TDR Targets

Basic information

Technical information

TDR Targets ID: 873371
Name: 4-[(1,4-dioxo-3,6,7,8,9,9a-hexahydropyrido[2, 1-c]pyrazin-2-yl)methyl]-N-(3-methoxypropyl)b enzamide
MW: 373.446 | Formula: C20H27N3O4
H donors: 1 H acceptors: 3 LogP: 0.92 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCCNC(=O)c1ccc(cc1)CN1CC(=O)N2C(C1=O)CCCC2
InChi: 1S/C20H27N3O4/c1-27-12-4-10-21-19(25)16-8-6-15(7-9-16)13-22-14-18(24)23-11-3-2-5-17(23)20(22)26/h6-9,17H,2-5,10-14H2,1H3,(H,21,25)
InChiKey: QCUSRGODQKJSPN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(1,4-diketo-3,6,7,8,9,9a-hexahydropyrido[2,1-c]pyrazin-2-yl)methyl]-N-(3-methoxypropyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	heat shock protein, putative	0.005	0.1469	0.3788
Trypanosoma cruzi	heat shock protein 85, putative	0.0054	0.159	0.4231
Leishmania major	DNA damage repair protein, putative	0.0019	0.0324	0.0749
Brugia malayi	hypothetical protein	0.0019	0.0315	0.0315
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0036	0.0926	0.2511
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0038	0.102	0.2664
Loa Loa (eye worm)	hypothetical protein	0.003	0.0701	0.0701
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0012	0.0066	0.0179
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0062	0.1903	0.2091
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0062	0.1903	0.5158
Leishmania major	DNA polymerase eta, putative	0.0049	0.1423	0.3771
Trypanosoma brucei	heat shock protein 84, putative	0.0036	0.0926	0.2406
Trypanosoma brucei	hypothetical protein, conserved	0.0019	0.0324	0.0749
Trypanosoma brucei	unspecified product	0.0043	0.1192	0.3137
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Brugia malayi	polk-prov protein	0.0051	0.1471	0.1471
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.3689	0.4054
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0012	0.0066	0.0179
Trypanosoma brucei	heat shock protein 90, putative	0.0054	0.159	0.4231
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0051	0.1477	0.3919
Trypanosoma brucei	DNA polymerase eta, putative	0.0092	0.3003	0.8112
Schistosoma mansoni	DNA helicase recq5	0.0012	0.004	0.0044
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0094	0.3051	0.8213
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1471	0.1471
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.3689	0.3689
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0701	0.1785
Schistosoma mansoni	flap endonuclease-1	0.0028	0.0629	0.0691
Trypanosoma brucei	DNA polymerase kappa, putative	0.0051	0.1471	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0066
Onchocerca volvulus		0.0069	0.214	0.214
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.007	0.2188	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0088	0.2831	0.7674
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1631	0.4241
Loa Loa (eye worm)	RecQ helicase	0.0028	0.0649	0.0649
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0038	0.102	0.2664
Trypanosoma cruzi	heat shock protein 90, putative	0.0046	0.1305	0.3445
Echinococcus multilocularis	bloom syndrome protein	0.0028	0.0649	0.1758
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Schistosoma mansoni	DNA helicase recq1	0.0012	0.004	0.0044
Schistosoma mansoni	DNA polymerase IV / kappa	0.0019	0.0324	0.0355
Trichomonas vaginalis	heat shock protein, putative	0.0054	0.159	0.4128
Brugia malayi	heat shock protein 90	0.0054	0.159	0.159
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0082	0.2614	0.7085
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.3689	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.4765	0.4765
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.1423	0.3771
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0012	0.0066	0.0072
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0046	0.1305	0.3536
Loa Loa (eye worm)	hypothetical protein	0.0012	0.004	0.004
Leishmania major	heat shock protein, putative	0.0036	0.0926	0.2406
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma cruzi	DNA damage repair protein, putative	0.0019	0.0324	0.0749
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0166	0.0317
Entamoeba histolytica	hypothetical protein	0.008	0.2544	0.6797
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.005	0.1469	0.6202
Trypanosoma cruzi	heat shock protein 85, putative	0.0054	0.159	0.4231
Plasmodium vivax	heat shock protein, putative	0.0204	0.7108	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.3689	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Schistosoma mansoni	tsg101-related	0.0068	0.2112	0.232
Mycobacterium ulcerans	heat shock protein 90	0.005	0.1469	0.4199
Echinococcus granulosus	expressed protein	0.0039	0.1054	0.2857
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.1305	0.3329
Trypanosoma brucei	DNA damage repair protein, putative	0.0019	0.0324	0.0749
Brugia malayi	Fli-1 protein	0.0258	0.9102	0.9102
Trichomonas vaginalis	DNA helicase recq, putative	0.0015	0.0166	0.0144
Schistosoma mansoni	DNA polymerase eta	0.0092	0.3003	0.3299
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.2544	0.6896
Giardia lamblia	Grp94/Hsp90	0.005	0.1469	0.3914
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0036	0.0926	0.2511
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.1305	0.3445
Giardia lamblia	Kinase, PLK	0.0111	0.3689	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Echinococcus multilocularis	endoplasmin	0.005	0.1469	0.3981
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Leishmania major	hypothetical protein, conserved	0.003	0.0701	0.1785
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0019	0.0313	0.0027
Schistosoma mansoni	kinase	0.0056	0.1685	0.1851
Loa Loa (eye worm)	endoplasmin	0.0054	0.159	0.159
Echinococcus granulosus	bloom syndrome protein	0.0028	0.0649	0.1758
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Giardia lamblia	Flap structure-specific endonuclease	0.0031	0.0737	0.1908
Brugia malayi	hypothetical protein	0.0082	0.2614	0.2614
Entamoeba histolytica	Flap nuclease, putative	0.0031	0.0737	0.174
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0036	0.0926	0.0926
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.004	0.004
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0115	0.0175
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0012	0.0066	0.0179
Schistosoma mansoni	gabp alpha	0.0085	0.2738	0.3008
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Trypanosoma brucei	DNA polymerase IV, putative	0.0094	0.3051	0.8245
Trypanosoma cruzi	DNA damage repair protein, putative	0.0019	0.0324	0.0749
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.3689	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0101	0.0273
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Schistosoma mansoni	ets-related	0.0012	0.0066	0.0072
Trypanosoma brucei	DNA polymerase kappa, putative	0.0051	0.1471	0.3903
Mycobacterium ulcerans	DNA polymerase IV	0.0094	0.3051	1
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0012	0.0051	0.0015
Schistosoma mansoni	tsg101-related	0.0068	0.2112	0.232
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0026	0.0572	0.1433
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0082	0.2614	0.7085
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0046	0.1305	0.3464
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.004	0.0109
Echinococcus granulosus	heat shock protein 90	0.0054	0.159	0.431
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0295	0.0798
Loa Loa (eye worm)	heat shock protein 90	0.0054	0.159	0.159
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Plasmodium falciparum	heat shock protein 90, putative	0.0031	0.0762	0.1021
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0701	0.0934
Toxoplasma gondii	heat shock protein HSP90	0.0054	0.159	0.2193
Onchocerca volvulus		0.0283	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.1054	0.2628
Schistosoma mansoni	hypothetical protein	0.0071	0.2228	0.2448
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0056	0.1654	0.4306
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0049	0.1423	0.1956
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0295	0.036
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Mycobacterium ulcerans	DNA polymerase IV	0.0094	0.3051	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0066	0.0072
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.3689	0.3689
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0295	0.0669
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.102	0.2664
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0115	0.0175
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0324	0.0749
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0027	0.0608	0.0804
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0324	0.0749
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0295	0.0798
Brugia malayi	Ets-domain containing protein	0.0085	0.2738	0.2738
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0062	0.1903	0.2091
Echinococcus granulosus	ewsr:fli fusion protein type	0.0012	0.0066	0.0179
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0295	0.0669
Echinococcus multilocularis	ets variant gene 4	0.0012	0.0066	0.0179
Echinococcus granulosus	dna polymerase kappa	0.0094	0.3051	0.8269
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Echinococcus granulosus	endoplasmin	0.005	0.1469	0.3981
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0039	0.1054	0.1054
Plasmodium vivax	heat shock protein 90, putative	0.0036	0.0926	0.0928
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.007	0.2188	0.5873
Trypanosoma brucei	DNA polymerase kappa, putative	0.0051	0.1477	0.3919
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Brugia malayi	Flap endonuclease-1	0.0031	0.0737	0.0737
Trichomonas vaginalis	DNA helicase recq, putative	0.0028	0.0649	0.1494
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.005	0.1469	0.3897
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.4765	0.4765
Schistosoma mansoni	heat shock protein	0.0054	0.159	0.1747
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0142	0.4828	0.4828
Loa Loa (eye worm)	pax transcription factor protein 2	0.0283	1	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0295	0.036
Trichomonas vaginalis	endoplasmin, putative	0.0039	0.1048	0.2611
Echinococcus multilocularis	jun protein	0.0088	0.2831	0.7674
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0031	0.0737	0.0985
Plasmodium falciparum	DNA repair protein REV1, putative	0.0019	0.0324	0.0401
Brugia malayi	bZIP transcription factor family protein	0.0088	0.2831	0.2831
Plasmodium falciparum	heat shock protein 90	0.0054	0.159	0.2193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0038	0.102	0.2533
Schistosoma mansoni	endoplasmin	0.0054	0.159	0.1747
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0166	0.0317
Echinococcus multilocularis	dna polymerase kappa	0.0094	0.3051	0.8269
Entamoeba histolytica	hypothetical protein	0.008	0.2544	0.6797
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Schistosoma mansoni	heat shock protein	0.0054	0.159	0.1747
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0166	0.0317
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0026	0.0572	0.1433
Echinococcus granulosus	GA binding protein alpha chain	0.0085	0.2738	0.7421
Plasmodium vivax	heat shock protein 86, putative	0.0054	0.159	0.1902
Schistosoma mansoni	hypothetical protein	0.0012	0.0066	0.0072
Brugia malayi	ImpB/MucB/SamB family protein	0.0062	0.1903	0.1903
Plasmodium falciparum	flap endonuclease 1	0.0031	0.0737	0.0985
Echinococcus multilocularis	heat shock protein 90	0.0046	0.1305	0.3536
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Schistosoma mansoni	hypothetical protein	0.008	0.2544	0.2795
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.004	0.0109
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0523	0.0683
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.004	0.004
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0066	0.0179
Brugia malayi	ImpB/MucB/SamB family protein	0.0092	0.3003	0.3003
Entamoeba histolytica	hypothetical protein	0.008	0.2544	0.6797
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0295	0.0798
Brugia malayi	Ets-domain containing protein	0.0085	0.2738	0.2738
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0012	0.0066	0.0179
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0066	0.0179
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Brugia malayi	hypothetical protein	0.003	0.0701	0.0701
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0062	0.1903	0.5158
Loa Loa (eye worm)	ets-domain-containing protein	0.0012	0.0066	0.0066
Echinococcus multilocularis	GA binding protein alpha chain	0.0085	0.2738	0.7421
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0295	0.0669
Schistosoma mansoni	ets	0.0012	0.0066	0.0072
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.004	0.0000000002756
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.004	0.004
Trypanosoma cruzi	heat shock protein, putative	0.0036	0.0926	0.2406
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Trypanosoma brucei	heat shock protein 90, putative	0.0054	0.159	0.4231
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0701	0.1785
Trypanosoma brucei	hypothetical protein, conserved	0.0019	0.0324	0.0749
Echinococcus multilocularis	protein C ets 2	0.0012	0.0066	0.0179
Echinococcus multilocularis	heat shock protein	0.0054	0.159	0.431
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0012	0.0066	0.0179
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Echinococcus granulosus	ETS transcription factor Elf 5	0.0012	0.0066	0.0179
Plasmodium falciparum	heat shock protein 90, putative	0.0204	0.7108	1
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Echinococcus multilocularis	heat shock protein 90	0.0054	0.159	0.431
Leishmania major	hypothetical protein, conserved	0.0026	0.0572	0.1433
Leishmania major	DNA polymerase eta, putative	0.0092	0.3003	0.8112
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2743	0.2743
Schistosoma mansoni	endoplasmin	0.0054	0.159	0.1747
Brugia malayi	MH2 domain containing protein	0.014	0.4765	0.4765
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2614	0.2614
Plasmodium vivax	flap endonuclease 1, putative	0.0031	0.0737	0.0649
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0295	0.0669
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0012	0.0066	0.0066
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0701	0.0934
Trypanosoma cruzi	Heat shock protein 83, putative	0.0054	0.159	0.4231
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0019	0.0324	0.0401
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0305	0.0374
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0762	0.1811
Brugia malayi	Ets-domain containing protein	0.0012	0.0066	0.0066
Loa Loa (eye worm)	flap endonuclease-1	0.0031	0.0737	0.0737
Leishmania major	heat shock protein 83-1	0.0054	0.159	0.4231
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0295	0.0295
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Schistosoma mansoni	rotamase	0.0039	0.1054	0.1158
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0295	0.0295
Echinococcus granulosus	protein C ets 2	0.0012	0.0066	0.0179
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0324	0.0749
Toxoplasma gondii	heat shock protein 90, putative	0.0054	0.159	0.2193
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.3689	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0295	0.036
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.004	0.0109
Plasmodium vivax	endoplasmin, putative	0.0054	0.159	0.1902
Trichomonas vaginalis	hypothetical protein	0.004	0.1074	0.2685
Treponema pallidum	heat shock protein 90	0.005	0.1469	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0062	0.1903	0.8496
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0088	0.2831	0.7674
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0066	0.0179
Echinococcus granulosus	heat shock protein	0.0054	0.159	0.431
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2285	0.2285
Loa Loa (eye worm)	heat shock protein 75	0.0036	0.0926	0.0926
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1631	0.4241
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0085	0.2738	0.2738
Echinococcus multilocularis	expressed protein	0.0039	0.1054	0.2857
Trypanosoma brucei	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Schistosoma mansoni	jun-related protein	0.0071	0.2228	0.2448
Trypanosoma brucei	DNA damage repair protein, putative	0.0019	0.0324	0.0749
Giardia lamblia	DINP protein human, muc B family	0.007	0.2188	0.5885
Brugia malayi	DNA-binding protein D-ETS-3	0.0012	0.0066	0.0066
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0295	0.0669
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0062	0.1903	0.1903
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0012	0.0066	0.0066
Echinococcus granulosus	ETS transcription factor Elf 1	0.0012	0.0066	0.0179
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0701	0.1785
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.005	0.1469	1
Brugia malayi	hypothetical protein	0.008	0.2544	0.2544
Trypanosoma brucei	DNA polymerase IV, putative	0.0086	0.2766	0.7462
Trichomonas vaginalis	rotamase, putative	0.0038	0.102	0.2533
Toxoplasma gondii	heat shock protein 75, putative	0.0036	0.0926	0.1254
Trypanosoma brucei	DNA polymerase kappa, putative	0.0051	0.1477	0.3919
Trypanosoma cruzi	heat shock protein 85, putative	0.0054	0.159	0.4231
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Brugia malayi	Endoplasmin precursor	0.0054	0.159	0.159
Leishmania major	DNA polymerase kappa, putative	0.007	0.2188	0.5873
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0039	0.1054	0.1054
Trypanosoma brucei	polo-like protein kinase	0.0111	0.3689	1
Brugia malayi	Hsp90 protein	0.0036	0.0926	0.0926
Brugia malayi	hypothetical protein	0.0069	0.214	0.214
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Giardia lamblia	DNA damage repair protein	0.0019	0.0324	0.0776
Trichomonas vaginalis	rotamase, putative	0.0039	0.1054	0.2628
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.2544	0.6896
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0062	0.1903	0.5003
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.005	0.1469	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0701	0.0596
Brugia malayi	transcription factor E74 isoform	0.0012	0.0066	0.0066
Plasmodium falciparum	endoplasmin, putative	0.0039	0.1048	0.1426
Schistosoma mansoni	hypothetical protein	0.0013	0.0101	0.0111
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.102	0.2664
Loa Loa (eye worm)	fli-1 protein	0.0258	0.9102	0.9102
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0066	0.0179
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0166	0.0144
Trypanosoma cruzi	heat shock protein 90, putative	0.0023	0.0441	0.1071
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0295	0.0798
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.1048	0.2611
Plasmodium vivax	DNA repair protein REV1, putative	0.0019	0.0324	0.0043
Trichomonas vaginalis	DNA polymerase eta, putative	0.0094	0.3051	0.8213
Trypanosoma cruzi	heat shock protein 90, putative	0.0054	0.159	0.4231
Entamoeba histolytica	heat shock protein 90, putative	0.0054	0.159	0.4128
Echinococcus granulosus	heat shock protein 90	0.0046	0.1305	0.3536
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0036	0.0926	0.2271
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0295	0.0295
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0295	0.0324
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0054	0.159	0.4247
Loa Loa (eye worm)	D-ets-2 protein	0.0012	0.0066	0.0066
Trypanosoma brucei	heat shock protein, putative	0.0054	0.159	0.4231
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0295	0.0798
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.3689	1
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.2544	0.2795
Entamoeba histolytica	hypothetical protein	0.008	0.2544	0.6797
Trypanosoma brucei	Heat shock protein 83, putative	0.0054	0.159	0.4231
Schistosoma mansoni	blooms syndrome DNA helicase	0.0022	0.0431	0.0473
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0101	0.0273
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0295	0.0798
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0701	0.0934
Brugia malayi	Bloom's syndrome protein homolog	0.0028	0.0649	0.0649
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.3689	0.3689
Schistosoma mansoni	tsg101-related	0.0056	0.1654	0.1817
Trypanosoma brucei	unspecified product	0.0043	0.1192	0.3137
Echinococcus granulosus	jun protein	0.0088	0.2831	0.7674
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0031	0.0737	0.1884
Schistosoma mansoni	ets-related	0.0258	0.9102	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.3689	1
Echinococcus multilocularis	dna polymerase eta	0.0092	0.3003	0.8138
Trypanosoma brucei	unspecified product	0.0086	0.2766	0.7462
Trypanosoma brucei	DNA polymerase IV, putative	0.0094	0.3051	0.8245
Echinococcus granulosus	flap endonuclease 1	0.0031	0.0737	0.1996
Trichomonas vaginalis	flap endonuclease-1, putative	0.0031	0.0737	0.174
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Trypanosoma cruzi	DNA polymerase eta, putative	0.0092	0.3003	0.8112
Toxoplasma gondii	peptidylprolyl isomerase	0.0038	0.102	0.1387
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0031	0.0737	0.1884
Entamoeba histolytica	heat shock protein 90, putative	0.0054	0.159	0.4128
Loa Loa (eye worm)	hypothetical protein	0.0092	0.3003	0.3003
Trypanosoma brucei	DNA polymerase kappa, putative	0.007	0.2188	0.5873
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.004	0.0109
Echinococcus multilocularis	flap endonuclease 1	0.0031	0.0737	0.1996
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Trichomonas vaginalis	heat shock protein, putative	0.005	0.1469	0.3788
Trichomonas vaginalis	DNA helicase recq1, putative	0.0028	0.0649	0.1494
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0094	0.3051	0.8245
Echinococcus granulosus	dna polymerase eta	0.0092	0.3003	0.8138
Schistosoma mansoni	elf1	0.0012	0.0066	0.0072
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0031	0.0737	0.1884
Schistosoma mansoni	heat shock protein	0.0036	0.0926	0.1018
Trypanosoma brucei	chrX additional, unordered contigs	0.0019	0.0324	0.0749
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0014	0.0115	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0066
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3689	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0204	0.7108	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 873371