Detailed information for compound 886321

Basic information

Technical information
  • TDR Targets ID: 886321
  • Name: N-[(2-chloro-6-fluorophenyl)methyl]-2,5-bis(2 ,2,2-trifluoroethoxy)benzenesulfonamide
  • MW: 495.796 | Formula: C17H13ClF7NO4S
  • H donors: 1 H acceptors: 2 LogP: 5.28 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1CNS(=O)(=O)c1cc(ccc1OCC(F)(F)F)OCC(F)(F)F)Cl
  • InChi: 1S/C17H13ClF7NO4S/c18-12-2-1-3-13(19)11(12)7-26-31(27,28)15-6-10(29-8-16(20,21)22)4-5-14(15)30-9-17(23,24)25/h1-6,26H,7-9H2
  • InChiKey: PWDKNVTYNXTONC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2-chloro-6-fluoro-phenyl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzenesulfonamide
  • N-(2-chloro-6-fluoro-benzyl)-2,5-bis(2,2,2-trifluoroethoxy)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.2221 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.1533 0.1611
Echinococcus multilocularis peregrin 0.0041 0.1467 0.1467
Onchocerca volvulus Alhambra homolog 0.0034 0.1017 0.5
Echinococcus multilocularis zinc finger protein 0.0027 0.0559 0.0559
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.1771 0.7712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0842 0.294
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.2221 1
Giardia lamblia PHD finger protein 15 0.0034 0.1017 0.3844
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.1521 0.6428
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1629 0.1629
Brugia malayi RNA binding protein 0.0074 0.3617 0.3617
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.1521 0.6514
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0097 0.0102
Giardia lamblia GTOR 0.0053 0.2217 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0268 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1518 0.6401
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.2591 0.2591
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.2217 0.2331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0643 0.1919
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Schistosoma mansoni hypothetical protein 0.0024 0.0369 0.0369
Echinococcus multilocularis dna polymerase eta 0.0023 0.0268 0.0268
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0369 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1518 0.6401
Trypanosoma brucei unspecified product 0.0023 0.0268 0.0241
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.2217 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0089 0.4568 0.4568
Loa Loa (eye worm) hypothetical protein 0.0054 0.2313 0.2313
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.1017 0.1017
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0268 0.0241
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.1017 0.1017
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0268 0.0268
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3617 0.3617
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0268 0.0282
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.1885 0.1885
Schistosoma mansoni zinc finger protein 0.0027 0.0559 0.0559
Brugia malayi Bromodomain containing protein 0.0049 0.1983 0.1983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.2221 0.2335
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0268 0.0241
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0268 0.0241
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0515 0.0515
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.1392 0.1392
Loa Loa (eye worm) hypothetical protein 0.0058 0.2601 0.2601
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0268 0.0268
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.1533 0.1533
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.1342 0.2696
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.606 0.6372
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.3377 0.3377
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.1521 0.6428
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.2217 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.361 0.3795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1518 0.6401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.2591 0.2591
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0268 0.0268
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.2217 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0822 0.2837
Echinococcus granulosus dna polymerase eta 0.0023 0.0268 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0842 0.294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0646 0.1933
Schistosoma mansoni hypothetical protein 0.004 0.1392 0.1392
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.2217 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0417 0.0985
Brugia malayi PHD-finger family protein 0.0033 0.0965 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0646 0.1933
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0097 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Loa Loa (eye worm) TAR-binding protein 0.0074 0.3617 0.3617
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2217 0.998
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.2217 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.606 0.606
Brugia malayi PHD-finger family protein 0.0034 0.1017 0.1017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0268 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0643 0.1919
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 1 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0097 0.0102
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.1629 0.1713
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.1484 0.1484
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0268
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0268 0.5
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.2221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0842 0.294
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.3617 0.3617
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0097 0.0097
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.2217 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.2217 0.2217
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0268 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.1017 0.1017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1718 0.7423
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2217 0.998
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0414 0.0414
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.1771 1
Echinococcus granulosus tar DNA binding protein 0.0074 0.3617 0.3803
Schistosoma mansoni bromodomain containing protein 0.0078 0.3882 0.3882
Echinococcus granulosus zinc finger protein 0.0027 0.0559 0.0588
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.3617 0.3617
Loa Loa (eye worm) acetyltransferase 0.0172 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0643 0.1919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0646 0.1933
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0034 0.1017 0.1017
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.2217 0.2217
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.2217 0.2217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.2217 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3617 0.3617
Brugia malayi Bromodomain containing protein 0.0041 0.1467 0.1467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1518 0.6401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0822 0.2837
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1392 0.1392
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3617 0.3617
Echinococcus multilocularis tar DNA binding protein 0.0074 0.3617 0.3617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0268 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0268 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3617 0.3617
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1629 0.1629
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0268 0.0268
Brugia malayi Bromodomain containing protein 0.0092 0.4773 0.4773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1518 0.6401
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0515 0.0541
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.2591 0.2591
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0034 0.1017 0.1017
Echinococcus granulosus peregrin 0.0041 0.1467 0.1543
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0083 0.4177 0.4177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1019 0.3844
Loa Loa (eye worm) hypothetical protein 0.0052 0.2168 0.2168
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3617 0.3617
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.2221 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.1771 0.7712
Loa Loa (eye worm) hypothetical protein 0.0045 0.1718 0.1718
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1629 0.1629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1093 0.4222
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Echinococcus granulosus dna polymerase kappa 0.0023 0.0268 0.0282
Loa Loa (eye worm) hypothetical protein 0.0058 0.2591 0.2591
Brugia malayi jmjC domain containing protein 0.0112 0.606 0.606
Echinococcus granulosus jumonji domain containing protein 0.0047 0.1885 0.1982
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0268 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.2217 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0268 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0646 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1342 0.5498
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.1017 0.107
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0097 0.0097
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.2221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2217 0.998
Brugia malayi TAR-binding protein 0.0074 0.3617 0.3617
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.9511 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.2217 0.2217
Brugia malayi jmjC domain containing protein 0.0043 0.1629 0.1629
Loa Loa (eye worm) RNA binding protein 0.0074 0.3617 0.3617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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