Detailed information for compound 797323

Basic information

Technical information
  • TDR Targets ID: 797323
  • Name: (3E)-3-(2-oxopropylidene)-4H-1,4-benzoxazin-2 -one
  • MW: 203.194 | Formula: C11H9NO3
  • H donors: 1 H acceptors: 2 LogP: 1.43 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)/C=c\1/[nH]c2ccccc2oc1=O
  • InChi: 1S/C11H9NO3/c1-7(13)6-9-11(14)15-10-5-3-2-4-8(10)12-9/h2-6,12H,1H3/b9-6+
  • InChiKey: WEAVOYWFPUXBBO-RMKNXTFCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-oxopropylidene)-4H-1,4-benzoxazin-2-one
  • (3E)-3-acetonylidene-4H-1,4-benzoxazin-2-one
  • 3-acetonylidene-4H-1,4-benzoxazin-2-one
  • ZINC00083413
  • 3-(2-Oxo-propylidene)-3,4-dihydro-benzo[1,4]oxazin-2-one
  • BAS 00702132
  • A2183/0091746

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0316 0.1406
Loa Loa (eye worm) hypothetical protein 0.0053 0.043 0.1945
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0066 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0207 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0316 0.1425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0394 0.1943
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0035 0.0175
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Echinococcus granulosus tissue type plasminogen activator 0.0054 0.0441 0.0424
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Plasmodium falciparum cysteine repeat modular protein 1 0.0054 0.0441 0.2158
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0066 0.0154
Echinococcus granulosus intermediate filament protein 0.0033 0.018 0.0163
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.043 0.1945
Brugia malayi casein kinase II, putaitve 0.0022 0.0047 0.0196
Trypanosoma brucei glucosidase, putative 0.0044 0.0316 0.442
Onchocerca volvulus 0.0035 0.0207 0.1641
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.2028 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.077
Plasmodium vivax casein kinase II beta chain, putative 0.0074 0.0692 0.3401
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0066 0.0285
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0035 0.0459
Loa Loa (eye worm) Csnk2b protein 0.0074 0.0692 0.3145
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.043 0.2103
Brugia malayi Cytochrome P450 family protein 0.0055 0.045 0.2039
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0649 0.2948
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0207 0.0509
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0074 0.0692 0.5828
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0649 0.308
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0066 0.0062
Toxoplasma gondii PAN domain-containing protein 0.0324 0.3755 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0035 0.0269
Onchocerca volvulus 0.0054 0.0441 0.3655
Onchocerca volvulus 0.0035 0.0207 0.1641
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Loa Loa (eye worm) hypothetical protein 0.0071 0.0649 0.2948
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Loa Loa (eye worm) casein kinase II 0.0022 0.0047 0.0196
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0207 0.0509
Echinococcus multilocularis dna polymerase eta 0.0023 0.0066 0.0049
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0316 0.1406
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0035 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0066 0.0467
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0649 0.9343
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0649 0.308
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Onchocerca volvulus 0.0021 0.0035 0.0157
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0649 0.308
Onchocerca volvulus 0.0021 0.0035 0.0157
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0035 0.0269
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0316 0.1425
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0066 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0035 0.0269
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0035 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0649 0.2948
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0316 0.442
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0066 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0441 0.6272
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0649 0.9373
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.043 0.2118
Leishmania major DNA polymerase kappa, putative 0.0023 0.0066 0.0905
Toxoplasma gondii ck2 beta subunit 0.0074 0.0692 0.1806
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0074 0.0692 0.5828
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.043 0.1978
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0035 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0649 0.308
Echinococcus granulosus lamin dm0 0.0033 0.018 0.0163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0133 0.1414 0.6441
Leishmania major hypothetical protein, conserved 0.0054 0.0441 0.6345
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0207 0.093
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0207 0.093
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0066 0.0724
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.2028 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0313 0.0309
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0074 0.0692 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2193 0.218
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0313 0.0309
Onchocerca volvulus 0.0035 0.0207 0.1641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0394 0.1943
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0207 0.0509
Brugia malayi intermediate filament protein 0.0033 0.018 0.0803
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0649 0.308
Schistosoma mansoni lamin 0.0033 0.018 0.0176
Loa Loa (eye worm) hypothetical protein 0.0071 0.0649 0.2948
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0035 0.0156
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0035 0.0175
Loa Loa (eye worm) hypothetical protein 0.0053 0.043 0.1945
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0035 0.0269
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2193 0.218
Loa Loa (eye worm) hypothetical protein 0.0053 0.043 0.1945
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0066 0.0049
Echinococcus multilocularis lamin dm0 0.0033 0.018 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0035 0.0049
Trypanosoma brucei unspecified product 0.0023 0.0066 0.0724
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0207 0.093
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0035 0.0175
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.4227
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.2028 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0649 0.308
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0066 0.0154
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0035 0.0175
Schistosoma mansoni hypothetical protein 0.0054 0.0441 0.0437
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0035 0.0175
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0649 0.308
Onchocerca volvulus 0.0035 0.0207 0.1641
Giardia lamblia Casein kinase II beta chain 0.0074 0.0692 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0035 0.0144
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0035 0.0269
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0316 0.1406
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0649 0.9373
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Brugia malayi Protein kinase domain containing protein 0.0054 0.0441 0.1996
Schistosoma mansoni alpha-glucosidase 0.0169 0.1857 0.1854
Schistosoma mansoni DNA polymerase eta 0.0023 0.0066 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0074 0.0692 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Toxoplasma gondii microneme protein, putative 0.0035 0.0207 0.0509
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0313 0.0296
Toxoplasma gondii kringle domain-containing protein 0.0054 0.0441 0.1133
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0035 0.0175
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.2028 1
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.4227
Leishmania major phospholipase c-like protein 0.0019 0.0017 0.0195
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.018 0.0803
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0074 0.0692 0.1806
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.045 0.2039
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0047 0.0057
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0047 0.0057
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.2028 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0066 0.0724
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0035 0.0032
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2193 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0066 0.0049
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.2028 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0035 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0316 0.1406
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0316 0.0299
Toxoplasma gondii microneme protein MIC4 0.0035 0.0207 0.0509
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0035 0.0156
Onchocerca volvulus 0.0033 0.018 0.1402
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0066 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Schistosoma mansoni alpha-glucosidase 0.0169 0.1857 0.1854
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Toxoplasma gondii hypothetical protein 0.0035 0.0207 0.0509
Onchocerca volvulus 0.0035 0.0207 0.1641
Brugia malayi Variant SH3 domain containing protein 0.0133 0.1414 0.6441
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.1996
Onchocerca volvulus 0.0035 0.0207 0.1641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0649 0.3201
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0316 0.4266
Brugia malayi hypothetical protein 0.0043 0.0313 0.1413
Echinococcus multilocularis musashi 0.0033 0.018 0.0163
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Plasmodium vivax casein kinase II beta chain, putative 0.0074 0.0692 0.3401
Onchocerca volvulus 0.0035 0.0207 0.1641
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0649 0.3201
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Onchocerca volvulus 0.0021 0.0035 0.0157
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0316 0.4266
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0207 0.0509
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0066 0.0154
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0035 0.0175
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0316 0.442
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.2028 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0316 0.1406
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0316 0.0799
Plasmodium falciparum casein kinase II beta chain 0.0074 0.0692 0.3401
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0066 0.0326
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0035 0.0459
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2193 0.218
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0066 0.0724
Plasmodium falciparum casein kinase II beta chain 0.0074 0.0692 0.3401
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0316 0.1406
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Toxoplasma gondii PAN domain-containing protein 0.0324 0.3755 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0803
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0035 0.0175
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0649 0.308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0144
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0066 0.0285
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0207 0.093
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0066 0.0905
Onchocerca volvulus 0.0035 0.0207 0.1641
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2193 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0316 0.1406
Toxoplasma gondii hypothetical protein 0.0035 0.0207 0.0509
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.4227
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0649 0.308
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0207 0.0509
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0207 0.0509
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0316 0.4529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Onchocerca volvulus 0.0033 0.018 0.1402
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0649 0.9373
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0074 0.0692 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0035 0.0175
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0316 0.1406
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0047 0.0172
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0066 0.0062
Onchocerca volvulus 0.0114 0.1176 1
Entamoeba histolytica hypothetical protein 0.0043 0.0313 0.4227
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0074 0.0692 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0017 0.0061
Echinococcus multilocularis casein kinase ii subunit beta 0.0074 0.0692 0.0676
Onchocerca volvulus 0.0071 0.0649 0.5455
Schistosoma mansoni casein kinase II beta subunit 0.0074 0.0692 0.0689
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0035 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Onchocerca volvulus 0.0035 0.0207 0.1641
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0074 0.0692 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0035 0.0459
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Schistosoma mansoni alpha glucosidase 0.0044 0.0316 0.0312
Echinococcus granulosus dna polymerase eta 0.0023 0.0066 0.0049
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0316 0.1406
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0649 0.9343
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0313 0.0296
Loa Loa (eye worm) hypothetical protein 0.0053 0.043 0.1945
Brugia malayi Csnk2b protein 0.0074 0.0692 0.3145
Echinococcus multilocularis tissue type plasminogen activator 0.0054 0.0441 0.0424
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0207 0.0509
Leishmania major DNA polymerase eta, putative 0.0023 0.0066 0.0905
Onchocerca volvulus 0.0021 0.0035 0.0157
Giardia lamblia DINP protein human, muc B family 0.0023 0.0066 0.03
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0035 0.0144
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0441 0.1996
Loa Loa (eye worm) hypothetical protein 0.0071 0.0649 0.2948
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0316 0.0299
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0066 0.0724
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0047 0.0172
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0035 0.0175
Toxoplasma gondii subtilisin SUB12 0.0035 0.0207 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0066 0.0154
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0394 0.1943
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.043 0.2103
Echinococcus granulosus lamin 0.0033 0.018 0.0163
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0017 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0649 0.2948
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.2028 0.5381
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0066 0.0724
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0074 0.0692 1
Onchocerca volvulus 0.0035 0.0207 0.1641
Loa Loa (eye worm) intermediate filament protein 0.0033 0.018 0.0803
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0047 0.0057
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0074 0.0692 1
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0207 0.0509
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Echinococcus multilocularis lamin 0.0033 0.018 0.0163
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0035 0.0018
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0207 0.093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.093
Schistosoma mansoni lamin 0.0033 0.018 0.0176
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0285
Schistosoma mansoni intermediate filament proteins 0.0033 0.018 0.0176
Trichomonas vaginalis casein kinase II beta chain, putative 0.0074 0.0692 0.3297
Echinococcus granulosus casein kinase ii subunit beta 0.0074 0.0692 0.0676
Brugia malayi Kringle domain containing protein 0.0054 0.0441 0.1996
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0649 0.9343
Brugia malayi PAN domain containing protein 0.0035 0.0207 0.093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0394 0.1943
Onchocerca volvulus 0.0035 0.0207 0.1641
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0054 0.0441 0.2158
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.018 0.0803
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0035 0.0269
Mycobacterium ulcerans hypothetical protein 0.0071 0.0649 0.308
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0035 0.0018
Trichomonas vaginalis hypothetical protein 0.0183 0.2028 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0066 0.0724

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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