni hypothetical protein 0.0125 0.2266 0.3037
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0715 0.0701
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0414 0.456
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0907 0.1778
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0054 0.0907 0.1382
Plasmodium falciparum importin beta, putative 0.0032 0.0498 0.0483
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0274
Loa Loa (eye worm) sugar transporter 0.0018 0.0217 0.0312
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0134 1
Toxoplasma gondii protein kinase, putative 0.0353 0.6617 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0597 0.0901
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0697 0.3078
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0611 0.0924
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0401
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0312
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0044
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 0.5587
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0907 0.1205
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0907 0.1778
Loa Loa (eye worm) hypothetical protein 0.0032 0.0498 0.0748
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Loa Loa (eye worm) hypothetical protein 0.0081 0.1428 0.219
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0621 0.274
Leishmania major GTP-binding protein, putative 0.0024 0.0335 0.3697
Entamoeba histolytica Ran family GTPase 0.0024 0.0335 0.469
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0217 0.2389
Loa Loa (eye worm) acetylcholinesterase 1 0.0081 0.1428 0.219
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0191 0.035
Toxoplasma gondii facilitative glucose transporter GT1 0.0125 0.2266 0.3424
Brugia malayi Cam kinase protein 1 0.0038 0.0611 0.1189
Schistosoma mansoni protein kinase 0.0038 0.0611 0.0807
Mycobacterium tuberculosis Carboxylesterase LipT 0.0014 0.0143 0.4282
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0498 0.5491
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0907 0.1205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0272
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Onchocerca volvulus 0.0018 0.0217 0.0151
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0191 0.024
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0612 0.0925
Schistosoma mansoni lamin 0.003 0.0458 0.06
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0217 0.0274
Loa Loa (eye worm) pax transcription factor protein 2 0.0269 0.5029 0.7773
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0907 0.1382
Trypanosoma brucei unspecified product 0.0011 0.0095 0.1047
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.0907 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.0907 0.1205
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0134 0.2978
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0414 0.6849
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.0143 0.0175
Trypanosoma brucei unspecified product 0.0039 0.0619 0.6819
Onchocerca volvulus 0.0018 0.0217 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Plasmodium falciparum carbonic anhydrase 0.0054 0.0907 0.0893
Plasmodium vivax sugar transporter, putative 0.0018 0.0217 0.0201
Echinococcus multilocularis geminin 0.019 0.3505 0.4709
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.3322 0.4461
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0414 0.054
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0016 0.0172
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0907 0.1205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.076 0.8375
Onchocerca volvulus 0.0018 0.0217 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Onchocerca volvulus Putative transporter 0.0018 0.0217 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0414 0.5444
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0007 0.0023 0.0677
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0907 0.1382
Onchocerca volvulus 0.003 0.0458 0.0646
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.1428 0.1907
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0202 0.3734 0.5643
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0172
Giardia lamblia DINP protein human, muc B family 0.0024 0.0332 0.5447
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0414 0.0399
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0043 0.0697 0.136
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0597 0.1159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.076 0.8375
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0202 0.3734 0.3724
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0697 0.0683
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0274
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0016 0.0205
Loa Loa (eye worm) hypothetical protein 0.0081 0.1428 0.219
Leishmania major carbonic anhydrase-like protein 0.0054 0.0907 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0044 0.0482
Onchocerca volvulus 0.0018 0.0217 0.0151
Echinococcus granulosus lamin 0.003 0.0458 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni importin beta-1 0.0032 0.0498 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Onchocerca volvulus 0.0269 0.5029 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.0143 0.0175
Schistosoma mansoni intermediate filament proteins 0.003 0.0458 0.06
Schistosoma mansoni glucose transporter 0.0018 0.0217 0.0274
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.6844
Trichomonas vaginalis helicase, putative 0.0006 0.0002 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2266 1
Onchocerca volvulus 0.0018 0.0217 0.0151
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0597 0.1159
Entamoeba histolytica hypothetical protein 0.0028 0.0414 0.5838
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0401
Echinococcus granulosus acetylcholinesterase 0.0081 0.1428 0.1907
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0335 0.0496
Schistosoma mansoni glucose transport protein 0.0125 0.2266 0.3037
Echinococcus granulosus snurportin 1 0.0345 0.6465 0.8698
Schistosoma mansoni hypothetical protein 0.019 0.3505 0.4709
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0335 0.3697
Echinococcus multilocularis dna polymerase eta 0.0016 0.0191 0.024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0217 0.6499
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.2602
Echinococcus granulosus General substrate transporter 0.0107 0.193 0.2585
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0217 0.2389
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0207
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.0143 0.0175
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Trypanosoma brucei unspecified product 0.0011 0.0095 0.1047
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0382 0.4206
Schistosoma mansoni carbonic anhydrase 0.0054 0.0907 0.1205
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0621 0.6844
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0043 0.0697 0.0922
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0597 0.0787
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0697 0.7687
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0566 0.0746
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0143 0.0175
Echinococcus granulosus carbonic anhydrase II 0.0054 0.0907 0.1205
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0715 0.1081
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0886 0.1338
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Loa Loa (eye worm) hypothetical protein 0.0054 0.0907 0.1382
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Onchocerca volvulus 0.0018 0.0217 0.0151
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0335 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 0.7885
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.076 0.8375
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 0.7885
Echinococcus granulosus carbonic anhydrase 0.0054 0.0907 0.1205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0191 0.2573
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni ran 0.0024 0.0335 0.0434
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0612 0.0597
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0414 0.0399
Echinococcus multilocularis lamin dm0 0.003 0.0458 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0175 0.0247
Echinococcus multilocularis lamin 0.003 0.0458 0.06
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0612 0.0597
Schistosoma mansoni DNA polymerase eta 0.0016 0.0191 0.024
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.7885
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0697 0.3078
Loa Loa (eye worm) sugar transporter 0.0125 0.2266 0.3489
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0619 0.6819
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.076 0.8375
Leishmania major DNA polymerase kappa, putative 0.0024 0.0332 0.3661
Brugia malayi RNA, U transporter 1 0.0092 0.1635 0.3231
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0016 0.0468
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.076 1
Schistosoma mansoni protein kinase 0.0038 0.0611 0.0807
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Loa Loa (eye worm) hypothetical protein 0.0028 0.0414 0.0617
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis carboxylesterase 5A 0.0081 0.1428 0.1907
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0612 0.0597
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0274
Schistosoma mansoni cpg binding protein 0.0029 0.0442 0.0578
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0414 0.6932
Brugia malayi Carboxylesterase family protein 0.0014 0.0143 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0458 0.0686
Loa Loa (eye worm) hypothetical protein 0.0037 0.0597 0.0901
Brugia malayi Carboxylesterase family protein 0.0081 0.1428 0.2817
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2266 0.3037
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0217 0.0274
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.076 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0014 0.0143 0.063
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0217 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0448 0.067
Plasmodium vivax hexose transporter 0.0125 0.2266 0.2253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.743 1
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.173 0.2315
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0612 0.0597
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.0016 0.0003
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.7885
Echinococcus granulosus lamin dm0 0.003 0.0458 0.06
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.0016 0.0003
Echinococcus granulosus insulin receptor 0.0058 0.0981 0.1305
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0274
Schistosoma mansoni acetylcholinesterase 0.0014 0.0143 0.0175
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.6844
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.016 0.0198
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0414 0.456
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0414 0.5444
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0401
Echinococcus multilocularis 0.0056 0.0946 0.1258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0016 0.0024
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0217 0.6499
Brugia malayi hypothetical protein 0.0018 0.0217 0.0401
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0312
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0907 0.1778
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.019 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0043 0.0697 0.7687
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0191 0.0272
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0143 0.0175
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0274
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0981 0.1497
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0191 0.035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0044
Onchocerca volvulus 0.0018 0.0217 0.0151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Mycobacterium ulcerans sugar transporter 0.0018 0.0217 0.2852
Schistosoma mansoni protein kinase 0.0038 0.0611 0.0807
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0217 0.2852
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0382 0.1684
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.0016 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.076 0.3353
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0335 0.0638
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0612 0.0597
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0274
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.6844
Schistosoma mansoni hypothetical protein 0.0345 0.6465 0.8698
Plasmodium falciparum protein kinase 7 0.0353 0.6617 0.6612
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0382 0.1684
Loa Loa (eye worm) carbonic anhydrase 3 0.0054 0.0907 0.1382
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0274
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0597 0.2634
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0217 0.2389
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0043 0.0697 0.7687
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0611 0.0807
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.173 0.2315
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0597 0.0787
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0191 0.573
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0621 0.274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1006 0.1338
Leishmania major glucose transporter, lmgt2 0.0039 0.0621 0.6844
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0007
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0414 0.054
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0907 0.1778
Toxoplasma gondii hypothetical protein 0.0054 0.0907 0.1371
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0612 0.0597
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0217 0.0274
Toxoplasma gondii sugar transporter ST2 0.0018 0.0217 0.0327
Giardia lamblia Hexose transporter 0.0018 0.0217 0.346
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0612 0.0925
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.2389
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0621 0.274
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0411 0.0614
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0191 0.024
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0697 0.1057
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0401
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0335 0.032
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.6844
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0274
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0597 0.8524
Onchocerca volvulus 0.0018 0.0217 0.0151
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0611 0.1189
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0197
Loa Loa (eye worm) hypothetical protein 0.0035 0.0546 0.0823
Trypanosoma brucei glucose transporter 2A 0.0039 0.0621 0.6844
Plasmodium falciparum mitogen-activated protein kinase 2 0.0202 0.3734 0.3724
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0335 0.5502
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0414 0.456
Onchocerca volvulus 0.0018 0.0217 0.0151
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0907 0.1205
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0612 0.0597
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.3322 0.5127
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.6844
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.0143 0.0175
Plasmodium vivax CDK-related protein kinase 6, putative 0.053 1 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0414 0.054
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0401
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0597 0.0787
Brugia malayi Pax transcription factor protein 2 0.0269 0.5029 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.076 0.8375
Echinococcus granulosus importin subunit beta 1 0.0032 0.0498 0.0654
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0312
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) intermediate filament protein 0.003 0.0458 0.0686
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0498 0.0753
Onchocerca volvulus 0.0018 0.0217 0.0151

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 120 nM Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells ChEMBL. 8627606
IC50 (binding) = 120 nM Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells ChEMBL. 8627606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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