Detailed information for compound 843304

Basic information

Technical information
  • TDR Targets ID: 843304
  • Name: N-(2-chlorophenyl)-2-[[3-(3-ethoxypropyl)-4-o xo-[1]benzoxolo[3,2-d]pyrimidin-2-yl]sulfanyl ]acetamide
  • MW: 471.956 | Formula: C23H22ClN3O4S
  • H donors: 1 H acceptors: 2 LogP: 4.66 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCCn1c(SCC(=O)Nc2ccccc2Cl)nc2c(c1=O)oc1c2cccc1
  • InChi: 1S/C23H22ClN3O4S/c1-2-30-13-7-12-27-22(29)21-20(15-8-3-6-11-18(15)31-21)26-23(27)32-14-19(28)25-17-10-5-4-9-16(17)24/h3-6,8-11H,2,7,12-14H2,1H3,(H,25,28)
  • InChiKey: IBKMHVRMCTUITG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chlorophenyl)-2-[3-(3-ethoxypropyl)-4-oxo-benzofurano[3,2-d]pyrimidin-2-yl]sulfanyl-acetamide
  • N-(2-chlorophenyl)-2-[[3-(3-ethoxypropyl)-4-oxo-2-benzofurano[3,2-d]pyrimidinyl]thio]acetamide
  • N-(2-chlorophenyl)-2-[[3-(3-ethoxypropyl)-4-keto-benzofurano[3,2-d]pyrimidin-2-yl]thio]acetamide
  • N-(2-chlorophenyl)-2-[[3-(3-ethoxypropyl)-4-oxo-[1]benzoxolo[3,2-d]pyrimidin-2-yl]sulfanyl]ethanamide
  • NCGC00112780-01
  • C764-0567

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0102 0.0097 0.0097
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0097 0.0097
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0773 0.4418 0.4418
Echinococcus granulosus heat shock protein 90 0.0169 0.0529 0.0529
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0153 0.0424 0.0424
Toxoplasma gondii histone deacetylase HDAC2 0.1639 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0722 0.4091 0.4091
Leishmania major regulatory subunit of protein kinase a-like protein 0.0102 0.0097 0.0097
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0169 0.0529 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0169 0.0529 0.0529
Plasmodium falciparum endoplasmin, putative 0.013 0.0279 0.0279
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0102 0.0097 0.0097
Echinococcus multilocularis histone deacetylase 1 0.1639 1 1
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0102 0.0097 0.0097
Echinococcus multilocularis histone deacetylase 8 0.0502 0.2671 0.2671
Brugia malayi Histone deacetylase family protein 0.0613 0.3386 0.3386
Trypanosoma cruzi histone deacetylase, putative 0.0502 0.2671 0.2671
Loa Loa (eye worm) histone deacetylase 3 0.1639 1 1
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0224 0.0224
Trypanosoma brucei histone deacetylase, putative 0.0613 0.3386 0.3386
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Echinococcus multilocularis voltage gated potassium channel 0.0224 0.0882 0.0882
Mycobacterium ulcerans heat shock protein 90 0.0169 0.0529 1
Echinococcus multilocularis histone deacetylase 0.0613 0.3386 0.3386
Trypanosoma brucei protein kinase A regulatory subunit 0.0102 0.0097 0.0097
Trichomonas vaginalis heat shock protein, putative 0.0169 0.0529 0.0529
Schistosoma mansoni endoplasmin 0.0212 0.0808 0.0808
Leishmania major histone deacetylase, putative 0.1639 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0613 0.3386 0.3386
Echinococcus granulosus endoplasmin 0.0169 0.0529 0.0529
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1639 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0153 0.0424 0.0424
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0102 0.0097 0.0097
Entamoeba histolytica heat shock protein 90, putative 0.0212 0.0808 0.0808
Trichomonas vaginalis heat shock protein, putative 0.0169 0.0529 0.0529
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0102 0.0097 0.0097
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0153 0.0424 0.0424
Schistosoma mansoni histone deacetylase hda2 0.0502 0.2671 0.2671
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0153 0.0424 0.0424
Giardia lamblia Heat shock protein HSP 90-alpha 0.0212 0.0808 0.0719
Toxoplasma gondii heat shock protein HSP90 0.0212 0.0808 0.0808
Echinococcus granulosus histone deacetylase 0.0613 0.3386 0.3386
Schistosoma mansoni voltage-gated potassium channel 0.0844 0.4876 0.4876
Trypanosoma cruzi heat shock protein 90, putative 0.0169 0.0529 0.0529
Schistosoma mansoni voltage-gated potassium channel 0.0153 0.0424 0.0424
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0102 0.0097 0.0097
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Schistosoma mansoni histone deacetylase 1 2 3 0.0502 0.2671 0.2671
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0153 0.0424 0.0424
Loa Loa (eye worm) AGC/PKG protein kinase 0.0102 0.0097 0.0097
Echinococcus granulosus histone deacetylase 6 0.0619 0.3426 0.3426
Echinococcus multilocularis heat shock protein 90 0.0212 0.0808 0.0808
Leishmania major hypothetical protein, conserved 0.0102 0.0097 0.0097
Schistosoma mansoni histone deacetylase 0.1639 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0613 0.3386 0.3386
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0102 0.0097 0.0097
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0102 0.0097 0.0097
Toxoplasma gondii histone deacetylase HDAC5 0.0502 0.2671 0.2671
Echinococcus granulosus histone deacetylase 1 0.1639 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0102 0.0097 0.0097
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0773 0.4418 0.4418
Plasmodium vivax histone deacetylase, putative 0.0613 0.3386 0.3386
Toxoplasma gondii histone deacetylase HDAC4 0.0502 0.2671 0.2671
Echinococcus multilocularis hyperpolarization activated cyclic 0.0153 0.0424 0.0424
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0102 0.0097 0.0097
Echinococcus granulosus histone deacetylase 8 0.0502 0.2671 0.2671
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1639 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0102 0.0097 0.0097
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0102 0.0097 0.0097
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0102 0.0097 0.0097
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0102 0.0097 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0097 0.0097
Brugia malayi Egg laying defective protein 4 0.0102 0.0097 0.0097
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Leishmania major histone deacetylase, putative 0.0613 0.3386 0.3386
Brugia malayi heat shock protein 90 0.0212 0.0808 0.0808
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0097 0.0097
Echinococcus multilocularis histone deacetylase 6 0.0613 0.3386 0.3386
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0102 0.0097 0.0097
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0169 0.0529 0.0529
Echinococcus granulosus histone deacetylase 6 0.0613 0.3386 0.3386
Brugia malayi N-terminal motif family protein 0.0102 0.0097 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0424 0.0424
Trypanosoma cruzi heat shock protein 85, putative 0.0212 0.0808 0.0808
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0153 0.0424 0.0424
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0102 0.0097 0.0097
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0153 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0153 0.0424 0.0424
Trypanosoma cruzi heat shock protein 85, putative 0.0169 0.0529 0.0529
Schistosoma mansoni histone deacetylase 4 5 0.0613 0.3386 0.3386
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0102 0.0097 0.0097
Echinococcus granulosus hyperpolarization activated cyclic 0.0153 0.0424 0.0424
Trypanosoma cruzi cAMP response protein 1, putative 0.0102 0.0097 0.0097
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0773 0.4418 0.4418
Echinococcus granulosus patatin phospholipase domain containing protein 0.0102 0.0097 0.0097
Trypanosoma cruzi histone deacetylase 1, putative 0.1639 1 1
Plasmodium falciparum histone deacetylase 1 0.1639 1 1
Echinococcus granulosus heat shock protein 0.0212 0.0808 0.0808
Leishmania major protein kinase, putative 0.0102 0.0097 0.0097
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0102 0.0097 0.0097
Brugia malayi Endoplasmin precursor 0.0212 0.0808 0.0808
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0102 0.0097 0.0097
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0153 0.0424 0.0424
Giardia lamblia Grp94/Hsp90 0.0169 0.0529 0.0437
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0102 0.0097 0.0097
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0102 0.0097 0.0097
Loa Loa (eye worm) histone deacetylase 1 0.1639 1 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0102 0.0097 0.0097
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0153 0.0424 0.0424
Trypanosoma brucei Flagellar Member 6 0.0102 0.0097 0.0097
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0102 0.0097 0.0097
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0102 0.0097 0.0097
Echinococcus granulosus cGMP dependent protein kinase 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0169 0.0529 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0224 0.0882 0.0882
Leishmania major hypothetical protein, unknown function 0.0102 0.0097 0.0097
Loa Loa (eye worm) histone deacetylase 7A 0.0613 0.3386 0.3386
Schistosoma mansoni histone deacetylase hda2 0.0619 0.3426 0.3426
Leishmania major histone deacetylase, putative 0.1639 1 1
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trichomonas vaginalis endoplasmin, putative 0.013 0.0279 0.0279
Entamoeba histolytica histone deacetylase, putative 0.1639 1 1
Leishmania major histone deacetylase, putative 0.0613 0.3386 0.3386
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Treponema pallidum heat shock protein 90 0.0169 0.0529 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0224 0.0882 0.0882
Echinococcus multilocularis histone deacetylase 3 0.1639 1 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0102 0.0097 0.0097
Echinococcus multilocularis expressed conserved protein 0.0102 0.0097 0.0097
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Giardia lamblia Heat shock protein HSP 90-alpha 0.0169 0.0529 0.0437
Trypanosoma cruzi Heat shock protein 83, putative 0.0212 0.0808 0.0808
Loa Loa (eye worm) endoplasmin 0.0212 0.0808 0.0808
Loa Loa (eye worm) histone deacetylase 0.0613 0.3386 0.3386
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0102 0.0097 0.0097
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0102 0.0097 0.0097
Echinococcus multilocularis heat shock protein 0.0212 0.0808 0.0808
Trichomonas vaginalis heat shock protein, putative 0.0169 0.0529 0.0529
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Trypanosoma brucei heat shock protein 90, putative 0.0212 0.0808 0.0808
Plasmodium falciparum heat shock protein 90 0.0212 0.0808 0.0808
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0102 0.0097 0.0097
Echinococcus granulosus histone deacetylase 6 0.0613 0.3386 0.3386
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0102 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0117 0.0193 0.0193
Plasmodium falciparum cGMP-dependent protein kinase 0.0102 0.0097 0.0097
Trypanosoma brucei histone deacetylase 3 0.0613 0.3386 0.3386
Echinococcus granulosus cGMP dependent protein kinase 1 0.0102 0.0097 0.0097
Trypanosoma brucei histone deacetylase 2 0.0502 0.2671 0.2671
Onchocerca volvulus 0.0102 0.0097 0.0361
Echinococcus multilocularis histone deacetylase 6 0.0619 0.3426 0.3426
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0102 0.0097 0.0097
Echinococcus multilocularis hyperpolarization activated cyclic 0.0153 0.0424 0.0424
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0722 0.4091 0.4091
Leishmania major protein kinase A regulatory subunit, putative 0.0102 0.0097 0.0097
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0102 0.0097 0.0361
Trypanosoma cruzi protein kinase A regulatory subunit 0.0102 0.0097 0.0097
Trypanosoma cruzi histone deacetylase, putative 0.0613 0.3386 0.3386
Schistosoma mansoni voltage-gated potassium channel 0.0844 0.4876 0.4876
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0224 0.0882 0.0882
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0102 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.1639 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0502 0.2671 0.2671
Trypanosoma cruzi cAMP response protein 1 0.0102 0.0097 0.0097
Onchocerca volvulus 0.0102 0.0097 0.0361
Leishmania major hypothetical protein, conserved 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trypanosoma cruzi cAMP binding protein, putative 0.0102 0.0097 0.0097
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0102 0.0097 0.0097
Plasmodium vivax endoplasmin, putative 0.0212 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0102 0.0097 0.0097
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0102 0.0097 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0102 0.0097 0.0097
Echinococcus multilocularis heat shock protein 90 0.0169 0.0529 0.0529
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0153 0.0424 0.0424
Schistosoma mansoni 60S ribosomal protein L21 0.0122 0.0224 0.0224
Trypanosoma cruzi Flagellar Member 6 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0671 0.3761 0.3761
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trypanosoma cruzi heat shock protein 90, putative 0.0125 0.0247 0.0247
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0153 0.0424 0.0424
Trypanosoma brucei histone deacetylase 1 0.1639 1 1
Brugia malayi histone deacetylase 1 (HD1) 0.1639 1 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0102 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0502 0.2671 0.2671
Brugia malayi Histone deacetylase 1 0.1639 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0153 0.0424 0.0424
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1639 1 1
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0102 0.0097 0.0097
Echinococcus granulosus histone deacetylase 7 0.0613 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0111 0.0154 0.0154
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0153 0.0424 0.0424
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0224 0.0882 0.0882
Leishmania major protein kinase, putative 0.0102 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Toxoplasma gondii histone deacetylase HDAC1 0.0613 0.3386 0.3386
Echinococcus granulosus voltage gated potassium channel 0.0224 0.0882 0.0882
Schistosoma mansoni heat shock protein 0.0212 0.0808 0.0808
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0102 0.0097 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0773 0.4418 0.4418
Brugia malayi histone deacetylase 11 0.0502 0.2671 0.2671
Plasmodium vivax histone deacetylase 2, putative 0.0613 0.3386 0.3386
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0102 0.0097 0.5
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Trichomonas vaginalis heat shock protein, putative 0.013 0.0279 0.0279
Plasmodium vivax histone deacetylase 1, putative 0.1639 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0212 0.0808 0.0808
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0613 0.3386 0.3386
Plasmodium falciparum histone deacetylase 2 0.0613 0.3386 0.3386
Echinococcus granulosus heat shock protein 90 0.0212 0.0808 0.0808
Toxoplasma gondii histone deacetylase HDAC3 0.1639 1 1
Echinococcus multilocularis endoplasmin 0.0169 0.0529 0.0529
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0102 0.0097 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0424 0.0424
Brugia malayi Histone deacetylase family protein 0.0613 0.3386 0.3386
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0102 0.0097 0.0097
Trypanosoma brucei histone deacetylase 4 0.0613 0.3386 0.3386
Schistosoma mansoni heat shock protein 0.0212 0.0808 0.0808
Echinococcus multilocularis histone deacetylase 6 0.0613 0.3386 0.3386
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0102 0.0097 0.0097
Trypanosoma cruzi histone deacetylase 1, putative 0.1639 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0212 0.0808 0.0808
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0102 0.0097 0.0097
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0153 0.0424 0.0424
Schistosoma mansoni histone deacetylase 0.1639 1 1
Loa Loa (eye worm) heat shock protein 90 0.0212 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0224 0.0882 0.0882
Trypanosoma brucei Heat shock protein 83, putative 0.0212 0.0808 0.0808
Loa Loa (eye worm) histone deacetylase 11 0.0502 0.2671 0.2671
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0169 0.0529 1
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0102 0.0097 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0224 0.0882 0.0882
Trypanosoma brucei heat shock protein 90, putative 0.0212 0.0808 0.0808
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0153 0.0424 0.0424
Echinococcus granulosus cGMP dependent protein kinase 1 0.0102 0.0097 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0097 0.0097
Brugia malayi Cyclic-nucleotide gated cation channel 0.0153 0.0424 0.0424
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0102 0.0097 0.0097
Echinococcus multilocularis histone deacetylase 7 0.0613 0.3386 0.3386
Trypanosoma brucei heat shock protein, putative 0.0212 0.0808 0.0808
Plasmodium vivax heat shock protein 86, putative 0.0212 0.0808 0.0808
Leishmania major heat shock protein 83-1 0.0212 0.0808 0.0808
Trypanosoma brucei cAMP response protein 1, putative 0.0102 0.0097 0.0097
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0102 0.0097 0.0097
Trypanosoma brucei cAMP binding protein, putative 0.0102 0.0097 0.0097
Leishmania major cyclic nucleotide-binding protein-like protein 0.0102 0.0097 0.0097
Leishmania major hypothetical protein, conserved 0.0102 0.0097 0.0097
Trypanosoma cruzi heat shock protein 85, putative 0.0212 0.0808 0.0808
Toxoplasma gondii heat shock protein 90, putative 0.0212 0.0808 0.0808
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0102 0.0097 0.0097
Plasmodium falciparum histone deacetylase, putative 0.0613 0.3386 0.3386
Plasmodium vivax histone deacetylase, putative 0.0502 0.2671 0.2671
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0212 0.0808 0.0808
Trichomonas vaginalis histone deacetylase, putative 0.1639 1 1
Echinococcus granulosus histone deacetylase 3 0.1639 1 1
Schistosoma mansoni endoplasmin 0.0212 0.0808 0.0808
Trichomonas vaginalis heat shock protein, putative 0.0212 0.0808 0.0808
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0102 0.0097 0.0097
Giardia lamblia Histone deacetylase 0.1639 1 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0502 0.2671 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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