Detailed information for compound 874883

Basic information

Technical information
  • TDR Targets ID: 874883
  • Name: 4-(2-fluorophenyl)-6-methyl-N-(4-methylphenyl )-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxami de
  • MW: 339.364 | Formula: C19H18FN3O2
  • H donors: 3 H acceptors: 2 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=C(C(N1)c1ccccc1F)C(=O)Nc1ccc(cc1)C)C
  • InChi: 1S/C19H18FN3O2/c1-11-7-9-13(10-8-11)22-18(24)16-12(2)21-19(25)23-17(16)14-5-3-4-6-15(14)20/h3-10,17H,1-2H3,(H,22,24)(H2,21,23,25)
  • InChiKey: CIPUDJMDEIRRKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-fluorophenyl)-2-keto-6-methyl-N-(4-methylphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • STK283485
  • BIM-0032637.P001
  • CBMicro_032655
  • AJ-292/12641059
  • BAS 00944027

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.003 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0094 0.0601 0.1464
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0132 0.0856 0.0849
Echinococcus granulosus expressed protein 0.0017 0.0071 0.0064
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0131 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.016 0.0153
Echinococcus granulosus lamin 0.0029 0.0155 0.0148
Brugia malayi Latrophilin receptor protein 2 0.003 0.016 0.0366
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0268 0.0261
Echinococcus multilocularis expressed protein 0.0017 0.0071 0.0064
Brugia malayi TAR-binding protein 0.0069 0.0424 0.0999
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0074 0.0706
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.003 0.0069
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0087 0.6617
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0424 0.1233
Brugia malayi Muscleblind-like protein 0.0162 0.1059 0.2523
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0147 0.0959 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.006 0.4281
Plasmodium falciparum importin beta, putative 0.0021 0.0102 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.003 0.0056
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0074 0.0706
Loa Loa (eye worm) hypothetical protein 0.0094 0.0601 0.1464
Plasmodium vivax importin-beta 2, putative 0.0021 0.0102 1
Onchocerca volvulus 0.0026 0.0131 0.0379
Loa Loa (eye worm) hypothetical protein 0.0053 0.0321 0.0774
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0618 0.4178 0.4173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.003 0.0071
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0131 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0147 0.0959 0.0953
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0016 0.0064 0.0593
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.016 0.0377
Onchocerca volvulus 0.0052 0.0312 0.0934
Echinococcus multilocularis fos transcription factor 0.0017 0.0071 0.0064
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0063 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.003 0.0056
Schistosoma mansoni ran 0.0016 0.0063 0.0166
Brugia malayi Importin beta-1 subunit 0.0021 0.0102 0.0227
Trichomonas vaginalis ran, putative 0.0016 0.0063 0.0591
Loa Loa (eye worm) RNA binding protein 0.0069 0.0424 0.1028
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0453 0.4678
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0268 0.2738
Loa Loa (eye worm) hypothetical protein 0.003 0.016 0.0377
Schistosoma mansoni hypothetical protein 0.0229 0.1518 0.447
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0101
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.006 0.4593
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.006 0.0556
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.003 0.0071
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0016 0.0064 0.0593
Brugia malayi hypothetical protein 0.0017 0.0071 0.0154
Schistosoma mansoni ran 0.0016 0.0063 0.0166
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0051 0.0302 0.3099
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0007 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0131 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0132 0.0856 0.2093
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0995 0.0989
Schistosoma mansoni hypothetical protein 0.0052 0.0312 0.0902
Brugia malayi bZIP transcription factor family protein 0.0618 0.4178 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.1703 0.4182
Trypanosoma brucei polo-like protein kinase 0.0147 0.0959 1
Schistosoma mansoni fos transcription factor-related 0.0017 0.0071 0.019
Loa Loa (eye worm) hypothetical protein 0.0132 0.0861 0.2105
Brugia malayi Death domain containing protein 0.0132 0.0856 0.2035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0017 0.0071 0.0064
Schistosoma mansoni camp-response element binding protein 0.0017 0.0071 0.019
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0087 0.8375
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.016 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Brugia malayi ecdysteroid receptor 0.0011 0.003 0.0056
Leishmania major importin beta-1 subunit, putative 0.0017 0.0074 0.0706
Schistosoma mansoni ankyrin 23/unc44 0.0132 0.0856 0.2512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0131 1
Echinococcus multilocularis muscleblind protein 0.0162 0.1059 0.1053
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.0071 0.0159
Brugia malayi bZIP transcription factor family protein 0.0017 0.0071 0.0154
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.003 0.0023
Onchocerca volvulus Netrin receptor homolog 0.0132 0.0856 0.2601
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0424 0.1028
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.0071 0.0159
Schistosoma mansoni netrin receptor unc5 0.0132 0.0856 0.2512
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0017 0.0071 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.003 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0011 0.003 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0132 0.0856 0.2035
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0007 0.0546
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.003 0.0023
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0062 0.0133
Echinococcus multilocularis jun protein 0.0618 0.4178 0.4173
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.1703 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.003 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.003 0.0069
Brugia malayi nuclear hormone receptor 0.0011 0.003 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0196
Schistosoma mansoni hypothetical protein 0.003 0.016 0.0452
Brugia malayi serine/threonine-protein kinase plk-2 0.0147 0.0959 0.2283
Echinococcus multilocularis expressed protein 0.0052 0.0311 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.003 0.0056
Leishmania major GTP-binding protein, putative 0.0016 0.0063 0.0591
Echinococcus granulosus netrin receptor unc 5 0.0132 0.0856 0.0849
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0268 0.0261
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0132 0.0861 0.2525
Schistosoma mansoni kinase 0.0075 0.0466 0.1357
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0094 0.0601 0.1424
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.003 0.0023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0131 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Schistosoma mansoni hypothetical protein 0.0044 0.0257 0.0738
Brugia malayi bZIP transcription factor family protein 0.0017 0.0071 0.0154
Loa Loa (eye worm) hypothetical protein 0.0065 0.0397 0.0961
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.006 0.0053
Brugia malayi Uncoordinated protein 44 0.0132 0.0856 0.2035
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0453 0.4678
Onchocerca volvulus 0.0112 0.0722 0.2192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.003 0.0057
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.003 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0063 0.0591
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0155 0.0365
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0268 0.0261
Loa Loa (eye worm) hypothetical protein 0.0162 0.1059 0.2595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.003 0.0057
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0007 0.0546
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.003 0.0023
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0016 0.0064 0.1914
Loa Loa (eye worm) hypothetical protein 0.0112 0.0722 0.1764
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.003 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.003 0.0056
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.003 0.0069
Echinococcus granulosus muscleblind protein 0.0162 0.1059 0.1053
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0397 0.0934
Echinococcus granulosus cAMP responsive element binding protein 3 0.0017 0.0071 0.0064
Echinococcus granulosus snurportin 1 0.0229 0.1518 0.1512
Echinococcus multilocularis cAMP responsive element binding protein 3 0.0017 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Schistosoma mansoni hypothetical protein 0.0017 0.0071 0.019
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0051 0.0302 0.3099
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.003 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.006 0.0556
Brugia malayi CHE-14 protein 0.0046 0.0268 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.003 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.003 0.0023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0062 0.0136
Loa Loa (eye worm) hypothetical protein 0.0132 0.0856 0.2093
Brugia malayi hypothetical protein 0.0112 0.0722 0.1715
Schistosoma mansoni jun-related protein 0.0502 0.3387 1
Echinococcus multilocularis lamin 0.0029 0.0155 0.0148
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.003 0.0057
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0618 0.4178 0.4173
Schistosoma mansoni hypothetical protein 0.0044 0.0257 0.0738
Schistosoma mansoni patched 1 0.0046 0.0268 0.0772
Entamoeba histolytica hypothetical protein 0.0017 0.0074 0.0706
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.003 0.0069
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0063 0.0056
Echinococcus multilocularis GPCR, family 2 0.003 0.016 0.0153
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.003 0.0023
Echinococcus granulosus fos transcription factor 0.0017 0.0071 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0683 0.0677
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.0071 0.019
Schistosoma mansoni ap endonuclease 0.0015 0.006 0.0157
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.006 0.0556
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0234
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0052 0.0045
Toxoplasma gondii exonuclease III APE 0.0015 0.006 0.1795
Echinococcus granulosus FTZ F1 alpha 0.0011 0.003 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.006 0.0556
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0017 0.0071 0.0064
Brugia malayi steroid hormone receptor 0.0011 0.003 0.0056
Echinococcus multilocularis musashi 0.0029 0.0155 0.0148
Schistosoma mansoni hypothetical protein 0.0044 0.0257 0.0738
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0131 1
Echinococcus granulosus death domain containing protein 0.0132 0.0856 0.0849
Brugia malayi RNA, U transporter 1 0.0061 0.0372 0.0874
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0995 0.0989
Toxoplasma gondii peptidylprolyl isomerase 0.0051 0.0302 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0102 0.0996
Schistosoma mansoni hypothetical protein 0.0044 0.0257 0.0738
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.003 0.0023
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0063 0.5928
Loa Loa (eye worm) hypothetical protein 0.0106 0.0683 0.1667
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0102 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0079 0.6071
Schistosoma mansoni rotamase 0.0052 0.0311 0.0898
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0959 0.2818
Echinococcus granulosus tar DNA binding protein 0.0069 0.0424 0.0417
Echinococcus granulosus expressed protein 0.0052 0.0311 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.003 0.0057
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0016 0.0064 0.0593
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0063 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0424 0.1233
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0424 0.1233
Schistosoma mansoni coup transcription factor 0.0011 0.003 0.0069
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0321 0.0929
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.003 0.0056
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.0071 0.0159
Echinococcus granulosus intermediate filament protein 0.0029 0.0155 0.0148
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.003 0.0069
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.016 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0311 0.3187
Onchocerca volvulus Serine\/threonine kinase homolog 0.0147 0.0959 0.2918
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.0071 0.0064
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0683 0.0677
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0007 0.0546
Echinococcus granulosus tumor protein p63 0.0365 0.2452 0.2447
Schistosoma mansoni nuclear hormone receptor 0.0011 0.003 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0079 0.6071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0159
Schistosoma mansoni lamin 0.0029 0.0155 0.0437
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0694 0.2034
Trypanosoma cruzi polo-like protein kinase, putative 0.0147 0.0959 1
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.003 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.003 0.0056
Echinococcus multilocularis snurportin 1 0.0229 0.1518 0.1512
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0051 0.0302 0.3099
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.003 0.0023
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0016 0.0064 0.0593
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0424 0.0417
Entamoeba histolytica serine/threonine protein kinase, putative 0.0147 0.0959 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.003 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0131 0.13
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0312 0.0731
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.003 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.006 0.0053
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0683 0.1621
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0063 0.0056
Mycobacterium ulcerans hypothetical protein 0.0026 0.0131 1
Echinococcus granulosus cyclic AMP dependent transcription factor ATF 6 0.0017 0.0071 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0424 0.1233
Schistosoma mansoni survival motor neuron protein 0.0052 0.0312 0.0902
Echinococcus multilocularis protein dispatched 1 0.0052 0.0312 0.0305
Echinococcus multilocularis nuclear factor of activated T cells 5 0.147 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0102 0.3215
Trichomonas vaginalis rotamase, putative 0.0051 0.0302 0.3099
Schistosoma mansoni hypothetical protein 0.003 0.016 0.0452
Echinococcus granulosus GPCR family 2 0.003 0.016 0.0153
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0051 0.0302 0.3099
Onchocerca volvulus 0.0017 0.0071 0.0197
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0147 0.0959 0.2349
Trichomonas vaginalis rotamase, putative 0.0052 0.0311 0.3187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.003 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0162 0.1059 0.2595
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0131 1
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.006 0.0556
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0063 0.5928
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0196
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0063 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.003 0.0056
Schistosoma mansoni ap endonuclease 0.0015 0.006 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0101
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0683 0.7099
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0007 0.0546
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0063 0.0036
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0155 0.0365
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0063 0.1906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.003 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.003 0.0023
Schistosoma mansoni hypothetical protein 0.0065 0.0397 0.1153
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0007 0.0546
Schistosoma mansoni lamin 0.0029 0.0155 0.0437
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0424 0.1233
Brugia malayi intermediate filament protein 0.0029 0.0155 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Brugia malayi Protein kinase domain containing protein 0.0132 0.0859 0.2043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.003 0.0023
Echinococcus multilocularis cyclic AMP dependent transcription factor ATF 6 0.0017 0.0071 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0131 0.13
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.003 0.0056
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0087 0.8375
Brugia malayi hypothetical protein 0.0485 0.3271 0.7826
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0305
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0074 0.0706
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.0071 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0877 0.5948 0.5945
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0052 0.0045
Echinococcus granulosus importin subunit beta 1 0.0021 0.0102 0.0095
Schistosoma mansoni hypothetical protein 0.0502 0.3387 1
Echinococcus granulosus Ankyrin 0.0132 0.0861 0.0854
Loa Loa (eye worm) hypothetical protein 0.0046 0.0268 0.0643
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0051 0.0302 0.3099
Echinococcus multilocularis Ankyrin 0.0132 0.0861 0.0854
Brugia malayi bZIP transcription factor family protein 0.0017 0.0071 0.0154
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.006 0.0131
Schistosoma mansoni hypothetical protein 0.003 0.016 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0079 0.6071
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.006 0.5583
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.006 0.5583
Schistosoma mansoni thyroid hormone receptor 0.0011 0.003 0.0069
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0131 0.13
Loa Loa (eye worm) hypothetical protein 0.0056 0.0338 0.0816
Onchocerca volvulus 0.0053 0.0321 0.0962
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0087 0.5
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.0071 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.003 0.0057
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0131 0.13
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0147 0.0959 0.0953
Echinococcus multilocularis protein patched 0.0046 0.0268 0.0261
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0087 0.6421
Trypanosoma cruzi polo-like protein kinase, putative 0.0147 0.0959 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0102 0.0996
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.006 0.0556
Giardia lamblia Kinase, PLK 0.0147 0.0959 1
Echinococcus granulosus lamin dm0 0.0029 0.0155 0.0148
Schistosoma mansoni hypothetical protein 0.0132 0.0856 0.2512
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0131 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0074 0.0706
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0007 0.0546
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.016 0.0153
Loa Loa (eye worm) hypothetical protein 0.0029 0.0155 0.0365
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.003 0.0056
Entamoeba histolytica Ran family GTPase 0.0016 0.0063 0.0591
Onchocerca volvulus 0.0029 0.0155 0.0453
Brugia malayi hypothetical protein 0.0256 0.1703 0.4066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0424 0.1028
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0132 0.0856 0.0849
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0052 0.0311 0.0728
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0007 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0424 0.0999
Brugia malayi bZIP transcription factor family protein 0.0017 0.0071 0.0154
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0196
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0311 0.0748
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0356
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0268 0.0643
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.003 0.0069
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0016 0.0064 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0131 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.016 0.0366
Echinococcus multilocularis lamin dm0 0.0029 0.0155 0.0148
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.006 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.003 0.0056
Onchocerca volvulus 0.0485 0.3271 1
Echinococcus multilocularis muscleblind protein 1 0.0162 0.1059 0.1053
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0007 0.0546
Echinococcus granulosus expressed conserved protein 0.01 0.0639 0.0632
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.003 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.003 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0131 0.0297
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.006 0.5
Onchocerca volvulus 0.0029 0.0155 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.003 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0601 0.4062 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0131 0.13
Schistosoma mansoni hypothetical protein 0.003 0.016 0.0452
Echinococcus multilocularis expressed conserved protein 0.01 0.0639 0.0632
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0131 0.13
Schistosoma mansoni importin beta-1 0.0021 0.0102 0.0281
Onchocerca volvulus 0.0011 0.003 0.0071
Brugia malayi RNA binding protein 0.0069 0.0424 0.0999
Echinococcus multilocularis tumor protein p63 0.0365 0.2452 0.2447
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0094 0.0601 0.1424
Echinococcus multilocularis netrin receptor unc 5 0.0132 0.0856 0.0849
Brugia malayi nuclear receptor NHR-88 0.0011 0.003 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0079 0.6071
Schistosoma mansoni intermediate filament proteins 0.0029 0.0155 0.0437
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0131 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0063 0.0591
Echinococcus granulosus jun protein 0.0618 0.4178 0.4173
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0131 0.0297
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0229 0.1518 0.3725
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0131 0.0297
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.1703 0.1697
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0155 0.0354
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.006 0.0556
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.0071 0.019
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0007 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0007 0.0546

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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