Detailed information for compound 886340

Basic information

Technical information
  • TDR Targets ID: 886340
  • Name: 2-(2,3-dihydro-1,4-benzodioxin-7-yl)-3-(2-met hylsulfanylethyl)-1,3-thiazolidin-4-one
  • MW: 311.42 | Formula: C14H17NO3S2
  • H donors: 0 H acceptors: 1 LogP: 2.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCN1C(=O)CSC1c1ccc2c(c1)OCCO2
  • InChi: 1S/C14H17NO3S2/c1-19-7-4-15-13(16)9-20-14(15)10-2-3-11-12(8-10)18-6-5-17-11/h2-3,8,14H,4-7,9H2,1H3
  • InChiKey: HMDWDKRIJQRBQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,3-dihydro-1,4-benzodioxin-7-yl)-3-(2-methylsulfanylethyl)thiazolidin-4-one
  • 2-(2,3-dihydro-1,4-benzodioxin-7-yl)-3-[2-(methylthio)ethyl]-4-thiazolidinone
  • 2-(2,3-dihydro-1,4-benzodioxin-7-yl)-3-[2-(methylthio)ethyl]thiazolidin-4-one
  • Oprea1_440844

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0144 0.0144
Echinococcus granulosus neuropeptide receptor 0.023 0.1994 0.3746
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Onchocerca volvulus Protein ultraspiracle homolog 0.0121 0.0993 0.0913
Brugia malayi nuclear receptor NHR-88 0.0057 0.0403 0.0403
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0167 0.4715
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0355 0.0666
Onchocerca volvulus Huntingtin homolog 0.0105 0.0842 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121 0.0993 0.0993
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121 0.0993 0.0993
Schistosoma mansoni P2X receptor subunit 0.0068 0.0501 0.094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0105 0.0842 0.0842
Schistosoma mansoni inositol monophosphatase 0.0032 0.0167 0.0313
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0993 0.1866
Echinococcus granulosus intermediate filament protein 0.0023 0.0088 0.0166
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0042 0.0263 1
Echinococcus granulosus ecdysone induced protein 78C 0.0121 0.0993 0.1866
Schistosoma mansoni P2X receptor subunit 0.0068 0.0501 0.094
Onchocerca volvulus 0.0057 0.0403 0.0317
Schistosoma mansoni inositol monophosphatase 0.0032 0.0167 0.0313
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121 0.0993 0.0913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121 0.0993 0.0993
Trichomonas vaginalis ribokinase, putative 0.0042 0.0263 1
Onchocerca volvulus 0.0042 0.0266 0.0179
Loa Loa (eye worm) hypothetical protein 0.0203 0.1742 0.1742
Echinococcus granulosus biogenic amine 5HT receptor 0.0383 0.34 0.6388
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0263 1
Leishmania major adenosine kinase, putative 0.0042 0.0263 0.743
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0266 0.0499
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0052 0.0355 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121 0.0993 0.1866
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0263 1
Brugia malayi hypothetical protein 0.0105 0.0842 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121 0.0993 0.0993
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0057 0.0403 0.0642
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0403 0.0317
Leishmania major adenosine kinase-like protein 0.0042 0.0263 0.743
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0121 0.0993 0.1866
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121 0.0993 0.1866
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121 0.0993 0.0993
Brugia malayi nuclear receptor NHR-88 0.0121 0.0993 0.0993
Echinococcus multilocularis adenosine kinase 0.0042 0.0263 0.042
Schistosoma mansoni P2X receptor subunit 0.0068 0.0501 0.094
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Onchocerca volvulus 0.0121 0.0993 0.0913
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0403 0.0642
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Echinococcus multilocularis ribokinase 0.0042 0.0263 0.042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0355 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0167 0.6332
Trypanosoma brucei adenosine kinase, putative 0.0042 0.0263 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121 0.0993 0.0993
Onchocerca volvulus Huntingtin homolog 0.0105 0.0842 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0993 0.0993
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0256 0.0256
Toxoplasma gondii kinase, pfkB family protein 0.0042 0.0263 0.743
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0403 0.0403
Brugia malayi nuclear receptor NHR-67 0.0057 0.0403 0.0403
Echinococcus multilocularis musashi 0.0023 0.0088 0.014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0 0.5
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0501 0.094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0383 0.34 0.5417
Onchocerca volvulus 0.0041 0.0256 0.0169
Trypanosoma brucei ribokinase, putative 0.0042 0.0263 1
Brugia malayi hypothetical protein 0.0203 0.1742 0.1742
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0403 0.0642
Loa Loa (eye worm) hypothetical protein 0.1099 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0383 0.34 0.6388
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.0993 0.0993
Echinococcus multilocularis microtubule associated protein 2 0.0591 0.5323 0.848
Echinococcus granulosus inositol monophosphatase 1 0.0032 0.0167 0.0313
Mycobacterium tuberculosis Ribokinase RbsK 0.0042 0.0263 0.743
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0167 0.0036
Brugia malayi tailless protein 0.0057 0.0403 0.0403
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121 0.0993 0.1866
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121 0.0993 0.1866
Schistosoma mansoni RAR-like nuclear receptor 0.0121 0.0993 0.1866
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0695 0.6277 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0993 0.1583
Echinococcus granulosus microtubule associated protein 2 0.0591 0.5323 1
Schistosoma mansoni nuclear hormone receptor 0.0121 0.0993 0.1866
Schistosoma mansoni coup transcription factor 0.0121 0.0993 0.1866
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0993 0.0993
Trypanosoma brucei adenosine kinase, putative 0.0042 0.0263 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0167 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0121 0.0993 0.1866
Entamoeba histolytica ribokinase, putative 0.0042 0.0263 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0057 0.0403 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0993 0.0993
Brugia malayi hypothetical protein 0.0057 0.0403 0.0403
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0167 0.6346
Brugia malayi photoreceptor-specific nuclear receptor 0.0121 0.0993 0.0993
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0167 0.0314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0167 0.0036
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0403 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0466 0.0875
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0403 0.0403
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0 0.5
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0263 1
Schistosoma mansoni lamin 0.0023 0.0088 0.0166
Entamoeba histolytica fructokinase, putative 0.0042 0.0263 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0042 0.0263 0.0495
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0167 0.6332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0042 0.0263 0.0263
Brugia malayi nuclear receptor RXR 0.0064 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Schistosoma mansoni intermediate filament proteins 0.0023 0.0088 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.0591 0.5323 1
Schistosoma mansoni ribokinase 0.0042 0.0263 0.0495
Trichomonas vaginalis ribokinase, putative 0.0042 0.0263 1
Onchocerca volvulus 0.0057 0.0403 0.0317
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121 0.0993 0.1583
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0032 0.0167 0.4705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121 0.0993 0.0993
Echinococcus multilocularis ecdysone induced protein 78C 0.0121 0.0993 0.1583
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0403 0.0403
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121 0.0993 0.1866
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.0993 0.1866
Brugia malayi Ribokinase 0.0042 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Echinococcus multilocularis survival motor neuron protein 1 0.0203 0.1742 0.2775
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Toxoplasma gondii kinase, pfkB family protein 0.0042 0.0263 0.743
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121 0.0993 0.1866
Brugia malayi conserved hypotetical protein 0.0057 0.0403 0.0403
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0167 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.0818 0.0818
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0355 0.0666
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0263 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121 0.0993 0.1866
Loa Loa (eye worm) DR-78 0.0057 0.0403 0.0403
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0501 0.094
Schistosoma mansoni hypothetical protein 0.0029 0.0144 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121 0.0993 0.0993
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0167 0.6332
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0263 1
Schistosoma mansoni survival motor neuron protein 0.0041 0.0256 0.0481
Schistosoma mansoni retinoic acid receptor RXR 0.0121 0.0993 0.1866
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0501 0.0798
Mycobacterium leprae Probable adenosine kinase adk 0.0042 0.0263 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0993 0.0993
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0403 0.0757
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0167 0.0266
Brugia malayi nuclear hormone receptor 0.0057 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Echinococcus granulosus adenosine kinase 0.0042 0.0263 0.0495
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0501 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121 0.0993 0.0993
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0167 0.4705
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0403 0.0757
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0167 0.0314
Brugia malayi hypothetical protein 0.0057 0.0403 0.0403
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Schistosoma mansoni adenosine kinase 0.0042 0.0263 0.0495
Leishmania major tagatose-6-phosphate kinase-like protein 0.0042 0.0263 0.743
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Brugia malayi Steroid receptor seven-up type 2 0.0121 0.0993 0.0993
Mycobacterium ulcerans fructokinase, PfkB 0.0042 0.0263 0.5147
Leishmania major putative PfkB family sugar kinase 0.0042 0.0263 0.743
Trichomonas vaginalis ribokinase, putative 0.0042 0.0263 1
Schistosoma mansoni P2X receptor subunit 0.0068 0.0501 0.094
Loa Loa (eye worm) inositol-1 0.0032 0.0167 0.0167
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0501 0.0798
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0403 0.0317
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0052 0.0355 0.0666
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0403 0.0757
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0403 0.0757
Echinococcus multilocularis neuropeptide receptor 0.023 0.1994 0.3177
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0403 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.0993 0.1866
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0167 0.6346
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121 0.0993 0.1866
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0466 0.0466
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0403 0.0757
Echinococcus multilocularis lamin 0.0023 0.0088 0.014
Schistosoma mansoni zinc finger protein 0.0057 0.0403 0.0757
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Brugia malayi hypothetical protein 0.0064 0.0466 0.0466
Toxoplasma gondii aldehyde dehydrogenase 0.0052 0.0355 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0167 0.0266
Echinococcus granulosus tumor protein p63 0.029 0.2543 0.4777
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0403 0.0757
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Giardia lamblia Ribokinase 0.0042 0.0263 1
Schistosoma mansoni hypothetical protein 0.0041 0.0256 0.0481
Mycobacterium tuberculosis Adenosine kinase 0.0042 0.0263 0.743
Schistosoma mansoni nuclear receptor 0.0057 0.0403 0.0757
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0052 0.0355 0.0565
Brugia malayi intermediate filament protein 0.0023 0.0088 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0088 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0088
Onchocerca volvulus Putative pyridoxal kinase 0.0042 0.0263 0.0177
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0403 0.0403
Echinococcus multilocularis G protein coupled receptor 139 0.023 0.1994 0.3177
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121 0.0993 0.1583
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0032 0.0167 0.5
Brugia malayi hypothetical protein 0.0064 0.0466 0.0466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0993 0.1583
Loa Loa (eye worm) hypothetical protein 0.0121 0.0993 0.0993
Brugia malayi MH2 domain containing protein 0.0102 0.0818 0.0818
Echinococcus multilocularis lamin dm0 0.0023 0.0088 0.014
Schistosoma mansoni neuropeptide receptor 0.023 0.1994 0.3746
Loa Loa (eye worm) transcription factor SMAD2 0.0102 0.0818 0.0818
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0466 0.0875
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0167 0.0314
Brugia malayi Adenosine kinase-like 0.0042 0.0263 0.0263
Echinococcus multilocularis inositol monophosphatase 1 0.0032 0.0167 0.0266
Echinococcus granulosus lamin dm0 0.0023 0.0088 0.0166
Trypanosoma cruzi ribokinase, putative 0.0042 0.0263 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0403 0.0642
Schistosoma mansoni lamin 0.0023 0.0088 0.0166
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0466 0.0875
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Echinococcus multilocularis FTZ F1 alpha 0.0121 0.0993 0.1583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0993 0.1866
Brugia malayi nuclear receptor RXR 0.0057 0.0403 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121 0.0993 0.0993
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0167 0.6346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0355 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121 0.0993 0.1583
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0501 0.094
Loa Loa (eye worm) hypothetical protein 0.0042 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Echinococcus multilocularis tumor protein p63 0.029 0.2543 0.4051
Loa Loa (eye worm) hypothetical protein 0.0042 0.0263 0.0263
Echinococcus granulosus survival motor neuron protein 1 0.0203 0.1742 0.3273
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.0993 0.0993
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0167 0.0036
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0403 0.0757
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121 0.0993 0.1866
Echinococcus granulosus ribokinase 0.0042 0.0263 0.0495
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0042 0.0263 0.5147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0052 0.0355 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0403 0.0642
Schistosoma mansoni nuclear receptor 0.0057 0.0403 0.0757
Leishmania major tagatose-6-phosphate kinase-like protein 0.0042 0.0263 0.743
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121 0.0993 0.1583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.0269 0.0269
Brugia malayi steroid hormone receptor 0.0121 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0105 0.0842 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.0993 0.0993
Leishmania major ribokinase, putative 0.0042 0.0263 0.743
Brugia malayi ecdysone receptor 0.0057 0.0403 0.0403
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0403 0.0403
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0403 0.0757
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0403 0.0757
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0136 0.3844
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0088 0.0088
Brugia malayi Inositol-1 0.0032 0.0167 0.0167
Onchocerca volvulus 0.1099 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0403 0.0403
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0167 0.0314
Schistosoma mansoni adenosine kinase 0.0042 0.0263 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0993 0.0993
Leishmania major adenosine kinase-like protein 0.0042 0.0263 0.743
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0167 0.0314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0993 0.1866
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0993 0.1866
Loa Loa (eye worm) steroid hormone receptor 0.0121 0.0993 0.0993
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.0993 0.1583
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0084
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0042 0.0263 0.042
Brugia malayi ecdysteroid receptor 0.0121 0.0993 0.0993
Echinococcus granulosus lamin 0.0023 0.0088 0.0166
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0466 0.0742
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0042 0.0263 1
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0466 0.0466
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0466 0.0466
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0042 0.0263 0.743
Trypanosoma brucei ribokinase, putative 0.0042 0.0263 1
Brugia malayi nuclear hormone receptor 0.0121 0.0993 0.0993
Onchocerca volvulus Bile acid receptor homolog 0.0121 0.0993 0.0913
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0403 0.0642
Loa Loa (eye worm) hypothetical protein 0.0064 0.0466 0.0466
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0403 0.0757
Entamoeba histolytica kinase, PfkB family 0.0042 0.0263 1
Onchocerca volvulus Ribokinase homolog 0.0042 0.0263 0.0177

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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