TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.439 | Formula: C25H21NO4
H donors: 1 H acceptors: 3 LogP: 4.88 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1N(c2cccc(c2)C)C(=O)C(=C1C(=O)c1ccccc1)O
InChi: 1S/C25H21NO4/c1-16-7-6-10-19(15-16)26-22(17-11-13-20(30-2)14-12-17)21(24(28)25(26)29)23(27)18-8-4-3-5-9-18/h3-15,22,28H,1-2H3
InChiKey: SXXBQRBZYAQCSJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.002	0.009	0.0748
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Onchocerca volvulus		0.0012	0.0041	0.0155
Leishmania major	acetyl-CoA synthetase, putative	0.0014	0.0054	0.038
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.002	0.009	0.0748
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0054	0.0035
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0054	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0012	0.0045	0.0763
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Brugia malayi	DKFZp564C0469 protein	0.002	0.009	0.0748
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0054	0.0219
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Schistosoma mansoni	hypothetical protein	0.0081	0.0478	0.0549
Schistosoma mansoni	hypothetical protein	0.0032	0.0166	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Echinococcus granulosus	sentrin specific protease 1	0.0012	0.0045	0.0052
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0054	0.0219
Echinococcus multilocularis	geminin	0.0164	0.1007	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0617	0.5124
Loa Loa (eye worm)	patched family protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.091	0.091
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.002	0.009	0.0385
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0544	0.0625
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.009	0.1674
Echinococcus multilocularis	microtubule associated protein 2	0.1379	0.8707	0.8707
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.009	0.1674
Mycobacterium ulcerans	hypothetical protein	0.0102	0.0611	0.1625
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0054	0.0035
Mycobacterium ulcerans	hypothetical protein	0.0102	0.0611	0.1625
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.003	0.0035
Echinococcus granulosus	Protein patched homolog 1	0.0084	0.0497	0.0571
Echinococcus multilocularis	cpg binding protein	0.0031	0.0162	0.0162
Trichomonas vaginalis	replication factor C large subunit, putative	0.002	0.009	0.1674
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Brugia malayi	Patched protein homolog 1	0.0012	0.0041	0.0343
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0264	0.0614
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.003	0.0035
Echinococcus multilocularis	expressed conserved protein	0.0183	0.1129	0.1129
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0054	0.0035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0177	0.0393
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0544	0.4521
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0264	0.2195
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0166	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0014	0.0054	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0264	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0054	0.0447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.003	0.025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0544	0.0625
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0754	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Loa Loa (eye worm)	Ulp1 protease	0.0012	0.0045	0.0378
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0045	0.0378
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0054	0.0933
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.002	0.009	0.1674
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.003	0.025
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.003	0.025
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0054	0.0035
Echinococcus granulosus	cpg binding protein	0.0031	0.0162	0.0186
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0555	0.3484	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0054	0.0447
Schistosoma mansoni	hypothetical protein	0.0164	0.1007	0.1156
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0343
Plasmodium falciparum	metacaspase 1	0.0026	0.0129	0.5953
Schistosoma mansoni	caspase-7 (C14 family)	0.0026	0.0129	0.0148
Onchocerca volvulus		0.0014	0.0054	0.0327
Schistosoma mansoni	caspase-7 (C14 family)	0.0096	0.0576	0.0661
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0054	0.038
Trypanosoma brucei	metacaspase MCA3	0.0026	0.0129	1
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0129	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0264	0.0647
Echinococcus multilocularis	Niemann Pick C1 protein	0.0195	0.1204	0.1204
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.003	0.025
Onchocerca volvulus		0.0012	0.0041	0.0155
Plasmodium falciparum	sentrin-specific protease 1	0.0012	0.0045	0.0281
Brugia malayi	Patched related family protein 10	0.0012	0.0041	0.0343
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.002	0.009	0.1674
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Brugia malayi	hypothetical protein	0.0124	0.0754	0.6265
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0189	0.157
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0754	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	protein C24B5.3	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.003	0.025
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0264	0.2195
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0264	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0166	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Onchocerca volvulus		0.0014	0.0054	0.0327
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0166	0.0166
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0129	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0598	0.4964
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0264	0.1889
Echinococcus multilocularis	caspase 8	0.0026	0.0129	0.0129
Onchocerca volvulus		0.0014	0.0054	0.0327
Brugia malayi	Patched related family protein 4	0.0012	0.0041	0.0343
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.003	0.025
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0054	0.0992
Trichomonas vaginalis	sentrin/sumo-specific protease, senp8, putative	0.0012	0.0045	0.0763
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0019	0.0088	0.1642
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0084	0.0497	0.4131
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0166	0.0191
Echinococcus multilocularis	caspase 3	0.007	0.0413	0.0413
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0544	0.0544
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.003	0.025
Schistosoma mansoni	hypothetical protein	0.0032	0.0166	0.0191
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0177	0.0393
Echinococcus granulosus	Niemann Pick C1 protein	0.0195	0.1204	0.1383
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0129	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0054	0.0447
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0264	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0398	0.3305
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.003	0.0035
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.003	0.0035
Schistosoma mansoni	hypothetical protein	0.0081	0.0478	0.0549
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0012	0.0012
Echinococcus granulosus	expressed conserved protein	0.0183	0.1129	0.1297
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0166	0.0166
Schistosoma mansoni	topbp1	0.002	0.009	0.0103
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.0611	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.002	0.009	0.0855
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0014	0.0054	0.0072
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.0455	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Schistosoma mansoni	microtubule-associated protein tau	0.1379	0.8707	1
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Treponema pallidum	licC protein (licC)	0.0102	0.0611	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.003	0.025
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0264	0.1889
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0023	0.0023
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0019	0.0088	0.1642
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.003	0.0035
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0264	0.0614
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.009	0.1674
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0012	0.0014
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0045	0.0052
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0264	0.2195
Schistosoma mansoni	chromosome transmission fidelity factor	0.002	0.009	0.0103
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.003	0.003
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.003	0.025
Echinococcus multilocularis	replication factor c subunit 1	0.002	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.003	0.025
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0189	0.0394
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0166	0.1379
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0012	0.0014
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	steroid hormone receptor	0.001	0.003	0.025
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0264	0.0614
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0045	0.0378
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0045	0.0052
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0012	0.0045	0.0073
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0166	0.1379
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0054	0.0062
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0012	0.0012
Brugia malayi	protein C24B5.3	0.0012	0.0041	0.0343
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0129	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Echinococcus granulosus	sterol regulatory element binding protein	0.0084	0.0497	0.0571
Schistosoma mansoni	topbp1	0.002	0.009	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0166	0.1379
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0598	0.4964
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0129	0.1542
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0054	0.0992
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0054	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Onchocerca volvulus		0.0012	0.0041	0.0155
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.0378
Brugia malayi	Myosin head containing protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.003	0.0035
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	Ulp1 protease	0.0012	0.0045	0.0378
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0023	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0264	0.2195
Echinococcus multilocularis	caspase 2	0.0026	0.0129	0.0129
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.0455	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Trypanosoma cruzi	metacaspase 5, putative	0.0026	0.0129	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.009	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0195	0.1204	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0177	0.0393
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0264	0.2195
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Schistosoma mansoni	hypothetical protein	0.0081	0.0478	0.0549
Leishmania major	acetyl-CoA synthetase, putative	0.0014	0.0054	0.038
Schistosoma mansoni	thyroid hormone receptor	0.001	0.003	0.0035
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.002	0.009	0.1674
Brugia malayi	topoisomerase	0.002	0.009	0.0748
Toxoplasma gondii	ATPase, AAA family protein	0.002	0.009	0.0855
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.003	0.025
Echinococcus granulosus	sentrin specific protease 7	0.0143	0.0873	0.1003
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0054	0.0992
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.002	0.009	0.1674
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.003	0.0035
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0054	0.0035
Echinococcus granulosus	geminin	0.0164	0.1007	0.1156
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0189	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0054	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0149	0.091	0.7556
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0544	0.4521
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0555	0.3484	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0398	0.3305
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.003	0.003
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0102	0.0611	1
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.003	0.025
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0019	0.0088	0.0371
Loa Loa (eye worm)	patched family protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0754	0.6265
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Schistosoma mansoni	caspase-3 (C14 family)	0.0096	0.0576	0.0661
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Echinococcus multilocularis	caspase	0.0096	0.0576	0.0576
Chlamydia trachomatis	DNA ligase	0.002	0.009	0.3105
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Entamoeba histolytica	hypothetical protein	0.002	0.009	0.0385
Schistosoma mansoni	DNA ligase IV	0.002	0.009	0.0103
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0054	0.0035
Onchocerca volvulus		0.0012	0.0041	0.0155
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.003	0.025
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0555	0.3484	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.003	0.0035
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0026	0.0129	0.1073
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.009	0.5321
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.009	0.5321
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0264	0.1889
Onchocerca volvulus		0.0012	0.0045	0.0212
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.003	0.003
Schistosoma mansoni	coup transcription factor	0.001	0.003	0.0035
Onchocerca volvulus		0.0012	0.0041	0.0155
Echinococcus multilocularis	sentrin specific protease 8	0.0012	0.0045	0.0045
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0264	1
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0014	0.0054	0.0844
Giardia lamblia	Replication factor C, subunit 1	0.002	0.009	0.1087
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0497	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.003	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.009	0.5321
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Brugia malayi	ecdysteroid receptor	0.001	0.003	0.025
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0358	0.0411
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.0378
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.009	0.1674
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0045	0.0378
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.003	0.0035
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0151	0.1254
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0054	0.0035
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Onchocerca volvulus		0.0047	0.0264	0.3234
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0054	0.0933
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0544	0.0625
Brugia malayi	Pax transcription activation domain interacting protein	0.002	0.009	0.0748
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0264	0.0614
Echinococcus granulosus	nibrin	0.002	0.009	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.003	0.025
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0054	0.0447
Brugia malayi	CHE-14 protein	0.0084	0.0497	0.4131
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0023	0.0189
Onchocerca volvulus		0.0029	0.0151	0.1669
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0264	0.0614
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0544	0.0625
Plasmodium vivax	sentrin-specific protease 2, putative	0.0012	0.0045	0.0281
Leishmania major	metacaspase, putative	0.0026	0.0129	0.3827
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0189	0.157
Loa Loa (eye worm)	patched family protein	0.0012	0.0041	0.0343
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.0611	0.1655
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.003	0.025
Echinococcus granulosus	replication factor c subunit 1	0.002	0.009	0.0103
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0264	0.0614
Echinococcus granulosus	caspase 3	0.007	0.0413	0.0474
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0054	0.0447
Schistosoma mansoni	hypothetical protein	0.0081	0.0478	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0316	0.4824
Entamoeba histolytica	hypothetical protein	0.0019	0.0088	0.0371
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0544	0.0544
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Brugia malayi	Muscleblind-like protein	0.0149	0.091	0.7556
Schistosoma mansoni	hypothetical protein	0.0032	0.0166	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0054	0.0447
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0019	0.0088	0.0371
Echinococcus granulosus	GPCR family 2	0.0032	0.0166	0.0191
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0143	0.0873	0.7144
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0102	0.0611	0.1625
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0264	0.0614
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.003	0.025
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Echinococcus multilocularis	muscleblind protein	0.0149	0.091	0.091
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0023	0.0195
Schistosoma mansoni	cpg binding protein	0.0031	0.0162	0.0186
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.003	0.025
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0264	0.2195
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0198	0.1223	0.1405
Brugia malayi	Patched related family protein 12	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0754	0.6265
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.0455	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0129	0.1073
Plasmodium vivax	sentrin-specific protease 1, putative	0.0012	0.0045	0.0281
Plasmodium vivax	metacaspase 1, putative	0.0026	0.0129	0.5953
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0129	0.5953
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.003	0.025
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0012	0.0045	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0497	0.4131
Brugia malayi	nuclear hormone receptor	0.001	0.003	0.025
Loa Loa (eye worm)	patched family protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0129	0.1073
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.0455	0.914
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0189	0.157
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.003	0.0035
Brugia malayi	Niemann-Pick C1 protein precursor	0.0195	0.1204	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1204	1
Onchocerca volvulus	Protein patched homolog	0.0012	0.0041	0.0155
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.003	0.003
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0177	0.0393
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.002	0.009	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0151	0.1254
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0096	0.0576	0.0576
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.003	0.003
Onchocerca volvulus	Protein patched homolog	0.0012	0.0041	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	Cell death protein 3 precursor	0.0026	0.0129	0.1073
Echinococcus granulosus	caspase	0.0096	0.0576	0.0661
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.0455	0.914
Brugia malayi	nuclear receptor NHR-88	0.001	0.003	0.025
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Loa Loa (eye worm)	hypothetical protein	0.01	0.0598	0.4964
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0054	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0054	0.0992
Trypanosoma brucei	Metacaspase-4	0.0026	0.0129	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Schistosoma mansoni	patched 1	0.0084	0.0497	0.0571
Onchocerca volvulus		0.002	0.009	0.0828
Echinococcus granulosus	dnaJ subfamily B	0.0415	0.2597	0.2983
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0189	0.157
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0189	0.0428
Plasmodium falciparum	replication factor C subunit 1, putative	0.002	0.009	0.3299
Echinococcus multilocularis	sentrin specific protease 7	0.0143	0.0873	0.0873
Echinococcus multilocularis	nibrin	0.002	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.003	0.0035
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0189	1
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0143	0.0873	0.1003
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0012	0.0045	0.0073
Schistosoma mansoni	cpg binding protein	0.0031	0.0162	0.0186
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0096	0.0576	0.0661
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0544	0.0625
Schistosoma mansoni	cpg binding protein	0.0029	0.0151	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.003	0.025
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Trypanosoma brucei	metacaspase 5, putative	0.0026	0.0129	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0279	0.1735	0.1735
Schistosoma mansoni	hypothetical protein	0.0068	0.0398	0.0457
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.003	0.0035
Echinococcus granulosus	caspase 8	0.0026	0.0129	0.0148
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0189	1
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0012	0.0045	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0045	0.0763
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0014	0.0054	0.0992
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0333	0.6643
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0264	0.0614
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Onchocerca volvulus		0.0012	0.0041	0.0155
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Echinococcus granulosus	FTZ F1 alpha	0.001	0.003	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Echinococcus granulosus	expressed conserved protein	0.0131	0.0794	0.0912
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.0455	0.914
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0343
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0012	0.0045	0.0378
Onchocerca volvulus	Cell death protein 3 homolog	0.0026	0.0129	0.1369
Echinococcus granulosus	muscleblind protein	0.0149	0.091	0.1045
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.003	0.025
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.003	0.025
Echinococcus multilocularis	protein dispatched 1	0.0096	0.0573	0.0573
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.003	0.025
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0264	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0166	0.0166
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0026	0.0129	0.0148
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.003	0.0035
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Schistosoma mansoni	hypothetical protein	0.0415	0.2597	0.2983
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0129	0.1542
Echinococcus multilocularis	sentrin specific protease 1	0.0012	0.0045	0.0045
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0264	0.0647
Plasmodium vivax	replication factor C subunit 1, putative	0.002	0.009	0.3299
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0129	0.2475
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.003	0.0035
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0054	0.0035
Onchocerca volvulus		0.0014	0.0054	0.0327
Echinococcus multilocularis	sterol regulatory element binding protein	0.0084	0.0497	0.0497
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0012	0.0014
Echinococcus granulosus	microtubule associated protein 2	0.1379	0.8707	1
Loa Loa (eye worm)	patched family protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.002	0.009	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Trypanosoma cruzi	metacaspase 5, putative	0.0026	0.0129	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0189	0.157
Echinococcus multilocularis	protein patched	0.0084	0.0497	0.0497
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0088	0.1642
Echinococcus granulosus	caspase 2	0.0026	0.0129	0.0148
Trypanosoma brucei	metacaspase	0.0026	0.0129	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0026	0.0129	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.0378
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0129	0.1542
Brugia malayi	hypothetical protein	0.002	0.009	0.0748
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.003	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0455	0.914
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.009	0.5321
Onchocerca volvulus		0.0012	0.0041	0.0155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.003	0.025
Schistosoma mansoni	hypothetical protein	0.0164	0.1007	0.1156
Brugia malayi	Patched family protein	0.0012	0.0041	0.0343
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0166	0.1379
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.003	0.0035
Echinococcus granulosus	sentrin specific protease 8	0.0012	0.0045	0.0052
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.003	0.0035
Echinococcus granulosus	Niemann Pick C1 protein	0.0279	0.1735	0.1993
Echinococcus multilocularis	expressed conserved protein	0.0131	0.0794	0.0794
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0054	0.0035
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0598	0.4964
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.0088	0.1642
Loa Loa (eye worm)	hypothetical protein	0.001	0.003	0.025
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0555	0.3484	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.003	0.025
Plasmodium falciparum	metacaspase-like protein	0.0026	0.0129	0.5953
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Echinococcus multilocularis	dnaJ subfamily B	0.0415	0.2597	0.2597
Trypanosoma brucei	metacaspase MCA2	0.0026	0.0129	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.003	0.0035
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0012	0.0045	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0149	0.091	0.7556
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0054	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0343
Trypanosoma cruzi	FHA domain containing protein, putative	0.002	0.009	0.5321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 819859