Detailed information for compound 847118

Basic information

Technical information
  • TDR Targets ID: 847118
  • Name: N-(2,3-dimethylphenyl)-5-methyl-1-(3-methylsu lfanylphenyl)triazole-4-carboxamide
  • MW: 352.453 | Formula: C19H20N4OS
  • H donors: 1 H acceptors: 3 LogP: 4.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1cccc(c1)n1nnc(c1C)C(=O)Nc1cccc(c1C)C
  • InChi: 1S/C19H20N4OS/c1-12-7-5-10-17(13(12)2)20-19(24)18-14(3)23(22-21-18)15-8-6-9-16(11-15)25-4/h5-11H,1-4H3,(H,20,24)
  • InChiKey: GAGRPUQTDSJONN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dimethylphenyl)-5-methyl-1-[3-(methylthio)phenyl]-4-triazolecarboxamide
  • N-(2,3-dimethylphenyl)-5-methyl-1-[3-(methylthio)phenyl]triazole-4-carboxamide
  • N-(2,3-dimethylphenyl)-5-methyl-1-(3-methylsulfanylphenyl)-1,2,3-triazole-4-carboxamide
  • ZINC04316180

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutaminase DH11.1 0.0313 0.116 0.6288
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0071
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0017 0.0344
Echinococcus granulosus heat shock protein 90 0.003 0.0062 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0083 0.2767
Echinococcus multilocularis potassium channel subfamily K 8 0.0088 0.029 0.0287
Brugia malayi isocitrate dehydrogenase 0.0018 0.0018 0.0074
Echinococcus multilocularis Niemann Pick C1 protein 0.0093 0.0309 0.0305
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0017 0.0013
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Leishmania major ion transport protein-like protein 0.0088 0.029 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0018 0.0078
Entamoeba histolytica hypothetical protein 0.0034 0.008 0.248
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0071
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0909 0.3474 0.3471
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0071
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.014 0.4453
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0075 0.0071
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0036 0.031
Schistosoma mansoni microtubule-associated protein tau 0.2088 0.8043 0.8042
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0017 0.0013
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0017 0.0013
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.014 0.4453
Loa Loa (eye worm) hypothetical protein 0.2592 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0075 0.0071
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0103 0.0099
Echinococcus granulosus endoplasmin 0.003 0.0062 0.0058
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0088 0.029 1
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0088 0.029 1
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0092 0.3061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0031 0.0886
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0075 0.0071
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0018 0.0476
Loa Loa (eye worm) hypothetical protein 0.014 0.0491 0.0487
Echinococcus multilocularis GPCR, family 2 0.0033 0.0075 0.0071
Echinococcus multilocularis heat shock protein 90 0.0037 0.0092 0.0088
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0062 0.2037
Brugia malayi Niemann-Pick C1 protein precursor 0.0093 0.0309 0.1658
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0031 0.0942
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0103 0.0099
Echinococcus multilocularis geminin 0.0513 0.1935 0.1932
Plasmodium falciparum heat shock protein 90 0.0037 0.0092 0.3061
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0208 0.0204
Schistosoma mansoni heat shock protein 0.0037 0.0092 0.0088
Onchocerca volvulus 0.0088 0.029 0.1559
Onchocerca volvulus 0.0088 0.029 0.1559
Brugia malayi hypothetical protein 0.0489 0.1842 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.029 0.2505
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0445 0.1673 0.167
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0208 0.0204
Plasmodium vivax heat shock protein 90, putative 0.0015 0.0007 0.0093
Echinococcus granulosus tumor protein p63 0.0386 0.1446 0.1442
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0091 0.0754
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.014 0.4736
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.029 0.2505
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0091 0.3041
Echinococcus granulosus survival motor neuron protein 1 0.0445 0.1673 0.167
Echinococcus granulosus potassium channel subfamily K 8 0.0088 0.029 0.0287
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0015
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0017 0.0013
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0476
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Trypanosoma brucei calcium-activated potassium channel, putative 0.0088 0.029 1
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Brugia malayi jmjC domain containing protein 0.0067 0.0208 0.1112
Schistosoma mansoni patched 1 0.004 0.0103 0.0099
Schistosoma mansoni hypothetical protein 0.0513 0.1935 0.1932
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0088 0.029 0.1559
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0092 0.3061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0083 0.2767
Schistosoma mansoni hypothetical protein 0.0088 0.029 0.0287
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0062 0.2037
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0224 0.1195
Brugia malayi CXXC zinc finger family protein 0.006 0.0179 0.0953
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.005 0.014 0.0136
Plasmodium vivax potassium channel, putative 0.0088 0.029 1
Plasmodium vivax heat shock protein, putative 0.0015 0.0007 0.0093
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0071
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0036 0.031
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0088 0.029 0.1559
Echinococcus multilocularis cpg binding protein 0.0063 0.0192 0.0188
Mycobacterium ulcerans glutaminase 0.0313 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Brugia malayi heat shock protein 90 0.0037 0.0092 0.0477
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0007 0.0003
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0093
Brugia malayi MH2 domain containing protein 0.0137 0.0477 0.2573
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0093 0.0309 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0062 0.4301
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0351 0.1891
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0088 0.029 0.1559
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0092 0.234
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0017 0.0013
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0007 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0005 0.0001
Toxoplasma gondii exonuclease III APE 0.0022 0.0031 0.0706
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0017 0.0013
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0222 0.0218
Mycobacterium ulcerans heat shock protein 90 0.003 0.0062 0.0505
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0088 0.029 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.014 0.1174
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0092 0.3061
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0092 0.2295
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.0477 0.0473
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.014 0.4736
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0351 0.1891
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Echinococcus granulosus Protein patched homolog 1 0.004 0.0103 0.0099
Echinococcus multilocularis twik family of potassium channels 0.0088 0.029 0.0287
Toxoplasma gondii heat shock protein 75, putative 0.0015 0.0007 0.0069
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0088 0.029 0.9402
Echinococcus granulosus potassium channel subfamily K 0.0088 0.029 0.0287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0075 0.0388
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) endoplasmin 0.0037 0.0092 0.0088
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.003 0.0026
Brugia malayi Fli-1 protein 0.0206 0.0745 0.4033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0351 0.0348
Echinococcus multilocularis dnaJ subfamily B 0.085 0.3245 0.3243
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0075 0.0388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0087
Toxoplasma gondii Hsp90 domain-containing protein 0.0015 0.0007 0.0069
Loa Loa (eye worm) TWK-7 protein 0.0088 0.029 0.0287
Brugia malayi hypothetical protein 0.0445 0.1673 0.9081
Schistosoma mansoni calcium-activated potassium channel 0.0088 0.029 0.0287
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0088 0.029 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.014 0.4736
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0092 0.3061
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni ets-related 0.0206 0.0745 0.0742
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0092 0.2878
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0018 0.0074
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0093
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0088 0.029 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0007 0.0093
Echinococcus granulosus expressed conserved protein 0.0087 0.0287 0.0283
Brugia malayi Ets-domain containing protein 0.0068 0.021 0.1123
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0088 0.029 0.1559
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.014 0.1174
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0017 0.0013
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0088 0.029 0.0287
Trypanosoma brucei heat shock protein 84, putative 0.0015 0.0007 0.0093
Plasmodium vivax JmjC domain containing protein 0.0018 0.0017 0.0459
Echinococcus granulosus potassium channel subfamily K 8 0.0088 0.029 0.0287
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.0134
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0075 0.0071
Leishmania major hypothetical protein, conserved 0.0018 0.0017 0.0459
Trypanosoma cruzi ion transport protein, putative 0.0088 0.029 1
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0092 0.2295
Brugia malayi hypothetical protein 0.0088 0.029 0.1559
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0088 0.029 0.1559
Brugia malayi AMP-binding enzyme family protein 0.005 0.014 0.0738
Giardia lamblia Grp94/Hsp90 0.003 0.0062 0.1209
Mycobacterium ulcerans hypothetical protein 0.005 0.014 0.1174
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0091 0.3041
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0357
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0208 0.0204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0083 0.2767
Loa Loa (eye worm) hypothetical protein 0.005 0.014 0.0136
Echinococcus granulosus dnaJ subfamily B 0.085 0.3245 0.3243
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0092 0.3061
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0018 0.0014
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0017 0.0459
Loa Loa (eye worm) glutaminase 2 0.0313 0.116 0.1156
Echinococcus multilocularis endoplasmin 0.003 0.0062 0.0058
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0088 0.029 0.1559
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.029 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0018 0.0476
Brugia malayi Hsp90 protein 0.0015 0.0007 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.014 0.1174
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0005 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0222 0.0218
Entamoeba histolytica hypothetical protein 0.0034 0.008 0.248
Toxoplasma gondii ion channel protein 0.0088 0.029 0.7495
Echinococcus multilocularis potassium channel subfamily K 0.0088 0.029 0.0287
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0103 0.0884
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0018 0.0476
Echinococcus multilocularis microtubule associated protein 2 0.2088 0.8043 0.8042
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0476
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0071 0.0224 0.022
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Leishmania major hypothetical protein, conserved 0.0088 0.029 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0017 0.0459
Brugia malayi hypothetical protein 0.0034 0.008 0.0411
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0017 0.0459
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Leishmania major potassium channel subunit-like protein 0.0088 0.029 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0088 0.029 0.1559
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0031 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0092 0.3061
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0088 0.029 0.1559
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0017 0.0459
Loa Loa (eye worm) glutaminase 0.0313 0.116 0.1156
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0062 0.2037
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0088 0.029 0.1559
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0031 0.0027
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Echinococcus multilocularis heat shock protein 90 0.003 0.0062 0.0058
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0027
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0027
Echinococcus granulosus heat shock protein 90 0.0037 0.0092 0.0088
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus granulosus Niemann Pick C1 protein 0.0093 0.0309 0.0305
Onchocerca volvulus 0.0091 0.0299 0.1608
Onchocerca volvulus 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0099
Onchocerca volvulus 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0087
Loa Loa (eye worm) hypothetical protein 0.0445 0.1673 0.167
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Brugia malayi AMP-binding enzyme family protein 0.005 0.014 0.0738
Echinococcus multilocularis protein patched 0.004 0.0103 0.0099
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0088 0.029 0.0287
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0942
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0088 0.029 0.0287
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0031 0.0027
Brugia malayi AMP-binding enzyme family protein 0.005 0.014 0.0738
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0092 0.2878
Echinococcus multilocularis GA binding protein alpha chain 0.0068 0.021 0.0206
Echinococcus multilocularis small conductance calcium activated potassium 0.2592 1 1
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0088 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0172 0.0168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0439 0.0435
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0942
Echinococcus granulosus phd:f box containing protein 0.0018 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Schistosoma mansoni hypothetical protein 0.0071 0.0224 0.022
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.003 0.0026
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0088 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus granulosus twik family of potassium channels 0.0088 0.029 0.0287
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0071
Echinococcus multilocularis Niemann Pick C1 protein 0.0133 0.0464 0.046
Trichomonas vaginalis heat shock protein, putative 0.003 0.0062 0.0537
Onchocerca volvulus 0.006 0.0179 0.0953
Plasmodium vivax potassium channel, putative 0.0088 0.029 1
Entamoeba histolytica hypothetical protein 0.0034 0.008 0.248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0167 0.0163
Onchocerca volvulus Huntingtin homolog 0.014 0.0491 0.2649
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1694 0.6518 0.6516
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0092 0.079
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0476
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0087
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Echinococcus multilocularis tumor protein p63 0.0386 0.1446 0.1442
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0015 0.0007 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0179 0.0175
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0071
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.014 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0222 0.0218
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0091 0.5
Schistosoma mansoni endoplasmin 0.0037 0.0092 0.0088
Echinococcus multilocularis potassium channel subfamily K 8 0.0088 0.029 0.0287
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0222 0.0218
Leishmania major heat shock protein, putative 0.0015 0.0007 0.0093
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.014 0.0491 0.0487
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.014 0.1174
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0088 0.029 0.1559
Echinococcus multilocularis heat shock protein 0.0037 0.0092 0.0088
Mycobacterium ulcerans ion transport protein 0.0088 0.029 0.2479
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.014 0.1174
Echinococcus granulosus cpg binding protein 0.0063 0.0192 0.0188
Entamoeba histolytica hypothetical protein 0.0034 0.008 0.248
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.014 0.1174
Schistosoma mansoni cpg binding protein 0.0063 0.0192 0.0188
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0019 0.0015
Plasmodium falciparum potassium channel 0.0088 0.029 1
Echinococcus multilocularis protein dispatched 1 0.0046 0.0124 0.0121
Trypanosoma cruzi heat shock protein, putative 0.0015 0.0007 0.0093
Trichomonas vaginalis heat shock protein, putative 0.003 0.0062 0.0537
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0088 0.029 0.1559
Schistosoma mansoni hypothetical protein 0.0091 0.0299 0.0296
Onchocerca volvulus 0.0489 0.1842 1
Onchocerca volvulus 0.005 0.014 0.0738
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0088 0.029 0.1559
Toxoplasma gondii ion channel protein 0.0088 0.029 0.7495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0005 0.0001
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0062 0.0058
Plasmodium falciparum potassium channel 0.0088 0.029 1
Onchocerca volvulus 0.0088 0.029 0.1559
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0005 0.0001
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0007 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.014 0.4736
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0017 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0087
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0088 0.029 1
Schistosoma mansoni cpg binding protein 0.0063 0.0192 0.0188
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.014 1
Onchocerca volvulus Huntingtin homolog 0.014 0.0491 0.2649
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0091 0.3041
Plasmodium falciparum endoplasmin, putative 0.0023 0.0036 0.1117
Treponema pallidum heat shock protein 90 0.003 0.0062 1
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0033 0.1
Loa Loa (eye worm) TWK-28 protein 0.0088 0.029 0.0287
Brugia malayi hypothetical protein 0.014 0.0491 0.2649
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0005 0.0001
Echinococcus multilocularis twik family of potassium channels 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0489 0.1842 0.1839
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.008 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0018 0.0476
Trypanosoma cruzi ion transport protein, putative 0.0088 0.029 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0018 0.0014
Brugia malayi Ets-domain containing protein 0.0068 0.021 0.1123
Echinococcus granulosus calcium activated potassium channel variant 0.0088 0.029 0.0287
Schistosoma mansoni calcium-activated potassium channel 0.1644 0.6321 0.632
Schistosoma mansoni hypothetical protein 0.0513 0.1935 0.1932
Mycobacterium ulcerans transmembrane cation transporter 0.0088 0.029 0.2479
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0267
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0088 0.029 0.0287
Brugia malayi hypothetical protein 0.0088 0.029 0.1559
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.0942
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0018 0.0014
Onchocerca volvulus 0.0088 0.029 0.1559
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.014 0.4736
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0017 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0092 0.3061
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0071
Echinococcus granulosus microtubule associated protein 2 0.2088 0.8043 0.8042
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.014 0.1174
Schistosoma mansoni hypothetical protein 0.085 0.3245 0.3243
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0088 0.029 0.1559
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0167 0.0163
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0071
Leishmania major calcium/potassium channel (CAKC), putative 0.0088 0.029 1
Schistosoma mansoni endoplasmin 0.0037 0.0092 0.0088
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0092 0.0088
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0357
Brugia malayi Endoplasmin precursor 0.0037 0.0092 0.0477
Schistosoma mansoni calcium-activated potassium channel 0.0088 0.029 0.0287
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0103 0.0099
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0092 0.3061
Schistosoma mansoni calcium-activated potassium channel 0.2592 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0351 0.0348
Trichomonas vaginalis heat shock protein, putative 0.003 0.0062 0.0537
Echinococcus multilocularis expressed conserved protein 0.0087 0.0287 0.0283
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0017 0.0344
Schistosoma mansoni gabp alpha 0.0068 0.021 0.0206
Schistosoma mansoni twik family of potassium channels-related 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0062 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0075 0.0071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0091 0.0299 0.1608
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Leishmania major hypothetical protein, conserved 0.0088 0.029 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0095 0.0314 0.031
Loa Loa (eye worm) hypothetical protein 0.0093 0.0309 0.0305
Brugia malayi jmjC domain containing protein 0.0071 0.0222 0.1184
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0062 0.1209
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0092 0.3061
Echinococcus granulosus geminin 0.0513 0.1935 0.1932
Onchocerca volvulus 0.0088 0.029 0.1559
Echinococcus multilocularis calcium activated potassium channel variant 0.0088 0.029 0.0287
Brugia malayi CHE-14 protein 0.004 0.0103 0.0536
Echinococcus granulosus Niemann Pick C1 protein 0.0133 0.0464 0.046
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus granulosus heat shock protein 0.0037 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0734 0.2795 0.2792
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0015
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0267
Loa Loa (eye worm) hypothetical protein 0.005 0.014 0.0136
Loa Loa (eye worm) fli-1 protein 0.0206 0.0745 0.0742
Plasmodium vivax endoplasmin, putative 0.0037 0.0092 0.3061
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0031 0.0234
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0386 1
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.0942
Schistosoma mansoni survival motor neuron protein 0.0091 0.0299 0.0296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0087
Schistosoma mansoni heat shock protein 0.0037 0.0092 0.0088
Schistosoma mansoni hypothetical protein 0.2592 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0208 0.0204
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.0076
Schistosoma mansoni glutaminase 0.0313 0.116 0.1156
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0071
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Schistosoma mansoni heat shock protein 0.0015 0.0007 0.0003
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0004 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.029 0.2505
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.014 0.4453
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0018 0.0014
Trypanosoma brucei heat shock protein, putative 0.0037 0.0092 0.3061
Echinococcus granulosus GA binding protein alpha chain 0.0068 0.021 0.0206
Onchocerca volvulus 0.0057 0.0167 0.0886
Echinococcus granulosus GPCR family 2 0.0033 0.0075 0.0071
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0062 0.2037
Loa Loa (eye worm) uncoordinated protein 58 0.0088 0.029 0.0287
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0068 0.021 0.0206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0031 0.0942
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0031 0.0147
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0015 0.0007 0.0087
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0017 0.0013
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0007 0.0003
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0004 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0031 0.0942
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.008 0.0076
Giardia lamblia Hypothetical protein 0.0088 0.029 1
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0007 0.0057
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.029 0.2505
Onchocerca volvulus 0.0088 0.029 0.1559
Loa Loa (eye worm) hypothetical protein 0.0088 0.029 0.0287
Echinococcus granulosus twik family of potassium channels 0.0088 0.029 0.0287
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.0477 0.0473
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0018 0.0476
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0083 0.2767
Leishmania major heat shock protein 83-1 0.0037 0.0092 0.3061
Loa Loa (eye worm) hypothetical protein 0.086 0.3283 0.3281
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0017 0.0013
Trichomonas vaginalis glutaminase, putative 0.0313 0.116 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0.029 0.2505
Schistosoma mansoni cpg binding protein 0.006 0.0179 0.0175

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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