Detailed information for compound 819859

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.439 | Formula: C25H21NO4
  • H donors: 1 H acceptors: 3 LogP: 4.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1N(c2cccc(c2)C)C(=O)C(=C1C(=O)c1ccccc1)O
  • InChi: 1S/C25H21NO4/c1-16-7-6-10-19(15-16)26-22(17-11-13-20(30-2)14-12-17)21(24(28)25(26)29)23(27)18-8-4-3-5-9-18/h3-15,22,28H,1-2H3
  • InChiKey: SXXBQRBZYAQCSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax sentrin-specific protease 2, putative 0.0012 0.0045 0.0281
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0054 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0358 0.0411
Schistosoma mansoni patched 1 0.0084 0.0497 0.0571
Trichomonas vaginalis Sentrin-specific protease, putative 0.0012 0.0045 0.0763
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trypanosoma brucei Metacaspase-4 0.0026 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.157
Treponema pallidum licC protein (licC) 0.0102 0.0611 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0054 0.0992
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0054 0.0219
Plasmodium vivax metacaspase 1, putative 0.0026 0.0129 0.5953
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Echinococcus multilocularis FTZ F1 alpha 0.001 0.003 0.003
Trypanosoma cruzi metacaspase, putative 0.0026 0.0129 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0023 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.003 0.025
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0023 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.003 0.025
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0012 0.0045 0.0052
Loa Loa (eye worm) patched family protein 0.0012 0.0041 0.0343
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0555 0.3484 1
Onchocerca volvulus 0.0014 0.0054 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.003 0.025
Loa Loa (eye worm) Ulp1 protease 0.0012 0.0045 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Echinococcus multilocularis muscleblind protein 1 0.0149 0.091 0.091
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0598 0.4964
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0378
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0054 0.0035
Plasmodium vivax sentrin-specific protease 1, putative 0.0012 0.0045 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) patched family protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0032 0.0166 0.1379
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0191
Onchocerca volvulus 0.0012 0.0041 0.0155
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0455 0.914
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trypanosoma brucei metacaspase MCA2 0.0026 0.0129 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0088 0.1642
Loa Loa (eye worm) hypothetical protein 0.0047 0.0264 0.2195
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Brugia malayi Cell death protein 3 precursor 0.0026 0.0129 0.1073
Brugia malayi hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.003 0.0035
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trypanosoma cruzi metacaspase, putative 0.0026 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.1223 0.1405
Schistosoma mansoni hypothetical protein 0.0081 0.0478 0.0549
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0264 0.0614
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Brugia malayi Steroid receptor seven-up type 2 0.001 0.003 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0544 0.0625
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0455 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0054 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.003 0.025
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0455 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.1674
Brugia malayi protein C24B5.3 0.0012 0.0041 0.0343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0012 0.0014
Schistosoma mansoni cpg binding protein 0.0029 0.0151 0.0173
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0012 0.0045 0.0378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0166 0.0191
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0054 0.0035
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.003 0.003
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Onchocerca volvulus Huntingtin homolog 0.0124 0.0754 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.1204 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0129 0.1542
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0264 1
Echinococcus multilocularis caspase 8 0.0026 0.0129 0.0129
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Schistosoma mansoni hypothetical protein 0.0164 0.1007 0.1156
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0012 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.157
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0555 0.3484 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0264 0.0614
Loa Loa (eye worm) hypothetical protein 0.0124 0.0754 0.6265
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus granulosus expressed conserved protein 0.0183 0.1129 0.1297
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0598 0.4964
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.009 0.0855
Loa Loa (eye worm) hypothetical protein 0.0047 0.0264 0.2195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.003 0.025
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.009 0.5321
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0012 0.0045 0.0073
Loa Loa (eye worm) patched family protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.003 0.025
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Brugia malayi CHE-14 protein 0.0084 0.0497 0.4131
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0143 0.0873 0.7144
Echinococcus multilocularis caspase 0.0096 0.0576 0.0576
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0088 0.1642
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0012 0.0045 0.0763
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Schistosoma mansoni nuclear hormone receptor 0.001 0.003 0.0035
Plasmodium falciparum metacaspase 1 0.0026 0.0129 0.5953
Echinococcus multilocularis muscleblind protein 0.0149 0.091 0.091
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0264 0.1889
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0012 0.0045 0.0073
Echinococcus granulosus sentrin specific protease 7 0.0143 0.0873 0.1003
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.009 0.0748
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0264 1
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0129 0.5953
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0191
Plasmodium falciparum sentrin-specific protease 1 0.0012 0.0045 0.0281
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0054 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.157
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.009 0.1674
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Loa Loa (eye worm) hypothetical protein 0.0195 0.1204 1
Trypanosoma brucei metacaspase 0.0026 0.0129 1
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0497 0.0571
Schistosoma mansoni hypothetical protein 0.0081 0.0478 0.0549
Echinococcus multilocularis cpg binding protein 0.0031 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0129 0.1369
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0054 0.038
Schistosoma mansoni caspase-3 (C14 family) 0.0096 0.0576 0.0661
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0398 0.3305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Brugia malayi Patched protein homolog 1 0.0012 0.0041 0.0343
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.003 0.025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.1674
Echinococcus granulosus geminin 0.0164 0.1007 0.1156
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.003 0.025
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0166 0.1379
Echinococcus granulosus caspase 0.0096 0.0576 0.0661
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0023 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.003 0.025
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0129 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0189 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0054 0.0072
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0096 0.0576 0.0576
Onchocerca volvulus 0.0012 0.0041 0.0155
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0012 0.0012
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.009 0.0748
Schistosoma mansoni hypothetical protein 0.0415 0.2597 0.2983
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0166 0.0166
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.003 0.0035
Echinococcus multilocularis sentrin specific protease 8 0.0012 0.0045 0.0045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0264 0.0647
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0544 0.4521
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.1204 0.1204
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.003 0.0035
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0129 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Echinococcus granulosus expressed conserved protein 0.0131 0.0794 0.0912
Brugia malayi Myosin head containing protein 0.0012 0.0041 0.0343
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.2597 0.2597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0151 0.1254
Schistosoma mansoni caspase-7 (C14 family) 0.0096 0.0576 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0102 0.0611 0.1625
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Echinococcus granulosus caspase 3 0.007 0.0413 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.003 0.025
Trypanosoma cruzi metacaspase, putative 0.0026 0.0129 1
Mycobacterium ulcerans hypothetical protein 0.0102 0.0611 0.1625
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.003 0.0035
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.1735 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Schistosoma mansoni hypothetical protein 0.0081 0.0478 0.0549
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0129 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0054 0.0992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0544 0.0625
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.009 0.3299
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.009 0.5321
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0054 0.0992
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0264 0.0647
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.003 0.025
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0012 0.0045 0.0073
Echinococcus multilocularis protein patched 0.0084 0.0497 0.0497
Brugia malayi hypothetical protein 0.0012 0.0041 0.0343
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.003 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0177 0.0393
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0096 0.0576 0.0661
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0081 0.0478 0.0549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0129 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Loa Loa (eye worm) steroid hormone receptor 0.001 0.003 0.025
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0455 0.914
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0497 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0012 0.0045 0.0378
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0264 0.0614
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0177 0.0393
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus granulosus cpg binding protein 0.0031 0.0162 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.003 0.003
Onchocerca volvulus 0.0012 0.0041 0.0155
Brugia malayi CXXC zinc finger family protein 0.0029 0.0151 0.1254
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0054 0.0219
Echinococcus granulosus FTZ F1 alpha 0.001 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.003 0.025
Echinococcus multilocularis protein dispatched 1 0.0096 0.0573 0.0573
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0544 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.003 0.025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0264 0.0614
Brugia malayi hypothetical protein 0.0124 0.0754 0.6265
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0129 0.1542
Brugia malayi protein C24B5.3 0.0012 0.0041 0.0343
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0019 0.0088 0.0371
Echinococcus granulosus caspase 8 0.0026 0.0129 0.0148
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0149 0.091 0.7556
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0054 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.003 0.003
Echinococcus multilocularis nibrin 0.002 0.009 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0014
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.009 0.1674
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0497 0.4131
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.009 0.5321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Entamoeba histolytica hypothetical protein 0.002 0.009 0.0385
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Onchocerca volvulus 0.0047 0.0264 0.3234
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0019 0.0088 0.0371
Loa Loa (eye worm) hypothetical protein 0.0084 0.0497 0.4131
Trypanosoma cruzi metacaspase, putative 0.0026 0.0129 1
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0019 0.0088 0.1642
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0598 0.4964
Onchocerca volvulus Huntingtin homolog 0.0124 0.0754 1
Trypanosoma brucei metacaspase MCA3 0.0026 0.0129 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0264 0.0614
Mycobacterium ulcerans hypothetical protein 0.0102 0.0611 0.1625
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.009 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.003 0.025
Schistosoma mansoni DNA ligase IV 0.002 0.009 0.0103
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0054 0.0035
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0129 0.0148
Loa Loa (eye worm) patched family protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus granulosus replication factor c subunit 1 0.002 0.009 0.0103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.003 0.025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.003 0.025
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0143 0.0873 0.1003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0378
Brugia malayi Patched related family protein 10 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Onchocerca volvulus 0.0014 0.0054 0.0327
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Echinococcus multilocularis GPCR, family 2 0.0032 0.0166 0.0166
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0054 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.009 0.5321
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0264 0.2195
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0455 1
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.1735 0.1993
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0264 0.0614
Loa Loa (eye worm) hypothetical protein 0.0103 0.0617 0.5124
Echinococcus granulosus sentrin specific protease 1 0.0012 0.0045 0.0052
Echinococcus multilocularis geminin 0.0164 0.1007 0.1007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0054 0.0992
Leishmania major metacaspase, putative 0.0026 0.0129 0.3827
Onchocerca volvulus 0.0012 0.0041 0.0155
Echinococcus multilocularis sentrin specific protease 1 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.157
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0054 0.0933
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0012 0.0045 0.0378
Onchocerca volvulus 0.0012 0.0045 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0544 0.0625
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0054 0.0992
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0129 0.1073
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0191
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0166 0.1379
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Onchocerca volvulus 0.0012 0.0041 0.0155
Plasmodium falciparum metacaspase-like protein 0.0026 0.0129 0.5953
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.003 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0054 0.0447
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.003 0.0035
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0189 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0264 0.0614
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.009 0.1674
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.003 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.003 0.025
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.003 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0611 0.1655
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0455 0.914
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0447
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Echinococcus granulosus caspase 2 0.0026 0.0129 0.0148
Echinococcus granulosus GPCR family 2 0.0032 0.0166 0.0191
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0264 0.0614
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0264 0.2195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.003 0.0035
Brugia malayi Patched related family protein 4 0.0012 0.0041 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.003 0.025
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni cpg binding protein 0.0031 0.0162 0.0186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0189 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.1674
Echinococcus multilocularis microtubule associated protein 2 0.1379 0.8707 0.8707
Loa Loa (eye worm) patched family protein 0.0012 0.0041 0.0343
Brugia malayi hypothetical protein 0.0012 0.0041 0.0343
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0054 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0611 0.1655
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Loa Loa (eye worm) hypothetical protein 0.0149 0.091 0.7556
Onchocerca volvulus 0.0012 0.0041 0.0155
Loa Loa (eye worm) hypothetical protein 0.0068 0.0398 0.3305
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.1204 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0054 0.0992
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0166 0.1379
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.1674
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0054 0.038
Brugia malayi nuclear hormone receptor 0.001 0.003 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Brugia malayi DKFZp564C0469 protein 0.002 0.009 0.0748
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0378
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0054 0.0447
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.003 0.0035
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.009 0.0103
Onchocerca volvulus 0.0014 0.0054 0.0327
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus granulosus sentrin specific protease 8 0.0012 0.0045 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0054 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.003 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0054 0.0844
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.009 0.0106
Echinococcus multilocularis replication factor c subunit 1 0.002 0.009 0.009
Brugia malayi ecdysteroid receptor 0.001 0.003 0.025
Schistosoma mansoni topbp1 0.002 0.009 0.0103
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Onchocerca volvulus 0.0012 0.0041 0.0155
Loa Loa (eye worm) hypothetical protein 0.01 0.0598 0.4964
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0045 0.0763
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0177 0.0393
Brugia malayi Muscleblind-like protein 0.0149 0.091 0.7556
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0054 0.038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0497 0.0497
Loa Loa (eye worm) oxidoreductase 0.0014 0.0054 0.0447
Onchocerca volvulus Protein patched homolog 0.0012 0.0041 0.0155
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0555 0.3484 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0019 0.0088 0.0371
Loa Loa (eye worm) hypothetical protein 0.0047 0.0264 0.2195
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0054 0.0844
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0189 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0012 0.0045 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0544 0.0544
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0264 0.2195
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0555 0.3484 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.1674
Echinococcus granulosus dnaJ subfamily B 0.0415 0.2597 0.2983
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0012 0.0045 0.0763
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0054 0.0054
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0054 0.0447
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0166 0.0166
Chlamydia trachomatis DNA ligase 0.002 0.009 0.3105
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0054 0.0035
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0054 0.0062
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Onchocerca volvulus 0.0029 0.0151 0.1669
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0129 1
Onchocerca volvulus 0.002 0.009 0.0828
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0264 0.0614
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.003 0.025
Echinococcus multilocularis expressed conserved protein 0.0131 0.0794 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Schistosoma mansoni thyroid hormone receptor 0.001 0.003 0.0035
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0054 0.0035
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.009 0.1674
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0129 0.2475
Schistosoma mansoni cpg binding protein 0.0031 0.0162 0.0186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.003 0.0035
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni hypothetical protein 0.0164 0.1007 0.1156
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0316 0.4824
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Schistosoma mansoni topbp1 0.002 0.009 0.0103
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0333 0.6643
Echinococcus multilocularis caspase 2 0.0026 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.003 0.0035
Brugia malayi hypothetical protein 0.0012 0.0041 0.0343
Mycobacterium ulcerans hypothetical protein 0.0047 0.0264 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.003 0.025
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0189 0.0428
Echinococcus multilocularis expressed conserved protein 0.0183 0.1129 0.1129
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.009 0.1674
Echinococcus granulosus muscleblind protein 0.0149 0.091 0.1045
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0054 0.0035
Schistosoma mansoni coup transcription factor 0.001 0.003 0.0035
Brugia malayi hypothetical protein 0.002 0.009 0.0748
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.1073
Loa Loa (eye worm) Ulp1 protease 0.0012 0.0045 0.0378
Echinococcus granulosus microtubule associated protein 2 0.1379 0.8707 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.009 0.0385
Schistosoma mansoni microtubule-associated protein tau 0.1379 0.8707 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0054 0.0933
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.1642
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.003 0.0035
Onchocerca volvulus 0.0014 0.0054 0.0327
Echinococcus granulosus nibrin 0.002 0.009 0.0103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.003 0.025
Brugia malayi Patched family protein 0.0012 0.0041 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0177 0.0393
Brugia malayi hypothetical protein 0.002 0.009 0.0748
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.009 0.3299
Giardia lamblia Replication factor C, subunit 1 0.002 0.009 0.1087
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0166 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.1204 0.1383
Echinococcus multilocularis sentrin specific protease 7 0.0143 0.0873 0.0873
Brugia malayi steroid hormone receptor 0.001 0.003 0.025
Schistosoma mansoni hypothetical protein 0.0068 0.0398 0.0457
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0264 0.1889
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0264 0.1889
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0012 0.0045 0.0378
Toxoplasma gondii ATPase, AAA family protein 0.002 0.009 0.0855
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Brugia malayi topoisomerase 0.002 0.009 0.0748
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0343
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0088 0.1642
Schistosoma mansoni thyroid hormone receptor 0.001 0.003 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0544 0.4521
Onchocerca volvulus Protein patched homolog 0.0012 0.0041 0.0155
Brugia malayi nuclear receptor NHR-88 0.001 0.003 0.025
Brugia malayi Patched related family protein 12 0.0012 0.0041 0.0343
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0264 1
Echinococcus multilocularis caspase 3 0.007 0.0413 0.0413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0544 0.0625
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0102 0.0611 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0455 0.914
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0497 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0129 0.2475
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.009 0.5321
Loa Loa (eye worm) hypothetical protein 0.0124 0.0754 0.6265

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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