Detailed information for compound 883922

Basic information

Technical information
  • TDR Targets ID: 883922
  • Name: 3-chloro-1-(5-chloro-2-methoxyphenyl)-4-[[3-( trifluoromethyl)phenyl]amino]pyrrole-2,5-dion e
  • MW: 431.193 | Formula: C18H11Cl2F3N2O3
  • H donors: 1 H acceptors: 2 LogP: 5.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N1C(=O)C(=C(C1=O)Cl)Nc1cccc(c1)C(F)(F)F)Cl
  • InChi: 1S/C18H11Cl2F3N2O3/c1-28-13-6-5-10(19)8-12(13)25-16(26)14(20)15(17(25)27)24-11-4-2-3-9(7-11)18(21,22)23/h2-8,24H,1H3
  • InChiKey: BZRNEXIBTRHCIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-1-(5-chloro-2-methoxy-phenyl)-4-[[3-(trifluoromethyl)phenyl]amino]pyrrole-2,5-dione
  • 3-chloro-1-(5-chloro-2-methoxy-phenyl)-4-[[3-(trifluoromethyl)phenyl]amino]-3-pyrroline-2,5-quinone
  • ZINC00947523
  • ST5190663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0543 0.3158
Schistosoma mansoni thyroid hormone receptor 0.014 0.2452 0.4358
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0718 0.1277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0229 0.1696
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0528 0.4188
Mycobacterium tuberculosis Conserved protein 0.0075 0.1225 0.1151
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0543 0.4319
Loa Loa (eye worm) beta-lactamase 0.0075 0.1225 0.1225
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0229 0.0229
Brugia malayi beta-lactamase family protein 0.0075 0.1225 0.1225
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0229 0.0406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Loa Loa (eye worm) thioredoxin reductase 0.0065 0.1031 0.1031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0543 0.0925
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0543 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0229 0.07
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Loa Loa (eye worm) animal heme peroxidase 0.0241 0.4357 0.4357
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.2255 0.4008
Plasmodium falciparum glutathione reductase 0.0065 0.1031 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0543 0.4319
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.2255 0.4008
Brugia malayi Animal haem peroxidase family protein 0.0241 0.4357 0.4357
Schistosoma mansoni hypothetical protein 0.013 0.2255 0.4008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0229 0.1696
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0051 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0073 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1225 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0528 0.4188
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.3068 0.3068
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1225 0.1203
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Onchocerca volvulus Protein cereblon homolog 0.0308 0.5626 0.8664
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1225 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.2452 0.4358
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0131 0.0233
Mycobacterium ulcerans lipase LipD 0.0075 0.1225 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0135
Onchocerca volvulus Peroxidasin homolog 0.0241 0.4357 0.671
Brugia malayi Animal haem peroxidase family protein 0.0241 0.4357 0.4357
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.3068 0.5452
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.3068 0.5452
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0718 0.1277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0718 0.1277
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0073 0.0398
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.1031 0.8385
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1225 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0065 0.1031 0.1833
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Schistosoma mansoni alpha glucosidase 0.0038 0.0528 0.0938
Echinococcus multilocularis peroxidasin 0.0241 0.4357 0.7745
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1225 0.1151
Onchocerca volvulus 0.0241 0.4357 0.671
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1089 0.1089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0718 0.1277
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1089 0.1935
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0229 0.1696
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0528 0.0504
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.054 1 1
Schistosoma mansoni thyroid hormone receptor 0.014 0.2452 0.4358
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0543 0.0966
Loa Loa (eye worm) RecQ helicase 0.0022 0.0219 0.0219
Toxoplasma gondii ABC1 family protein 0.0075 0.1225 1
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0229 0.1292
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0528 0.0897
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0229 0.1696
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0718 0.1277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0718 0.1277
Schistosoma mansoni peroxidasin 0.0241 0.4357 0.7745
Schistosoma mansoni peroxidasin 0.0241 0.4357 0.7745
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0543 0.4042
Echinococcus granulosus thioredoxin glutathione reductase 0.0065 0.1031 0.1833
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0229 0.1267
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0528 0.0504
Schistosoma mansoni hypothetical protein 0.0308 0.5626 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1089 0.8866
Loa Loa (eye worm) inositol-1 0.0039 0.0543 0.0543
Brugia malayi follicle stimulating hormone receptor 0.0239 0.4314 0.4314
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0528 0.0504
Entamoeba histolytica hypothetical protein, conserved 0.0308 0.5626 1
Onchocerca volvulus 0.0075 0.1225 0.1886
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1225 0.1203
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0073 0.0048
Loa Loa (eye worm) hypothetical protein 0.0327 0.5982 0.5982
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1225 0.1151
Loa Loa (eye worm) hypothetical protein 0.0013 0.0051 0.0051
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0229 0.5
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0073 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0065 0.1031 0.8301
Onchocerca volvulus Dual oxidase homolog 0.0241 0.4357 0.671
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1225 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Schistosoma mansoni lamin 0.0027 0.0317 0.0563
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0317 0.0563
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1225 0.1225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1225 0.2177
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.6854 0.6846
Plasmodium vivax glutathione reductase, putative 0.0065 0.1031 0.8301
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0528 0.0504
Toxoplasma gondii thioredoxin reductase 0.0065 0.1031 0.8306
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1089 0.1899
Loa Loa (eye worm) hypothetical protein 0.0027 0.0307 0.0307
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0229 0.1696
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.4314 0.4314
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0528 0.3905
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0317 0.0317
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0219 0.0389
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Plasmodium falciparum thioredoxin reductase 0.0065 0.1031 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0219 0.0194
Onchocerca volvulus 0.0241 0.4357 0.671
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0229 0.0204
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Brugia malayi hypothetical protein 0.0241 0.4357 0.4357
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1089 0.1935
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1089 0.8866
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0065 0.1031 0.0927
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Echinococcus multilocularis protein cereblon 0.0308 0.5626 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0073 0.0085
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0073 0.0398
Schistosoma mansoni hypothetical protein 0.0175 0.3103 0.5516
Loa Loa (eye worm) animal heme peroxidase 0.0241 0.4357 0.4357
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0116 0.0116
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0229 0.1696
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Loa Loa (eye worm) glutathione reductase 0.0065 0.1031 0.1031
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0229 0.0204
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0528 0.0504
Schistosoma mansoni alpha-glucosidase 0.0149 0.2613 0.4644
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0073 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0718 0.0718
Loa Loa (eye worm) blistered cuticle protein 3 0.0241 0.4357 0.4357
Mycobacterium ulcerans hypothetical protein 0.0075 0.1225 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Mycobacterium tuberculosis Conserved protein 0.0075 0.1225 0.1151
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1089 0.8866
Onchocerca volvulus Peroxidase homolog 0.0241 0.4357 0.671
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0229 0.1696
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1225 0.1203
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1225 0.1151
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Trichomonas vaginalis esterase, putative 0.0075 0.1225 0.1203
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0229 0.07
Onchocerca volvulus Peroxidase homolog 0.0241 0.4357 0.671
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Trypanosoma brucei glucosidase, putative 0.0038 0.0528 0.4188
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0051 0.0091
Echinococcus multilocularis musashi 0.0027 0.0317 0.0563
Schistosoma mansoni inositol monophosphatase 0.0039 0.0543 0.0966
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0543 0.0519
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0073 0.0398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0229 0.0406
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Echinococcus granulosus lamin dm0 0.0027 0.0317 0.0563
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1225 0.2177
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.3068 0.3068
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0528 0.0897
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0528 0.0504
Loa Loa (eye worm) animal heme peroxidase 0.0241 0.4357 0.4357
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0229 0.1267
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0073 0.0048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0175 0.3103 0.5516
Echinococcus granulosus peroxidasin 0.0241 0.4357 0.7745
Mycobacterium tuberculosis Conserved protein 0.0075 0.1225 0.1151
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0528 0.0504
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Loa Loa (eye worm) hypothetical protein 0.0027 0.0317 0.0317
Onchocerca volvulus Glucosylceramidase homolog 0.0354 0.6494 1
Onchocerca volvulus Peroxidasin homolog 0.0241 0.4357 0.671
Brugia malayi Blistered cuticle protein 3 0.0241 0.4357 0.4357
Brugia malayi Thioredoxin reductase 0.0065 0.1031 0.1031
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1225 1
Leishmania major hypothetical protein, conserved 0.0075 0.1225 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1225 0.2177
Mycobacterium leprae Probable lipase LipE 0.0075 0.1225 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0073 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0078 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0073 0.0073
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0219 0.0219
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0073 0.0398
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Onchocerca volvulus Chorion peroxidase homolog 0.0241 0.4357 0.671
Schistosoma mansoni lamin 0.0027 0.0317 0.0563
Echinococcus multilocularis lamin dm0 0.0027 0.0317 0.0563
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0528 0.0504
Echinococcus multilocularis lamin 0.0027 0.0317 0.0563
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0073 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1225 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1225 0.1225
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1089 0.8866
Loa Loa (eye worm) animal heme peroxidase 0.0241 0.4357 0.4357
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0219 0.0194
Echinococcus granulosus bloom syndrome protein 0.0022 0.0219 0.0389
Brugia malayi Animal haem peroxidase family protein 0.0241 0.4357 0.4357
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.8885 1
Onchocerca volvulus 0.01 0.1691 0.2604
Onchocerca volvulus 0.0027 0.0317 0.0487
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1225 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0073 0.0048
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0528 0.0938
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0116 0.0116
Treponema pallidum NADH oxidase 0.0023 0.0229 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0528 0.0528
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0317 0.0317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1225 0.2177
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0528 0.0504
Trypanosoma brucei trypanothione reductase 0.0065 0.1031 0.8385
Plasmodium falciparum glutathione reductase 0.0023 0.0229 0.07
Echinococcus granulosus lamin 0.0027 0.0317 0.0563
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0229 0.1696
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1089 0.1935
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1225 0.1151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1225 0.1225
Brugia malayi hypothetical protein 0.0308 0.5626 0.5626
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0229 0.1292
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0229 0.5
Onchocerca volvulus 0.0075 0.1225 0.1886
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0073
Onchocerca volvulus 0.0027 0.0317 0.0487
Onchocerca volvulus 0.0241 0.4357 0.671
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.3068 0.5452
Brugia malayi beta-lactamase family protein 0.0075 0.1225 0.1225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0543 0.4319
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1225 0.1203
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0528 0.4188
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Trichomonas vaginalis glucosylceramidase, putative 0.054 1 1
Leishmania major trypanothione reductase 0.0065 0.1031 0.8385
Brugia malayi intermediate filament protein 0.0027 0.0317 0.0317
Brugia malayi Peroxidasin 0.0241 0.4357 0.4357
Onchocerca volvulus 0.0075 0.1225 0.1886
Echinococcus granulosus protein cereblon 0.0308 0.5626 1
Brugia malayi beta-lactamase 0.0075 0.1225 0.1225
Brugia malayi Animal haem peroxidase family protein 0.0241 0.4357 0.4357
Schistosoma mansoni intermediate filament proteins 0.0027 0.0317 0.0563
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0073 0.0048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0543 0.4319
Mycobacterium ulcerans beta-lactamase 0.0075 0.1225 1
Brugia malayi Inositol-1 0.0039 0.0543 0.0543
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0543 0.0519
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0718 0.0718
Schistosoma mansoni alpha-glucosidase 0.0149 0.2613 0.4644
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1225 0.1151
Brugia malayi hypothetical protein 0.0126 0.2174 0.2174
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.6854 0.6846
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.6494 0.6485
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1225 0.1203
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0547 0.0973
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0528 0.0938
Loa Loa (eye worm) hypothetical protein 0.0308 0.5626 0.5626
Loa Loa (eye worm) hypothetical protein 0.0241 0.4357 0.4357
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0543 0.0966
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0466 0.2379
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0543 0.0519
Plasmodium falciparum thioredoxin reductase 0.0023 0.0229 0.07
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0466 0.0274
Brugia malayi glutathione reductase 0.0065 0.1031 0.1031
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1225 0.1151
Echinococcus granulosus geminin 0.0175 0.3103 0.5516
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0229 0.1696
Brugia malayi Animal haem peroxidase family protein 0.0241 0.4357 0.4357
Echinococcus multilocularis geminin 0.0175 0.3103 0.5516
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1089 0.1089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0229 0.1696
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1225 0.1151
Schistosoma mansoni inositol monophosphatase 0.0039 0.0543 0.0966
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0547 0.0973
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0718 0.1277
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0229 0.0406

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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