TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.338 | Formula: C17H19NO3
H donors: 1 H acceptors: 1 LogP: 2.64 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NCC(C1)c1cc(OC2CCCC2)c2c(c1)cco2
InChi: 1S/C17H19NO3/c19-16-9-13(10-18-16)12-7-11-5-6-20-17(11)15(8-12)21-14-3-1-2-4-14/h5-8,13-14H,1-4,9-10H2,(H,18,19)
InChiKey: ZJOMIFCTGFIUAW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	penicillin-binding protein (pbp-3)	0.0161	0.0423	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0008	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0017	0.0177
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0132	0.0338	0.5001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Leishmania major	cathepsin L-like protease	0.0019	0.0008	0.0038
Echinococcus multilocularis	lamin dm0	0.003	0.0041	0.0533
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0017	0.0177
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0161	0.0423	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0239	0.3513
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Mycobacterium ulcerans	lipase LipD	0.0246	0.0671	0.0666
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0008	0.0038
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0279	0.411
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0041	0.061
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Trichomonas vaginalis	D-aminoacylase, putative	0.0246	0.0671	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0246	0.0671	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Brugia malayi	intermediate filament protein	0.003	0.0041	0.061
Mycobacterium tuberculosis	Conserved protein	0.0246	0.0671	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0257
Mycobacterium ulcerans	esterase/lipase LipP	0.0246	0.0671	0.0666
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0008	0.0038
Leishmania major	cathepsin L-like protease	0.0019	0.0008	0.0038
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0018	0.0005	0.0081
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.0279	0.411
Onchocerca volvulus		0.003	0.0041	0.0533
Mycobacterium leprae	conserved hypothetical protein	0.0246	0.0671	0.1395
Schistosoma mansoni	polycystin 1-related	0.0022	0.0017	0.0177
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0279	0.411
Loa Loa (eye worm)	ctsf protein	0.0019	0.0008	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0246	0.0671	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0239	0.3566
Echinococcus granulosus	lamin dm0	0.003	0.0041	0.0533
Schistosoma mansoni	rab6-interacting	0.0022	0.0017	0.0177
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0246	0.0671	0.0666
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0118	0.1691
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0008	0.0038
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0041	0.061
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0008	0.0038
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0017	0.0257
Mycobacterium tuberculosis	Probable esterase LipL	0.0246	0.0671	0.0666
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.0163	0.2367
Toxoplasma gondii	cathepsin CPL	0.0019	0.0008	0.0038
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0008	0.2123
Onchocerca volvulus		0.003	0.0041	0.0533
Onchocerca volvulus		0.0019	0.0008	0.0038
Leishmania major	cathepsin L-like protease	0.0072	0.0163	0.2367
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0017	0.0177
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.0279	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Echinococcus multilocularis	RUN	0.0022	0.0017	0.0177
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0246	0.0671	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0161	0.0423	1
Leishmania major	cathepsin L-like protease	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0161	0.0423	0.0418
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Loa Loa (eye worm)	beta-lactamase	0.0246	0.0671	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0017	0.0177
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0163	0.2367
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0246	0.0671	0.0666
Onchocerca volvulus		0.0019	0.0008	0.0038
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0279	0.411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0008	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Schistosoma mansoni	loxhd1	0.0022	0.0017	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0081
Loa Loa (eye worm)	cysteine protease	0.0019	0.0008	0.0119
Leishmania major	cathepsin L-like protease	0.0072	0.0163	0.2367
Trypanosoma cruzi	hypothetical protein, conserved	0.0246	0.0671	1
Mycobacterium tuberculosis	Conserved protein	0.0246	0.0671	0.0666
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0018	0.0005	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Leishmania major	cathepsin L-like protease	0.0072	0.0163	0.2367
Mycobacterium tuberculosis	Probable lipase LipD	0.0246	0.0671	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Plasmodium vivax	vivapain-2	0.0019	0.0008	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0008	0.0038
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0145	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Echinococcus multilocularis	lamin	0.003	0.0041	0.0533
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0017	0.0177
Mycobacterium ulcerans	beta-lactamase	0.0246	0.0671	0.0666
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0423	0.6278
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0008	0.0038
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0161	0.0423	0.0876
Brugia malayi	Doublecortin family protein	0.0022	0.0017	0.0257
Schistosoma mansoni	lipoxygenase	0.0132	0.0338	0.5001
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0163	0.2367
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0017	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Echinococcus granulosus	RUN	0.0022	0.0017	0.0177
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0017	1
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0161	0.0423	0.0418
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0246	0.0671	0.0666
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0008	0.0038
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0008	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0163	0.2367
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0132	0.0338	0.5001
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0008	0.2123
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Trypanosoma brucei	hypothetical protein, conserved	0.0246	0.0671	0.1395
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.0279	0.411
Loa Loa (eye worm)	hypothetical protein	0.003	0.0041	0.061
Echinococcus granulosus	cathepsin l1	0.0019	0.0008	0.0038
Onchocerca volvulus		0.0246	0.0671	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0081
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0081
Schistosoma mansoni	lamin	0.003	0.0041	0.0533
Mycobacterium tuberculosis	Conserved protein	0.0246	0.0671	0.0666
Echinococcus granulosus	lamin	0.003	0.0041	0.0533
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0081
Onchocerca volvulus		0.0022	0.0017	0.0177
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0041	0.061
Echinococcus multilocularis	cysteine protease	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0018	0.0005	0.0081
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0279	0.411
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0161	0.0423	0.0418
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0161	0.0423	0.0876
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0161	0.0423	1
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0161	0.0423	0.0418
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0008	0.0119
Chlamydia trachomatis	transglycolase/transpeptidase	0.0161	0.0423	1
Schistosoma mansoni	intermediate filament proteins	0.003	0.0041	0.0533
Schistosoma mansoni	rab6-interacting	0.0022	0.0017	0.0177
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0008	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0008	0.0038
Brugia malayi	ethe1-prov protein	0.0018	0.0005	0.0081
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.157	0.4539	0.4536
Schistosoma mansoni	hypothetical protein	0.0022	0.0017	0.0177
Brugia malayi	hypothetical protein	0.0022	0.0017	0.0257
Onchocerca volvulus		0.0022	0.0017	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Brugia malayi	beta-lactamase family protein	0.0246	0.0671	1
Brugia malayi	beta-lactamase family protein	0.0246	0.0671	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Mycobacterium tuberculosis	Probable lipase LipE	0.0246	0.0671	0.0666
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0161	0.0423	0.0418
Onchocerca volvulus		0.0019	0.0008	0.0038
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.344	1	1
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0161	0.0423	0.0876
Trichomonas vaginalis	esterase, putative	0.0246	0.0671	1
Loa Loa (eye worm)	fibroinase	0.0019	0.0008	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Onchocerca volvulus		0.0019	0.0008	0.0038
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0246	0.0671	1
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0161	0.0423	0.0418
Toxoplasma gondii	ABC1 family protein	0.0246	0.0671	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0246	0.0671	1
Chlamydia trachomatis	transglycolase/transpeptidase	0.0161	0.0423	1
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0018	0.0005	0.0081
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0008	0.0038
Mycobacterium tuberculosis	Probable hydrolase	0.0246	0.0671	0.0666
Mycobacterium leprae	Probable lipase LipE	0.0246	0.0671	0.1395
Trichomonas vaginalis	penicillin-binding protein, putative	0.0246	0.0671	1
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0018	0.0005	0.0081
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0017	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Plasmodium vivax	hypothetical protein, conserved	0.0246	0.0671	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0279	0.4158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0008	0.0038
Onchocerca volvulus		0.0246	0.0671	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0039	0.0586
Plasmodium vivax	vivapain-2	0.0019	0.0008	0.0038
Echinococcus granulosus	intermediate filament protein	0.003	0.0041	0.0533
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0008	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0008	0.0038
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0008	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Trichomonas vaginalis	D-aminoacylase, putative	0.0246	0.0671	1
Leishmania major	cathepsin L-like protease	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0671	1
Echinococcus multilocularis	cysteine protease	0.0019	0.0008	0.0038
Onchocerca volvulus		0.0019	0.0008	0.0038
Mycobacterium ulcerans	hypothetical protein	0.0246	0.0671	0.0666
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0008	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0008	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0246	0.0671	0.0666
Brugia malayi	hypothetical protein	0.0022	0.0017	0.0257
Schistosoma mansoni	lamin	0.003	0.0041	0.0533
Echinococcus multilocularis	musashi	0.003	0.0041	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0008	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0008	0.0038
Trypanosoma brucei	beta lactamase	0.1651	0.4775	1
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.0161	0.0423	0.0418
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0008	0.0119
Onchocerca volvulus		0.0019	0.0008	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0246	0.0671	1
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.1651	0.4775	1
Onchocerca volvulus		0.0246	0.0671	1
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.1651	0.4775	0.4773
Schistosoma mansoni	lipoxygenase	0.0092	0.0222	0.3258
Brugia malayi	beta-lactamase	0.0246	0.0671	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0246	0.0671	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0008	0.2123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0246	0.0671	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0239	0.3566
Onchocerca volvulus		0.0019	0.0008	0.0038
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0161	0.0423	0.0876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0163	0.033
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0018	0.0005	0.0081
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0161	0.0423	0.0418
Leishmania major	cathepsin L-like protease	0.0019	0.0008	0.0038
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0239	0.3513
Mycobacterium ulcerans	lipoprotein LpqF	0.1651	0.4775	0.4773
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0246	0.0671	1
Leishmania major	hypothetical protein, conserved	0.0246	0.0671	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.03 uM	Inhibition of rolipram binding to Phosphodiesterase 4	ChEMBL.	No reference
Kd (binding)	= 0.03 uM	Inhibition of rolipram binding to Phosphodiesterase 4	ChEMBL.	No reference
Ki (binding)	= 0.26 uM	Inhibition of cAMP-specific Phosphodiesterase 4 (PDE IV)	ChEMBL.	No reference
Ki (binding)	= 0.26 uM	Inhibition of cAMP-specific Phosphodiesterase 4 (PDE IV)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 82332