Detailed information for compound 809050

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.656 | Formula: C33H36FN3O2
  • H donors: 0 H acceptors: 2 LogP: 5.95 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(Cc1cccc2c1nccc2)Cc1cccc(c1)OCCC1CCCCN1C(=O)Cc1ccc(cc1)F
  • InChi: 1S/C33H36FN3O2/c1-36(24-28-9-5-8-27-10-6-18-35-33(27)28)23-26-7-4-12-31(21-26)39-20-17-30-11-2-3-19-37(30)32(38)22-25-13-15-29(34)16-14-25/h4-10,12-16,18,21,30H,2-3,11,17,19-20,22-24H2,1H3
  • InChiKey: IYINNTBICUZMEA-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0534 0.0896
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0084
Echinococcus granulosus tumor protein p63 0.0337 0.2014 0.3432
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0028 0.0064
Entamoeba histolytica hypothetical protein 0.0036 0.0148 0.0539
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0035
Echinococcus multilocularis expressed conserved protein 0.0092 0.0497 0.0486
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0012
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0599 0.2322
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0956 0.5845 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0028 0.0048
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0219 0.0818
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0306 0.1195
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0012 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0105 0.0403
Trichomonas vaginalis thymidine kinase, putative 0.0203 0.1185 0.4638
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0028 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0012 0.0043
Toxoplasma gondii hypothetical protein 0.0027 0.0092 0.0318
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0046 0.0211 0.0828
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0028 0.0064
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.002
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0012 0.0035
Trypanosoma cruzi thymidylate kinase, putative 0.0422 0.2541 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.09
Entamoeba histolytica hypothetical protein 0.0036 0.0148 0.0539
Schistosoma mansoni survival motor neuron protein 0.0048 0.0224 0.0871
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0219 0.0818
Brugia malayi glutathione reductase 0.0048 0.0221 0.0866
Plasmodium falciparum thioredoxin reductase 0.0048 0.0221 0.0827
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0219 0.0818
Brugia malayi CHE-14 protein 0.0042 0.0187 0.0732
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0219 0.0355
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0012 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0145 0.0525
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0443
Schistosoma mansoni hypothetical protein 0.0041 0.0178 0.0688
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0187 0.0175
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Plasmodium falciparum glutathione reductase 0.0017 0.0028 0.0064
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.027 0.1597 0.2717
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1387 0.1377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0266 0.1003
Echinococcus multilocularis ryanodine receptor 44f 0.0026 0.0084 0.0072
Mycobacterium tuberculosis Probable reductase 0.0109 0.0599 0.1025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0219 0.0355
Loa Loa (eye worm) hypothetical protein 0.0044 0.0199 0.0771
Mycobacterium ulcerans thymidine phosphorylase 0.0956 0.5845 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0243 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0028 0.0064
Trypanosoma brucei thymidine kinase 0.0203 0.1185 0.4638
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Echinococcus granulosus thymidine phosphorylase 0.0956 0.5845 1
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.027 0.1597 0.2732
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1387 0.2358
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0219 0.0355
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0038 0.0158 0.0611
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0092 0.0255
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0599 0.1025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0611
Loa Loa (eye worm) hypothetical protein 0.0052 0.0246 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0187 0.0692
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0219 0.0375
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0559
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0187 0.03
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0145 0.0525
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.0681
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.002
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0409 0.16
Brugia malayi cation channel family protein 0.007 0.0362 0.1422
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0219 0.0818
Brugia malayi Thioredoxin reductase 0.0048 0.0221 0.0866
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0409 0.157
Entamoeba histolytica thymidine kinase, putative 0.0203 0.1185 0.4638
Schistosoma mansoni hypothetical protein 0.0169 0.0973 0.3822
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0012 0.002
Plasmodium vivax glutathione reductase, putative 0.0048 0.0221 0.0827
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0024 0.0092
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0084
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0028 0.0064
Echinococcus multilocularis tumor protein p63 0.0337 0.2014 0.2004
Leishmania major thymidylate kinase-like protein 0.0422 0.2541 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0064
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0092 0.0318
Brugia malayi hypothetical protein 0.0236 0.1387 0.5457
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0534 0.2099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0221 0.0209
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0219 0.0355
Entamoeba histolytica hypothetical protein 0.0036 0.0148 0.0539
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0057 0.0281 0.1095
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0145 0.0248
Trichomonas vaginalis thymidine kinase, putative 0.0203 0.1185 0.4638
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0166 0.0952 0.3718
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0412 0.248 0.9757
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0409 0.157
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0219 0.0375
Mycobacterium ulcerans hypothetical protein 0.0047 0.0219 0.0355
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0219 0.0818
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0028 0.0064
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.1516
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0028 0.0107
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0219 0.0851
Plasmodium falciparum thioredoxin reductase 0.0017 0.0028 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0021
Toxoplasma gondii thioredoxin reductase 0.0048 0.0221 0.0827
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0243 0.0396
Schistosoma mansoni hypothetical protein 0.0036 0.0148 0.0572
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0148 0.0234
Schistosoma mansoni cpg binding protein 0.0029 0.0105 0.0403
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0534 0.0523
Loa Loa (eye worm) hypothetical protein 0.0236 0.1387 0.5453
Entamoeba histolytica hypothetical protein 0.0036 0.0148 0.0539
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0028 0.0064
Echinococcus granulosus GPCR family 2 0.0016 0.0024 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0024 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0219 0.0858
Schistosoma mansoni hypothetical protein 0.0041 0.0178 0.0688
Loa Loa (eye worm) oxidoreductase 0.0014 0.0012 0.0035
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0221 0.0859
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0219 0.0858
Trichomonas vaginalis thymidine kinase, putative 0.0203 0.1185 0.4638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0221 0.0378
Schistosoma mansoni hypothetical protein 0.0041 0.0178 0.0688
Echinococcus granulosus ryanodine receptor 44f 0.0033 0.013 0.0203
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0219 0.0818
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0099
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0092 0.0318
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0795 0.1343
Echinococcus granulosus geminin 0.0169 0.0973 0.1648
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0221 0.0359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0559
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0221 0.0827
Echinococcus multilocularis protein dispatched 1 0.0048 0.0224 0.0212
Echinococcus multilocularis thymidylate kinase 0.0422 0.2541 0.2532
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0675 0.1154
Schistosoma mansoni thymidylate kinase 0.0422 0.2541 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0012 0.0043
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.1516
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0028 0.0064
Trypanosoma cruzi thymidine kinase, putative 0.0203 0.1185 0.4638
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0422 0.2541 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0012 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0559
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0871
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0028 0.0064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0012
Entamoeba histolytica Thymidylate kinase, putative 0.0422 0.2541 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0219 0.0858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0133 0.0227
Trypanosoma cruzi thymidine kinase, putative 0.0203 0.1185 0.4638
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0795 0.0784
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0145 0.0464
Plasmodium falciparum glutathione reductase 0.0048 0.0221 0.0827
Giardia lamblia Thymidine kinase 0.0203 0.1185 0.4604
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0599 0.1025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Echinococcus multilocularis GPCR, family 2 0.0016 0.0024 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0145 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0219 0.0355
Toxoplasma gondii thymidylate kinase 0.0422 0.2541 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0016
Plasmodium vivax thymidylate kinase, putative 0.0422 0.2541 1
Mycobacterium ulcerans thymidylate kinase 0.0422 0.2541 0.4336
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0243 0.0912
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0133 0.0227
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0187 0.03
Giardia lamblia CDC8 0.0422 0.2541 1
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0166 0.0952 0.3718
Leishmania major thymidine kinase, putative 0.0203 0.1185 0.4638
Echinococcus granulosus thymidylate kinase 0.0422 0.2541 0.4336
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0409 0.0398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0219 0.0818
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0035
Brugia malayi hypothetical protein 0.0036 0.0148 0.0579
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Echinococcus granulosus expressed conserved protein 0.0092 0.0497 0.0832
Trichomonas vaginalis thymidylate kinase, putative 0.0422 0.2541 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0133 0.0227
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0219 0.0355
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.248 0.2471
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0028 0.0064
Brugia malayi CXXC zinc finger family protein 0.0029 0.0105 0.041
Schistosoma mansoni hypothetical protein 0.0422 0.2541 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0028 0.0064
Schistosoma mansoni hypothetical protein 0.0169 0.0973 0.3822
Trypanosoma brucei thymidylate kinase, putative 0.0422 0.2541 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0534 0.2065
Echinococcus granulosus dnaJ subfamily B 0.0412 0.248 0.4231
Loa Loa (eye worm) hypothetical protein 0.0045 0.0204 0.0792
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.157
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0028 0.0064
Loa Loa (eye worm) hypothetical protein 0.0248 0.1463 0.5751
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0012 0.002
Echinococcus multilocularis protein patched 0.0042 0.0187 0.0175
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0243 0.0415
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0028 0.0064
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0409 0.0681
Trypanosoma brucei trypanothione reductase 0.0048 0.0221 0.0827
Brugia malayi thymidylate kinase 0.0422 0.2541 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0559
Onchocerca volvulus 0.0049 0.0232 0.0868
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0219 0.0818
Trichomonas vaginalis thymidylate kinase, putative 0.0422 0.2541 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0675 0.2619
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0599 0.1025
Loa Loa (eye worm) hypothetical protein 0.0098 0.0534 0.2093
Echinococcus multilocularis thymidine phosphorylase 0.0956 0.5845 0.584
Brugia malayi Probable ClpP-like protease 0.0078 0.0409 0.1607
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.1516
Loa Loa (eye worm) hypothetical protein 0.005 0.0237 0.0922
Loa Loa (eye worm) hypothetical protein 0.0047 0.0219 0.0851
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0187 0.0725
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0012 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0501
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0422 0.2541 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0133 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0237 0.0922
Treponema pallidum thymidylate kinase (tmk) 0.0422 0.2541 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0599 0.1025
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.0681
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0012 0.0043
Onchocerca volvulus Putative thymidylate kinase 0.0422 0.2541 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Schistosoma mansoni thymidylate kinase 0.0422 0.2541 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0221 0.0859
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0219 0.0355
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0028 0.0064
Echinococcus granulosus cpg binding protein 0.0031 0.0115 0.0177
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0675 0.1154
Echinococcus multilocularis ryanodine receptor 44f 0.0033 0.013 0.0118
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0092 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0237 0.0929
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0148 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0012 0.0043
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0443
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0409 0.1516
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0148 0.0572
Echinococcus multilocularis cpg binding protein 0.0031 0.0115 0.0104
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.0725
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0139 0.0542
Loa Loa (eye worm) thymidylate kinase 0.0422 0.2541 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0232 0.09
Loa Loa (eye worm) hypothetical protein 0.0078 0.0409 0.16
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0224 0.0878
Loa Loa (eye worm) hypothetical protein 0.0047 0.0219 0.0851
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0237 0.0929
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0012 0.0043
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0243 0.0415
Echinococcus multilocularis geminin 0.0169 0.0973 0.0962
Trypanosoma cruzi thymidylate kinase, putative 0.0422 0.2541 1
Onchocerca volvulus 0.0029 0.0105 0.0369
Trypanosoma brucei thymidylate kinase, putative 0.0422 0.2541 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0012 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0028 0.0064
Chlamydia trachomatis thymidylate kinase 0.0422 0.2541 1
Onchocerca volvulus 0.0047 0.0219 0.0818
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0012 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0409 0.157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0544 0.213
Brugia malayi photoreceptor-specific nuclear receptor 0.0248 0.1463 0.5754
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0675 0.1154
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0039 0.0167 0.0612
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0221 0.0827
Plasmodium falciparum thymidylate kinase 0.0422 0.2541 1
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0084
Onchocerca volvulus 0.0048 0.0224 0.0838
Leishmania major trypanothione reductase 0.0048 0.0221 0.0827
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0064
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0028 0.0028
Echinococcus granulosus ryanodine receptor 44f 0.0026 0.0084 0.0124
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0409 0.157
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0422 0.2541 0.4348
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0534
Schistosoma mansoni patched 1 0.0042 0.0187 0.0725
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0599 0.1025
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0064
Schistosoma mansoni hypothetical protein 0.0041 0.0178 0.0688
Leishmania major hypothetical protein, conserved 0.0026 0.009 0.0307
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.027 0.1597 0.6265
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0028 0.0028
Schistosoma mansoni ryanodine receptor related 0.0046 0.0211 0.0821
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0559
Leishmania major hypothetical protein, conserved 0.0166 0.0952 0.3718
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0039 0.0167 0.0612

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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