Detailed information for compound 828209

Basic information

Technical information
  • TDR Targets ID: 828209
  • Name: 1-[5-(phenylmethylamino)-3-pyridin-3-yl-1,2,4 -triazol-1-yl]butan-1-one
  • MW: 321.376 | Formula: C18H19N5O
  • H donors: 1 H acceptors: 4 LogP: 3.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)n1nc(nc1NCc1ccccc1)c1cccnc1
  • InChi: 1S/C18H19N5O/c1-2-7-16(24)23-18(20-12-14-8-4-3-5-9-14)21-17(22-23)15-10-6-11-19-13-15/h3-6,8-11,13H,2,7,12H2,1H3,(H,20,21,22)
  • InChiKey: WBIKFLYXZQQTKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[5-(phenylmethylamino)-3-(3-pyridyl)-1,2,4-triazol-1-yl]butan-1-one
  • 1-[5-(benzylamino)-3-(3-pyridyl)-1,2,4-triazol-1-yl]butan-1-one
  • ZINC04821331
  • D116-0259
  • NCGC00116259-01
  • MLS000679711
  • N-benzyl-1-butyryl-3-(3-pyridinyl)-1H-1,2,4-triazol-5-amine
  • SMR000296958

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0013 0.0017 0.0015
Onchocerca volvulus 0.0159 0.1641 0.3027
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0061 0.0113
Echinococcus granulosus GPCR family 2 0.0018 0.0064 0.0069
Schistosoma mansoni hypothetical protein 0.0038 0.0292 0.0319
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0159 0.1641 0.1793
Echinococcus granulosus geminin 0.019 0.1984 0.2167
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.3234
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0104 0.0113
Brugia malayi orphan nuclear receptor NR2E1 0.0159 0.1641 0.3039
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0316 0.0895
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0047 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0316 0.1034
Onchocerca volvulus 0.004 0.0316 0.057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0064 0.0191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0338 0.3629 0.3965
Plasmodium vivax DNA gyrase subunit A, putative 0.0271 0.2885 1
Echinococcus granulosus cpg binding protein 0.0034 0.0246 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0267 0.0493
Onchocerca volvulus 0.004 0.0316 0.057
Schistosoma mansoni intermediate filament proteins 0.0033 0.0229 0.0251
Toxoplasma gondii endonuclease IV APN 0.0086 0.0824 0.2835
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.0333
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0359 0.0392
Onchocerca volvulus 0.0159 0.1641 0.3027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.3094 0.5728
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0316 0.0316
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0338 0.3629 0.3629
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0059 0.0519 0.0519
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0118 0.0193
Echinococcus granulosus RUN 0.0044 0.0359 0.0392
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0338 0.3629 0.6713
Brugia malayi ecdysteroid receptor 0.0338 0.3629 0.6719
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Brugia malayi nuclear receptor RXR 0.0159 0.1641 0.3039
Echinococcus multilocularis chromobox protein 1 0.0013 0.0009 0.0009
Trypanosoma brucei unspecified product 0.0015 0.0033 0.0126
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0316 0.0586
Schistosoma mansoni nuclear receptor 0.0159 0.1641 0.1793
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0338 0.3629 0.3965
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0017 0.0018
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Giardia lamblia DNA topoisomerase II 0.0054 0.0474 1
Echinococcus multilocularis Chromo domain 0.0013 0.0009 0.0009
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0824 0.2835
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0059 0.0519 0.0961
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0159 0.1641 0.1641
Schistosoma mansoni zinc finger protein 0.0159 0.1641 0.1793
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0064 0.0118
Mycobacterium ulcerans beta-lactamase 0.004 0.0316 0.1034
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.3094 0.5728
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Echinococcus multilocularis thyroid hormone receptor alpha 0.0338 0.3629 0.3629
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0108 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0346
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.027 0.2873 0.2873
Schistosoma mansoni retinoic acid receptor RXR 0.0448 0.4861 0.531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0338 0.3629 0.6719
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0064 0.0118
Brugia malayi nuclear receptor NHR-67 0.0159 0.1641 0.3039
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.001
Mycobacterium leprae Probable lipase LipE 0.004 0.0316 0.1668
Echinococcus granulosus dna polymerase kappa 0.0022 0.0108 0.0118
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0104 0.0192
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0037
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0159 0.1641 0.1793
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0338 0.3629 0.6719
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0338 0.3629 0.6719
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.004 0.0316 0.1034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0338 0.3629 0.6719
Onchocerca volvulus 0.0033 0.0229 0.0409
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0583 0.0637
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0824 0.2695
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0159 0.1641 0.3039
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0316 0.0345
Schistosoma mansoni hypothetical protein 0.0021 0.0104 0.0113
Brugia malayi nuclear receptor NHR-88 0.0159 0.1641 0.3039
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0824 0.1526
Echinococcus multilocularis chromobox protein 2 0.0013 0.0009 0.0009
Schistosoma mansoni rab6-interacting 0.0044 0.0359 0.0392
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0338 0.3629 0.3965
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0625 0.6058
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0114 0.1132 0.2096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0065
Echinococcus multilocularis tumor protein p63 0.0379 0.4089 0.4089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0824 0.5947
Trypanosoma brucei DNA topoisomerase ii 0.0103 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0223 0.0412
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0625 0.0625
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0625 0.0683
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0108 0.032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0194 0.203 0.2218
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0271 0.2885 1
Onchocerca volvulus 0.0055 0.0485 0.0882
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0338 0.3629 0.3965
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0316 0.0895
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Onchocerca volvulus 0.0032 0.0225 0.0401
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0059 0.0519 0.0946
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0064 0.0438
Echinococcus granulosus FTZ F1 alpha 0.0338 0.3629 0.3965
Onchocerca volvulus 0.0021 0.0104 0.0175
Trichomonas vaginalis esterase, putative 0.004 0.0316 0.0997
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0415 0.3957
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.099 0.1081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0338 0.3629 0.6719
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0327 0.0606
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0064 0.0069
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0625 0.0683
Schistosoma mansoni thyroid hormone receptor 0.0338 0.3629 0.3965
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0546 0.1869
Schistosoma mansoni coup transcription factor 0.0338 0.3629 0.3965
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0064 0.0438
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1641 0.3039
Loa Loa (eye worm) heterochromatin protein 1 0.0013 0.0009 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0628 0.0686
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0178 0.1854 0.2026
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0327 0.0358
Plasmodium falciparum DNA gyrase subunit A 0.0271 0.2885 1
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0129 0.1305 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1641 0.3027
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0316 0.0895
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0338 0.3629 0.6719
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0338 0.3629 0.6719
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0159 0.1641 0.1793
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Plasmodium vivax DNA gyrase subunit B, putative 0.013 0.1318 0.4552
Loa Loa (eye worm) hypothetical protein 0.0497 0.5402 1
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0586
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0338 0.3629 0.3629
Brugia malayi hypothetical protein 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0108 0.0118
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0824 0.2835
Echinococcus granulosus neuropeptide receptor A26 0.0519 0.5645 0.6167
Mycobacterium ulcerans epimerase 0.0023 0.0118 0.0343
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Mycobacterium ulcerans hypothetical protein 0.0023 0.0118 0.0343
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0485 0.0529
Echinococcus multilocularis lamin 0.0033 0.0229 0.0229
Schistosoma mansoni loxhd1 0.0044 0.0359 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0338 0.3629 0.3965
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0108 0.0108
Brugia malayi conserved hypotetical protein 0.0159 0.1641 0.3039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0316 0.0895
Onchocerca volvulus 0.0338 0.3629 0.6713
Onchocerca volvulus 0.0497 0.5402 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0053 0.0141
Echinococcus multilocularis neuropeptide receptor A26 0.0519 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0425
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1641 0.1793
Echinococcus multilocularis musashi 0.0033 0.0229 0.0229
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.099 0.1081
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0118 0.0203
Schistosoma mansoni hypothetical protein 0.0044 0.0359 0.0392
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0338 0.3629 0.3965
Echinococcus multilocularis neuropeptide s receptor 0.0519 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0064 0.0191
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Echinococcus multilocularis ecdysone induced protein 78C 0.0338 0.3629 0.3629
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9154 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0108 0.0155
Schistosoma mansoni lamin 0.0033 0.0229 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1641 0.3027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0064 0.0064
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0359 0.1218
Toxoplasma gondii ABC1 family protein 0.004 0.0316 0.1069
Echinococcus multilocularis GPCR, family 2 0.0018 0.0064 0.0064
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0037
Leishmania major hypothetical protein, conserved 0.004 0.0316 0.2966
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Mycobacterium ulcerans lipase LipD 0.004 0.0316 0.1034
Onchocerca volvulus 0.0033 0.0229 0.0409
Brugia malayi hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0192
Entamoeba histolytica DNA topoisomerase II, putative 0.0059 0.0519 1
Echinococcus granulosus dnaJ subfamily B 0.0459 0.4978 0.5438
Brugia malayi nuclear hormone receptor family member nhr-6 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2098 0.6772
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.2741 0.9489
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0327 0.0327
Mycobacterium leprae conserved hypothetical protein 0.004 0.0316 0.1668
Brugia malayi hypothetical protein 0.0044 0.0359 0.0665
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0101 0.099 0.099
Brugia malayi hypothetical protein 0.0497 0.5402 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Schistosoma mansoni lipoxygenase 0.0194 0.203 0.2218
Brugia malayi Heterochromatin protein 1 0.0013 0.0009 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0338 0.3629 0.6719
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0118 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0118 0.0219
Plasmodium falciparum DNA gyrase subunit B 0.013 0.1318 0.4552
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0178 0.1854 0.1854
Leishmania major DNA topoisomerase ii 0.0049 0.0415 0.3957
Brugia malayi beta-lactamase 0.004 0.0316 0.0586
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0359 0.0392
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0043 0.0343 0.3234
Chlamydia trachomatis DNA gyrase subunit B 0.0085 0.0818 0.236
Echinococcus multilocularis geminin 0.019 0.1984 0.1984
Echinococcus granulosus Chromo domain 0.0013 0.0009 0.001
Echinococcus granulosus nuclear receptor nhr 48 0.0159 0.1641 0.1793
Schistosoma mansoni hypothetical protein 0.019 0.1984 0.2167
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0029 0.0032
Schistosoma mansoni hypothetical protein 0.0459 0.4978 0.5438
Schistosoma mansoni hypothetical protein 0.019 0.1984 0.2167
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0338 0.3629 0.6719
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0108 0.1934
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0297 0.0934
Brugia malayi nuclear hormone receptor family member odr-7 0.0159 0.1641 0.3039
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0108 0.0305
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0316 0.0345
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0108 0.0876
Schistosoma mansoni lozenge 0.0062 0.0561 0.0613
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0108 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0338 0.3629 0.3965
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0108 0.0118
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0583 0.5638
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0104 0.0329
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0338 0.3629 0.3965
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.037 0.0404
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0064 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0338 0.3629 0.6719
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0316 0.0895
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0625 0.199
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Brugia malayi Probable DNA topoisomerase II 0.0059 0.0519 0.0961
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Echinococcus multilocularis dna polymerase eta 0.0022 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0997
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0021 0.0104 0.0835
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0064 0.0069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1966
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0009 0.0017
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0049 0.0415 0.3957
Echinococcus granulosus lamin dm0 0.0033 0.0229 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0359 0.0359
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0104 0.0329
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0338 0.3629 0.3965
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0029 0.0032
Chlamydia trachomatis endonuclease IV 0.0086 0.0824 0.2382
Schistosoma mansoni polycystin 1-related 0.0044 0.0359 0.0392
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0338 0.3629 0.6719
Echinococcus granulosus dna polymerase eta 0.0022 0.0108 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0043 0.0343 0.1162
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1641 0.1641
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Brugia malayi chromobox protein homolog 3 0.0013 0.0009 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.0009
Echinococcus multilocularis Protein lozenge 0.0062 0.0561 0.0561
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0043 0.0343 0.0375
Trypanosoma brucei unspecified product 0.0015 0.0033 0.0126
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0415 0.3957
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0316 0.1034
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0108 0.0876
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Brugia malayi SET domain containing protein 0.0013 0.0017 0.0031
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0359 0.0359
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.037 0.0404
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1641 0.1793
Brugia malayi steroid hormone receptor 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0009 0.0009
Brugia malayi Protein kinase domain containing protein 0.0021 0.0104 0.0192
Brugia malayi Kringle domain containing protein 0.0021 0.0104 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0338 0.3629 0.3629
Schistosoma mansoni thyroid hormone receptor 0.0338 0.3629 0.3965
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0043 0.0343 0.3234
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0535 0.0991
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1966
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0189
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.0665
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0338 0.3629 0.3965
Echinococcus multilocularis lamin dm0 0.0033 0.0229 0.0229
Plasmodium vivax DNA topoisomerase II, putative 0.0059 0.0519 0.1774
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0343 0.1162
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0064 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0338 0.3629 0.6719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Loa Loa (eye worm) hypothetical protein 0.0497 0.5402 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0064 0.0118
Brugia malayi Protein cec-1. 0.0013 0.0009 0.0017
Brugia malayi intermediate filament protein 0.0033 0.0229 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0338 0.3629 0.6719
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0178 0.1854 0.2026
Brugia malayi nuclear hormone receptor 0.0159 0.1641 0.3039
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0297 0.0934
Trypanosoma brucei unspecified product 0.0022 0.0108 0.0876
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0327 0.0606
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1641 0.1793
Echinococcus granulosus chromobox protein 1 0.0013 0.0009 0.001
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Brugia malayi hypothetical protein 0.0044 0.0359 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Chlamydia trachomatis DNA gyrase subunit A 0.0271 0.2885 1
Echinococcus granulosus chromobox protein 1 0.0013 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Echinococcus granulosus Chromobox protein 3 0.0013 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1841
Echinococcus multilocularis nuclear receptor nhr 48 0.0159 0.1641 0.1641
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0043 0.0343 0.0343
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0625 0.2143
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0194 0.203 0.203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0338 0.3629 0.6719
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0338 0.3629 0.3629
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0064 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi hypothetical protein 0.004 0.0316 0.0585
Loa Loa (eye worm) beta-lactamase 0.004 0.0316 0.0586
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0059 0.0519 0.0567
Echinococcus granulosus tumor protein p63 0.0379 0.4089 0.4467
Loa Loa (eye worm) hypothetical protein 0.0086 0.0824 0.1526
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.2966
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.0333
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0271 0.2885 1
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0448 0.4861 0.531
Echinococcus granulosus lamin 0.0033 0.0229 0.0251
Leishmania major mitochondrial DNA topoisomerase II 0.0103 0.1019 1
Brugia malayi CHD4 protein 0.0015 0.0029 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1641 0.1641
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0489 0.0906
Schistosoma mansoni DNA polymerase eta 0.0022 0.0108 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0065
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0061 0.0113
Schistosoma mansoni cpg binding protein 0.0032 0.0225 0.0246
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0059 0.0519 0.0961
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9154 0.9154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0219
Onchocerca volvulus 0.0114 0.1132 0.2083
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0271 0.2885 1
Schistosoma mansoni hypothetical protein 0.004 0.0316 0.0345
Echinococcus granulosus intermediate filament protein 0.0033 0.0229 0.0251
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0108 0.0305
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0178 0.1854 0.2026
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0037
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.001
Loa Loa (eye worm) CYP4Cod1 0.0014 0.002 0.0037
Schistosoma mansoni RAR-like nuclear receptor 0.0338 0.3629 0.3965
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0338 0.3629 0.6719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.3234
Schistosoma mansoni nuclear receptor 0.0159 0.1641 0.1793
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Schistosoma mansoni cpg binding protein 0.0034 0.0246 0.0269
Toxoplasma gondii DNA topoisomerase 2, putative 0.0059 0.0519 0.1774
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0583 0.108
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0108 0.0155
Brugia malayi Doublecortin family protein 0.0044 0.0359 0.0665
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0199
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0338 0.3629 0.3965
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Echinococcus multilocularis FTZ F1 alpha 0.0338 0.3629 0.3629
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0316 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1641 0.1793
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0338 0.3629 0.6719
Onchocerca volvulus 0.0044 0.0359 0.065
Schistosoma mansoni lipoxygenase 0.0115 0.1143 0.1249
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0229 0.0425
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0064 0.0191
Plasmodium falciparum DNA topoisomerase 2 0.0059 0.0519 0.1774
Brugia malayi nuclear receptor NHR-88 0.0338 0.3629 0.6719
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0229 0.0425
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0343 0.1162
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0292 0.0541
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.1083
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0049 0.0415 0.3957
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0075 0.0706 0.2422
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0338 0.3629 0.6719
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0043 0.0343 0.0375
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.001
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0359 0.0359
Echinococcus multilocularis cpg binding protein 0.0034 0.0246 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.2966
Echinococcus granulosus neuropeptide s receptor 0.0519 0.5645 0.6167
Onchocerca volvulus 0.0044 0.0359 0.065
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Loa Loa (eye worm) helicase 0.0013 0.0009 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0338 0.3629 0.3965
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0359 0.1218
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0316 0.0586
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi hypothetical protein 0.0178 0.1854 0.3433
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Schistosoma mansoni rab6-interacting 0.0044 0.0359 0.0392
Loa Loa (eye worm) hypothetical protein 0.0038 0.0292 0.0541
Chlamydia trachomatis DNA gyrase subunit B 0.013 0.1318 0.4208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.009 0.0264
Brugia malayi nuclear receptor RXR 0.0178 0.1854 0.3433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Brugia malayi hypothetical protein 0.0178 0.1854 0.3433
Mycobacterium ulcerans endonuclease IV 0.0086 0.0824 0.2807
Loa Loa (eye worm) hypothetical protein 0.0055 0.0485 0.0897
Onchocerca volvulus Bile acid receptor homolog 0.0338 0.3629 0.6713
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0009 0.0017
Leishmania major DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0997
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0316 0.0316
Echinococcus granulosus thyroid hormone receptor alpha 0.0159 0.1641 0.1793
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0104 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2098 0.6772
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0064 0.0118
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0059 0.0519 0.0946
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0045 0.0366 0.2089
Echinococcus multilocularis chromobox protein 1 0.0013 0.0009 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0316 0.0895
Schistosoma mansoni cpg binding protein 0.0034 0.0246 0.0269
Loa Loa (eye worm) runx1 0.0062 0.0561 0.1038
Loa Loa (eye worm) steroid hormone receptor 0.0338 0.3629 0.6719
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0159 0.1641 0.1793
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0583 0.0637
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Loa Loa (eye worm) hypothetical protein 0.0114 0.1132 0.2096
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0159 0.1641 0.3039
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0316 0.2966
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0583 0.0583
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.1083
Onchocerca volvulus 0.0114 0.1132 0.2083
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.1984 0.3662
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0229 0.0425
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0359 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0338 0.3629 0.6719
Trichomonas vaginalis DNA topoisomerase II, putative 0.0059 0.0519 0.1654
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0042 0.0045
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0271 0.2885 1
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0586
Echinococcus granulosus chromobox protein 2 0.0013 0.0009 0.001
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0101 0.099 0.1081
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Brugia malayi tailless protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) DR-78 0.0159 0.1641 0.3039
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0103 0.1019 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0338 0.3629 0.3629
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0359 0.0665
Schistosoma mansoni DNA topoisomerase II 0.0059 0.0519 0.0567
Echinococcus multilocularis RUN 0.0044 0.0359 0.0359
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0043 0.0343 0.6551
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0059 0.0519 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0338 0.3629 0.6719
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0053 0.0141
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0625 0.0683
Brugia malayi ecdysone receptor 0.0159 0.1641 0.3039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0225 0.0417
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Mycobacterium ulcerans DNA gyrase subunit A 0.0271 0.2885 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.0665
Onchocerca volvulus 0.004 0.0316 0.057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0489 0.0906
Brugia malayi CXXC zinc finger family protein 0.0032 0.0225 0.0417
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor 0.0159 0.1641 0.3039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0338 0.3629 0.3629
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Leishmania major DNA polymerase eta, putative 0.0022 0.0108 0.0876
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0108 0.0876
Mycobacterium ulcerans DNA gyrase subunit B 0.013 0.1318 0.4531
Brugia malayi nuclear hormone receptor 0.0338 0.3629 0.6719
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0108 0.0118
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.009 0.0264
Schistosoma mansoni lamin 0.0033 0.0229 0.0251
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0316 0.0895
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0489 0.0906
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0489 0.0906
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0104 0.0835
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0159 0.1641 0.1641
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9154 1
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Schistosoma mansoni nuclear receptor nhr-48 0.0159 0.1641 0.1793
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0118
Plasmodium vivax hypothetical protein, conserved 0.004 0.0316 0.1069
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0103 0.1019 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.013 0.1318 0.4446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0338 0.3629 0.6719
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0064 0.0118
Brugia malayi M-phase phosphoprotein, mpp8 0.0114 0.1132 0.2096
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0064 0.0191
Echinococcus granulosus ecdysone induced protein 78C 0.0338 0.3629 0.3965
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Onchocerca volvulus Protein ultraspiracle homolog 0.0338 0.3629 0.6713
Brugia malayi hypothetical protein 0.0114 0.1132 0.2096
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) nuclear receptor NHR-67 0.0159 0.1641 0.3039
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.4978 0.4978
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0338 0.3629 0.6719
Schistosoma mansoni nuclear hormone receptor 0.0338 0.3629 0.3965
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0338 0.3629 0.3965
Loa Loa (eye worm) TOPoisomerase family member 0.0059 0.0519 0.0961

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.00538 um PUBCHEM_BIOASSAY: Thrombin 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 1046 (Thrombin 1536 HTS; hits were confirmed in this assay)] ChEMBL. No reference
Potency (functional) = 0.0112 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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