Detailed information for compound 85001

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 689.414 | Formula: C28H27Cl4N4O6S+
  • H donors: 3 H acceptors: 6 LogP: 5.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](NC(=O)[C@]1(C)CCCN1S(=O)(=O)c1cc(Cl)cc(c1)Cl)Cc1ccc(cc1)NC(=O)c1c(Cl)c[n+](cc1Cl)C
  • InChi: 1S/C28H26Cl4N4O6S/c1-28(8-3-9-36(28)43(41,42)20-12-17(29)11-18(30)13-20)27(40)34-23(26(38)39)10-16-4-6-19(7-5-16)33-25(37)24-21(31)14-35(2)15-22(24)32/h4-7,11-15,23H,3,8-10H2,1-2H3,(H2-,33,34,37,38,39,40)/p+1/t23-,28-/m0/s1
  • InChiKey: NFLKOACGNNGCMZ-FIPFOOKPSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0217 0.0956
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0174 0.2429
Echinococcus granulosus lamin 0.003 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.003 0.0174 0.0482
Echinococcus granulosus transient receptor potential ion channel A 0.0107 0.0934 0.1074
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0035 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0174 0.0158
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.3588 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0073 0.0597 0.0686
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0227 0.0258
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0073 0.0597 0.1661
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Leishmania major importin beta-1 subunit, putative 0.0027 0.0144 0.201
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0014 0.0016 0.0017
Mycobacterium ulcerans sugar transporter 0.0034 0.0217 0.4269
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0085 0.0715 1
Loa Loa (eye worm) integrin beta-2 0.0378 0.3588 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0112 0.0128
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.012 0.0181
Echinococcus multilocularis synaptic vesicle 2 protein 0.0034 0.0217 0.0248
Plasmodium falciparum lysine--tRNA ligase 0.0054 0.0414 0.0399
Plasmodium vivax proline--tRNA ligase, putative 0.0085 0.0715 0.0701
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0243 0.2266 0.2607
Schistosoma mansoni glucose transporter 0.0034 0.0217 0.0246
Brugia malayi hypothetical protein 0.028 0.2623 0.7309
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.465 0.5352
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.012 0.0137
Schistosoma mansoni sugar transporter 0.0034 0.0217 0.0246
Onchocerca volvulus 0.0034 0.0217 0.4325
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0112 0.031
Onchocerca volvulus 0.0034 0.0217 0.4325
Loa Loa (eye worm) sugar transporter 0.0243 0.2266 0.6313
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0227 0.063
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0112 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0217 0.0956
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0112 0.031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0441 0.1226
Echinococcus granulosus Sugar transporter ERD6 protein 0.0034 0.0217 0.0248
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0014 0.0016 0.0218
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0393 0.3734 0.3724
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0174 0.2429
Trichomonas vaginalis myo-inositol transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) intermediate filament protein 0.003 0.0175 0.0484
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0035 0.0039
Chlamydia trachomatis proline--tRNA ligase 0.0026 0.0134 0.2978
Plasmodium falciparum calcium-dependent protein kinase 1 0.0075 0.0612 0.0597
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0034 0.0217 1
Echinococcus granulosus lamin dm0 0.003 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Schistosoma mansoni hypothetical protein 0.0057 0.0441 0.0504
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0034 0.0217 0.4269
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0348 0.1536
Trypanosoma cruzi hexose transporter 0.0075 0.0621 0.868
Plasmodium vivax calcium-dependent protein kinase, putative 0.0075 0.0612 0.0597
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0044 0.0621
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0075 0.0612 0.0925
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0044 0.0067
Loa Loa (eye worm) major facilitator superfamily transporter 0.0034 0.0217 0.0601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Onchocerca volvulus 0.0034 0.0217 0.4325
Treponema pallidum prolyl-tRNA synthetase 0.0026 0.0134 1
Brugia malayi CXXC zinc finger family protein 0.0063 0.05 0.1391
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.0484
Schistosoma mansoni importin beta-1 0.0033 0.0205 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Trypanosoma brucei glucose transporter 1E 0.0075 0.0621 0.868
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0014 0.0016 0.0218
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0074 0.0611 0.1702
Schistosoma mansoni hypothetical protein 0.0352 0.3335 0.3836
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Echinococcus granulosus survival motor neuron protein 1 0.028 0.2623 0.3018
Leishmania major lysyl-tRNA synthetase, putative 0.0054 0.0414 0.5783
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0034 0.0217 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0973 0.2711
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0112 0.031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Schistosoma mansoni transient receptor potential channel 0.0073 0.0602 0.0689
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0379 0.1053
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Schistosoma mansoni protein kinase 0.0074 0.0611 0.07
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0112 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0112 0.031
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0144 0.201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0379 0.0435
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0003 0.0006
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0044 0.0875
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0012 0.0001 0.0004
Trypanosoma brucei sugar transporter, putative 0.0034 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0695
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.012 0.1991
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Plasmodium vivax importin-beta 2, putative 0.0033 0.0205 0.019
Schistosoma mansoni transient receptor potential channel 0.0111 0.097 0.1114
Entamoeba histolytica hypothetical protein 0.0054 0.0414 0.6679
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0112 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0025
Schistosoma mansoni intermediate filament proteins 0.003 0.0175 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0112 0.031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0414 0.8148
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0227 0.026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0044 0.005
Trichomonas vaginalis glucose transporter, putative 0.0075 0.0621 0.274
Schistosoma mansoni ran 0.0024 0.012 0.0134
Echinococcus granulosus lysyl tRNA synthetase 0.0054 0.0414 0.0475
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0112 0.2227
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.0602 0.0692
Echinococcus multilocularis GPCR, family 2 0.0035 0.0227 0.026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0597 0.1661
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0034 0.0217 0.0248
Leishmania major glucose transporter/membrane transporter D2, putative 0.0075 0.0621 0.868
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0112 0.031
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0112 0.0125
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0044 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0112 0.0125
Brugia malayi hypothetical protein 0.0012 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0112 0.031
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.003 0.0174 0.2429
Schistosoma mansoni integrin beta subunit 0.0223 0.2064 0.2373
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0144 0.0635
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0034 0.0217 0.4269
Leishmania major glucose transporter, lmgt2 0.0075 0.0621 0.868
Brugia malayi Cam kinase protein 1 0.0074 0.0611 0.1702
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0611 0.07
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0112 0.0125
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0174 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0112 0.0125
Toxoplasma gondii transporter, major facilitator family protein 0.0034 0.0217 0.0327
Echinococcus multilocularis lamin 0.003 0.0175 0.02
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0014 0.0016 0.0307
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0144 0.0635
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0073 0.0083
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0073 0.0597 0.2634
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0044 0.005
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0014 0.0016 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0112 0.031
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0628 0.1748
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Trichomonas vaginalis hypothetical protein 0.0012 0.0001 0.0004
Onchocerca volvulus 0.003 0.0175 0.3481
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0073 0.0597 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0112 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0044 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0112 0.0128
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.012 0.0104
Toxoplasma gondii sugar transporter ST2 0.0034 0.0217 0.0327
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0075 0.0612 0.0597
Loa Loa (eye worm) major facilitator superfamily transporter 0.0034 0.0217 0.0601
Giardia lamblia Lysyl-tRNA synthetase 0.0054 0.0414 0.6927
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0217 0.0956
Toxoplasma gondii protein kinase, putative 0.0687 0.6617 1
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.465 0.5352
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0508 0.0583
Brugia malayi Major Facilitator Superfamily protein 0.0034 0.0217 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0379 0.0432
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0174 0.2429
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0611 0.2699
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0169 0.0469
Echinococcus granulosus importin subunit beta 1 0.0033 0.0205 0.0235
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0205 0.2866
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0044 0.0067
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0014 0.0016 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0379 0.0435
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0205 0.0235
Schistosoma mansoni cpg binding protein 0.0067 0.0535 0.0612
Loa Loa (eye worm) hypothetical protein 0.0033 0.0205 0.0569
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0508 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0243 0.2266 0.6313
Onchocerca volvulus 0.0034 0.0217 0.4325
Echinococcus granulosus glycyl tRNA synthetase 0.0014 0.0016 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0112 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0112 0.031
Loa Loa (eye worm) hypothetical protein 0.0074 0.0611 0.1702
Toxoplasma gondii glycyl-tRNA synthetase 0.0014 0.0016 0.0024
Schistosoma mansoni glucose transport protein 0.0243 0.2266 0.2605
Loa Loa (eye worm) hypothetical protein 0.0111 0.0973 0.2711
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Onchocerca volvulus Putative transporter 0.0034 0.0217 0.4325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0621 0.274
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.012 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Brugia malayi ecdysteroid receptor 0.0024 0.0112 0.031
Schistosoma mansoni hypothetical protein 0.0076 0.0628 0.0719
Onchocerca volvulus 0.003 0.0175 0.3481
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0112 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0508 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0073 0.0597 0.1661
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0014 0.0016 0.0218
Schistosoma mansoni hypothetical protein 0.0178 0.1629 0.1872
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0379 0.1053
Echinococcus multilocularis glycyl tRNA synthetase 0.0014 0.0016 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0899 0.8688 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0075 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Onchocerca volvulus 0.0034 0.0217 0.4325
Schistosoma mansoni survival motor neuron protein 0.0057 0.0441 0.0504
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.3335 0.9293
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0035 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) histone methyltransferase 0.002 0.0073 0.02
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0227 0.026
Echinococcus granulosus solute carrier family 22 0.0034 0.0217 0.0248
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0286 0.0796
Brugia malayi hypothetical protein 0.0034 0.0217 0.0601
Echinococcus multilocularis cpg binding protein 0.0067 0.0535 0.0615
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0112 0.0125
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0112 0.031
Schistosoma mansoni transient receptor potential channel 0.0073 0.0602 0.0689
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.012 0.1672
Brugia malayi major facilitator superfamily protein 0.0034 0.0217 0.0601
Echinococcus granulosus solute carrier family 22 0.0034 0.0217 0.0248
Onchocerca volvulus 0.0034 0.0217 0.4325
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0217 0.0956
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.012 0.1672
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0034 0.0217 0.303
Brugia malayi nuclear receptor RXR 0.0012 0.0003 0.0006
Schistosoma mansoni protein kinase 0.0074 0.0611 0.07
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0112 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Echinococcus granulosus GPCR family 2 0.0035 0.0227 0.026
Plasmodium falciparum mitogen-activated protein kinase 2 0.0393 0.3734 0.3724
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0175 0.0484
Schistosoma mansoni cpg binding protein 0.0063 0.05 0.0572
Plasmodium vivax CDK-related protein kinase 6, putative 0.1032 1 1
Trichomonas vaginalis ran, putative 0.0024 0.012 0.0528
Loa Loa (eye worm) hypothetical protein 0.0054 0.0414 0.115
Loa Loa (eye worm) hypothetical protein 0.028 0.2623 0.7309
Brugia malayi glycyl-tRNA synthetase 0.0014 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Plasmodium falciparum proline--tRNA ligase 0.0085 0.0715 0.0701
Schistosoma mansoni hypothetical protein 0.0035 0.0227 0.0258
Brugia malayi nuclear receptor NHR-88 0.0024 0.0112 0.031
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0508 0.0767
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0508 0.0583
Echinococcus granulosus geminin 0.0178 0.1629 0.1874
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.0033 0.0205 0.019
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.0602 0.0692
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0414 0.0472
Toxoplasma gondii lysine-tRNA ligase 0.0054 0.0414 0.0625
Echinococcus multilocularis solute carrier family 22 0.0034 0.0217 0.0248
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0227 0.063
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.0602 0.0692
Echinococcus multilocularis lamin dm0 0.003 0.0175 0.02
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.012 0.0331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0508 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0445 0.1237
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0046 0.0333 0.5587
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0112 0.031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.012 0.0104
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0013 0.0013
Schistosoma mansoni ran 0.0024 0.012 0.0134
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0046 0.0333 0.6568
Leishmania major glucose transporter, lmgt3 0.0075 0.0621 0.868
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0075 0.0612 0.0597
Giardia lamblia Glycyl-tRNA synthetase 0.0014 0.0016 0.0246
Brugia malayi hypothetical protein 0.0057 0.0445 0.1237
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0014 0.0016 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.007 0.0565 0.1573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0112 0.031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0112 0.0125
Schistosoma mansoni hypothetical protein 0.0035 0.0227 0.0258
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0054 0.0414 0.6932
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0085 0.0715 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0014 0.0016 0.0218
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0044 0.005
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0112 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0112 0.0128
Echinococcus granulosus calcium dependent protein kinase 0.007 0.0566 0.0651
Trichomonas vaginalis sugar transport protein, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0075 0.0621 0.274
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.007 0.0193
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0046 0.0333 0.6568
Brugia malayi isocitrate dehydrogenase 0.0017 0.0044 0.0121
Brugia malayi nuclear hormone receptor 0.0024 0.0112 0.031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0112 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0076 0.0628 0.1748
Echinococcus granulosus neuropeptide s receptor 0.0487 0.465 0.5352
Echinococcus multilocularis dnaJ subfamily B 0.0899 0.8688 1
Echinococcus multilocularis geminin 0.0178 0.1629 0.1874
Echinococcus multilocularis transient receptor potential gamma protein 0.0111 0.097 0.1116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0112 0.031
Echinococcus multilocularis General substrate transporter 0.0209 0.193 0.2221
Mycobacterium ulcerans integral membrane transport protein 0.0034 0.0217 0.4269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0379 0.0432
Echinococcus multilocularis lysyl tRNA synthetase 0.0054 0.0414 0.0475
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0243 0.2266 0.2605
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0073 0.0597 0.0686
Trichomonas vaginalis helicase, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Brugia malayi Major Facilitator Superfamily protein 0.0034 0.0217 0.0601
Brugia malayi RNA, U transporter 1 0.0094 0.0801 0.2231
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0112 0.031
Leishmania major glucose transporter, lmgt1 0.0075 0.0621 0.868
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0014 0.0016 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0075 0.0621 0.274
Leishmania major hypothetical protein, conserved 0.0034 0.0217 0.303
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0085 0.0715 1
Brugia malayi hypothetical protein 0.0034 0.0217 0.0601
Echinococcus multilocularis integrin beta 2 0.028 0.2628 0.3024
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0073 0.0597 0.0683
Onchocerca volvulus 0.0034 0.0217 0.4325
Brugia malayi steroid hormone receptor 0.0024 0.0112 0.031
Schistosoma mansoni hypothetical protein 0.0035 0.0227 0.0258
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0112 0.0128
Echinococcus multilocularis solute carrier family 22 0.0034 0.0217 0.0248
Entamoeba histolytica protein kinase, putative 0.0074 0.0611 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0112 0.2227
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Echinococcus multilocularis transient receptor potential ion channel A 0.0107 0.0934 0.1074
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.2266 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0014 0.0016 0.0041
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0075 0.0621 0.868
Echinococcus multilocularis musashi 0.003 0.0175 0.02
Brugia malayi hypothetical protein 0.0019 0.007 0.0193
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.465 0.5352
Echinococcus granulosus General substrate transporter 0.0209 0.193 0.2221
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0112 0.0125
Echinococcus granulosus solute carrier family 22 0.0034 0.0217 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Onchocerca volvulus 0.0034 0.0217 0.4325
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Onchocerca volvulus 0.0057 0.0441 0.8814
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.012 0.0331
Giardia lamblia Hexose transporter 0.0034 0.0217 0.3621
Schistosoma mansoni sugar transporter 0.0034 0.0217 0.0246
Echinococcus granulosus cpg binding protein 0.0067 0.0535 0.0615
Schistosoma mansoni hypothetical protein 0.0178 0.1629 0.1872
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0074 0.0611 0.1702
Toxoplasma gondii sugar transporter ST3 0.0034 0.0217 0.0327
Brugia malayi Sugar transporter family protein 0.0034 0.0217 0.0601
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1053 0.1591
Trypanosoma cruzi glucose transporter, putative 0.0034 0.0217 0.303
Echinococcus multilocularis survival motor neuron protein 1 0.028 0.2623 0.3018
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0508 0.0581
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0508 1
Plasmodium vivax sugar transporter, putative 0.0034 0.0217 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0621 0.274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0227 0.026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0112 0.0128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0973 0.2711
Onchocerca volvulus 0.0034 0.0217 0.4325
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0044 0.0621
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Loa Loa (eye worm) hypothetical protein 0.0059 0.0463 0.1287
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0112 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0227 0.026
Onchocerca volvulus 0.0063 0.05 1
Onchocerca volvulus 0.0024 0.0112 0.2227
Echinococcus granulosus transient receptor potential gamma protein 0.0111 0.097 0.1116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0074 0.0611 0.1702
Brugia malayi Sugar transporter family protein 0.0034 0.0217 0.0601
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0112 0.031
Schistosoma mansoni protein kinase 0.0074 0.0611 0.07
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0044 0.005
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0085 0.0715 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0074 0.0611 0.0703
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Toxoplasma gondii sugar transporter ST1 0.0034 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Schistosoma mansoni glucose transport protein 0.0243 0.2266 0.2605
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0414 0.8148
Onchocerca volvulus 0.0034 0.0217 0.4325
Echinococcus granulosus intermediate filament protein 0.003 0.0175 0.02
Giardia lamblia Threonyl-tRNA synthetase 0.0014 0.0016 0.0246
Schistosoma mansoni cpg binding protein 0.0067 0.0535 0.0612
Echinococcus multilocularis snurportin 1 0.0352 0.3335 0.3838
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0112 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0075 0.0621 0.274
Entamoeba histolytica Ran family GTPase 0.0024 0.012 0.1745
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0054 0.0414 0.1826
Schistosoma mansoni coup transcription factor 0.0024 0.0112 0.0125
Trypanosoma brucei glucose transporter 2A 0.0075 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Brugia malayi hypothetical protein 0.0012 0.0003 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0073 0.0083
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0044 0.0621
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0286 0.0329
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0414 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0508 0.7097
Onchocerca volvulus 0.0034 0.0217 0.4325
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0085 0.0715 1
Brugia malayi Major Facilitator Superfamily protein 0.0034 0.0217 0.0601
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0073 0.0597 0.0683
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0227 0.063
Echinococcus multilocularis solute carrier family 22 0.0034 0.0217 0.0248
Loa Loa (eye worm) sugar transporter 0.0034 0.0217 0.0601
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0112 0.031
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0039 0.0105
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0205 0.2866
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0112 0.0128
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0621 0.868
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0057 0.0445 0.1237
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0044 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0144 0.0635
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Onchocerca volvulus 0.0034 0.0217 0.4325
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0035 0.0039
Schistosoma mansoni sugar transporter 0.0034 0.0217 0.0246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Leishmania major threonyl-tRNA synthetase, putative 0.0014 0.0016 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0112 0.031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.05 0.1391
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0112 0.0125
Plasmodium vivax lysine--tRNA ligase, putative 0.0054 0.0414 0.0399
Leishmania major GTP-binding protein, putative 0.0024 0.012 0.1672
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0044 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Plasmodium vivax hexose transporter 0.0243 0.2266 0.2253
Schistosoma mansoni hypothetical protein 0.0899 0.8688 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0034 0.0217 0.0201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0085 0.0715 0.1081
Brugia malayi Kelch motif family protein 0.0057 0.0445 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Echinococcus multilocularis solute carrier family 22 0.0034 0.0217 0.0248
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0044 0.005
Giardia lamblia Prolyl-tRNA synthetase 0.0073 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0046
Plasmodium falciparum hexose transporter 0.0243 0.2266 0.2253
Schistosoma mansoni glycyl-tRNA synthetase 0.0014 0.0016 0.0014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0112 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0112 0.031
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.0602 0.0692
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0175 0.0484
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0286 0.0329
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0073 0.0597 0.9752
Echinococcus granulosus integrin beta 2 0.028 0.2628 0.3024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0044 0.0621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0379 0.0435
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0039 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 2 0.0075 0.0612 0.0597
Toxoplasma gondii hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni lamin 0.003 0.0175 0.0197
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0034 0.0217 0.4269
Echinococcus granulosus synaptic vesicle 2 protein 0.0034 0.0217 0.0248
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0611 0.0703
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0044 0.0621
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0074 0.0611 0.855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0112 0.031
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0073 0.0597 0.1661
Onchocerca volvulus 0.0034 0.0217 0.4325
Echinococcus granulosus snurportin 1 0.0352 0.3335 0.3838
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0796
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0112 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0112 0.0128
Schistosoma mansoni sugar transporter 0.0034 0.0217 0.0246
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0014 0.0016 0.0262
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0075 0.0612 0.0925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Brugia malayi major facilitator superfamily protein 0.0034 0.0217 0.0601
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0508 0.0581
Brugia malayi hypothetical protein 0.0034 0.0217 0.0601
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Plasmodium falciparum calcium-dependent protein kinase 4 0.0075 0.0612 0.0597
Plasmodium falciparum calcium-dependent protein kinase 5 0.0075 0.0612 0.0597
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0014 0.0016 0.0024
Schistosoma mansoni transient receptor potential channel 4 0.0111 0.097 0.1114
Onchocerca volvulus 0.0034 0.0217 0.4325
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0174 0.0158
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.003 0.0175 0.0485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0601
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0035 0.0039
Brugia malayi intermediate filament protein 0.003 0.0175 0.0484
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0217 0.303
Onchocerca volvulus 0.0034 0.0217 0.4325
Echinococcus multilocularis calcium dependent protein kinase 0.007 0.0566 0.0651
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0054 0.0414 0.5783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0112 0.031
Trypanosoma cruzi sugar transporter, putative 0.0034 0.0217 0.303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0227 0.063
Plasmodium falciparum protein kinase 7 0.0687 0.6617 0.6612
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0205 0.031
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0393 0.3734 0.5643
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0379 0.0432
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0014 0.0016 0.0307
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0174 0.0158
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0112 0.0128
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0621 0.868
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0112 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0095
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0112 0.0125
Echinococcus granulosus solute carrier family 22 0.0034 0.0217 0.0248
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0243 0.2266 0.2607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0379 0.0435
Trypanosoma cruzi hexose transporter, putative 0.0041 0.0286 0.3994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0112 0.031
Brugia malayi hypothetical protein 0.003 0.0174 0.0482
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0973 0.2711
Schistosoma mansoni lamin 0.003 0.0175 0.0197
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 3 0.0075 0.0612 0.0597
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.031
Entamoeba histolytica protein kinase, putative 0.0074 0.0611 1
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0112 0.0125
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0044 0.0029
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0026 0.0134 0.2642
Chlamydia trachomatis lysine--tRNA ligase 0.0054 0.0414 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0014 0.0016 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1193 0.137
Loa Loa (eye worm) hypothetical protein 0.0111 0.097 0.2702
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Brugia malayi lysyl-tRNA synthetase 0.0054 0.0414 0.115
Trypanosoma brucei THT1 - hexose transporter, putative 0.0075 0.0621 0.868
Leishmania major myo-inositol/proton symporter (MIT) 0.0034 0.0217 0.303
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0112 0.2227
Brugia malayi Importin beta-1 subunit 0.0033 0.0205 0.0569
Onchocerca volvulus 0.0034 0.0217 0.4325
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0075 0.0612 0.0597
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.012 0.1672
Giardia lamblia Sugar-proton symporter 0.0034 0.0217 0.3621
Toxoplasma gondii facilitative glucose transporter GT1 0.0243 0.2266 0.3424
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0013 0.0013
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0034 0.0217 0.4269
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0054 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0075 0.0621 0.274
Schistosoma mansoni glucose transport protein 0.0243 0.2266 0.2605
Leishmania major protein kinase, putative 0.0074 0.0611 0.855
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0112 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Trypanosoma brucei THT1 - hexose transporter, putative 0.0075 0.0621 0.868
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0075 0.0612 0.0925
Echinococcus granulosus Threonyl tRNA synthetase C 0.0014 0.0016 0.0017
Entamoeba histolytica hypothetical protein 0.0027 0.0144 0.2151

Activities

Activity type Activity value Assay description Source Reference
Bound (binding) = 61 % Dissociation from Very late antigen 4 (VLA-4) ChEMBL. 12749892
Bound (binding) = 61 % Dissociation from Very late antigen 4 (VLA-4) ChEMBL. 12749892
IC50 (binding) = 0.1 nM Inhibition of [125I]-VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+] ChEMBL. 12749892
IC50 (binding) = 0.1 nM Inihibition of VLA-4 binding in Jurkat cells in the presence of Mg2+ ChEMBL. 12749892
IC50 (binding) = 0.1 nM Inhibition of [125I]-VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+] ChEMBL. 12749892
IC50 (binding) = 0.1 nM Inihibition of VLA-4 binding in Jurkat cells in the presence of Mg2+ ChEMBL. 12749892
IC50 (binding) = 0.19 nM Inhibition of [125I]-VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+ ChEMBL. 12749892
IC50 (binding) = 0.19 nM Inhibition of [125I]-VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+ ChEMBL. 12749892

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.