Detailed information for compound 797468

Basic information

Technical information
  • TDR Targets ID: 797468
  • Name: 2-methylbut-3-yn-2-yl 4-oxo-4-(1,3-thiazol-2- ylamino)butanoate
  • MW: 266.316 | Formula: C12H14N2O3S
  • H donors: 1 H acceptors: 3 LogP: 0.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CC(OC(=O)CCC(=O)Nc1nccs1)(C)C
  • InChi: 1S/C12H14N2O3S/c1-4-12(2,3)17-10(16)6-5-9(15)14-11-13-7-8-18-11/h1,7-8H,5-6H2,2-3H3,(H,13,14,15)
  • InChiKey: CQOHUEOADQAHAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,1-dimethylprop-2-ynyl 4-oxo-4-(thiazol-2-ylamino)butanoate
  • 4-oxo-4-(2-thiazolylamino)butanoic acid 1,1-dimethylprop-2-ynyl ester
  • 4-keto-4-(thiazol-2-ylamino)butyric acid 1,1-dimethylprop-2-ynyl ester
  • ZINC03671071
  • A2207/0092956
  • EU-0018944

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0455 0.2124
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5803
Giardia lamblia Casein kinase II beta chain 0.0073 0.0784 1
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0028 0.0334
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0823 0.3846
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Mycobacterium leprae Probable lipase LipE 0.0035 0.0295 0.1379
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0295 0.3766
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5803
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0086 0.11
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0295 0.1954
Brugia malayi hypothetical protein 0.0014 0.0028 0.0182
Mycobacterium ulcerans hypothetical protein 0.0048 0.0455 0.2124
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Echinococcus granulosus casein kinase ii subunit beta 0.0073 0.0784 0.9519
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0111
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.301
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0028 0.0182
Schistosoma mansoni hypothetical protein 0.0014 0.0028 0.0334
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0301 0.1404
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0024 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0295 0.3585
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.0784 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0295 0.1084
Brugia malayi casein kinase II, putaitve 0.0021 0.0119 0.0787
Mycobacterium ulcerans beta-lactamase 0.0035 0.0295 0.1379
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0073 0.0784 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1989
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0455 0.5803
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0119 0.045
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Leishmania major hypothetical protein, conserved 0.0053 0.053 0.6764
Onchocerca volvulus 0.0019 0.0086 0.11
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0024 0.0157
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Leishmania major phospholipase c-like protein 0.0019 0.0086 0.11
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0288 0.1905
Toxoplasma gondii hypothetical protein 0.0035 0.0288 0.0725
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0302
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0024 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0157
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.053 0.2476
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0455 0.2124
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0014 0.0028 0.0351
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.2141 0.786
Schistosoma mansoni egf-like domain protein 0.0014 0.0023 0.0276
Schistosoma mansoni hypothetical protein 0.0053 0.053 0.6439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Onchocerca volvulus 0.0035 0.0288 0.3672
Plasmodium vivax casein kinase II beta chain, putative 0.0073 0.0784 0.3661
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0486 0.5904
Onchocerca volvulus 0.0014 0.0024 0.0302
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.053 0.053
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.301
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0086 0.0571
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0455 0.5803
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0028 0.0028
Onchocerca volvulus 0.0035 0.0295 0.3766
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1989
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0024 0.0024
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0073 0.0784 0.1974
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.0784 1
Onchocerca volvulus 0.0014 0.0024 0.0302
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0024 0.0111
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0182 0.0849
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.015
Brugia malayi Trypsin family protein 0.0014 0.0028 0.0182
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0288 0.1905
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0302
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.053 0.6764
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0024 0.0111
Brugia malayi Fibulin-1 precursor 0.0014 0.0023 0.015
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0301 0.1103
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0302
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0295 0.1954
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.2141 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Toxoplasma gondii ck2 beta subunit 0.0073 0.0784 0.1974
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0823 1
Brugia malayi beta-lactamase family protein 0.0035 0.0295 0.1954
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0119 0.1517
Toxoplasma gondii subtilisin SUB12 0.0035 0.0288 0.0725
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Onchocerca volvulus 0.0035 0.0288 0.3672
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0295 0.3585
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0014 0.0028 0.0351
Onchocerca volvulus 0.0053 0.053 0.6764
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0823 0.2074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0455 0.5803
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.0784 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0302
Onchocerca volvulus 0.0035 0.0288 0.3672
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0024 0.0111
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0024 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Toxoplasma gondii hypothetical protein 0.0026 0.0182 0.0458
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0455 0.2124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0295 0.1379
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0023 0.015
Toxoplasma gondii ABC1 family protein 0.0035 0.0295 0.0743
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.2141 0.5392
Brugia malayi beta-lactamase 0.0035 0.0295 0.1954
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0024 0.0111
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0455 0.167
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.015
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0028 0.0334
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Onchocerca volvulus 0.0035 0.0288 0.3672
Toxoplasma gondii microneme protein MIC4 0.0035 0.0288 0.0725
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0486 0.1785
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0288 0.0725
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.015
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0295 0.1282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.015
Toxoplasma gondii PAN domain-containing protein 0.0322 0.397 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0024 0.0111
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0023 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.3766
Onchocerca volvulus 0.0035 0.0288 0.3672
Plasmodium falciparum casein kinase II beta chain 0.0073 0.0784 0.3661
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0072 0.0925
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0024 0.0111
Echinococcus granulosus Tolloid protein 1 0.0014 0.0023 0.0276
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0024 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0024 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Onchocerca volvulus 0.0035 0.0288 0.3672
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0302
Onchocerca volvulus 0.0048 0.0455 0.5803
Echinococcus multilocularis enteropeptidase 0.0014 0.0028 0.0028
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.2141 1
Brugia malayi Trypsin family protein 0.0014 0.0028 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0571
Schistosoma mansoni casein kinase II beta subunit 0.0073 0.0784 0.9519
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0288 0.1905
Onchocerca volvulus 0.0014 0.0024 0.0302
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0302
Loa Loa (eye worm) variant SH3 domain-containing protein 0.013 0.1511 1
Onchocerca volvulus 0.0035 0.0288 0.3672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Toxoplasma gondii hypothetical protein 0.0035 0.0288 0.0725
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.301
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0295 0.1084
Schistosoma mansoni hypothetical protein 0.0014 0.0028 0.0334
Echinococcus multilocularis casein kinase ii subunit beta 0.0073 0.0784 0.0784
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0302
Onchocerca volvulus 0.0019 0.0086 0.11
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0823 0.2074
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Toxoplasma gondii kringle domain-containing protein 0.0053 0.053 0.1335
Onchocerca volvulus 0.0035 0.0295 0.3766
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5803
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0072 0.0339
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0301 0.1404
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0288 0.1905
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Brugia malayi Variant SH3 domain containing protein 0.013 0.1511 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.2141 1
Echinococcus granulosus enteropeptidase 0.0014 0.0028 0.0334
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0182 0.0849
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0302
Onchocerca volvulus 0.0014 0.0028 0.0351
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0024 0.0111
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0288 0.0725
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.301
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0072 0.048
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0028 0.0334
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0024 0.0087
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0823 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0023 0.015
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0295 0.1379
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0024 0.0157
Onchocerca volvulus 0.0035 0.0295 0.3766
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0301 0.1404
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0119 0.045
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0486 0.2271
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0295 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0072 0.048
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Loa Loa (eye worm) hypothetical protein 0.0076 0.0823 0.5449
Echinococcus granulosus Mastin 0.0014 0.0028 0.0334
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0024 0.006
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0288 0.0725
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0024 0.0087
Toxoplasma gondii microneme protein, putative 0.0035 0.0288 0.0725
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0028 0.0334
Plasmodium vivax casein kinase II beta chain, putative 0.0073 0.0784 0.3661
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0295 0.1379
Loa Loa (eye worm) oxidoreductase 0.0014 0.0024 0.0157
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1989
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0024 0.0087
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Toxoplasma gondii PAN domain-containing protein 0.0322 0.397 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0288 0.0725
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0073 0.0784 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0072 0.0925
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Brugia malayi Trypsin family protein 0.0014 0.0028 0.0182
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0073 0.0784 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0823 0.3846
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0073 0.0784 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0024 0.0087
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0295 0.1379
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0086 0.0571
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Plasmodium falciparum casein kinase II beta chain 0.0073 0.0784 0.3661
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0028 0.0182
Onchocerca volvulus 0.0014 0.0028 0.0351
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0295 0.1282
Loa Loa (eye worm) trypsin family protein 0.0014 0.0028 0.0182
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0288 0.0725
Echinococcus granulosus laminin 0.0014 0.0023 0.0276
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2724 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0024 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.048
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0571
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0023 0.015
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.2141 1
Loa Loa (eye worm) Csnk2b protein 0.0073 0.0784 0.5188
Trichomonas vaginalis esterase, putative 0.0035 0.0295 0.1282
Brugia malayi Probable ClpP-like protease 0.0076 0.0823 0.5449
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0086 0.1047
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0301 0.1404
Schistosoma mansoni phospholipase C beta 0.0018 0.0072 0.088
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0024 0.0302
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0028 0.0028
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0073 0.0784 1
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0288 0.0725
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0111
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0486 0.0486
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0295 0.3585
Brugia malayi Csnk2b protein 0.0073 0.0784 0.5188
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0295 0.1084
Brugia malayi Protein kinase domain containing protein 0.0053 0.053 0.3509
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.3766
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Trichomonas vaginalis hypothetical protein 0.0179 0.2141 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0455 0.2124
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0455 0.167
Onchocerca volvulus Arrow homolog 0.0014 0.0023 0.0289
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0157
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1954
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.053 0.3509
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0182 0.0849
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0288 0.1905
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0086 0.0217
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0023 0.0057
Loa Loa (eye worm) beta-lactamase 0.0035 0.0295 0.1954
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Leishmania major hypothetical protein, conserved 0.0035 0.0295 0.3766
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0024 0.0111
Mycobacterium ulcerans hypothetical protein 0.0035 0.0295 0.1379
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0288 0.0725
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0823 0.0823
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0087
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0073 0.0784 1
Onchocerca volvulus 0.0014 0.0028 0.0351
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0486 0.1785
Onchocerca volvulus 0.0035 0.0288 0.3672
Onchocerca volvulus 0.0014 0.0024 0.0302
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0072 0.048
Loa Loa (eye worm) casein kinase II 0.0021 0.0119 0.0787
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1989
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0455 0.2124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.053 0.2476
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Echinococcus multilocularis Mastin 0.0014 0.0028 0.0028
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0119 0.1517
Echinococcus multilocularis fibrillin 1 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.015
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0086 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0295 0.1084
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0028 0.0028
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0288 0.0725
Loa Loa (eye worm) hypothetical protein 0.0035 0.0288 0.1905
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0295 0.1084
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0295 0.0295
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Echinococcus multilocularis laminin 0.0014 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0035 0.0295 0.1954
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0295 0.1084
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0024 0.0288
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Mycobacterium ulcerans hypothetical protein 0.0014 0.0028 0.0129
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0023 0.0276
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.2141 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.053 0.3509
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.301
Mycobacterium ulcerans lipase LipD 0.0035 0.0295 0.1379
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0072 0.0339
Brugia malayi Trypsin family protein 0.0014 0.0028 0.0182
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0086 0.11
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1989
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Onchocerca volvulus 0.0035 0.0288 0.3672
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0182
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0119 0.045
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.2141 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0024 0.0288
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.053 0.6439
Onchocerca volvulus 0.0014 0.0028 0.0351
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0023 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Onchocerca volvulus 0.0035 0.0288 0.3672
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Onchocerca volvulus 0.0035 0.0288 0.3672
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0455 0.2124
Brugia malayi Kringle domain containing protein 0.0053 0.053 0.3509
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.301
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0028 0.0334
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Brugia malayi PAN domain containing protein 0.0035 0.0288 0.1905
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.0784 0.359
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0023 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0288 0.0725

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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