TDR Targets

Basic information

Technical information

TDR Targets ID: 829123
Name: N-(2-ethylphenyl)-1-methylsulfonyl-3,4-dihydr o-2H-quinoline-6-carboxamide
MW: 358.455 | Formula: C19H22N2O3S
H donors: 1 H acceptors: 3 LogP: 3.09 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1NC(=O)c1ccc2c(c1)CCCN2S(=O)(=O)C
InChi: 1S/C19H22N2O3S/c1-3-14-7-4-5-9-17(14)20-19(22)16-10-11-18-15(13-16)8-6-12-21(18)25(2,23)24/h4-5,7,9-11,13H,3,6,8,12H2,1-2H3,(H,20,22)
InChiKey: RYIAVSIMLSMKFU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-ethylphenyl)-1-mesyl-3,4-dihydro-2H-quinoline-6-carboxamide
T6003404
ZINC06767094
D256-0736
NCGC00117741-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0501	0.1932
Echinococcus granulosus	Small ubiquitin modifier 2	0.003	0.0294	0.0294
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0691	0.2868
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.2422	0.2422
Toxoplasma gondii	small ubiquitin family modifier, putative	0.003	0.0294	0.1158
Trypanosoma brucei	phosphoglycerate kinase	0.0165	0.2347	1
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0165	0.2347	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0501	0.121
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.2595	0.6263
Loa Loa (eye worm)	SMO-1 protein	0.003	0.0294	0.1131
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0165	0.2347	0.5194
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0025	0.0002
Trypanosoma cruzi	small ubiquitin protein, putative	0.003	0.0294	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0578	0.2226
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0271	0.1045
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0501	0.121
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0691	0.1667
Schistosoma mansoni	phosphoglycerate kinase	0.0165	0.2347	0.233
Trypanosoma brucei	phosphoglycerate kinase	0.0061	0.0762	0.3173
Giardia lamblia	Sentrin	0.003	0.0294	0.0653
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0361	0.1393
Echinococcus granulosus	peregrin	0.0033	0.0336	0.0336
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.003	0.0294	0.0272
Onchocerca volvulus		0.0043	0.0501	0.1932
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0623	0.2575
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0165	0.2347	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0271	0.0271
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0025	0.006
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.4055	1
Echinococcus multilocularis	peregrin	0.0033	0.0336	0.0336
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0501	0.048
Mycobacterium ulcerans	phosphoglycerate kinase	0.0165	0.2347	0.8815
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.2497	0.248
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0095
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0501	0.1932
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0165	0.2347	1
Leishmania major	small ubiquitin protein, putative	0.003	0.0294	0.1158
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0012	0.0025	0.006
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0558	0.2295
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0623	0.1503
Leishmania major	hypothetical protein, conserved	0.0056	0.0691	0.2868
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0025	0.0002
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2029	0.7816
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.2497	0.2497
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0501	0.2053
Brugia malayi	beta-lactamase family protein	0.0043	0.0501	0.1932
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2595	0.6263
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0501	0.2053
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Brugia malayi	Phosphoglycerate kinase	0.0165	0.2347	0.9044
Plasmodium falciparum	small ubiquitin-related modifier	0.003	0.0294	0.1158
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0012	0.0025	0.0025
Echinococcus multilocularis		0.0012	0.0025	0.0025
Brugia malayi	Ubiquitin-like protein SMT3	0.003	0.0294	0.1131
Trichomonas vaginalis	esterase, putative	0.0043	0.0501	0.121
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0012	0.0025	0.0025
Trypanosoma cruzi	small ubiquitin protein, putative	0.003	0.0294	0.1158
Leishmania major	hypothetical protein, conserved	0.0043	0.0501	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2347	0.9044
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0501	0.121
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0294	0.0708
Giardia lamblia	PHD finger protein 15	0.0028	0.0271	0.0598
Plasmodium vivax	small ubiquitin-related modifier, putative	0.003	0.0294	0.1158
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0061	0.0762	0.3173
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2595	0.6263
Plasmodium falciparum	phosphoglycerate kinase	0.0165	0.2347	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0691	0.1667
Brugia malayi	beta-lactamase	0.0043	0.0501	0.1932
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0501	0.1932
Schistosoma mansoni	hypothetical protein	0.0028	0.0271	0.0249
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0501	0.121
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0361	0.0361
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0025	0.006
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.4144	1
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0439	0.0439
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0558	0.1346
Chlamydia trachomatis	phosphoglycerate kinase	0.0165	0.2347	0.5
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0025	0.006
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0691	0.2868
Toxoplasma gondii	ABC1 family protein	0.0043	0.0501	0.2053
Onchocerca volvulus		0.0043	0.0501	0.1932
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0501	0.0501
Echinococcus granulosus	CTD small phosphatase protein like	0.0012	0.0025	0.0025
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2595	0.6263
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0271	0.1045
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0271	0.1061
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0165	0.2347	0.5
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0558	0.1294
Onchocerca volvulus		0.0182	0.2595	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.4144	1
Brugia malayi	Bromodomain containing protein	0.0033	0.0336	0.1295
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0025	0.006
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.2595	0.6263
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0182	0.2595	0.624
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0623	0.0623
Brugia malayi	PHD-finger family protein	0.0028	0.0271	0.1045
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0361	0.034
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0728	0.2805
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0165	0.2347	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0623	0.1503
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0025	0.006
Loa Loa (eye worm)	acetyltransferase	0.0175	0.2497	0.962
Brugia malayi	MH2 domain containing protein	0.0144	0.2029	0.7816
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0271	0.0249
Giardia lamblia	Phosphoglycerate kinase	0.0165	0.2347	0.5638
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0165	0.2347	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0623	0.2575
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0182	0.2595	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0623	0.2575
Plasmodium vivax	phosphoglycerate kinase, putative	0.0165	0.2347	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0165	0.2347	0.5664
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.1944	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0501	0.0501
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.4144	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0361	0.034
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0501	0.048
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2595	0.6263
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0086
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.1944	0.7813
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Echinococcus multilocularis	microtubule associated protein 2	0.067	1	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.4144	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0271	0.1061
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0501	0.2053
Onchocerca volvulus		0.0043	0.0501	0.1932
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0165	0.2347	0.5664
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0271	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0959	0.0938
Brugia malayi	Phosphoglycerate kinase	0.0061	0.0762	0.2935
Brugia malayi	jmjC domain containing protein	0.0034	0.0361	0.1393
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0165	0.2347	0.5664
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0061	0.0762	0.3173
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0501	0.121
Brugia malayi	beta-lactamase family protein	0.0043	0.0501	0.1932
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0691	0.2868
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.2497	0.962
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0025	0.006
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0501	0.2053
Schistosoma mansoni	microtubule-associated protein tau	0.067	1	1
Onchocerca volvulus	Alhambra homolog	0.0028	0.0271	0.1045
Trypanosoma brucei	phosphoglycerate kinase	0.0165	0.2347	1
Entamoeba histolytica	ubiquitin like protein	0.003	0.0294	0.0708
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0182	0.2595	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2595	0.6263
Echinococcus granulosus	phosphoglycerate kinase 1	0.0165	0.2347	0.2347
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.1248	0.1248
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0165	0.2347	0.2347
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0126	0.1747	0.3504
Trypanosoma brucei	small ubiquitin-related modifier	0.003	0.0294	0.1158
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2595	0.6263
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0025	0.006
Schistosoma mansoni	phosphoglycerate kinase	0.0165	0.2347	0.233
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.1248	0.1248
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0182	0.2595	1
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0165	0.2347	1
Brugia malayi	jmjC domain containing protein	0.0093	0.1248	0.4807
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0501	0.1932
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0165	0.2347	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.1944	0.4059
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2029	0.7816
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.4144	1
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0439	0.0439
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0361	0.0361
Echinococcus multilocularis	Small ubiquitin modifier 2	0.003	0.0294	0.0294
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0012	0.0025	0.0095
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0271	0.1061

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1712825
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829123