TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.573 | Formula: C26H34N4O4
H donors: 1 H acceptors: 3 LogP: 3.07 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)c1cn(cc(c1=O)C(=O)N1CCN(CC1)Cc1ccccc1OC)C1CCCCC1
InChi: 1S/C26H34N4O4/c1-27-25(32)21-17-30(20-9-4-3-5-10-20)18-22(24(21)31)26(33)29-14-12-28(13-15-29)16-19-8-6-7-11-23(19)34-2/h6-8,11,17-18,20H,3-5,9-10,12-16H2,1-2H3,(H,27,32)
InChiKey: DPEIEHUGBQXWDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0026	0.0073	0.156
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0073	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0026	0.0073	0.0242
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0073	0.002
Loa Loa (eye worm)	hypothetical protein	0.048	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0147	0.2706	0.5
Onchocerca volvulus		0.0025	0.0053	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Schistosoma mansoni	alpha-glucosidase	0.024	0.4742	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0026	0.0073	0.0087
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Leishmania major	tyrosine specific protein phosphatase, putative	0.0026	0.0073	0.1332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0073	0.002
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0065	0.0927	0.0879
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0468	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0026	0.0073	0.002
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Onchocerca volvulus		0.0026	0.0073	0.0242
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0026	0.0073	0.002
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0048	0.0548	1
Onchocerca volvulus		0.0026	0.0073	0.0242
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0548	0.5913
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0073	0.002
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0065	0.0927	0.0879
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0073	0.002
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0048	0.0548	1
Echinococcus multilocularis	hypothetical protein	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0073	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Echinococcus multilocularis		0.0026	0.0073	0.002
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0026	0.0073	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0468	0.5051
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0406	0.8387	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0073	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0073	0.002
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0073	0.156
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0026	0.0073	0.002
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0087
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0406	0.8387	0.8379
Onchocerca volvulus		0.0026	0.0073	0.0242
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0073	0.002
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0548	0.5913
Onchocerca volvulus		0.0026	0.0073	0.0242
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0468	0.8542
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Toxoplasma gondii	melibiase subfamily protein	0.0065	0.0927	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0048	0.0548	0.0498
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0468	0.0468
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0468	0.8542
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0048	0.0548	1
Plasmodium vivax	hypothetical protein, conserved	0.0147	0.2706	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0073	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0548	0.0498
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Onchocerca volvulus		0.0026	0.0073	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Trypanosoma brucei	protein kinase, putative	0.0048	0.0548	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus multilocularis	beta galactosidase	0.048	1	1
Trichomonas vaginalis	pten, drome, putative	0.0026	0.0073	0.0788
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Onchocerca volvulus		0.0026	0.0073	0.0242
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Schistosoma mansoni	alpha glucosidase	0.0044	0.0468	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0927	0.0927
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0073	0.002
Loa Loa (eye worm)	intermediate filament protein	0.0025	0.0053	0.0053
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0026	0.0073	0.0087
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus granulosus	mitogen activated protein kinase	0.0048	0.0548	0.0498
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0026	0.0073	0.1332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0468	0.8542
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0468	0.0418
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0065	0.0927	0.0879
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0468	0.5051
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0468	0.5051
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0548	0.5913
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0151	0.2806	0.2768
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0073	0.002
Echinococcus granulosus	lysosomal alpha glucosidase	0.0261	0.521	0.5185
Onchocerca volvulus		0.0026	0.0073	0.0242
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0073	0.1332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0048	0.0548	1
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0548	0.5913
Onchocerca volvulus		0.0026	0.0073	0.0242
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0026	0.0073	0.002
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0151	0.2806	0.2768
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Schistosoma mansoni	alpha-glucosidase	0.024	0.4742	0.4714
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0026	0.0073	0.0073
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0073	0.1332
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0026	0.0073	0.0242
Schistosoma mansoni	beta-galactosidase	0.048	1	1
Onchocerca volvulus		0.0161	0.3021	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0073	0.002
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0468	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0468	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0261	0.521	0.521
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0073	0.002
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0048	0.0548	0.0548
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0261	0.521	0.6212
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Trypanosoma brucei	glucosidase, putative	0.0044	0.0468	0.8542
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0468	0.5051
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0073	0.002
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0151	0.2806	0.2768
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0073	0.002
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0073	0.002
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0026	0.0073	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0065	0.0927	0.0879
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0026	0.0073	0.002
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0048	0.0548	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0151	0.2806	0.2806
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0073	0.002
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0468	0.0558
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0073	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0073	0.0073
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0468	0.5051
Giardia lamblia	Kinase, CMGC MAPK	0.0048	0.0548	1
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0087
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0073	0.002
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0026	0.0073	0.002
Onchocerca volvulus		0.0026	0.0073	0.0242
Loa Loa (eye worm)	hypothetical protein	0.048	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0406	0.8387	0.8379
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0026	0.0073	0.0242
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0468	0.5051
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0048	0.0548	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0043	0.0043
Onchocerca volvulus		0.0025	0.0053	0.0176
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0261	0.521	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0151	0.2806	0.2768
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0026	0.0073	0.002
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0073	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Onchocerca volvulus		0.0026	0.0073	0.0242
Brugia malayi	MAP kinase sur-1	0.0048	0.0548	0.0654
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0048	0.0548	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0468	0.5051
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0073	0.0087
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0048	0.0548	0.0498
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0468	0.5051
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0151	0.2806	0.2768
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0261	0.521	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0406	0.8387	0.8379
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0025	0.0053	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0468	0.5051
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0026	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase 1	0.0026	0.0073	0.0087
Brugia malayi	hypothetical protein	0.0026	0.0073	0.0087
Schistosoma mansoni	pcd6 interacting protein-related	0.0026	0.0073	0.002
Brugia malayi	Melibiase family protein	0.0065	0.0927	0.1106
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0406	0.8387	0.8387
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0151	0.2806	0.3346
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0073	0.002
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0048	0.0548	0.1742
Onchocerca volvulus		0.0026	0.0073	0.0242
Brugia malayi	Intermediate filament tail domain containing protein	0.0025	0.0053	0.0063
Onchocerca volvulus		0.0026	0.0073	0.0242
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Brugia malayi	intermediate filament protein	0.0025	0.0053	0.0063
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0073	0.002
Echinococcus multilocularis	mitogen activated protein kinase	0.0048	0.0548	0.0498
Onchocerca volvulus	4.1 G protein, putative homolog	0.0026	0.0073	0.0242
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0026	0.0073	0.1332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0073	0.0087
Onchocerca volvulus		0.0026	0.0073	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0073	0.002
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0065	0.0927	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0073	0.156
Onchocerca volvulus		0.0026	0.0073	0.0242

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 806561