Detailed information for compound 843967

Basic information

Technical information
  • TDR Targets ID: 843967
  • Name: methyl 2-[(2-pyrrol-1-yl-4,5,6,7-tetrahydro-1 -benzothiophen-3-yl)methylcarbamoylamino]benz oate
  • MW: 409.501 | Formula: C22H23N3O3S
  • H donors: 2 H acceptors: 2 LogP: 4.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1NC(=O)NCc1c(sc2c1CCCC2)n1cccc1
  • InChi: 1S/C22H23N3O3S/c1-28-21(26)16-9-2-4-10-18(16)24-22(27)23-14-17-15-8-3-5-11-19(15)29-20(17)25-12-6-7-13-25/h2,4,6-7,9-10,12-13H,3,5,8,11,14H2,1H3,(H2,23,24,27)
  • InChiKey: UOFUWSQMMZCJCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[(2-pyrrol-1-yl-4,5,6,7-tetrahydrobenzothiophen-3-yl)methylcarbamoylamino]benzoate
  • 2-[[oxo-[[2-(1-pyrrolyl)-4,5,6,7-tetrahydrobenzothiophen-3-yl]methylamino]methyl]amino]benzoic acid methyl ester
  • 2-[(2-pyrrol-1-yl-4,5,6,7-tetrahydrobenzothiophen-3-yl)methylcarbamoylamino]benzoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni atypical protein kinase C 0.0011 0.0163 0.0171
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0984 0.1028
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.009 0.3108 0.3066
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0169 0.0534
Loa Loa (eye worm) hypothetical protein 0.0098 0.3414 0.3568
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0529 0.1673
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.3406 0.3559
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0456 0.1442
Leishmania major DNA polymerase eta, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) AGC/NDR protein kinase 0.0011 0.0163 0.0171
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0509 0.1612
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0095 0.01
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0008 0.0061 0.0193
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0095 0.01
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0456 0.1442
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Giardia lamblia Kinase, AGC PKA 0.0021 0.0529 0.1398
Schistosoma mansoni DNA polymerase eta 0.0019 0.0456 0.0476
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0055 0.0174
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0456 0.0397
Echinococcus granulosus dna polymerase kappa 0.0019 0.0456 0.1442
Schistosoma mansoni dep domain containing protein 0.0009 0.0095 0.01
Treponema pallidum hypothetical protein 0.0276 1 1
Schistosoma mansoni 6-phosphogluconolactonase 0.0008 0.0061 0.0064
Echinococcus granulosus serine:threonine protein kinase N2 0.0011 0.0163 0.0517
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0276 1 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Schistosoma mansoni hypothetical protein 0.0031 0.0919 0.096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1404 0.4443
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.009 0.3108 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.6509 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.316 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Echinococcus granulosus protein kinase C gamma type 0.0011 0.0163 0.0517
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0604 0.0631
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0529 0.1673
Brugia malayi Smad1 0.0008 0.0055 0.0058
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0011 0.0163 0.0517
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.01
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.316 0.4855
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0668 0.1957
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0008 0.0061 0.0064
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0011 0.0163 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0919 0.2907
Giardia lamblia DINP protein human, muc B family 0.0019 0.0456 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1404 0.1467
Toxoplasma gondii AGC kinase 0.0031 0.0909 0.2459
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.316 1
Brugia malayi Hr1 repeat family protein 0.0011 0.0163 0.0171
Schistosoma mansoni kinase 0.0047 0.1494 0.1561
Brugia malayi MH1 domain containing protein 0.0008 0.0055 0.0058
Echinococcus multilocularis GPCR, family 2 0.0031 0.0919 0.2907
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1404 0.1467
Loa Loa (eye worm) AGC/PKN protein kinase 0.0011 0.0163 0.0171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0919 0.2907
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0095 0.01
Trypanosoma brucei polo-like protein kinase 0.0091 0.316 1
Trypanosoma brucei unspecified product 0.0013 0.0241 0.058
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.009 0.3108 0.9833
Schistosoma mansoni Smad4 0.0008 0.0055 0.0058
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0095 0.01
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1404 0.4443
Brugia malayi Protein kinase domain containing protein 0.0011 0.0163 0.0171
Brugia malayi MH2 domain containing protein 0.0008 0.0055 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.316 0.3302
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0008 0.0061 0.0193
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0604 0.191
Echinococcus granulosus 6 phosphogluconolactonase 0.0008 0.0061 0.0193
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0604 0.191
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0011 0.0163 0.0517
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0919 0.096
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0095 0.0302
Entamoeba histolytica protein kinase, putative 0.0033 0.0984 0.3114
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0919 0.2907
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0456 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Mycobacterium ulcerans glutaminase 0.0264 0.957 0.9567
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0008 0.0061 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0919 0.096
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.009 0.3108 0.3248
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.4046 0.4228
Echinococcus multilocularis serine:threonine protein kinase 38 0.0011 0.0163 0.0517
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0163 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0241 0.058
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0095 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0456 0.1273
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1449 0.1514
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Brugia malayi glucose-6-phosphate dehydrogenase 0.009 0.3108 0.3248
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0095 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1404 0.1467
Brugia malayi MH1 domain containing protein 0.0008 0.0055 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) glutaminase 2 0.0264 0.957 1
Echinococcus granulosus nervana 2 0.002 0.0509 0.1612
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0909 0.095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0456 0.1442
Brugia malayi glutaminase DH11.1 0.0264 0.957 1
Echinococcus granulosus NDR protein kinase 0.0011 0.0163 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Trypanosoma brucei unspecified product 0.0013 0.0241 0.058
Schistosoma mansoni dishevelled 0.0009 0.0095 0.01
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.3108 0.9833
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.001 0.0144 0.015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0456 0.0476
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0095 0.0302
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.1948 0.5596
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.3414 0.3568
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0169 0.0534
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0668 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0055 0.0058
Echinococcus granulosus protein kinase c epsilon type 0.0011 0.0163 0.0517
Schistosoma mansoni glutaminase 0.0264 0.957 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0456 0.0476
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.2259 0.2361
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0509 0.1612
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) glutaminase 0.0264 0.957 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0055 0.0058
Giardia lamblia Kinase, PLK 0.0091 0.316 0.9265
Schistosoma mansoni smad 0.0008 0.0055 0.0058
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.316 0.3302
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0031 0.0924 0.049
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0984 0.2978
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Schistosoma mansoni hypothetical protein 0.0031 0.0919 0.096
Schistosoma mansoni hypothetical protein 0.0067 0.2259 0.2361
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.009 0.3108 0.3248
Schistosoma mansoni 6-phosphogluconolactonase 0.0008 0.0061 0.0064
Brugia malayi hypothetical protein 0.0009 0.0095 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) hypothetical protein 0.0024 0.0668 0.0698
Echinococcus granulosus protein kinase c iota type 0.0011 0.0163 0.0517
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.4046 0.4228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0456 0.1442
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.1948 0.1899
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0529 0.1673
Echinococcus multilocularis Smad4 0.0008 0.0055 0.0174
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0095 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1404 0.4443
Entamoeba histolytica protein kinase, putative 0.0011 0.0163 0.0517
Schistosoma mansoni serine/threonine kinase 0.0011 0.0163 0.0171
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0456 0.0476
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0668 0.0146
Brugia malayi Protein kinase domain containing protein 0.0011 0.0163 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1404 0.4443
Echinococcus multilocularis smad 0.0008 0.0055 0.0174
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.084 0.2657
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0055 0.0174
Echinococcus multilocularis nervana 2 0.002 0.0509 0.1612
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0456 0.1442
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.009 0.3108 0.9836
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0095 0.0302
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0098 0.3406 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0984 0.1028
Echinococcus granulosus Protein kinase C brain isozyme 0.0011 0.0163 0.0517
Schistosoma mansoni smad1 5 8 and 0.0008 0.0055 0.0058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0456 0.0476
Echinococcus granulosus GPCR family 2 0.0031 0.0919 0.2907
Loa Loa (eye worm) hypothetical protein 0.0182 0.6509 0.6802
Loa Loa (eye worm) Smad1 0.0008 0.0055 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Onchocerca volvulus 0.0009 0.0095 0.0146
Leishmania major hypothetical protein, conserved 0.0024 0.0668 0.1957
Echinococcus multilocularis 6 phosphogluconolactonase 0.0008 0.0061 0.0193
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.316 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0456 0.1442
Leishmania major DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0456 0.1442
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0241 0.058
Loa Loa (eye worm) hypothetical protein 0.0067 0.2259 0.2361
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0241 0.058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0919 0.2907
Brugia malayi 6-phosphogluconolactonase family protein 0.0008 0.0061 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0604 0.191
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0276 1 1
Echinococcus granulosus nervana 2 0.002 0.0509 0.1612
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0095 0.0302
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0276 1 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0909 0.2878
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0098 0.3406 0.3559
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.316 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Brugia malayi MH2 domain containing protein 0.0008 0.0055 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.3414 0.3568
Schistosoma mansoni hypothetical protein 0.0031 0.0919 0.096
Echinococcus granulosus Smad4 0.0008 0.0055 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0668 0.2112
Brugia malayi hypothetical protein 0.0016 0.0347 0.0363
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0604 0.191
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0163 0.0171
Brugia malayi MH2 domain containing protein 0.0115 0.4046 0.4228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.3414 0.3568
Echinococcus multilocularis protein kinase c epsilon type 0.0011 0.0163 0.0517
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0163 0.0171
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0456 0.0476
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0008 0.0061 0.0193
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0011 0.0163 0.0517
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.316 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1404 0.1467
Schistosoma mansoni hypothetical protein 0.0031 0.0919 0.096
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0095 0.0302
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0055 0.0174
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0456 0.1442
Brugia malayi protein kinase C II. 0.0011 0.0163 0.0171
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.009 0.3108 0.9836
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0011 0.0163 0.0517
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0604 0.0631
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.3406 0.3559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0163 0.0171
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.3108 0.9836
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0163 0.0517
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0011 0.0163 0.0517
Schistosoma mansoni dishevelled 0.0009 0.0095 0.01
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0456 0.0476
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0456 0.0476
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0909 0.095
Echinococcus multilocularis protein kinase c iota type 0.0011 0.0163 0.0517
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0529 0.1673
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0098 0.3406 0.3038
Trypanosoma cruzi Protein kinase B 0.0023 0.0604 0.191
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0011 0.0163 0.0517
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0055 0.0174
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0095 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.316 0.3302
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0095 0.01
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.01
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0095 0.0146
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0011 0.0163 0.0171
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0095 0.0302
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0163 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0509 0.1612
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1404 0.1467
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0668 0.0146
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0011 0.0163 0.0171
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0872 0.2758
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0008 0.0061 0.0193
Echinococcus multilocularis serine threonine protein kinase 0.0011 0.0163 0.0517
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0095 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0008 0.0061 0.0193
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0055 0.0058
Schistosoma mansoni smad1 5 8 and 0.0008 0.0055 0.0058
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0276 1 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0919 0.096
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0456 0.0476
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0095 0.0302
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.316 1
Echinococcus multilocularis nervana 2 0.002 0.0509 0.1612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0456 0.1442
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1449 0.1514
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0011 0.0163 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0984 0.1028
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.316 0.3302
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0668 0.2112
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.009 0.3108 0.3066
Trichomonas vaginalis glutaminase, putative 0.0264 0.957 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0919 0.096
Brugia malayi DIX domain containing protein 0.0009 0.0095 0.01
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0098 0.3406 1
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0604 0.191
Echinococcus granulosus smad 0.0008 0.0055 0.0174
Trypanosoma brucei unspecified product 0.0019 0.0456 0.1273
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0095 0.0302
Schistosoma mansoni hypothetical protein 0.0011 0.0169 0.0176
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0098 0.3406 0.3038
Schistosoma mansoni smad1 5 8 and 0.0008 0.0055 0.0058
Echinococcus multilocularis dna polymerase eta 0.0019 0.0456 0.1442
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0668 0.1728
Entamoeba histolytica protein kinase, putative 0.0033 0.0984 0.3114
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0163 0.0171
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0529 0.1673
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0509 0.1612
Brugia malayi N-terminal motif family protein 0.0182 0.6509 0.6802
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273
Brugia malayi hypothetical protein 0.0024 0.0668 0.0698
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0008 0.0061 0.0064
Echinococcus granulosus dna polymerase eta 0.0019 0.0456 0.1442
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0456 0.1273
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0011 0.0163 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0238 0.0249
Brugia malayi hypothetical protein 0.0009 0.0095 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0456 0.1273

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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