TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.496 | Formula: C23H21N3O4S
H donors: 1 H acceptors: 1 LogP: 4.91 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccsc1N1N=C(c2ccc(cc2)N)c2c(C[C@H]1C)cc1c(c2)OCO1
InChi: 1S/C23H21N3O4S/c1-13-9-15-10-19-20(30-12-29-19)11-18(15)21(14-3-5-16(24)6-4-14)25-26(13)22-17(7-8-31-22)23(27)28-2/h3-8,10-11,13H,9,12,24H2,1-2H3/t13-/m1/s1
InChiKey: HILOWXKTDNFWGP-CYBMUJFWSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.016	0.0274	1
Schistosoma mansoni	ferritin light chain	0.0028	0.0019	0.0019
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0104	0.0225
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	1
Onchocerca volvulus		0.0072	0.0104	0.3349
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0257	0.0462	0.4873
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Schistosoma mansoni	hypothetical protein	0.0041	0.0043	0.0043
Toxoplasma gondii	NADPH-glutathione reductase	0.0052	0.0065	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0038	0.0038	0.0405
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0028	0.0019	0.002
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0052	0.0065	0.0686
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0052	0.0065	0.0131
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.0263	0.2773
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0104	0.366
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Plasmodium vivax	thioredoxin reductase, putative	0.015	0.0254	0.9202
Mycobacterium tuberculosis	Probable oxidoreductase	0.0379	0.0698	0.1654
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0104	0.0225
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0046	0.0046
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.2242
Brugia malayi	hypothetical protein	0.0027	0.0018	0.0189
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0341	0.0624	0.1477
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.001	0.011
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0059	0.0624
Echinococcus granulosus	ferritin	0.0028	0.0019	0.0019
Loa Loa (eye worm)	transcription factor SMAD2	0.0267	0.0481	0.5082
Echinococcus multilocularis	thioredoxin glutathione reductase	0.015	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0104	0.1935
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0272	0.2869
Schistosoma mansoni	hypothetical protein	0.0105	0.0168	0.0168
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0379	0.0698	0.1651
Loa Loa (eye worm)	hypothetical protein	0.016	0.0274	0.2897
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0046	0.0046
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0104	0.0226
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0104	0.0226
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0341	0.0624	0.1477
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0154	0.0154
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0154	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0018	0.0308
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0341	0.0624	0.1474
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0052	0.0065	0.1995
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0263	0.2773
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0046	0.0486
Toxoplasma gondii	ABC1 family protein	0.0072	0.0104	0.3368
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0098	0.1038
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0308	0.654
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0807	0.1525	0.1525
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Mycobacterium ulcerans	transcriptional regulator	0.2178	0.4176	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.0065
Trichomonas vaginalis	glutathione reductase, putative	0.0052	0.0065	0.1048
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2178	0.4176	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Schistosoma mansoni	ferritin	0.0028	0.0019	0.0019
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0104	0.366
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0124	0.1306
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	0.0634
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0104	0.0226
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.016	0.0274	0.0274
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0105	0.0168	0.0168
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.016	0.0274	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0104	0.1101
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0104	0.3368
Onchocerca volvulus		0.0072	0.0104	0.3349
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.2242
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0105	0.0168	0.0378
Brugia malayi	MH2 domain containing protein	0.0267	0.0481	0.5082
Loa Loa (eye worm)	hypothetical protein	0.0024	0.001	0.011
Brugia malayi	beta-lactamase	0.0072	0.0104	0.1101
Brugia malayi	beta-lactamase family protein	0.0072	0.0104	0.1101
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0104	0.0226
Brugia malayi	beta-lactamase family protein	0.0072	0.0104	0.1101
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0104	0.366
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.0065
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0257	0.0462	0.4873
Schistosoma mansoni	hypothetical protein	0.0077	0.0114	0.0114
Mycobacterium ulcerans	bacterioferritin BfrB	0.0028	0.0019	0.002
Schistosoma mansoni	hypothetical protein	0.0041	0.0043	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0098	0.0098
Leishmania major	trypanothione reductase	0.015	0.0254	1
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2178	0.4176	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0052	0.0065	0.0131
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0059	0.0624
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0065	0.1995
Echinococcus multilocularis	survival motor neuron protein 1	0.0508	0.0947	0.0947
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0104	0.1935
Brugia malayi	TAR-binding protein	0.0069	0.0098	0.1038
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0098	0.0098
Leishmania major	hypothetical protein, conserved	0.0072	0.0104	0.3855
Schistosoma mansoni	hypothetical protein	0.0049	0.0059	0.0059
Treponema pallidum	NADH oxidase	0.0052	0.0065	0.1815
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0104	0.0226
Schistosoma mansoni	hypothetical protein	0.0041	0.0043	0.0043
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0082	0.0124	0.7878
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0058	0.0058
Plasmodium falciparum	glutathione reductase	0.015	0.0254	0.9202
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0104	0.0226
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0055	0.0071	0.0147
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0104	0.0165	0.1744
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0104	0.0104
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0038	0.0038	0.0405
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0052	0.0065	0.1836
Schistosoma mansoni	hypothetical protein	0.0049	0.0059	0.0059
Echinococcus granulosus	survival motor neuron protein 1	0.0508	0.0947	0.0947
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.016	0.0274	0.0634
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0114	0.0114
Schistosoma mansoni	apoferritin-2	0.0028	0.0019	0.0019
Schistosoma mansoni	ferritin	0.0028	0.0019	0.0019
Loa Loa (eye worm)	glutathione reductase	0.015	0.0254	0.2681
Brugia malayi	Thioredoxin reductase	0.015	0.0254	0.2681
Entamoeba histolytica	hypothetical protein	0.0077	0.0114	0.7224
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0052	0.0065	0.1836
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.015	0.0254	0.0586
Echinococcus granulosus	peptidase Clp S14 family	0.0105	0.0168	0.0168
Brugia malayi	glutathione reductase	0.015	0.0254	0.2681
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0341	0.0624	0.1477
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0104	0.0225
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0059	0.0059
Trypanosoma cruzi	trypanothione reductase, putative	0.015	0.0254	1
Trypanosoma brucei	trypanothione reductase	0.015	0.0254	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.0131
Entamoeba histolytica	hypothetical protein	0.0077	0.0114	0.7224
Schistosoma mansoni	peptidase Clp (S14 family)	0.016	0.0274	0.0274
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0046	0.0486
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0098	0.1038
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0059	0.0624
Plasmodium falciparum	thioredoxin reductase	0.015	0.0254	0.9202
Mycobacterium ulcerans	lipase LipD	0.0072	0.0104	0.0225
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0379	0.0698	0.1654
Echinococcus granulosus	tumor protein p63	0.1085	0.2062	0.2062
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0148	0.0251	0.0251
Schistosoma mansoni	hypothetical protein	0.0137	0.023	0.023
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0052	0.0065	0.2242
Brugia malayi	RNA binding protein	0.0069	0.0098	0.1038
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0105	0.0168	0.0379
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0104	0.1935
Loa Loa (eye worm)	thioredoxin reductase	0.015	0.0254	0.2681
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.001	0.011
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0098	0.0098
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0059	0.0059
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.0065
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0098	0.0098
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0098	0.1038
Brugia malayi	hypothetical protein	0.0077	0.0114	0.1206
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0104	0.0225
Mycobacterium tuberculosis	Probable dehydrogenase	0.0341	0.0624	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0154	0.1628
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0308	0.654
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0098	0.0098
Echinococcus granulosus	GPCR family 2	0.0049	0.0059	0.0059
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0104	0.0226
Schistosoma mansoni	hypothetical protein	0.0049	0.0059	0.0059
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0098	0.0098
Echinococcus granulosus	expressed conserved protein	0.0092	0.0143	0.0143
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0059	0.0624
Toxoplasma gondii	thioredoxin reductase	0.015	0.0254	0.9202
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.0263	0.2773
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0104	0.1935
Onchocerca volvulus	Glucosylceramidase homolog	0.0169	0.0291	1
Toxoplasma gondii	hypothetical protein	0.0055	0.0071	0.2088
Echinococcus multilocularis	protein patched	0.0042	0.0046	0.0046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	1
Mycobacterium tuberculosis	Probable reductase	0.0341	0.0624	0.1477
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0104	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0168	0.1778
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0104	0.1101
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0059	0.0059
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Schistosoma mansoni	hypothetical protein	0.0049	0.0059	0.0059
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0052	0.0065	0.2242
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0104	0.1101
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0052	0.0065	0.1995
Loa Loa (eye worm)	hypothetical protein	0.0024	0.001	0.011
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0157	0.0157
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0059	0.0059
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Schistosoma mansoni	ferritin	0.0028	0.0019	0.0019
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0028	0.0019	0.002
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0028	0.0019	0.002
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0052	0.0065	0.1815
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.0251	0.0251
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Echinococcus multilocularis	tumor protein p63	0.1085	0.2062	0.2062
Loa Loa (eye worm)	MH2 domain-containing protein	0.0267	0.0481	0.5082
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0104	0.0225
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0098	0.0098
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0114	0.0114
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0055	0.0071	0.2088
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0104	0.0226
Plasmodium vivax	glutathione reductase, putative	0.015	0.0254	0.9202
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0052	0.0065	0.1815
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0104	0.0104
Echinococcus multilocularis	microtubule associated protein 2	0.5191	1	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0052	0.0065	0.1995
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0104	0.0104
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0341	0.0624	0.1477
Schistosoma mansoni	hypothetical protein	0.0041	0.0043	0.0043
Schistosoma mansoni	survival motor neuron protein	0.0104	0.0165	0.0165
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0143	0.0143
Schistosoma mansoni	apoferritin-2	0.0028	0.0019	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0046	0.0621
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.1995
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0104	0.1935
Brugia malayi	CHE-14 protein	0.0042	0.0046	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0064	0.0679
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0059	0.0059
Onchocerca volvulus		0.0072	0.0104	0.3349
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0137	0.023	0.023
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0154	0.1628
Trichomonas vaginalis	esterase, putative	0.0072	0.0104	0.1935
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.0235	0.0235
Entamoeba histolytica	hypothetical protein	0.0077	0.0114	0.7224
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0052	0.0065	0.1995
Schistosoma mansoni	cellular tumor antigen P53	0.0159	0.0272	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Loa Loa (eye worm)	hypothetical protein	0.0508	0.0947	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0052	0.0065	0.0131
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0105	0.0168	0.0379
Onchocerca volvulus		0.0159	0.0272	0.9324
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.0168	0.1778
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0052	0.0065	0.1995
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0052	0.0065	0.1836
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0024	0.001	0.011
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0065	0.1836
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.016	0.0274	0.0274
Echinococcus multilocularis	ferritin	0.0028	0.0019	0.0019
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Mycobacterium ulcerans	bacterioferritin BfrA	0.0028	0.0019	0.002
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0052	0.0065	0.1836
Trichomonas vaginalis	glucosylceramidase, putative	0.0257	0.0462	1
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2178	0.4176	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0052	0.0065	0.1995
Schistosoma mansoni	ferritin light chain	0.0028	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0189
Echinococcus granulosus	expressed protein	0.0028	0.0019	0.0019
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	0.0634
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0154	0.0154
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0379	0.0698	0.1654
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0082	0.0124	0.7878
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0055	0.0071	0.2088
Brugia malayi	Probable ClpP-like protease	0.016	0.0274	0.2897
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.016	0.0274	1
Schistosoma mansoni	ferritin	0.0028	0.0019	0.0019
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0104	0.0226
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0461	0.0856	0.2034
Schistosoma mansoni	hypothetical protein	0.0104	0.0165	0.0165
Schistosoma mansoni	patched 1	0.0042	0.0046	0.0046
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0291	0.6144
Entamoeba histolytica	hypothetical protein	0.0077	0.0114	0.7224
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0104	0.1101
Onchocerca volvulus		0.0104	0.0165	0.5521
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	1
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0104	0.0225
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0046	0.0046
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.0263	0.2773
Echinococcus multilocularis	expressed protein	0.0028	0.0019	0.0019
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0052	0.0065	0.1836
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0055	0.0071	0.2068
Echinococcus granulosus	thioredoxin glutathione reductase	0.015	0.0254	0.0254
Schistosoma mansoni	microtubule-associated protein tau	0.5191	1	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.016	0.0274	1
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2174	0.4168	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0137	0.023	0.023
Trichomonas vaginalis	mercuric reductase, putative	0.0052	0.0065	0.1048
Brugia malayi	hypothetical protein	0.0508	0.0947	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0052	0.0065	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0104	0.0104
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.001	0.011
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0098	0.1038
Plasmodium falciparum	glutathione reductase	0.0052	0.0065	0.1836

Activities

Activity type	Activity value	Assay description	Source	Reference
Protection (functional)	= 40 %	Ability to abolish the hindlimb tonic extensor components of a maximal electroshock-induced seizure in vivo at 10 mg/kg	ChEMBL.	10450961
Protection (functional)	= 40 %	Ability to abolish the hindlimb tonic extensor components of a maximal electroshock-induced seizure in vivo at 10 mg/kg	ChEMBL.	10450961

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 88518