Detailed information for compound 893728

Basic information

Technical information
  • TDR Targets ID: 893728
  • Name: 3-chloro-N-[(3-chloro-4,5-dimethoxyphenyl)met hyl]-4-methylaniline
  • MW: 326.218 | Formula: C16H17Cl2NO2
  • H donors: 1 H acceptors: 0 LogP: 4.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(Cl)cc(cc1OC)CNc1ccc(c(c1)Cl)C
  • InChi: 1S/C16H17Cl2NO2/c1-10-4-5-12(8-13(10)17)19-9-11-6-14(18)16(21-3)15(7-11)20-2/h4-8,19H,9H2,1-3H3
  • InChiKey: XKJZHWJQZTUDBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-[(3-chloro-4,5-dimethoxy-phenyl)methyl]-4-methyl-aniline
  • (3-chloro-4,5-dimethoxy-benzyl)-(3-chloro-4-methyl-phenyl)amine
  • ZINC00469789

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0056 0.0538 1
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0155 1
Brugia malayi steroid hormone receptor 0.0012 0.0077 0.084
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0005 0.0006 0.0066
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.0921 0.2641
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0006 0.0112
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0155 0.0445
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0538 0.5841
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0286 0.0804
Leishmania major NADH dehydrogenase, putative 0.0005 0.0006 0.0112
Brugia malayi nuclear hormone receptor 0.0012 0.0077 0.084
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0077 0.0154
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0155 0.0445
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0005 0.0006 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0155 0.2884
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0011 0.0122
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0005 0.0006 0.0112
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0077 0.0154
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0005 0.0006 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0077 0.084
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0011 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0077 0.0154
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0005 0.0006 1
Toxoplasma gondii hypothetical protein 0.0032 0.0286 0.3105
Loa Loa (eye worm) histone methyltransferase 0.001 0.0062 0.0676
Trichomonas vaginalis glutamate synthase, putative 0.0005 0.0006 0.0389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0077 0.0154
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0077 0.084
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Treponema pallidum NADH oxidase 0.0019 0.0155 0.0428
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0018 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0538 0.1543
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0041 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Trypanosoma brucei NADH dehydrogenase 0.0005 0.0006 0.0112
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0011 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0155 0.1685
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0011 0.0364
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0005 0.0006 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0077 0.0154
Echinococcus granulosus geminin 0.0199 0.2052 0.4087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0077 0.084
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0077 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0707 0.1408
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0077 0.084
Loa Loa (eye worm) programmed cell death 8 0.0005 0.0006 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0005 0.0006 0.0066
Leishmania major hypothetical protein, conserved 0.0005 0.0006 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0199
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0155 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0005 0.0006 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0077 0.0154
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.0921 0.0921
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0155 0.163
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0005 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0077 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0077 0.084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0155 0.1685
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0199
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0077 0.0154
Echinococcus multilocularis geminin 0.0199 0.2052 0.2052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Brugia malayi hypothetical protein 0.0006 0.0011 0.0122
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0011 0.0122
Toxoplasma gondii thioredoxin reductase 0.0056 0.0538 0.5841
Schistosoma mansoni glutamate synthase 0.0005 0.0006 0.0012
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0005 0.0006 0.0112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0077 0.0154
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0077 0.084
Trichomonas vaginalis helicase, putative 0.0008 0.0033 0.2112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0062 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Brugia malayi glutamate synthase 0.0005 0.0006 0.0066
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0005 0.0006 0.0112
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0005 0.0006 0.0012
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0005 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0199 0.2052 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0077 0.084
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Trypanosoma brucei hypothetical protein, conserved 0.0005 0.0006 0.0112
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0005 0.0006 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0538 0.1543
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0155 0.2884
Loa Loa (eye worm) hypothetical protein 0.0092 0.0921 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0005 0.0006 0.0112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.1438 0.4122
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0155 0.0445
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0005 0.0006 0.0112
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0005 0.0006 0.0066
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 0.2641
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0077 0.0077
Trypanosoma cruzi NADH dehydrogenase, putative 0.0005 0.0006 0.0112
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0011 0.0022
Onchocerca volvulus 0.0006 0.0011 0.0364
Brugia malayi tailless protein 0.0006 0.0011 0.0122
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0005 0.0006 1
Echinococcus granulosus glutamate synthase 0.0005 0.0006 0.0012
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0005 0.0006 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0077 0.084
Mycobacterium ulcerans NADH dehydrogenase 0.0005 0.0006 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Trichomonas vaginalis apoptosis inducing factor, putative 0.0005 0.0006 0.0389
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0077 0.0077
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0101 0.11
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0077 0.084
Trichomonas vaginalis glutamate synthase, putative 0.0005 0.0006 0.0389
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0155 0.1685
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0538 1
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0005 0.0006 0.0389
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0011 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Giardia lamblia Glutamate synthase 0.0005 0.0006 0.0389
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0005 0.0006 0.0066
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0155 0.1685
Schistosoma mansoni cpg binding protein 0.0036 0.0328 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0077 0.084
Schistosoma mansoni hypothetical protein 0.0199 0.2052 0.4087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.1289 0.3695
Schistosoma mansoni hypothetical protein 0.0005 0.0006 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0011 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.1289 0.3695
Brugia malayi Thioredoxin reductase 0.0056 0.0538 0.5841
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0005 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0041 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0077 0.0154
Leishmania major hypothetical protein, conserved 0.0005 0.0006 0.0112
Brugia malayi Probable ClpP-like protease 0.0092 0.0921 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0062 0.0124
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0041 0.0041
Brugia malayi glutathione reductase 0.0056 0.0538 0.5841
Onchocerca volvulus 0.0012 0.0077 0.2512
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0077 0.0154
Schistosoma mansoni glutamate synthase 0.0005 0.0006 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0155 0.0445
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0011 0.0022
Schistosoma mansoni glutamate synthase 0.0005 0.0006 0.0012
Echinococcus multilocularis cpg binding protein 0.0036 0.0328 0.0328
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0041 0.0081
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0005 0.0006 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0077 0.0154
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0077 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0077 0.084
Brugia malayi nuclear hormone receptor 0.0006 0.0011 0.0122
Schistosoma mansoni nuclear receptor 0.0006 0.0011 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0077 0.084
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0005 0.0006 0.0017
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0077 0.2512
Echinococcus granulosus dnaJ subfamily B 0.0481 0.502 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.1289 0.3695
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0005 0.0006 0.0112
Brugia malayi nuclear receptor RXR 0.0006 0.0018 0.0199
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0011 0.0022
Schistosoma mansoni zinc finger protein 0.0006 0.0011 0.0022
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0011 0.0364
Schistosoma mansoni cpg binding protein 0.0034 0.0308 0.0614
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0005 0.0006 0.0066
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.1289 0.3695
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0587 0.1684
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0005 0.0006 0.0017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0587 0.1684
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0005 0.0006 0.0017
Mycobacterium ulcerans ferredoxin reductase 0.0005 0.0006 0.0017
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0286 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Onchocerca volvulus 0.0006 0.0011 0.0364
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0005 0.0006 0.0017
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0101 0.11
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0155 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0077 0.084
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0018 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0077 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0077 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0155 0.2884
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0011 0.0011
Onchocerca volvulus 0.0034 0.0308 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Brugia malayi nuclear receptor RXR 0.0006 0.0011 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0077 0.0077
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0005 0.0006 0.0017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0077 0.0154
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.1438 0.4122
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0011 0.0122
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0061 0.066
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0005 0.0006 0.0389
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0005 0.0006 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0077 0.0077
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0005 0.0006 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0077 0.084
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0308 0.3344
Mycobacterium ulcerans glutamate synthase subunit beta 0.0005 0.0006 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0077 0.084
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0077 0.0154
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Brugia malayi nuclear receptor NHR-67 0.0006 0.0011 0.0122
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0005 0.0006 0.0012
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0155 0.2884
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 0.2628
Leishmania major hypothetical protein, conserved 0.0005 0.0006 0.0112
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0005 0.0006 0.0066
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0155 0.2884
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Entamoeba histolytica thioredoxin reductase, putative 0.0005 0.0006 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0005 0.0006 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0155 0.0155
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0155 0.0445
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.0921 0.1835
Mycobacterium ulcerans monoxygenase 0.0005 0.0006 0.0017
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0005 0.0006 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0011 0.0122
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0005 0.0006 0.0112
Schistosoma mansoni coup transcription factor 0.0012 0.0077 0.0154
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0011 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0155 0.2884
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0921 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0005 0.0006 0.0112
Brugia malayi ecdysone receptor 0.0006 0.0011 0.0122
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0286 0.082
Loa Loa (eye worm) glutathione reductase 0.0056 0.0538 0.5841
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0005 0.0006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Treponema pallidum hypothetical protein 0.0336 0.3488 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.1438 0.4122
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Trypanosoma brucei trypanothione reductase 0.0056 0.0538 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0077 0.084
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0011 0.0022
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0005 0.0006 0.0017
Brugia malayi hypothetical protein 0.0006 0.0018 0.0199
Plasmodium vivax ferrodoxin reductase, putative 0.0005 0.0006 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0011 0.0011
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0005 0.0006 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0155 0.2884
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0155 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0077 0.084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0077 0.084
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0155 0.0309
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0005 0.0006 0.0066
Plasmodium falciparum glutathione reductase 0.0019 0.0155 0.0445
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0538 0.1072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0041 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0005 0.0006 0.0389
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0005 0.0006 0.0066
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0077 0.2512
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0005 0.0006 0.0066
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0005 0.0006 0.0112
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0155 0.1685
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0005 0.0006 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0005 0.0006 0.0006
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0286 0.082
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0077 0.084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0005 0.0006 0.0017
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0011 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0077 0.084
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0155 0.0445
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0005 0.0006 0.0066
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0155 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0005 0.0006 0.0017
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0005 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0005 0.0006 0.0066
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0005 0.0006 0.0389
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0033 0.2112
Mycobacterium ulcerans hypothetical protein 0.0005 0.0006 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0336 0.3488 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0005 0.0006 1
Brugia malayi nuclear receptor NHR-88 0.0006 0.0011 0.0122
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0155 0.2884
Schistosoma mansoni sulfide quinone reductase 0.0005 0.0006 0.0012
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0005 0.0006 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0077 0.0077
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.1438 0.4122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0077 0.084
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0011 0.0122
Plasmodium vivax glutathione reductase, putative 0.0056 0.0538 0.1543
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0336 0.3488 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0011 0.0122
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0336 0.3488 1
Echinococcus multilocularis dnaJ subfamily B 0.0481 0.502 0.502
Onchocerca volvulus 0.0005 0.0006 0.0196
Schistosoma mansoni nuclear receptor 0.0006 0.0011 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0033 0.2112
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0005 0.0006 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 0.2641
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0077 0.0154
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0005 0.0006 0.0389
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0587 0.1684
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0006 0.0112
Schistosoma mansoni hypothetical protein 0.0481 0.502 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0005 0.0006 0.0017
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.1289 0.3695
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0336 0.3488 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0587 0.0587
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0011 0.0011
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0005 0.0006 0.0012
Giardia lamblia Thioredoxin reductase 0.0005 0.0006 0.0389
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0921 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0199
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0005 0.0006 0.0389
Schistosoma mansoni sulfide quinone reductase 0.0005 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Brugia malayi ecdysteroid receptor 0.0012 0.0077 0.084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0077 0.2512
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0155 0.0445
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0155 0.2884
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0018 0.0036
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0011 0.0022
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0011 0.0122
Mycobacterium ulcerans dehydrogenase 0.0005 0.0006 0.0017
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0005 0.0006 0.0006
Brugia malayi conserved hypotetical protein 0.0006 0.0011 0.0122
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0005 0.0006 0.0017
Brugia malayi nuclear receptor NHR-88 0.0012 0.0077 0.084
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0077 0.0154
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0077 0.0154
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0005 0.0006 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0033 0.2112
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Plasmodium falciparum ferrodoxin reductase-like protein 0.0005 0.0006 0.0017
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0018
Brugia malayi hypothetical protein 0.0006 0.0018 0.0199
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0077 0.0154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0538 0.0538
Schistosoma mansoni cpg binding protein 0.0036 0.0328 0.0654
Plasmodium falciparum thioredoxin reductase 0.0056 0.0538 0.1543
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0336 0.3488 1
Echinococcus multilocularis glutamate synthase 0.0005 0.0006 0.0006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0199
Plasmodium falciparum glutathione reductase 0.0056 0.0538 0.1543
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0011 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.1289 0.3695
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0033 0.2112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0626 0.68
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0921 0.2641
Trypanosoma cruzi NADH dehydrogenase, putative 0.0005 0.0006 0.0112
Brugia malayi CXXC zinc finger family protein 0.0034 0.0308 0.3344
Echinococcus granulosus cpg binding protein 0.0036 0.0328 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0077 0.084
Brugia malayi hypothetical protein 0.0006 0.0011 0.0122
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0587 0.117
Mycobacterium tuberculosis Probable reductase 0.0127 0.1289 0.3695
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0077 0.0077
Loa Loa (eye worm) DR-78 0.0006 0.0011 0.0122
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0005 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0077 0.084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0155 0.2884
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0011 0.0011
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0005 0.0006 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.0921 0.1835
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0077 0.084
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0011 0.0022
Plasmodium falciparum thioredoxin reductase 0.0019 0.0155 0.0445
Schistosoma mansoni disulfide oxidoreductase 0.0005 0.0006 0.0012
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0005 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0199
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.0921 0.2641
Toxoplasma gondii selenide, water dikinase 0.0005 0.0006 0.0066
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0122

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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