TDR Targets

Basic information

Technical information

TDR Targets ID: 870672
Name: (2,3-dimethoxyphenyl)-(1-propan-2-ylbenzimida zol-2-yl)methanol
MW: 326.39 | Formula: C19H22N2O3
H donors: 1 H acceptors: 2 LogP: 2.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)cccc1C(c1nc2c(n1C(C)C)cccc2)O
InChi: 1S/C19H22N2O3/c1-12(2)21-15-10-6-5-9-14(15)20-19(21)17(22)13-8-7-11-16(23-3)18(13)24-4/h5-12,17,22H,1-4H3
InChiKey: BPWOPLTZPNDAOR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2,3-dimethoxyphenyl)-(1-isopropylbenzimidazol-2-yl)methanol
(2,3-dimethoxyphenyl)-(1-isopropyl-2-benzimidazolyl)methanol
EU-0069951
Oprea1_036367

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.1227	0.1227
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.016	0.0232
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0083	0.0736	0.5022
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0276	0.5
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0255	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0228	0.1557
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0276	0.1886
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0022	0.0067
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0063	0.0528	0.1639
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0276	0.0858
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0255	0.0792
Schistosoma mansoni	zinc finger protein	0.0063	0.0528	0.1639
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0098	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0134	0.1261	0.2144
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0063	0.0528	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0149
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1154	0.3405
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0236	0.0732
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.016	0.0232
Schistosoma mansoni	ap endonuclease	0.0039	0.0276	0.0858
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0134	0.1261	0.3918
Schistosoma mansoni	hypothetical protein	0.0131	0.1227	0.381
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.0183	0.0311
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0083	0.0736	0.2285
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0099	0.0307
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0134	0.1261	0.3918
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0365	0.1132
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0098	0.0262
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0154	0.1465	0.455
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0158	0.0268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0134	0.1261	0.2144
Brugia malayi	beta-NAC-like protein	0.0034	0.0228	0.0388
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0134	0.1261	0.3918
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.016	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0365	0.0365
Schistosoma mansoni	ap endonuclease	0.0039	0.0276	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0158	0.0268
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0228	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0134	0.1261	0.1261
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0098	0.0262
Brugia malayi	hypothetical protein	0.0201	0.1951	0.3316
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0134	0.1261	0.1261
Schistosoma mansoni	nuclear hormone receptor	0.0063	0.0528	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Schistosoma mansoni	RAR-like nuclear receptor	0.0134	0.1261	0.3918
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0276	0.0469
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.1154	0.3585
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0228	0.0388
Schistosoma mansoni	lozenge	0.0065	0.0547	0.1698
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0256	0.2519	0.7826
Brugia malayi	nuclear hormone receptor	0.0134	0.1261	0.2144
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0146	0.1383	0.2351
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0134	0.1261	0.2144
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0071	0.0606	0.103
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0365	0.1132
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0228	0.0666
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.016	0.0232
Brugia malayi	steroid hormone receptor	0.0134	0.1261	0.2144
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0276	0.0569
Echinococcus multilocularis	muscleblind protein 1	0.0157	0.1499	0.1499
Schistosoma mansoni	coup transcription factor	0.0134	0.1261	0.3918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0134	0.1261	0.2144
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.1227	0.381
Toxoplasma gondii	FATC domain-containing protein	0.003	0.0183	0.0525
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0228	0.0449
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0022	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0606	0.103
Schistosoma mansoni	hypothetical protein	0.0035	0.0236	0.0732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0134	0.1261	0.2144
Brugia malayi	Inositol-1	0.0037	0.0255	0.0433
Echinococcus multilocularis	muscleblind protein	0.0157	0.1499	0.1499
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0134	0.1261	0.3918
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0134	0.1261	0.3918
Echinococcus granulosus	FTZ F1 alpha	0.0134	0.1261	0.3918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0365	0.1132
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0022	0.0037
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0236	0.0236
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0025	0.0043
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0134	0.1261	0.2144
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0063	0.0528	0.0969
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.2416	0.7504
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0124	0.1154	0.3382
Loa Loa (eye worm)	acetyltransferase	0.0175	0.1683	0.286
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0255	0.174
Echinococcus granulosus	transcription factor btf3	0.0034	0.0228	0.0708
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0228	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0134	0.1261	0.2144
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0255	0.0792
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0098	0.0306
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0014	0.0022	0.0067
Loa Loa (eye worm)	steroid hormone receptor	0.0134	0.1261	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0063	0.0528	0.1639
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.016	0.0272
Echinococcus granulosus	thymidylate synthase	0.0324	0.3219	1
Brugia malayi	nuclear receptor RXR	0.0063	0.0528	0.0897
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0134	0.1261	0.2144
Schistosoma mansoni	thyroid hormone receptor	0.0265	0.2615	0.8124
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.016	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0028	0.016	0.0272
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0228	0.0449
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0134	0.1261	0.2144
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0276	0.0858
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0228	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0023	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.016	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0149
Schistosoma mansoni	thyroid hormone receptor	0.0265	0.2615	0.8124
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0228	0.1557
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0134	0.1261	0.3918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus granulosus	transcription factor Dp 1	0.0085	0.0747	0.2321
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0146	0.1383	0.4297
Brugia malayi	hypothetical protein	0.0063	0.0528	0.0897
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.016	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0236	0.0401
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1154	0.3405
Brugia malayi	orphan nuclear receptor NR2E1	0.0063	0.0528	0.0897
Echinococcus granulosus	death domain containing protein	0.0014	0.0022	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0063	0.0528	0.0528
Brugia malayi	hypothetical protein	0.0154	0.1465	0.2489
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.1383	0.4297
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0022	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Brugia malayi	Muscleblind-like protein	0.0157	0.1499	0.2548
Loa Loa (eye worm)	hypothetical protein	0.052	0.5246	0.8916
Onchocerca volvulus		0.0324	0.3219	0.612
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0134	0.1261	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2447	0.4159
Echinococcus multilocularis	Ankyrin	0.0015	0.0023	0.0023
Echinococcus multilocularis	Protein lozenge	0.0065	0.0547	0.0547
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0146	0.1383	0.4297
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.016	0.0198
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0098	0.0098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0134	0.1261	0.2144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0405	0.1218
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0088	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0276	0.0602
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0236	0.0732
Echinococcus granulosus	lamin dm0	0.0028	0.0158	0.049
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.016	0.0232
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0098	0.0098
Onchocerca volvulus		0.052	0.5246	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0324	0.3219	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0098	0.0167
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0361	0.4114
Echinococcus granulosus	GPCR family 2	0.0035	0.0236	0.0732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Onchocerca volvulus		0.0028	0.016	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1499	0.2548
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0158	0.0268
Schistosoma mansoni	hypothetical protein	0.0035	0.0236	0.0732
Schistosoma mansoni	nuclear receptor nhr-48	0.0063	0.0528	0.1639
Brugia malayi	tailless protein	0.0063	0.0528	0.0897
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0146	0.1383	0.4117
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.0183	0.0525
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0139	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0146	0.1383	1
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0228	0.0228
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0098	0.0306
Schistosoma mansoni	nuclear hormone receptor	0.0063	0.0528	0.1639
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0063	0.0528	0.1639
Echinococcus granulosus	jun protein	0.0256	0.2519	0.7826
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0657	0.1117
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0098	0.0167
Loa Loa (eye worm)	inositol-1	0.0037	0.0255	0.0433
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0098	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0015	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2416	0.4106
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0256	0.2519	0.2519
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0134	0.1261	0.3918
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0063	0.0528	0.1639
Schistosoma mansoni	lamin	0.0028	0.0158	0.049
Brugia malayi	Nuclear hormone receptor E75	0.0063	0.0528	0.0897
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0134	0.1261	0.3918
Schistosoma mansoni	nuclear receptor	0.0063	0.0528	0.1639
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0134	0.1261	0.2144
Echinococcus multilocularis	transcription factor Dp 1	0.0085	0.0747	0.0747
Brugia malayi	hypothetical protein	0.0078	0.0682	0.1159
Toxoplasma gondii	aldehyde dehydrogenase	0.0124	0.1154	0.3555
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0098	0.0167
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.001	0.001
Brugia malayi	Nuclear hormone receptor-like 1	0.0071	0.0606	0.103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Brugia malayi	Nuclear hormone receptor E75	0.0063	0.0528	0.0897
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0134	0.1261	0.3918
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0146	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Echinococcus multilocularis	lamin	0.0028	0.0158	0.0158
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0255	0.0501
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0134	0.1261	0.1261
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.016	0.0232
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0111	0.102	0.1734
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0255	0.075
Brugia malayi	thymidylate synthase	0.0324	0.3219	0.5471
Schistosoma mansoni	nuclear hormone receptor	0.0134	0.1261	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Toxoplasma gondii	exonuclease III APE	0.0039	0.0276	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0255	0.0255
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0365	0.1132
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0276	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0111	0.102	0.1734
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0365	0.062
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0134	0.1261	0.2144
Echinococcus multilocularis	hormone sensitive lipase	0.0246	0.2416	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0606	0.103
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0228	0.1557
Brugia malayi	ecdysone receptor	0.0063	0.0528	0.0897
Loa Loa (eye worm)	hypothetical protein	0.052	0.5246	0.8916
Brugia malayi	Uncoordinated protein 44	0.0014	0.0022	0.0037
Entamoeba histolytica	hypothetical protein	0.003	0.0183	0.1322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0022	0.0022
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0098	0.0262
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.0635	0.0635
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0015	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Onchocerca volvulus		0.0063	0.0528	0.0969
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0134	0.1261	0.2144
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0063	0.0528	0.1639
Echinococcus multilocularis	lamin dm0	0.0028	0.0158	0.0158
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0134	0.1261	0.3918
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0111	0.102	0.1734
Schistosoma mansoni	hypothetical protein	0.0076	0.0657	0.2041
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0098	0.0306
Mycobacterium ulcerans	thymidylate synthase	0.0324	0.3219	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0005	0.0008
Brugia malayi	nuclear receptor RXR	0.0071	0.0606	0.103
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0063	0.0528	0.0528
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0158	0.049
Schistosoma mansoni	lamin	0.0028	0.0158	0.049
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0276	0.0816
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0083	0.0736	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0071	0.0606	0.1883
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.0183	0.0568
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0255	0.1842
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0134	0.1261	0.2144
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.016	0.0269
Echinococcus multilocularis	jun protein	0.0256	0.2519	0.2519
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0236	0.0401
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0276	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0083	0.0736	0.5022
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0111	0.102	0.1734
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0071	0.0606	0.1883
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0405	0.1258
Echinococcus granulosus	ecdysone induced protein 78C	0.0134	0.1261	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0028	0.016	0.0272
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0083	0.0736	0.5022
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.1683	0.286
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0022	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Echinococcus multilocularis	FTZ F1 alpha	0.0134	0.1261	0.1261
Echinococcus multilocularis	musashi	0.0028	0.0158	0.0158
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0098	0.0306
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.016	0.0232
Echinococcus granulosus	lamin	0.0028	0.0158	0.049
Loa Loa (eye worm)	nuclear hormone receptor	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0276	0.2789
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.0682	0.2118
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.001	0.0032
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0606	0.103
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0265	0.2615	0.2615
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0071	0.0606	0.0606
Brugia malayi	hypothetical protein	0.052	0.5246	0.8916
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0276	0.0602
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0071	0.0606	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0736	0.125
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1465	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0255	0.174
Schistosoma mansoni	retinoic acid receptor RXR	0.0134	0.1261	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0606	0.103
Loa Loa (eye worm)	thymidylate synthase	0.0324	0.3219	0.5471
Echinococcus multilocularis	ecdysone induced protein 78C	0.0134	0.1261	0.1261
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0236	0.0401
Schistosoma mansoni	nuclear receptor	0.0063	0.0528	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0139	0.0237
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.0635	0.1973
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0025	0.0043
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0255	0.0792
Loa Loa (eye worm)	runx1	0.0065	0.0547	0.0929
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.2416	0.7504
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0063	0.0528	0.0969
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0134	0.1261	0.2144
Entamoeba histolytica	hypothetical protein	0.0078	0.0682	0.4928
Echinococcus granulosus	hormone sensitive lipase	0.0246	0.2416	0.7504
Entamoeba histolytica	hypothetical protein	0.0034	0.0228	0.1648
Brugia malayi	conserved hypotetical protein	0.0063	0.0528	0.0897
Brugia malayi	nuclear receptor NHR-67	0.0063	0.0528	0.0897
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0023	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Brugia malayi	photoreceptor-specific nuclear receptor	0.0134	0.1261	0.2144
Brugia malayi	hypothetical protein	0.0071	0.0606	0.103
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.016	0.1158
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0098	0.0262
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0255	0.075
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0276	0.1996
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.0099	0.0001
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.1632	0.5069
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0063	0.0528	0.0528
Brugia malayi	hypothetical protein	0.0071	0.0606	0.103
Brugia malayi	intermediate filament protein	0.0028	0.0158	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0017
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0098	0.0306
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0124	0.1154	0.343
Onchocerca volvulus		0.0063	0.0528	0.0969
Brugia malayi	Death domain containing protein	0.0014	0.0022	0.0037
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0405	0.2765
Onchocerca volvulus	Protein ultraspiracle homolog	0.0134	0.1261	0.2373
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.016	0.0272
Schistosoma mansoni	hypothetical protein	0.0208	0.2024	0.6286
Onchocerca volvulus		0.0134	0.1261	0.2373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.1383	0.4271
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0134	0.1261	0.2144
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.0682	0.2118
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0405	0.1218
Mycobacterium ulcerans	hypothetical protein	0.0028	0.016	0.0232
Entamoeba histolytica	hypothetical protein	0.0078	0.0682	0.4928
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.1154	0.3585
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.016	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.0682	0.0682
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0183	0.1248
Mycobacterium tuberculosis	Hypothetical protein	0.0154	0.1465	0.4418
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0149
Schistosoma mansoni	chromatin regulatory protein sir2	0.0083	0.0736	0.2285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Onchocerca volvulus		0.0201	0.1951	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0005	0.0008
Echinococcus granulosus	intermediate filament protein	0.0028	0.0158	0.049
Schistosoma mansoni	hypothetical protein	0.0035	0.0236	0.0732
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0134	0.1261	0.3918
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0215	0.0178
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0361	0.2607
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0083	0.0736	0.5022
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0405	0.1013
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0158	0.0268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0134	0.1261	0.3918
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0255	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.0025
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0098	0.0306
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0276	0.1886
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0022	0.0067
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0255	0.174
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0361	0.0872
Brugia malayi	nuclear hormone receptor family member odr-7	0.0063	0.0528	0.0897
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0276	0.0469
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0088	0.0037
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0098	0.0262
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0276	0.0276
Brugia malayi	Nuclear hormone receptor-like 1	0.0071	0.0606	0.103
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0236	0.0236
Brugia malayi	bZIP transcription factor family protein	0.0256	0.2519	0.4282
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.0183	0.0568
Echinococcus granulosus	muscleblind protein	0.0157	0.1499	0.4656
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0134	0.1261	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0149
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0022	0.0022
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0276	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.1383	0.4297
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0134	0.1261	0.2144
Brugia malayi	nuclear receptor NHR-88	0.0134	0.1261	0.2144
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0146	0.1383	0.2351
Echinococcus multilocularis	thymidylate synthase	0.0324	0.3219	0.3219
Echinococcus granulosus	thyroid hormone receptor alpha	0.0063	0.0528	0.1639
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0255	0.0792
Brugia malayi	small heat shock protein	0.0581	0.5884	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0098	0.0712
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0405	0.2765
Echinococcus granulosus	nuclear receptor nhr 48	0.0063	0.0528	0.1639
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0324	0.3219	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0622	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0037
Schistosoma mansoni	hypothetical protein	0.0035	0.0236	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.0897
Brugia malayi	latrophilin 2 splice variant baaae	0.0076	0.0657	0.1117
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0063	0.0528	0.0528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0228	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1499	0.2548
Schistosoma mansoni	jun-related protein	0.0208	0.2024	0.6286
Schistosoma mansoni	hypothetical protein	0.0078	0.0682	0.2118
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0098	0.0306
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0134	0.1261	0.3918
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.2379	0.4042
Entamoeba histolytica	hypothetical protein	0.0078	0.0682	0.4928
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0228	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0149
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0236	0.0401
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0022	0.0037
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.016	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0152	0.0259
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.1683	0.5227
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.2416	0.7504
Echinococcus granulosus	Ankyrin	0.0015	0.0023	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0134	0.1261	0.2144
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0083	0.0736	0.125
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0098	0.0672
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0063	0.0528	0.0897
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0063	0.0528	0.0528
Onchocerca volvulus		0.0028	0.0158	0.026
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0324	0.3219	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.016	0.0232
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0098	0.0712
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0134	0.1261	0.3918
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0098	0.0306
Echinococcus multilocularis	nuclear receptor nhr 48	0.0063	0.0528	0.0528
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.2379	0.4042
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0134	0.1261	0.2373
Loa Loa (eye worm)	hypothetical protein	0.0028	0.016	0.0272
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0124	0.1154	0.3585
Onchocerca volvulus		0.0028	0.0158	0.026
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0083	0.0736	0.0736
Brugia malayi	hypothetical protein	0.0063	0.0528	0.0897
Loa Loa (eye worm)	DR-78	0.0063	0.0528	0.0897
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0134	0.1261	0.2144
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0098	0.0306
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0124	0.1154	0.1154
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1154	0.3405
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0581	0.5884	1
Brugia malayi	nuclear receptor NHR-88	0.0063	0.0528	0.0897
Onchocerca volvulus	Bile acid receptor homolog	0.0134	0.1261	0.2373
Brugia malayi	Steroid receptor seven-up type 2	0.0134	0.1261	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1261	0.2144
Brugia malayi	nuclear hormone receptor	0.0063	0.0528	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0606	0.103
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0365	0.062
Brugia malayi	Nuclear hormone receptor-like 1	0.0134	0.1261	0.2144
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0276	0.0637
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0215	0.0442
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0134	0.1261	0.1261
Echinococcus granulosus	serine protein kinase ATM	0.003	0.0183	0.0568
Entamoeba histolytica	hypothetical protein	0.0078	0.0682	0.4928
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.0183	0.0183
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.1683	0.1683
Brugia malayi	ecdysteroid receptor	0.0134	0.1261	0.2144
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0365	0.1132
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0134	0.1261	0.2144
Schistosoma mansoni	transcription factor btf3	0.0034	0.0228	0.0708
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0324	0.3219	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	9.1962 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1486615
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 870672