TDR Targets

Basic information

Technical information

TDR Targets ID: 807300
Name: benzotriazol-1-yl-(3-dimethylaminophenyl)meth anone
MW: 266.298 | Formula: C15H14N4O
H donors: 0 H acceptors: 3 LogP: 2.78 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1cccc(c1)C(=O)n1nnc2c1cccc2)C
InChi: 1S/C15H14N4O/c1-18(2)12-7-5-6-11(10-12)15(20)19-14-9-4-3-8-13(14)16-17-19/h3-10H,1-2H3
InChiKey: VUHLNBHMODVKIU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-benzotriazolyl-(3-dimethylaminophenyl)methanone
Oprea1_212699
ZINC00434633
CBMicro_006290
BIM-0006185.P001
CBChromo1_000014
Oprea1_241162

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0067	0.0104
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0126	0.0059
Echinococcus granulosus	snurportin 1	0.0305	0.6457	0.6433
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Brugia malayi	jmjC domain containing protein	0.0015	0.0148	0.041
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0014	0.0116	0.0639
Schistosoma mansoni	ran	0.0021	0.0269	0.0287
Leishmania major	hypothetical protein, conserved	0.0015	0.0148	0.0318
Loa Loa (eye worm)	sugar transporter	0.0014	0.0126	0.0195
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0067	0.0104
Entamoeba histolytica	protein kinase, putative	0.0031	0.0497	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0505	0.8143
Onchocerca volvulus		0.0014	0.0126	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0148	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Schistosoma mansoni	hypothetical protein	0.0305	0.6457	0.9065
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0148	0.0082
Plasmodium falciparum	hexose transporter	0.0103	0.205	0.2094
Schistosoma mansoni	ran	0.0021	0.0269	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.019	0.155
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0306	0.0473
Echinococcus multilocularis	neuropeptide receptor A26	0.0467	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0269	0.3195
Brugia malayi	jmjC domain containing protein	0.0058	0.1076	0.509
Schistosoma mansoni	glucose transport protein	0.0103	0.205	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0357	0.0552
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0126	0.0059
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0594	0.051
Echinococcus multilocularis		0.0014	0.0116	0.005
Leishmania major	glucose transporter, lmgt3	0.0032	0.0505	0.3885
Onchocerca volvulus		0.0014	0.0126	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0126	0.0059
Leishmania major	glucose transporter, lmgt2	0.0032	0.0505	0.3885
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1076	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0015	0.0148	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0316	0.0987
Brugia malayi	hypothetical protein	0.0014	0.0126	0.0296
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.343	0.3595
Brugia malayi	Sugar transporter family protein	0.0014	0.0126	0.0296
Brugia malayi	jmjC domain containing protein	0.0015	0.0148	0.041
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0148	0.023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0235	0.1188
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0126	0.0092
Schistosoma mansoni	glucose transporter	0.0014	0.0126	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Brugia malayi	major facilitator superfamily protein	0.0014	0.0126	0.0296
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0454	0.039
Plasmodium falciparum	importin beta, putative	0.0029	0.0433	0.0335
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0269	0.3195
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0126	0.0194
Echinococcus multilocularis	geminin	0.0335	0.7116	0.7096
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0148	0.0667
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0497	0.0404
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0505	0.8143
Entamoeba histolytica	hypothetical protein	0.0023	0.0316	0.2049
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0316	0.0987
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0126	0.0725
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0148	0.0025
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.205	0.1997
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0235	0.3246
Onchocerca volvulus		0.0014	0.0126	1
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0116	0.018
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0311	0.0245
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	sugar transporter	0.0103	0.205	0.3175
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0497	0.0404
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0249	0.0641
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0505	0.1973
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0505	0.3885
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0311	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0014	0.0116	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0014	0.0116	0.0639
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0483	0.0748
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0795	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0148	0.0115
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0311	0.0346
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0311	0.2455
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1117	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0311	0.0245
Mycobacterium ulcerans	sugar transporter	0.0014	0.0126	0.0725
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1076	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Leishmania major	protein kinase, putative	0.0031	0.0497	0.3797
Entamoeba histolytica	hypothetical protein	0.0023	0.0311	0.1831
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.1076	0.1016
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0311	0.5304
Onchocerca volvulus		0.0014	0.0126	1
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0126	0.0194
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0483	0.1855
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0311	0.0201
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0148	0.0115
Echinococcus granulosus	solute carrier family 22	0.0014	0.0126	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0497	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Schistosoma mansoni	sugar transporter	0.0014	0.0126	0.0083
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0014	0.0116	0.0639
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0311	0.0201
Schistosoma mansoni	glucose transport protein	0.0103	0.205	0.2814
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0436	0.9316	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0014	0.0116	0.0639
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0594	0.4771
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0505	0.1973
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0316	0.4171
Echinococcus multilocularis	snurportin 1	0.0305	0.6457	0.6433
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0433	0.0369
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0126	0.0194
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0433	0.6637
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0126	0.0059
Trichomonas vaginalis	ran, putative	0.0021	0.0269	0.0745
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0497	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0483	0.059
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0454	0.039
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0014	0.0116	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0148	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0497	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0269	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	Sugar transporter family protein	0.0103	0.205	1
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0126	0.0296
Brugia malayi	cytochrome P450	0.0014	0.0116	0.0249
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0594	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0126	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Leishmania major	cytochrome p450-like protein	0.0023	0.0306	0.189
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0148	0.0053
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0497	0.0404
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0306	0.1203
Brugia malayi	RNA, U transporter 1	0.0081	0.1581	0.7635
Brugia malayi	Sugar transporter family protein	0.0014	0.0126	0.0296
Echinococcus multilocularis	neuropeptide s receptor	0.0467	1	1
Schistosoma mansoni	sugar transporter	0.0014	0.0126	0.0083
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Brugia malayi	hypothetical protein	0.0014	0.0126	0.0296
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0497	0.0404
Onchocerca volvulus		0.0014	0.0126	1
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0126	0.0194
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.343	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0148	0.023
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0594	1
Onchocerca volvulus	Putative transporter	0.0014	0.0126	1
Schistosoma mansoni	sugar transporter	0.0014	0.0126	0.0083
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0014	0.0116	0.0639
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0594	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0306	0.1203
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0483	0.2096
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0014	0.0116	0.0639
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.1076	0.1016
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.1117	0.1058
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0505	0.8143
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0269	0.3195
Schistosoma mansoni	sugar transporter	0.0014	0.0126	0.0083
Plasmodium falciparum	protein kinase 6	0.0436	0.9316	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0433	0.0369
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0269	0.0156
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0067	0.0104
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0311	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Schistosoma mansoni	glucose transport protein	0.0103	0.205	0.2814
Onchocerca volvulus		0.0014	0.0126	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0505	0.8143
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0126	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0048	0.5
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0483	0.939
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0497	0.0432
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0126	0.0059
Schistosoma mansoni	protein kinase	0.0031	0.0497	0.0609
Echinococcus multilocularis	General substrate transporter	0.0088	0.1735	0.168
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Brugia malayi	Cytochrome P450 family protein	0.0052	0.094	0.4404
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0126	0.0725
Plasmodium vivax	hexose transporter	0.0103	0.205	0.2094
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0148	0.0667
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0014	0.0116	0.0639
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0126	0.0059
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0126	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0497	0.0769
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0126	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.094	0.1456
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0594	0.4771
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0306	0.0473
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0483	1
Onchocerca volvulus		0.0014	0.0126	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0148	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0148	0.023
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1117	0.149
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0483	0.0748
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0269	0.0156
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0311	0.1229
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0316	0.0987
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1076	0.1432
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0126	0.0059
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.1076	0.1016
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.1117	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0087	0.0134
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0126	0.0015
Schistosoma mansoni	importin beta-1	0.0029	0.0433	0.052
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0311	0.194
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0014	0.0116	0.0639
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0497	0.2166
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0497	0.0404
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0148	0.0115
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0505	0.8143
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0269	0.0253
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.1076	0.1432
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0126	0.0725
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0014	0.0116	0.0639
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0148	0.0115
Entamoeba histolytica	protein kinase, putative	0.0031	0.0497	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0311	0.4067
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0014	0.0116	0.0639
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0014	0.0116	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0269	0.0203
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0126	0.0059
Onchocerca volvulus		0.0014	0.0126	1
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0148	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0311	0.0481
Brugia malayi	jmjC domain containing protein	0.0058	0.1076	0.509
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0015	0.0148	0.0082
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0505	0.8143
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0148	0.023
Brugia malayi	hypothetical protein	0.0014	0.0126	0.0296
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0497	0.0404
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0126	0.0194
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0067	0.0104
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0497	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Onchocerca volvulus		0.0014	0.0126	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0483	0.059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0306	0.2408
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0505	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0067	0.0104
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0497	0.0632
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0483	0.0418
Onchocerca volvulus		0.0014	0.0126	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	jmjC domain containing protein	0.0015	0.0148	0.041
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0433	0.0335
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.343	0.5502
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0505	0.8143
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0067	0.0104
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0311	0.5182
Brugia malayi	Cam kinase protein 1	0.0031	0.0497	0.2166
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0148	0.0667
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0483	0.2096
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0311	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0505	0.1973
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0014	0.0116	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Leishmania major	glucose transporter, lmgt1	0.0032	0.0505	0.3885
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0014	0.0116	0.0639
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0235	0.1188
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0311	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.1117	0.1058
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0306	0.3961
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0014	0.0116	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0795	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0126	0.5
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0497	0.0404
Schistosoma mansoni	hypothetical protein	0.0335	0.7116	1
Echinococcus granulosus	neuropeptide receptor A26	0.0467	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1117	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.1076	0.1016
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1117	1
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0116	0.005
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0269	0.0203
Schistosoma mansoni	cytochrome P450	0.0014	0.0116	0.007
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0269	0.4015
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0795	0.0733
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0126	0.0092
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1117	0.149
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Echinococcus granulosus	geminin	0.0335	0.7116	0.7096
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0116	0.0249
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0014	0.0116	0.0639
Echinococcus granulosus	General substrate transporter	0.0088	0.1735	0.168
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0316	0.199
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0014	0.0116	0.0639
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0126	0.0015
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0126	0.0059
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0483	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0148	0.023
Onchocerca volvulus		0.0014	0.0126	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Leishmania major	hypothetical protein, conserved	0.0014	0.0126	0.0092
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0311	0.4067
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0795	0.1033
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0126	0.0296
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.6457	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0148	0.0082
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0148	0.023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	Importin beta-1 subunit	0.0029	0.0433	0.1847
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0795	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Trypanosoma cruzi	hexose transporter	0.0032	0.0505	0.8143
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0067	0.0104
Schistosoma mansoni	protein kinase	0.0031	0.0497	0.0609
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0148	0.0115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0795	0.0733
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0306	0.0473
Toxoplasma gondii	protein kinase, putative	0.029	0.6138	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0497	0.7959
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0433	0.0671
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0015	0.0148	0.0025
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0148	0.0082
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0483	0.0418
Onchocerca volvulus		0.0014	0.0126	1
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0594	0.051
Leishmania major	GTP-binding protein, putative	0.0021	0.0269	0.1524
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0433	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0795	0.3671
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0594	0.0793
Plasmodium falciparum	protein kinase 7	0.029	0.6138	0.6542
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0126	0.0092
Schistosoma mansoni	hypothetical protein	0.0335	0.7116	1
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.1117	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Echinococcus granulosus	solute carrier family 22	0.0014	0.0126	0.0059
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0505	0.1973
Onchocerca volvulus		0.0014	0.0126	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0067	0.0104
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0306	0.3961
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0148	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0014	0.0116	0.0639
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0311	0.0961
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0067	0.0104
Schistosoma mansoni	hypothetical protein	0.0014	0.0116	0.007
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0148	0.0082
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0497	0.1927
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0497	0.0769
Echinococcus granulosus	solute carrier family 22	0.0014	0.0126	0.0059
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.1117	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0433	0.6637
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0497	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Onchocerca volvulus		0.0014	0.0126	1
Schistosoma mansoni	hypothetical protein	0.0103	0.205	0.2814
Onchocerca volvulus		0.0014	0.0126	1
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0014	0.0116	0.0639
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0067	0.0104
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0126	0.0015
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0795	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0067	0.0104
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.205	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0126	0.0195
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0497	0.0632
Brugia malayi	jmjC domain containing protein	0.0015	0.0148	0.041
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0306	0.3961
Onchocerca volvulus		0.0014	0.0126	1
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0126	0.0015
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0269	0.0417
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.205	0.3211
Brugia malayi	major facilitator superfamily protein	0.0014	0.0126	0.0296
Schistosoma mansoni	protein kinase	0.0031	0.0497	0.0609
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0505	0.8143
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0505	0.8143
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0795	0.1033
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.205	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0505	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0497	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0067	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0505	0.1973

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 807300