TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.558 | Formula: C26H33N3O4
H donors: 2 H acceptors: 3 LogP: 3.27 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccc(cc1)NC(=O)c1cc(CN2CCCC2)c(c(c1)CN1CCCC1)O
InChi: 1S/C26H33N3O4/c1-2-33-26(32)19-7-9-23(10-8-19)27-25(31)20-15-21(17-28-11-3-4-12-28)24(30)22(16-20)18-29-13-5-6-14-29/h7-10,15-16,30H,2-6,11-14,17-18H2,1H3,(H,27,31)
InChiKey: WLNLSBBQWJUFNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0009	0.0108	0.0106
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0729	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0009	0.0108	0.0106
Toxoplasma gondii	ABC1 family protein	0.0036	0.0729	0.9978
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Schistosoma mansoni	ferritin	0.0009	0.0112	0.0167
Brugia malayi	beta-lactamase	0.0036	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0003
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0009	0.0108	0.0106
Brugia malayi	hypothetical protein	0.001	0.0134	0.0134
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0004	0.0002	0.0002
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0004	0.0002	0.0002
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0645	0.8849
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0729	0.9978
Entamoeba histolytica	beta-N-acetylhexosaminidase, alpha subunit	0.0175	0.3842	0.4956
Plasmodium falciparum	importin beta, putative	0.0028	0.0553	1
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0112	0.0214
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0134	0.0134
Onchocerca volvulus	Hexosaminidase D homolog	0.0041	0.0829	0.161
Echinococcus multilocularis	3'(2'),5' bisphosphate nucleotidase 1	0.0004	0.0003	0.0001
Schistosoma mansoni	pap-inositol-14-phosphatase	0.0004	0.0003	0.0004
Echinococcus multilocularis	beta hexosaminidase subunit alpha	0.011	0.237	0.2368
Brugia malayi	hypothetical protein	0.0004	0.0002	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0024	0.0035
Echinococcus granulosus	c src tyrosine kinase	0.0009	0.0108	0.0106
Echinococcus multilocularis	beta hexosaminidase subunit beta	0.0175	0.3842	0.3841
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0731	0.0729
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0731	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0134	0.1874
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0731	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0729	0.1424
Schistosoma mansoni	tyrosine kinase	0.0005	0.0026	0.0038
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0553	0.7559
Onchocerca volvulus		0.0233	0.5136	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0026	0.0031
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Schistosoma mansoni	hypothetical protein	0.0004	0.0003	0.0004
Echinococcus multilocularis	inositol monophosphatase	0.0004	0.0003	0.0001
Entamoeba histolytica	DNA repair protein, putative	0.0008	0.0098	0.0123
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0729	0.1424
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0134	0.0256
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.0038	0.048
Trichomonas vaginalis	esterase, putative	0.0036	0.0729	0.1414
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0134	0.0256
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0026	0.0026
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0553	0.7454
Echinococcus granulosus	transportin 1	0.0005	0.0038	0.0036
Schistosoma mansoni	topbp1	0.001	0.0134	0.0201
Schistosoma mansoni	tyrosine kinase	0.0009	0.0108	0.0161
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0005	0.0038	0.0038
Schistosoma mansoni	tyrosine kinase	0.0009	0.0108	0.0161
Onchocerca volvulus		0.0036	0.0729	0.1416
Schistosoma mansoni	DNA repair and recombination protein rad54-related	0.0008	0.0098	0.0146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Schistosoma mansoni	GTPase activating protein	0.0004	0.0002	0.0003
Echinococcus granulosus	beta hexosaminidase subunit alpha	0.011	0.237	0.2368
Brugia malayi	SRC-1	0.0009	0.0108	0.0108
Brugia malayi	Inositol monophosphatase family protein	0.0004	0.0003	0.0003
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0134	0.0201
Echinococcus granulosus	3'2'5' bisphosphate nucleotidase 1	0.0004	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0729	0.1424
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0134	0.0256
Echinococcus multilocularis	dna repair and recombination protein rad54	0.0008	0.0097	0.0095
Onchocerca volvulus		0.0005	0.0026	0.0046
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0134	0.1807
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0553	0.0553
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0005	0.0026	0.0024
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0134	0.1397
Schistosoma mansoni	myo inositol monophosphatase	0.0004	0.0003	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0084	0.0084
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0004	0.0002	0.0003
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0134	0.0132
Onchocerca volvulus		0.0005	0.0026	0.0046
Schistosoma mansoni	DNA ligase IV	0.001	0.0134	0.0201
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0729	0.9978
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0134	0.0256
Trichomonas vaginalis	beta-hexosaminidase, putative	0.0041	0.0829	0.1609
Echinococcus multilocularis	SPRY domain containing protein	0.0008	0.0097	0.0095
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0004	0.0002	0.0003
Entamoeba histolytica	beta-N-acetylhexosaminidase, beta subunit	0.0175	0.3842	0.4956
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0005	0.0026	0.0024
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.4503	0.4503
Trypanosoma cruzi	DNA repair and recombination protein RAD54, putative	0.0008	0.0098	0.1301
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0433	0.5908
Entamoeba histolytica	HEAT repeat domain containing protein	0.0005	0.0038	0.0046
Schistosoma mansoni	apoferritin-2	0.0009	0.0112	0.0167
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0097	0.0095
Echinococcus multilocularis	SPRY domain containing protein	0.0008	0.0097	0.0095
Schistosoma mansoni	tensin-related	0.0004	0.0002	0.0003
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0009	0.0108	0.0161
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0729	0.0729
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0731	1
Brugia malayi	topoisomerase	0.001	0.0134	0.0134
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0731	1
Plasmodium vivax	DNA repair protein RAD54, putative	0.0008	0.0098	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0729	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0731	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0003
Echinococcus multilocularis	dna repair and recombination protein rad54	0.0008	0.0097	0.0095
Echinococcus granulosus	tyrosine protein kinase Srms	0.0005	0.0026	0.0024
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0729	0.1414
Brugia malayi	Importin beta-1 subunit	0.0028	0.0553	0.0553
Echinococcus granulosus	tyrosine kinase	0.0005	0.0026	0.0024
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0005	0.0026	0.0024
Loa Loa (eye worm)	type III restriction enzyme	0.0008	0.0098	0.0098
Echinococcus granulosus	tyrosine protein kinase Blk	0.0005	0.0026	0.0024
Trypanosoma cruzi	DNA repair and recombination protein RAD54, putative	0.0008	0.0098	0.1301
Schistosoma mansoni	adapter molecule crk	0.0007	0.0084	0.0126
Brugia malayi	Inositol-1	0.0036	0.0731	0.0731
Entamoeba histolytica	hypothetical protein	0.001	0.0134	0.0171
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0007	0.0084	0.0082
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0008	0.0098	0.0098
Echinococcus multilocularis	nibrin	0.001	0.0134	0.0132
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0004	0.0002	0.0002
Leishmania major	hypothetical protein, conserved	0.0005	0.0038	0.048
Brugia malayi	RhoGAP domain containing protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0729	0.1424
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0553	0.7559
Onchocerca volvulus	Inositol monophosphatase 3 homolog	0.0004	0.0003	0.0002
Echinococcus multilocularis	tyrosine protein kinase shark	0.0005	0.0026	0.0024
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0009	0.0108	0.0106
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0433	0.0838
Brugia malayi	hypothetical protein	0.0005	0.0026	0.0026
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0134	0.0171
Echinococcus granulosus	snurportin 1	0.0303	0.6699	0.6699
Schistosoma mansoni	hypothetical protein	0.0004	0.0003	0.0004
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0175	0.3842	0.3842
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0553	0.0551
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.5136	1
Schistosoma mansoni	tyrosine kinase	0.0005	0.0026	0.0038
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0005	0.0038	0.048
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.035	0.7751	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0729	0.0729
Schistosoma mansoni	ferritin	0.0009	0.0112	0.0167
Entamoeba histolytica	hypothetical protein	0.0023	0.0433	0.0556
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0134	0.0256
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0112	0.0214
Entamoeba histolytica	beta-N-acetylhexosaminidase, putative	0.0175	0.3842	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0575	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Echinococcus multilocularis	NCK adaptor protein	0.0007	0.0084	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0004	0.0002	0.0003
Mycobacterium ulcerans	lipase LipD	0.0036	0.0729	0.9978
Schistosoma mansoni	importin beta-1	0.0028	0.0553	0.0825
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0041	0.0829	0.0829
Echinococcus multilocularis	dna repair and recombination protein rad54	0.0008	0.0098	0.0096
Onchocerca volvulus		0.0036	0.0729	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0729	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	inositol-1	0.0036	0.0731	0.0731
Schistosoma mansoni	DNA repair and recombination protein rad54-related	0.0008	0.0098	0.0146
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0041	0.0829	0.0829
Schistosoma mansoni	vav2	0.0004	0.0002	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0134	0.0256
Leishmania major	hypothetical protein, conserved	0.0036	0.0729	0.9978
Echinococcus granulosus	expressed protein	0.0009	0.0112	0.011
Echinococcus multilocularis	tyrosine kinase	0.0005	0.0026	0.0024
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0112	0.1501
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0134	0.1807
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Brugia malayi	Tyrosine-protein kinase abl-1	0.0009	0.0108	0.0108
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0026	0.0026
Trichomonas vaginalis	hypothetical protein	0.0005	0.0038	0.0068
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0005	0.0026	0.0024
Brugia malayi	recombination factor GdRad54	0.0008	0.0098	0.0098
Schistosoma mansoni	tyrosine kinase	0.0009	0.0108	0.0161
Onchocerca volvulus		0.0005	0.0026	0.0046
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0729	0.1424
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0134	0.1807
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0134	0.1807
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0009	0.0108	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0729	0.9978
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0729	0.1088
Brugia malayi	SH2 domain containing protein	0.0005	0.0026	0.0026
Schistosoma mansoni	tensin	0.0004	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Brugia malayi	Tensin	0.0004	0.0002	0.0002
Schistosoma mansoni	suppressor of cytokine signaling	0.0004	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0731	0.1418
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	STAT protein	0.0004	0.0002	0.0002
Loa Loa (eye worm)	SH2 domain-containing protein	0.0004	0.0002	0.0002
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0002	0.0002
Trichomonas vaginalis	beta-hexosaminidase, putative	0.011	0.237	0.461
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.01	0.2146	0.2767
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0645	0.126
Echinococcus granulosus	ferritin	0.0009	0.0112	0.011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0729	0.1414
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0575	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0731	1
Schistosoma mansoni	beta-hexosaminidase B	0.0175	0.3842	0.5735
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Echinococcus multilocularis	transportin 1	0.0005	0.0038	0.0036
Leishmania major	DNA repair and recombination protein RAD54, putative	0.0008	0.0098	0.1301
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0575	0.0573
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0729	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0098	0.0098
Schistosoma mansoni	ferritin	0.0009	0.0112	0.0167
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0729	0.1088
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0731	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0729	0.0727
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Echinococcus multilocularis	muscleblind protein	0.045	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0575	0.0575
Schistosoma mansoni	tensin	0.0004	0.0002	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0026	0.0026
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.6699	0.6699
Brugia malayi	DKFZp564C0469 protein	0.001	0.0134	0.0134
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	0.0004	0.0003	0.0001
Echinococcus granulosus	growth factor receptor bound protein 2	0.0007	0.0084	0.0082
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0009	0.0108	0.0106
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0731	0.094
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0007	0.0084	0.0126
Echinococcus multilocularis		0.0008	0.0098	0.0096
Schistosoma mansoni	importin-beta 2	0.0005	0.0038	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Plasmodium vivax	SET domain protein, putative	0.0029	0.0575	0.7778
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0134	0.0256
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0134	0.0256
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0005	0.0026	0.0024
Plasmodium falciparum	DNA repair and recombination protein RAD54, putative	0.0008	0.0098	0.1159
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0729	1
Brugia malayi	Pre-SET motif family protein	0.0205	0.4503	0.4503
Loa Loa (eye worm)	TK protein kinase	0.0005	0.0026	0.0026
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0729	0.9978
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0134	0.1807
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Schistosoma mansoni	tensin	0.0004	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0729	0.0729
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0134	0.1807
Chlamydia trachomatis	DNA ligase	0.001	0.0134	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0009	0.0108	0.0106
Echinococcus granulosus	tyrosine protein kinase shark	0.0005	0.0026	0.0024
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0112	0.1501
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0134	0.0256
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0009	0.0108	0.0106
Brugia malayi	RNA, U transporter 1	0.0081	0.1724	0.1724
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0731	0.1418
Echinococcus multilocularis	expressed protein	0.0009	0.0112	0.011
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0009	0.0108	0.0106
Onchocerca volvulus		0.001	0.0134	0.0258
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0097	0.0095
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0729	0.1424
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0026	0.0026
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0005	0.0038	0.048
Brugia malayi	kap beta 3 protein	0.0005	0.0038	0.0038
Schistosoma mansoni	shc transforming protein	0.0004	0.0002	0.0003
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0004	0.0002	0.0002
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0729	0.1424
Echinococcus multilocularis	translational activator gcn1	0.0005	0.0038	0.0036
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0134	0.036
Echinococcus granulosus	DNA repair and recombination protein RAD54B	0.0008	0.0098	0.0096
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0007	0.0084	0.0084
Loa Loa (eye worm)	TK/ABL protein kinase	0.0005	0.0026	0.0026
Echinococcus granulosus	importin 5	0.0005	0.0038	0.0036
Schistosoma mansoni	nck2/grb4	0.0007	0.0084	0.0126
Schistosoma mansoni	tyrosine kinase	0.0009	0.0108	0.0161
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0005	0.0026	0.0024
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0553	0.7559
Loa Loa (eye worm)	glycosyl hydrolase family 20	0.0175	0.3842	0.3842
Loa Loa (eye worm)	hypothetical protein	0.045	1	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0729	0.0729
Echinococcus granulosus	translational activator gcn1	0.0005	0.0038	0.0036
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0829	0.0829
Trichomonas vaginalis	beta-hexosaminidase, putative	0.011	0.237	0.461
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0729	0.9978
Trichomonas vaginalis	ferritin, putative	0.0009	0.0112	0.0213
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	0.0004	0.0003	0.0001
Echinococcus granulosus	inositol monophosphatase	0.0004	0.0003	0.0001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0026	0.0026
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0009	0.0108	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0098	0.0098
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0134	0.0132
Onchocerca volvulus		0.0029	0.0575	0.1117
Brugia malayi	beta-lactamase family protein	0.0036	0.0729	0.0729
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0729	0.1414
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0575	0.7867
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0134	0.1811
Echinococcus granulosus	NCK adaptor protein	0.0007	0.0084	0.0082
Schistosoma mansoni	ferritin	0.0009	0.0112	0.0167
Schistosoma mansoni	signal transduction protein lnk-related	0.0004	0.0002	0.0003
Echinococcus multilocularis	importin 5	0.0005	0.0038	0.0036
Onchocerca volvulus		0.0005	0.0026	0.0046
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0004	0.0002	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0575	0.0859
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0134	0.1807
Brugia malayi	hypothetical protein	0.001	0.0134	0.0134
Brugia malayi	Inositol monophosphatase family protein	0.0004	0.0003	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0097	0.0097
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0084	0.0084
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0134	0.0134
Entamoeba histolytica	beta-N-acetylhexosaminidase, putative	0.0175	0.3842	0.4956
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0551	0.0549
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0729	0.1414
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0002	0.0002
Brugia malayi	SH2 domain containing protein	0.0005	0.0026	0.0026
Loa Loa (eye worm)	SH2 domain-containing protein	0.0004	0.0002	0.0002
Giardia lamblia	DNA repair protein RAD52	0.035	0.7751	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.0084	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0004	0.0002	0.0002
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.0084	0.0126
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0004	0.0002	0.0003
Echinococcus multilocularis	c src tyrosine kinase	0.0009	0.0108	0.0106
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0729	0.1424
Onchocerca volvulus		0.0036	0.0729	0.1416
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0731	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0575	0.0859
Onchocerca volvulus		0.0005	0.0026	0.0046
Loa Loa (eye worm)	SRC-1	0.0009	0.0108	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0005	0.0026	0.0024
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0112	0.1504
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0026	0.0026
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0731	0.0729
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0729	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0829	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0026	0.0026
Echinococcus multilocularis		0.0008	0.0097	0.0095
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0005	0.0026	0.0024
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0433	0.5908
Schistosoma mansoni	SH2A	0.0004	0.0002	0.0003
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0433	0.0838
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0134	0.0256
Loa Loa (eye worm)	hypothetical protein	0.001	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.045	1	1
Schistosoma mansoni	topbp1	0.001	0.0134	0.0201
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.0038	0.048
Entamoeba histolytica	hypothetical protein	0.01	0.2146	0.2767
Loa Loa (eye worm)	kap beta 3 protein	0.0005	0.0038	0.0038
Echinococcus granulosus	tyrosine kinase	0.0005	0.0026	0.0024
Onchocerca volvulus		0.0005	0.0026	0.0046
Echinococcus multilocularis	ferritin	0.0009	0.0112	0.011
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0134	0.1807
Schistosoma mansoni	suppressor of cytokine signaling	0.0004	0.0002	0.0003
Echinococcus multilocularis	snurportin 1	0.0303	0.6699	0.6699
Schistosoma mansoni	beta-hexosaminidase B	0.0175	0.3842	0.5735
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0084	0.0084
Brugia malayi	Sex muscle abnormal protein 5	0.0007	0.0084	0.0084
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0004	0.0002	0.0002
Trichomonas vaginalis	beta-hexosaminidase, putative	0.011	0.237	0.461
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.5101	1
Schistosoma mansoni	ferritin light chain	0.0009	0.0112	0.0167
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0731	0.1091
Trichomonas vaginalis	beta-hexosaminidase B, putative	0.011	0.237	0.461
Brugia malayi	SH2 domain containing protein	0.0004	0.0002	0.0002
Echinococcus granulosus	nibrin	0.001	0.0134	0.0132
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0004	0.0002	0.0002
Brugia malayi	protein-tyrosine kinase	0.0005	0.0026	0.0026
Entamoeba histolytica	DNA repair protein, putative	0.0008	0.0098	0.0123
Echinococcus granulosus	dna repair and recombination protein rad54	0.0008	0.0098	0.0096
Schistosoma mansoni	tensin-related	0.0004	0.0002	0.0003
Echinococcus multilocularis	muscleblind protein 1	0.045	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0575	0.0573
Schistosoma mansoni	apoferritin-2	0.0009	0.0112	0.0167
Trypanosoma brucei	DNA repair and recombination protein RAD54, putative	0.0008	0.0098	0.1301
Loa Loa (eye worm)	SH2 domain-containing protein	0.0004	0.0002	0.0002
Echinococcus granulosus	muscleblind protein	0.045	1	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0002	0.0002
Echinococcus granulosus	beta hexosaminidase subunit beta	0.0175	0.3842	0.3841
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0731	0.1418
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0729	0.9978
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0729	0.1424
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0729	0.0729
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0097	0.0095
Schistosoma mansoni	hypothetical protein	0.0004	0.0002	0.0003
Schistosoma mansoni	ferritin light chain	0.0009	0.0112	0.0167
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0108	0.0106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0575	0.0859
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0004	0.0002	0.0002
Brugia malayi	Pre-SET motif family protein	0.0029	0.0575	0.0575
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0433	0.0838
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0729	0.9978
Schistosoma mansoni	hypothetical protein	0.0303	0.6699	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0553	0.0551
Treponema pallidum	DNA ligase (lig)	0.001	0.0134	1
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0134	0.017

Activities

Activity type	Activity value	Assay description	Source	Reference
Active dose (functional)	= 19 mg kg-1	Inhibition of oubain induced arrythmia in the dog.	ChEMBL.	2754714

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 86117