Detailed information for compound 810285

Basic information

Technical information
  • TDR Targets ID: 810285
  • Name: [(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylide ne)amino] 4-methoxy-3-nitrobenzoate
  • MW: 370.356 | Formula: C19H18N2O6
  • H donors: 0 H acceptors: 3 LogP: 3.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)CCCC2=NOC(=O)c1ccc(c(c1)[N+](=O)[O-])OC
  • InChi: 1S/C19H18N2O6/c1-25-14-7-8-15-12(10-14)4-3-5-16(15)20-27-19(22)13-6-9-18(26-2)17(11-13)21(23)24/h6-11H,3-5H2,1-2H3/b20-16-
  • InChiKey: AMKNKIKTAKVVBI-SILNSSARSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(6-methoxytetralin-1-ylidene)amino] 4-methoxy-3-nitro-benzoate
  • 4-methoxy-3-nitrobenzoic acid [(6-methoxy-1-tetralinylidene)amino] ester
  • 4-methoxy-3-nitro-benzoic acid [(6-methoxytetralin-1-ylidene)amino] ester
  • [(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)amino] 4-methoxy-3-nitro-benzoate
  • BIM-0017260.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-glucosidase 0.0138 0.1099 0.1765
Brugia malayi Bromodomain containing protein 0.003 0.0143 0.064
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1507 0.2442
Plasmodium vivax hypothetical protein, conserved 0.003 0.0143 0.3803
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.2576 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0214 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0999 0.1599
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1507 0.1413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.019 0.0847
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1142 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.1233 0.5509
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.168 0.1588
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0214 1
Onchocerca volvulus Alhambra homolog 0.003 0.0143 0.0173
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1804 0.8057
Echinococcus granulosus peregrin 0.003 0.0143 0.0034
Brugia malayi RNA binding protein 0.0127 0.0999 0.4462
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0109 0.0489
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.6059 0.6016
Toxoplasma gondii exonuclease III APE 0.0038 0.0214 0.4162
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0249 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0215 0.0959
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.019 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.047
Echinococcus granulosus tar DNA binding protein 0.0127 0.0999 0.0899
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0304 0.1357
Loa Loa (eye worm) hypothetical protein 0.0153 0.1233 0.5509
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.1194 0.1028
Schistosoma mansoni alpha-glucosidase 0.0138 0.1099 0.1765
Schistosoma mansoni cpg binding protein 0.0031 0.0146 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0304 0.0197
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0999 0.1599
Brugia malayi intermediate filament protein 0.0027 0.0109 0.0489
Echinococcus multilocularis peregrin 0.003 0.0143 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0999 0.1599
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0109 0.0489
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0155 0.2026
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0143 0.0178
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0304 0.1357
Brugia malayi mbt repeat family protein 0.005 0.0315 0.1406
Loa Loa (eye worm) glutaminase 2 0.0267 0.2239 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0143 0.0034
Echinococcus granulosus GPCR family 2 0.0049 0.0304 0.0197
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0143 0.064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0757 0.0654
Schistosoma mansoni hypothetical protein 0.0049 0.0304 0.0445
Brugia malayi glutaminase DH11.1 0.0267 0.2239 1
Onchocerca volvulus 0.0035 0.0185 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1507 0.2442
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0999 0.4462
Leishmania major hypothetical protein, conserved 0.0035 0.0185 0.7499
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0248
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0373 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.043 0.1922
Onchocerca volvulus 0.0248 0.207 1
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.6059 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1507 0.1413
Brugia malayi CXXC zinc finger family protein 0.0029 0.0132 0.0588
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0315 0.0208
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.1194 0.1028
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0827
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.019 0.7893
Loa Loa (eye worm) glutaminase 0.0267 0.2239 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0575 0.0895
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.019 0.3285
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.1233 0.5509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1507 0.2442
Echinococcus multilocularis thymidine phosphorylase 0.1142 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Schistosoma mansoni glutaminase 0.0267 0.2239 0.3657
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0376 0.0269
Echinococcus granulosus microtubule associated protein 2 0.0698 0.6059 0.6016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0155 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.019 0.7893
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.1194 0.3961
Echinococcus granulosus geminin 0.0516 0.4447 0.4385
Mycobacterium ulcerans thymidine phosphorylase 0.1142 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.02 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0304 0.1357
Loa Loa (eye worm) hypothetical protein 0.0032 0.0155 0.0694
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.0447
Schistosoma mansoni hypothetical protein 0.0516 0.4447 0.7322
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0315 0.1406
Schistosoma mansoni hypothetical protein 0.0049 0.0304 0.0445
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0214 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.019 0.0019
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0322 0.2732 0.2595
Schistosoma mansoni hypothetical protein 0.003 0.0143 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.7499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.1507 0.6732
Brugia malayi PHD-finger family protein 0.003 0.0143 0.064
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.019 0.0019
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.019 0.0847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0155 0.0198
Schistosoma mansoni cpg binding protein 0.0029 0.0132 0.0159
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0051 0.0227
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0376 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0155 0.0198
Echinococcus multilocularis cpg binding protein 0.0031 0.0146 0.0037
Plasmodium falciparum phd finger protein, putative 0.003 0.0143 0.3803
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0185 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0304 0.1357
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.019 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0304 0.0197
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.1507 0.6732
Schistosoma mansoni hypothetical protein 0.0105 0.0803 0.1273
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0214 0.0954
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.2576 1
Echinococcus multilocularis geminin 0.0516 0.4447 0.4385
Schistosoma mansoni intermediate filament proteins 0.0027 0.0109 0.0122
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0214 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0155 0.0198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0109 0.0489
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.019 0.7893
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0185 0.7499
Loa Loa (eye worm) beta-lactamase 0.0035 0.0185 0.0827
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0304 0.0197
Brugia malayi hypothetical protein 0.0026 0.01 0.0447
Echinococcus multilocularis GPCR, family 2 0.0049 0.0304 0.0197
Trypanosoma brucei glucosidase, putative 0.0036 0.019 0.7893
Schistosoma mansoni ap endonuclease 0.0038 0.0214 0.0295
Echinococcus granulosus dnaJ subfamily B 0.0414 0.3548 0.3477
Loa Loa (eye worm) hypothetical protein 0.005 0.0315 0.1406
Schistosoma mansoni hypothetical protein 0.0049 0.0304 0.0445
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0315 0.0463
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0215 0.0106
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1864 0.171
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0214 0.01
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2576 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0999 0.1599
Schistosoma mansoni alpha glucosidase 0.0036 0.019 0.0255
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0214 0.0029
Onchocerca volvulus 0.0093 0.0697 0.2999
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1298 0.5796
Echinococcus granulosus cpg binding protein 0.0031 0.0146 0.0037
Brugia malayi jmjC domain containing protein 0.01 0.0757 0.338
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0304 0.0197
Schistosoma mansoni hypothetical protein 0.0414 0.3548 0.5831
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0214 0.0119
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0185 0.0827
Toxoplasma gondii ABC1 family protein 0.0035 0.0185 0.3121
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0132 0.0588
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.168 0.1588
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0376 0.0564
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.019 0.0019
Plasmodium vivax SET domain protein, putative 0.0032 0.0155 0.4868
Onchocerca volvulus 0.005 0.0315 0.1048
Mycobacterium ulcerans glutaminase 0.0267 0.2239 0.2092
Loa Loa (eye worm) hypothetical protein 0.0052 0.0336 0.15
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0249 0.0141
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0376 0.1679
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0322 0.2732 0.2595
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2576 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0431 0.0656
Brugia malayi hypothetical protein 0.0016 0.002 0.0089
Loa Loa (eye worm) MBCTL1 0.0057 0.0376 0.1679
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.3548 0.3477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0185 0.7499
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0803 0.3587
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.1233 0.5509
Onchocerca volvulus 0.0032 0.0155 0.0234
Onchocerca volvulus 0.0035 0.0185 0.0387
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0315 0.0463
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0214 0.0105
Schistosoma mansoni lamin 0.0027 0.0109 0.0122
Brugia malayi beta-lactamase 0.0035 0.0185 0.0827
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0999 0.0899
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1298 0.1201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0155 0.0198
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0827
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0185 0.0077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0214 0.0105
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0376 0.0269
Trichomonas vaginalis set domain proteins, putative 0.0248 0.207 0.7881
Onchocerca volvulus 0.0035 0.0185 0.0387
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.019 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0214 0.0954
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0214 1
Loa Loa (eye worm) RNA binding protein 0.0127 0.0999 0.4462
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0999 0.1599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0185 0.0827
Brugia malayi mbt repeat family protein 0.005 0.0315 0.1406
Brugia malayi jmjC domain containing protein 0.0038 0.0215 0.0959
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.1583
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1298 0.5796
Schistosoma mansoni ap endonuclease 0.0038 0.0214 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0999 0.4462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Schistosoma mansoni hypothetical protein 0.0049 0.0304 0.0445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1507 0.1413
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0214 1
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0322 0.2732 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.019 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2576 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0155 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0315 0.1048
Schistosoma mansoni cpg binding protein 0.0031 0.0146 0.0183
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0315 0.0208
Schistosoma mansoni hypothetical protein 0.0516 0.4447 0.7322
Schistosoma mansoni hypothetical protein 0.031 0.2624 0.4296
Brugia malayi Pre-SET motif family protein 0.0032 0.0155 0.0694
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0315 0.0208
Onchocerca volvulus 0.0029 0.0132 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.7499
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1298 0.1201
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0143 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0215 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.064
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0214 0.0289
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0315 0.0208
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0109 0.0489
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0214 1
Trichomonas vaginalis glutaminase, putative 0.0267 0.2239 0.8589
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.014 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0757 0.0654
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.1583
Schistosoma mansoni lamin 0.0027 0.0109 0.0122
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0155 0.0046
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1298 0.1201
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0999 0.4462
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1507 0.1413
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0827
Brugia malayi Pre-SET motif family protein 0.0218 0.1804 0.8057
Brugia malayi TAR-binding protein 0.0127 0.0999 0.4462
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0248
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0214 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0376 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.019 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0215 0.0297
Loa Loa (eye worm) hypothetical protein 0.0105 0.0803 0.3587
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0315 0.0463

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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