TDR Targets

Basic information

Technical information

TDR Targets ID: 835368
Name: ST009836
MW: 341.403 | Formula: C18H16FN3OS
H donors: 1 H acceptors: 2 LogP: 3.76 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCc2c(C1)cc1c(n2)sc(c1N)C(=O)c1ccc(cc1)F
InChi: 1S/C18H16FN3OS/c1-22-7-6-14-11(9-22)8-13-15(20)17(24-18(13)21-14)16(23)10-2-4-12(19)5-3-10/h2-5,8H,6-7,9,20H2,1H3
InChiKey: IYMAWQSGPSVNJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

BAS 07415621
C611-0573
NCGC00110666-01
Oprea1_608239

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania infantum	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Babesia bovis	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania donovani	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Toxoplasma gondii	peptidylprolyl isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus granulosus	expressed protein	Get druggable targets OG5_128367	All targets in OG5_128367
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trypanosoma congolense	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma mansoni	rotamase	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania braziliensis	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Neospora caninum	peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t	Get druggable targets OG5_128367	All targets in OG5_128367
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trypanosoma brucei gambiense	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania mexicana	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Theileria parva	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	163 aa	133 aa	27.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0444	0.5126	0.5123
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0146	0.1397	0.2717
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0298	0.3294	0.3294
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Entamoeba histolytica	ankyrin repeat protein	0.0146	0.1397	0.2642
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	adapter molecule crk	0.0298	0.3294	0.329
Trichomonas vaginalis	rotamase, putative	0.004	0.007	0.0039
Onchocerca volvulus		0.0444	0.5126	1
Brugia malayi	hypothetical protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0298	0.3294	0.329
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0146	0.1397	0.1392
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0017	0.0011
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0444	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	SH2 domain-containing protein	0.0298	0.3294	0.6422
Onchocerca volvulus		0.0146	0.1397	0.2717
Onchocerca volvulus		0.0298	0.3294	0.6422
Brugia malayi	Pre-SET motif family protein	0.0036	0.0017	0.0021
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	ephrin receptor	0.0146	0.1397	0.1392
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0146	0.1397	0.1392
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0298	0.3294	0.6422
Echinococcus multilocularis	protein kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Echinococcus multilocularis	activin receptor type	0.0146	0.1397	0.1392
Echinococcus multilocularis	c src tyrosine kinase	0.0444	0.5126	0.5123
Schistosoma mansoni	vav2	0.0298	0.3294	0.329
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0146	0.1397	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Plasmodium falciparum	tyrosine kinase-like protein	0.0146	0.1397	1
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.1397	0.1397
Onchocerca volvulus		0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Echinococcus multilocularis	signal transduction protein lnk realted	0.0298	0.3294	0.329
Echinococcus multilocularis	tyrosine protein kinase	0.0146	0.1397	0.1392
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein kinase, putative	0.0298	0.3294	0.6385
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0298	0.3294	0.3294
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.1397	0.1397
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0146	0.1397	0.2717
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Leishmania major	hypothetical protein, conserved	0.0146	0.1397	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0146	0.1397	0.1397
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0298	0.3294	0.3294
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.1397	0.1392
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Onchocerca volvulus		0.0146	0.1397	0.2717
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0444	0.5126	0.5123
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.1397	0.1392
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.1397	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0444	0.5126	0.5126
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0146	0.1397	0.1392
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Echinococcus granulosus	N chimaerin	0.0298	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0444	0.5126	0.5123
Onchocerca volvulus	Tyrosine kinase homolog	0.0146	0.1397	0.2717
Echinococcus granulosus	kinase suppressor of Ras 1	0.0146	0.1397	0.1397
Trichomonas vaginalis	esterase, putative	0.0043	0.011	0.0166
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Onchocerca volvulus		0.0298	0.3294	0.6422
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0298	0.3294	0.6422
Brugia malayi	ephrin receptor 1 precursor	0.0146	0.1397	0.2717
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.011	0.0745
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1009	0.1009
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Loa Loa (eye worm)	TK protein kinase	0.0444	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Schistosoma mansoni	tensin	0.0298	0.3294	0.329
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0298	0.3294	0.329
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Onchocerca volvulus		0.0043	0.011	0.0202
Brugia malayi	protein-tyrosine kinase	0.0444	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0017	0.0011
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0099	0.0093
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	tensin	0.0298	0.3294	0.329
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0146	0.1397	0.2717
Echinococcus multilocularis	protein kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0146	0.1397	1
Onchocerca volvulus		0.0444	0.5126	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0298	0.3294	0.3294
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0298	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase shark	0.0444	0.5126	0.5123
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0146	0.1397	0.1397
Echinococcus granulosus	hypothetical protein	0.0298	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0146	0.1397	0.1397
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.011	0.0104
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0146	0.1397	0.1392
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0146	0.1397	0.1397
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Brugia malayi	Protein kinase domain containing protein	0.0444	0.5126	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0146	0.1397	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0444	0.5126	0.5126
Trichomonas vaginalis	CAMK family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.011	0.0166
Mycobacterium leprae	Probable lipase LipE	0.0043	0.011	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase, putative	0.0153	0.1487	0.2819
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	cysteine surface protein, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0146	0.1397	1
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	SHC transforming protein 3	0.0298	0.3294	0.329
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	hypothetical protein	0.0146	0.1397	0.1392
Echinococcus granulosus	protein kinase	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	TK/ROR protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	beta-lactamase	0.0043	0.011	0.0202
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0444	0.5126	0.5126
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.011	0.0383
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Loa Loa (eye worm)	STAT protein	0.0298	0.3294	0.6422
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0146	0.1397	0.1392
Echinococcus granulosus	activated cdc42 kinase 1	0.0146	0.1397	0.1397
Echinococcus multilocularis	insulin receptor	0.0146	0.1397	0.1392
Schistosoma mansoni	SH2A	0.0298	0.3294	0.329
Loa Loa (eye worm)	hypothetical protein	0.0444	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0146	0.1397	0.2717
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0146	0.1397	0.1397
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Brugia malayi	Raf kinase	0.0146	0.1397	0.2717
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0146	0.1397	0.1392
Schistosoma mansoni	hypothetical protein	0.0298	0.3294	0.329
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0298	0.3294	0.329
Brugia malayi	Protein kinase domain containing protein	0.0444	0.5126	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0444	0.5126	0.5123
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0146	0.1397	0.1392
Loa Loa (eye worm)	SH2 domain-containing protein	0.0298	0.3294	0.6422
Onchocerca volvulus		0.0286	0.3147	0.6135
Leishmania major	hypothetical protein, conserved	0.0043	0.011	0.0383
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0017	0.0017
Echinococcus granulosus	signal transduction protein lnk realted	0.0298	0.3294	0.3294
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Brugia malayi	jmjC domain containing protein	0.0115	0.1009	0.1959
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.1397	0.1397
Echinococcus granulosus	peregrin	0.0035	0.0006	0.0006
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0712	0.0707
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Onchocerca volvulus		0.0146	0.1397	0.2717
Echinococcus granulosus	c src tyrosine kinase	0.0444	0.5126	0.5126
Leishmania major	protein kinase, putative	0.0146	0.1397	1
Brugia malayi	beta-lactamase	0.0043	0.011	0.0202
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0146	0.1397	1
Giardia lamblia	Kinase, NEK	0.0146	0.1397	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Onchocerca volvulus		0.0444	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0006	0.0006
Loa Loa (eye worm)	TK/ALK protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0298	0.3294	0.6422
Echinococcus granulosus	SH2 domain containing protein 7	0.0298	0.3294	0.3294
Onchocerca volvulus		0.0043	0.011	0.0202
Echinococcus multilocularis	FL cytokine receptor	0.0146	0.1397	0.1392
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0146	0.1397	0.1392
Brugia malayi	Variant SH3 domain containing protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0444	0.5126	0.5123
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0298	0.3294	0.329
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0146	0.1397	0.1392
Plasmodium falciparum	protein kinase, putative	0.0146	0.1397	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0444	0.5126	0.5126
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Onchocerca volvulus		0.0043	0.011	0.0202
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Plasmodium vivax	SET domain protein, putative	0.0036	0.0017	0.0076
Plasmodium vivax	protein kinase, putative	0.0146	0.1397	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0298	0.3294	0.329
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.011	0.0104
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0444	0.5126	0.5123
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.011	0.5
Schistosoma mansoni	tensin	0.0298	0.3294	0.329
Trypanosoma brucei	Pseudokinase, putative	0.0146	0.1397	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0444	0.5126	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0146	0.1397	0.1397
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.1397	0.1392
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Echinococcus multilocularis	SH2 motif	0.0298	0.3294	0.329
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0444	0.5126	0.5123
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.1397	0.1397
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus granulosus	tyrosine protein kinase Srms	0.0444	0.5126	0.5126
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Onchocerca volvulus		0.0146	0.1397	0.2717
Echinococcus granulosus	expressed protein	0.004	0.007	0.007
Loa Loa (eye worm)	TK/CSK protein kinase	0.0146	0.1397	0.2717
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.007	0.0039
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	TK/ABL protein kinase	0.0444	0.5126	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0444	0.5126	0.5126
Brugia malayi	Furin-like cysteine rich region family protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	tensin	0.0298	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	NCK adaptor protein	0.0298	0.3294	0.3294
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Onchocerca volvulus		0.0146	0.1397	0.2717
Brugia malayi	Guanylyl cyclase protein 23	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK/INSR protein kinase	0.0146	0.1397	0.2717
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.011	0.0202
Echinococcus multilocularis	tensin	0.0298	0.3294	0.329
Plasmodium falciparum	protein kinase, putative	0.0146	0.1397	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0146	0.1397	0.1392
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.1397	0.1392
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1009	0.1004
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.1397	0.1397
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0146	0.1397	0.2717
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.1397	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	rotamase	0.004	0.007	0.0064
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Toxoplasma gondii	protein kinase	0.0146	0.1397	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0099	0.0099
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0146	0.1397	0.4335
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0146	0.1397	0.1397
Brugia malayi	Protein kinase domain containing protein	0.0444	0.5126	1
Schistosoma mansoni	serine/threonine RGC	0.0146	0.1397	0.1392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Schistosoma mansoni	protein tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0146	0.1397	0.1392
Onchocerca volvulus		0.0298	0.3294	0.6422
Schistosoma mansoni	ephrin receptor	0.0146	0.1397	0.1392
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0444	0.5126	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0444	0.5126	0.5123
Entamoeba histolytica	ankyrin repeat protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0298	0.3294	0.329
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.1397	0.1392
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0298	0.3294	0.329
Schistosoma mansoni	GTPase activating protein	0.0298	0.3294	0.329
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0444	0.5126	0.5123
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	STE family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.1397	0.1397
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Echinococcus multilocularis	tyrosine kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Mycobacterium ulcerans	lipase LipD	0.0043	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	growth factor receptor-bound protein	0.0298	0.3294	0.329
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Giardia lamblia	Protein 21.1	0.0146	0.1397	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Onchocerca volvulus		0.0146	0.1397	0.2717
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.1397	1
Entamoeba histolytica	hypothetical protein, conserved	0.0146	0.1397	0.2642
Echinococcus granulosus	insulin receptor	0.0146	0.1397	0.1397
Brugia malayi	Tensin	0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	activin receptor type	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0298	0.3294	0.329
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0146	0.1397	1
Onchocerca volvulus		0.0444	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0017	0.0011
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Echinococcus granulosus	SHC transforming protein 3	0.0298	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0444	0.5126	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK/EPH protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0298	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase shark	0.0444	0.5126	0.5126
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0298	0.3294	0.6422
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0146	0.1397	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0017	0.0021
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Brugia malayi	MH2 domain containing protein	0.0144	0.137	0.2665
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0017	0.0076
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	nck2/grb4	0.0298	0.3294	0.329
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.011	0.0104
Echinococcus granulosus	tyrosine protein kinase Blk	0.0444	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	N chimaerin	0.0298	0.3294	0.329
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0146	0.1397	0.1392
Brugia malayi	beta-lactamase family protein	0.0043	0.011	0.0202
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0146	0.1397	0.2717
Mycobacterium ulcerans	beta-lactamase	0.0043	0.011	0.5
Brugia malayi	SH2 domain containing protein	0.0444	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	suppressor of cytokine signaling	0.0298	0.3294	0.329
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0017	0.0011
Echinococcus granulosus	tyrosine kinase	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0146	0.1397	0.1392
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Entamoeba histolytica	receptor protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.1397	0.1397
Schistosoma mansoni	hypothetical protein	0.0298	0.3294	0.329
Echinococcus granulosus	receptor type guanylyl cyclase	0.0146	0.1397	0.1397
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0146	0.1397	1
Onchocerca volvulus		0.0298	0.3294	0.6422
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.011	0.0166
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0146	0.1397	0.2717
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0146	0.1397	0.1392
Echinococcus multilocularis	expressed protein	0.004	0.007	0.0064
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0298	0.3294	0.329
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0146	0.1397	0.1397
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0179	0.0179
Echinococcus granulosus	tyrosine protein kinase	0.0146	0.1397	0.1397
Echinococcus granulosus	SH2 motif	0.0298	0.3294	0.3294
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	TK/RYK protein kinase	0.0146	0.1397	0.2717
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.004	0.007	0.0125
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0444	0.5126	0.5123
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.011	0.0166
Plasmodium falciparum	tyrosine kinase-like protein	0.0146	0.1397	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Brugia malayi	Protein kinase domain containing protein	0.0444	0.5126	1
Brugia malayi	C-terminal src kinase protein 1	0.0146	0.1397	0.2717
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.011	0.5
Brugia malayi	jmjC domain containing protein	0.0043	0.0099	0.0181
Echinococcus granulosus	expressed conserved protein	0.0298	0.3294	0.3294
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.011	0.0166
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	Pre-SET motif family protein	0.0251	0.2712	0.5286
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.011	0.0166
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0298	0.3294	0.6422
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.004	0.007	0.0125
Brugia malayi	Receptor family ligand binding region containing protein	0.0146	0.1397	0.2717
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.011	0.0383
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0179	0.0173
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	protein tyrosine kinase	0.0146	0.1397	0.1397
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	Sex muscle abnormal protein 5	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	hypothetical protein	0.0153	0.1487	0.2819
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0017	0.0011
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0444	0.5126	0.5126
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0146	0.1397	0.1392
Echinococcus multilocularis	transfer RNA-Thr	0.0146	0.1397	0.1392
Echinococcus granulosus	integrin linked protein kinase	0.0146	0.1397	0.1397
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Entamoeba histolytica	SH2 domain containing protein	0.0298	0.3294	0.6385
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0099	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	hypothetical protein	0.006	0.0321	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0146	0.1397	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	ephrin type A receptor 4 A	0.0146	0.1397	0.1397
Echinococcus granulosus	raf serine:threonine protein kinase	0.0146	0.1397	0.1397
Schistosoma mansoni	signal transduction protein lnk-related	0.0298	0.3294	0.329
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	tyrosine protein kinase HCK	0.0146	0.1397	0.1397
Echinococcus granulosus	growth factor receptor bound protein 2	0.0298	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0444	0.5126	0.5123
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0444	0.5126	0.5123
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0444	0.5126	0.5123
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.3147	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Trypanosoma cruzi	protein kinase, putative	0.0146	0.1397	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	tyrosine kinase	0.0444	0.5126	0.5126
Loa Loa (eye worm)	TK/DDR protein kinase	0.0146	0.1397	0.2717
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0298	0.3294	0.3294
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0146	0.1397	0.1392
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0298	0.3294	0.3294
Echinococcus multilocularis	tyrosine kinase	0.0444	0.5126	0.5123
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0444	0.5126	0.5123
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Toxoplasma gondii	peptidylprolyl isomerase	0.0039	0.0058	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Entamoeba histolytica	receptor protein kinase, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.1397	0.2717
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0146	0.1397	0.1392
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0298	0.3294	0.329
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Mycobacterium ulcerans	hypothetical protein	0.0043	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0298	0.3294	0.6422
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Schistosoma mansoni	shc transforming protein	0.0298	0.3294	0.329
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	TK/ACK protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	natriuretic peptide receptor 1	0.0146	0.1397	0.1397
Schistosoma mansoni	growth factor receptor-bound protein	0.0298	0.3294	0.329
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	integrin linked protein kinase	0.0146	0.1397	0.1392
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1397	0.1392
Brugia malayi	beta-lactamase family protein	0.0043	0.011	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	suppressor of cytokine signaling	0.0298	0.3294	0.329
Leishmania major	protein kinase, putative	0.0146	0.1397	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0444	0.5126	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	Variant SH3 domain containing protein	0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK/Met protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	tensin-related	0.0298	0.3294	0.329
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0146	0.1397	0.1397
Loa Loa (eye worm)	serine/threonine protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	tyrosine protein kinase pr2	0.0146	0.1397	0.1397
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0298	0.3294	0.329
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0444	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0298	0.3294	0.329
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	SH2 domain containing protein	0.0444	0.5126	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.1397	0.1392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	protein tyrosine kinase	0.0146	0.1397	0.1392
Brugia malayi	hypothetical protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.1397	0.1392
Echinococcus multilocularis	heat shock protein 70	0.0146	0.1397	0.1392
Onchocerca volvulus		0.0036	0.0017	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.1397	0.2717
Brugia malayi	SRC-1	0.0444	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.1397	0.4335
Toxoplasma gondii	protein kinase domain-containing protein	0.0146	0.1397	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0298	0.3294	0.329
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0146	0.1397	0.4335
Giardia lamblia	Kinase	0.0146	0.1397	1
Echinococcus multilocularis	SH2 motif	0.0298	0.3294	0.329
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0298	0.3294	0.6422
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.0202
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.011	0.0202
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3294	0.6422
Entamoeba histolytica	hypothetical protein	0.0146	0.1397	0.2642
Loa Loa (eye worm)	TK protein kinase	0.0146	0.1397	0.2717
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Schistosoma mansoni	tyrosine kinase	0.0444	0.5126	0.5123
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0146	0.1397	0.1392
Echinococcus multilocularis	activated cdc42 kinase 1	0.0146	0.1397	0.1392
Trichomonas vaginalis	protein kinase atn1, putative	0.0146	0.1397	0.4335
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3043	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0298	0.3294	0.6422
Entamoeba histolytica	hypothetical protein	0.0153	0.1487	0.2819
Brugia malayi	Variant SH3 domain containing protein	0.0298	0.3294	0.6422
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Echinococcus granulosus	tyrosine kinase	0.0444	0.5126	0.5126
Brugia malayi	hypothetical protein	0.0298	0.3294	0.6422
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	TK/FAK protein kinase	0.0146	0.1397	0.2717
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.1397	0.1392
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	RhoGAP domain containing protein	0.0298	0.3294	0.6422
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1397	0.2717
Schistosoma mansoni	tensin-related	0.0298	0.3294	0.329
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0298	0.3294	0.6422
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0146	0.1397	0.1392
Plasmodium falciparum	protein kinase, putative	0.0146	0.1397	1
Echinococcus multilocularis		0.0298	0.3294	0.329
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	integrin-linked kinase	0.0146	0.1397	0.2717
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.1397	0.2642
Brugia malayi	Variant SH3 domain containing protein	0.0298	0.3294	0.6422
Echinococcus multilocularis	SH2 motif	0.0298	0.3294	0.329
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0146	0.1397	0.1397
Brugia malayi	Protein kinase domain containing protein	0.0444	0.5126	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0298	0.3294	0.6385
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0298	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0444	0.5126	0.5123
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0146	0.1397	0.1397
Schistosoma mansoni	tyrosine protein kinase	0.0146	0.1397	0.1392
Brugia malayi	SH2 domain containing protein	0.0298	0.3294	0.6422
Onchocerca volvulus		0.0146	0.1397	0.2717
Trichomonas vaginalis	TK family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0475	0.0917
Loa Loa (eye worm)	SH2 domain-containing protein	0.0298	0.3294	0.6422
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase, putative	0.0146	0.1397	0.2642
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Onchocerca volvulus		0.0298	0.3294	0.6422
Giardia lamblia	Kinase, NEK	0.0146	0.1397	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Schistosoma mansoni	tyrosine kinase	0.0146	0.1397	0.1392
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0444	0.5126	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0146	0.1397	0.2717
Echinococcus granulosus	activated cdc42 kinase 1	0.0146	0.1397	0.1397
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0146	0.1397	0.1392
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.137	0.2665
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0444	0.5126	0.5126
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.1397	0.2642
Onchocerca volvulus		0.0444	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0298	0.3294	0.329
Loa Loa (eye worm)	SRC-1	0.0444	0.5126	1
Brugia malayi	hypothetical protein	0.0444	0.5126	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2712	0.5286
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.1397	0.2642
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0017	0.0011
Onchocerca volvulus		0.0298	0.3294	0.6422
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.5126	1
Trypanosoma brucei	protein kinase, putative	0.0146	0.1397	1
Entamoeba histolytica	hypothetical protein	0.0153	0.1487	0.2819
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0444	0.5126	0.5123
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Toxoplasma gondii	STE kinase	0.0146	0.1397	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0099	0.0181
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.1397	0.2717
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0153	0.1487	0.2819
Schistosoma mansoni	tensin	0.0298	0.3294	0.329
Onchocerca volvulus		0.0444	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.1397	0.2642
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0099	0.0093
Echinococcus granulosus	SH2 motif	0.0298	0.3294	0.3294
Trypanosoma cruzi	protein kinase, putative	0.0146	0.1397	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0298	0.3294	0.329
Echinococcus multilocularis	NCK adaptor protein	0.0298	0.3294	0.329
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0444	0.5126	0.5123
Schistosoma mansoni	protein kinase	0.0146	0.1397	0.1392
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.011	0.0383
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.137	0.2665
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0298	0.3294	0.329
Toxoplasma gondii	ABC1 family protein	0.0043	0.011	0.0745
Onchocerca volvulus		0.0146	0.1397	0.2717
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.1397	0.4335
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1397	0.2717

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.35 uM	DNDI	DNDI.	No reference
IC50	> 41.67 uM	DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells.	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	30.1313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1526692
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 835368