Detailed information for compound 839487

Basic information

Technical information
  • TDR Targets ID: 839487
  • Name: CBMicro_021070
  • MW: 355.389 | Formula: C22H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 5.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1cc(Nc2ccccc2)c2c3c1noc3c1c(C2=O)cccc1
  • InChi: 1S/C22H17N3O2/c1-2-23-17-12-16(24-13-8-4-3-5-9-13)18-19-20(17)25-27-22(19)15-11-7-6-10-14(15)21(18)26/h3-12,23-24H,2H2,1H3
  • InChiKey: COGWHXZSZMLINQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • BIM-0021070.P001
  • Oprea1_394358
  • ZINC01215794
  • EU-0066890
  • ChemDiv1_019055

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1062 0.1395
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1062 0.3501
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0299 0.0875
Loa Loa (eye worm) transcription factor SMAD2 0.0472 0.4884 0.4881
Echinococcus granulosus dnaJ subfamily B 0.0419 0.4313 0.5679
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0229 0.029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0376 0.0484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0376 0.0372
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0299 0.0389
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1401 0.1487
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0209 0.0263
Schistosoma mansoni Smad4 0.0032 0.0199 0.025
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0264 0.0342
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.1062 0.1405
Entamoeba histolytica hypothetical protein 0.0035 0.0229 0.7624
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0204
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.1062 0.3398
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0299 0.5
Brugia malayi MH2 domain containing protein 0.0014 0.001 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0169 0.0211
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1062 0.1389
Brugia malayi glutaminase DH11.1 0.0298 0.3026 0.3985
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0264 0.0336
Schistosoma mansoni tyrosine kinase 0.0093 0.085 0.111
Onchocerca volvulus 0.0033 0.0209 0.0785
Brugia malayi hypothetical protein 0.0076 0.0666 0.0873
Schistosoma mansoni alpha-glucosidase 0.0145 0.1398 0.1833
Echinococcus granulosus Smad4 0.0032 0.0199 0.025
Echinococcus multilocularis epidermal growth factor receptor 0.0093 0.085 0.0899
Onchocerca volvulus 0.0097 0.0892 0.3417
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0199 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0533 0.0691
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1648 0.1751
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0254 0.846
Trichomonas vaginalis set domain proteins, putative 0.0258 0.2604 0.8603
Trichomonas vaginalis esterase, putative 0.0113 0.1062 0.3501
Loa Loa (eye worm) hypothetical protein 0.0076 0.0666 0.0662
Loa Loa (eye worm) hypothetical protein 0.0105 0.0979 0.0975
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0018 0.0052 0.0068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0299 0.031
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0666 0.0873
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0109 0.0346
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0726 0.7587 1
Schistosoma mansoni hypothetical protein 0.0419 0.4313 0.5679
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0264 0.0075
Leishmania major 0.0726 0.7587 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.1398 0.1833
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.1062 0.1125
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0264 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1401 0.1836
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0299 0.1063
Echinococcus multilocularis tumor protein p63 0.0328 0.3352 0.3573
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0666 0.0873
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1401 0.1397
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Schistosoma mansoni ap endonuclease 0.0042 0.0299 0.0382
Brugia malayi hypothetical protein 0.0049 0.0379 0.0494
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0254 0.846
Trichomonas vaginalis glutaminase, putative 0.0298 0.3026 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0526 0.0682
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0018 0.0052 0.0068
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0109 0.0346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.1499 0.1495
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1401 0.1841
Entamoeba histolytica hypothetical protein 0.0035 0.0229 0.7624
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1062 0.1389
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1401 0.1836
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0299 0.0976
Loa Loa (eye worm) hypothetical protein 0.0154 0.1499 0.1495
Echinococcus granulosus epidermal growth factor receptor 0.0174 0.1706 0.2239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0299 0.0389
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0498 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0526 0.0682
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0437 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.0329
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0169 0.0165
Echinococcus granulosus tumor protein p63 0.0328 0.3352 0.4411
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.1062 0.1395
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0526 0.0522
Brugia malayi MH1 domain containing protein 0.0018 0.0046 0.0055
Brugia malayi MH1 domain containing protein 0.0032 0.0199 0.0256
Loa Loa (eye worm) hypothetical protein 0.0048 0.0368 0.0364
Echinococcus multilocularis lamin dm0 0.0055 0.0437 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0526 0.0682
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1648 0.2162
Schistosoma mansoni lamin 0.0055 0.0437 0.0564
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0018 0.0052 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0526 0.0682
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.027 0.2731 0.3596
Echinococcus multilocularis epidermal growth factor receptor 0.0174 0.1706 0.1814
Brugia malayi fructose-1,6-bisphosphatase 0.0726 0.7587 1
Brugia malayi MH1 domain containing protein 0.0032 0.0199 0.0256
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0299 0.0295
Mycobacterium leprae conserved hypothetical protein 0.0113 0.1062 1
Mycobacterium ulcerans hypothetical protein 0.0113 0.1062 0.3398
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0254 0.0826
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0254 0.0323
Schistosoma mansoni hypothetical protein 0.0369 0.3781 0.4978
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.027 0.2731 0.3419
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0264 0.0342
Echinococcus multilocularis cpg binding protein 0.0031 0.0187 0.019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.1062 0.3398
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.1062 0.1405
Onchocerca volvulus 0.0113 0.1062 0.4069
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0979 0.1286
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0137 0.0168
Onchocerca volvulus 0.0048 0.0368 0.1399
Onchocerca volvulus 0.0165 0.1608 0.6171
Schistosoma mansoni tyrosine kinase 0.0092 0.084 0.1096
Echinococcus granulosus cpg binding protein 0.0031 0.0187 0.0234
Brugia malayi TAR-binding protein 0.0063 0.0526 0.0688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.1062 0.1405
Mycobacterium ulcerans beta-lactamase 0.0113 0.1062 0.3398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0209 0.0263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0376 0.0392
Echinococcus granulosus GPCR family 2 0.0049 0.0376 0.0484
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0209 0.0213
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0498 0.0523
Loa Loa (eye worm) MH2 domain-containing protein 0.0472 0.4884 0.4881
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0299 0.0389
Mycobacterium tuberculosis Conserved protein 0.0113 0.1062 0.1405
Loa Loa (eye worm) hypothetical protein 0.0054 0.0426 0.0422
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0209 0.0263
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.022 0.0225
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0056 0.0448 0.0468
Schistosoma mansoni lamin 0.0055 0.0437 0.0564
Schistosoma mansoni glutaminase 0.0298 0.3026 0.3981
Echinococcus multilocularis geminin 0.0369 0.3781 0.4032
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0299 0.0389
Loa Loa (eye worm) hypothetical protein 0.0049 0.0376 0.0372
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.1062 0.1405
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0264 0.0651
Schistosoma mansoni smad1 5 8 and 0.0032 0.0199 0.025
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0254 0.0826
Toxoplasma gondii fructose-bisphospatase I 0.027 0.2731 0.3419
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0299 0.0976
Schistosoma mansoni hypothetical protein 0.0105 0.0979 0.128
Mycobacterium tuberculosis Conserved protein 0.0113 0.1062 0.1405
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0254 0.0826
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0376 0.049
Echinococcus granulosus lamin 0.0055 0.0437 0.0564
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0189 0.0237
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0109 0.0346
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0209 0.0213
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0299 0.0396
Leishmania major hypothetical protein, conserved 0.0076 0.0666 0.0873
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0109 0.2317
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0299 0.0833
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0109 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0209 0.0263
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0666 0.0621
Loa Loa (eye worm) RNA binding protein 0.0063 0.0526 0.0522
Echinococcus granulosus smad 0.0032 0.0199 0.025
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0254 0.0261
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0376 0.0392
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0254 0.0826
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0137 0.0136
Schistosoma mansoni hypothetical protein 0.0049 0.0376 0.0484
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0014 0.001 0.0019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0254 0.0826
Onchocerca volvulus 0.0258 0.2604 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0254 0.0329
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0498 0.0393
Brugia malayi hypothetical protein 0.0035 0.0229 0.0296
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0229 0.029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1648 0.2167
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0254 0.0826
Entamoeba histolytica hypothetical protein 0.0035 0.0229 0.7624
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0005
Brugia malayi Smad1 0.0032 0.0199 0.0256
Mycobacterium ulcerans lipase LipD 0.0113 0.1062 0.3398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0041
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0234
Brugia malayi Augmenter of liver regeneration 0.0038 0.0264 0.0342
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0167 0.0215
Loa Loa (eye worm) beta-lactamase 0.0113 0.1062 0.1058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0498 0.0651
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.4313 0.46
Schistosoma mansoni smad1 5 8 and 0.0032 0.0199 0.025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0254 0.0329
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0109 0.0346
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0018 0.0052 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1062 0.1395
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0299 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0199 0.025
Brugia malayi hypothetical protein 0.0165 0.1608 0.2115
Brugia malayi MH2 domain containing protein 0.0032 0.0199 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0462 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0209 0.0263
Schistosoma mansoni tyrosine kinase 0.0092 0.084 0.1096
Loa Loa (eye worm) nuclear factor I 0.0018 0.0046 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0437 0.0433
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0299 0.0389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.1499 0.1971
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.001 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0199 0.0202
Brugia malayi beta-lactamase family protein 0.0113 0.1062 0.1395
Onchocerca volvulus 0.0113 0.1062 0.4069
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0199 0.025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1648 0.1751
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0498 0.1502
Schistosoma mansoni tyrosine kinase 0.0056 0.0448 0.0578
Schistosoma mansoni tyrosine kinase 0.0056 0.0448 0.0578
Mycobacterium ulcerans glutaminase 0.0298 0.3026 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0109 0.0346
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0526 0.0522
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0122
Entamoeba histolytica hypothetical protein 0.0035 0.0229 0.7624
Schistosoma mansoni hypothetical protein 0.0035 0.0229 0.029
Leishmania major hypothetical protein, conserved 0.0038 0.0264 0.0342
Onchocerca volvulus 0.0055 0.0437 0.1664
Loa Loa (eye worm) hypothetical protein 0.0165 0.1608 0.1605
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0299 0.5
Loa Loa (eye worm) Smad1 0.0032 0.0199 0.0195
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0229 0.0235
Schistosoma mansoni alpha glucosidase 0.0037 0.0254 0.0323
Brugia malayi Protein kinase domain containing protein 0.0056 0.0448 0.0584
Echinococcus granulosus epidermal growth factor receptor 0.0093 0.085 0.111
Schistosoma mansoni ap endonuclease 0.0042 0.0299 0.0382
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.1062 0.1395
Trypanosoma brucei glucosidase, putative 0.0037 0.0254 0.0329
Onchocerca volvulus 0.0029 0.0169 0.0634
Echinococcus multilocularis Smad4 0.0032 0.0199 0.0202
Brugia malayi Pre-SET motif family protein 0.0227 0.2271 0.2989
Schistosoma mansoni tyrosine kinase 0.0092 0.084 0.1096
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Mycobacterium leprae Probable lipase LipE 0.0113 0.1062 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0018 0.0052 0.5
Brugia malayi Furin-like cysteine rich region family protein 0.0174 0.1706 0.2244
Brugia malayi beta-lactamase 0.0113 0.1062 0.1395
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0299 0.0382
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0018 0.0052 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0254 0.0826
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1401 0.1487
Loa Loa (eye worm) hypothetical protein 0.0953 1 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.027 0.2731 0.3596
Echinococcus multilocularis musashi 0.0055 0.0437 0.0457
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0726 0.7587 0.81
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0264 0.0272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1401 0.1836
Brugia malayi MH1 domain containing protein 0.0018 0.0046 0.0055
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0199 0.0202
Brugia malayi MH2 domain containing protein 0.0032 0.0199 0.0256
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0526 0.0682
Schistosoma mansoni tyrosine kinase 0.0174 0.1706 0.2239
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.027 0.2731 0.3596
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1648 0.1644
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0724 0.756 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.1062 0.1389
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0254 0.0826
Echinococcus granulosus lamin dm0 0.0055 0.0437 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0526 0.0682
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0264 0.0075
Echinococcus multilocularis insulin receptor 0.0056 0.0448 0.0468
Loa Loa (eye worm) glutaminase 2 0.0298 0.3026 0.3023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.2271 0.2267
Loa Loa (eye worm) hypothetical protein 0.0055 0.0437 0.0433
Plasmodium vivax hypothetical protein, conserved 0.0113 0.1062 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0056 0.0448 0.0578
Brugia malayi MH2 domain containing protein 0.0472 0.4884 0.6435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0137 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0498 0.1502
Schistosoma mansoni hypothetical protein 0.0369 0.3781 0.4978
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0122
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0109 0.0346
Loa Loa (eye worm) TK/EGFR protein kinase 0.0174 0.1706 0.1702
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1062 0.3501
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0376 0.0484
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0726 0.7587 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0498 0.0645
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0726 0.7587 0.7586
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0018 0.0052 0.0068
Schistosoma mansoni hypothetical protein 0.0049 0.0376 0.0484
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0199 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1062 0.3501
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0167 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.1499 0.1971
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1062 0.3501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1401 0.1836
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Schistosoma mansoni smad 0.0032 0.0199 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0254 0.0826
Schistosoma mansoni smad1 5 8 and 0.0032 0.0199 0.025
Echinococcus multilocularis lamin 0.0055 0.0437 0.0457
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0018 0.0052 0.0068
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0368 0.0473
Schistosoma mansoni tyrosine kinase 0.0093 0.085 0.111
Echinococcus granulosus intermediate filament protein 0.0055 0.0437 0.0564
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0726 0.7587 1
Brugia malayi intermediate filament protein 0.0055 0.0437 0.057
Leishmania major hypothetical protein, conserved 0.0113 0.1062 0.1395
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0234
Toxoplasma gondii ABC1 family protein 0.0113 0.1062 0.1157
Brugia malayi mothers against decapentaplegic homolog 3 0.0014 0.001 0.0007
Brugia malayi CXXC zinc finger family protein 0.0029 0.0169 0.0217
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0666 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0299 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1401 0.1836
Schistosoma mansoni hypothetical protein 0.0049 0.0376 0.0484
Toxoplasma gondii exonuclease III APE 0.0042 0.0299 0.0123
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0254 0.025
Echinococcus granulosus geminin 0.0369 0.3781 0.4978
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0498 0.0645
Onchocerca volvulus 0.0055 0.0437 0.1664
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0437 0.057
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.022 0.0277
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0093 0.085 0.111
Brugia malayi RNA binding protein 0.0063 0.0526 0.0688
Brugia malayi beta-lactamase family protein 0.0113 0.1062 0.1395
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0264 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0498 0.1502
Echinococcus multilocularis 0.0054 0.0429 0.0448
Schistosoma mansoni hypothetical protein 0.0049 0.0376 0.0484
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.1062 0.1405
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.001 0.0005
Loa Loa (eye worm) glutaminase 0.0298 0.3026 0.3023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.1062 0.1058
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0666 0.5364
Echinococcus multilocularis GPCR, family 2 0.0049 0.0376 0.0392
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0526 0.0552
Loa Loa (eye worm) TK/INSR protein kinase 0.0056 0.0448 0.0443
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0264 0.0342
Echinococcus multilocularis smad 0.0032 0.0199 0.0202
Brugia malayi Pre-SET motif family protein 0.0033 0.0209 0.0269
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0726 0.7587 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0666 0.0873
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0254 0.0329
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0666 1
Schistosoma mansoni hypothetical protein 0.0034 0.022 0.0277
Echinococcus granulosus insulin receptor 0.0056 0.0448 0.0578
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0726 0.7587 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1062 0.3501
Toxoplasma gondii fructose-bisphospatase II 0.0726 0.7587 1
Onchocerca volvulus 0.0113 0.1062 0.4069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0893 0.9364 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0498 0.0659
Schistosoma mansoni intermediate filament proteins 0.0055 0.0437 0.0564
Mycobacterium tuberculosis Conserved protein 0.0113 0.1062 0.1405
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.1062 0.1405
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.1062 0.1405
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0199 0.025
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0526 0.0688
Loa Loa (eye worm) hypothetical protein 0.0113 0.1062 0.1058
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0376 0.049
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0254 0.0061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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