TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 484.526 | Formula: C26H20N4O4S
H donors: 1 H acceptors: 4 LogP: 6.57 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C(=O)c1c(N)c(c2n1cccc2)c1scc(n1)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C26H20N4O4S/c1-2-34-19-12-8-17(9-13-19)25(31)24-23(27)22(21-5-3-4-14-29(21)24)26-28-20(15-35-26)16-6-10-18(11-7-16)30(32)33/h3-15H,2,27H2,1H3
InChiKey: STAMIEOASUSANY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0042	0.0432	0.0486
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0096	0.118	0.4221
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0455	0.0431
Brugia malayi	glycyl-tRNA synthetase	0.0219	0.2904	0.2886
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0013	0.0025	0.0034
Plasmodium vivax	basic transcription factor 3b, putative	0.0031	0.0275	0.0299
Schistosoma mansoni	prolyl-tRNA synthetase	0.0613	0.8389	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0213	0.2822	0.3344
Leishmania major	histidyl-tRNA synthetase, putative	0.0116	0.1457	0.5233
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0213	0.2822	0.3344
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Entamoeba histolytica	seryl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Treponema pallidum	glycyl-tRNA synthetase	0.0116	0.1457	0.1277
Entamoeba histolytica	hypothetical protein	0.0032	0.0288	0.096
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0455	0.1571
Echinococcus multilocularis	isocitrate dehydrogenase	0.0014	0.004	0.0016
Plasmodium vivax	threonine--tRNA ligase, putative	0.0192	0.2528	0.2993
Giardia lamblia	Glycyl-tRNA synthetase	0.0192	0.2528	0.9086
Schistosoma mansoni	6-phosphofructokinase	0.0096	0.118	0.1381
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0212	0.0188
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0213	0.2822	0.3344
Toxoplasma gondii	anticodon binding domain-containing protein	0.0116	0.1457	0.5233
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0276	0.0377
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0209	0.2762	1
Plasmodium vivax	glycine--tRNA ligase, putative	0.0192	0.2528	0.2993
Brugia malayi	mbt repeat family protein	0.0042	0.0432	0.0408
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0014	0.004	0.0018
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0026	0.0207	0.0664
Schistosoma mansoni	hypothetical protein	0.0032	0.0288	0.0314
Schistosoma mansoni	sex comb on midleg homolog	0.0042	0.0432	0.0486
Echinococcus multilocularis	Seryl tRNA Synthetase	0.0077	0.0917	0.0913
Onchocerca volvulus		0.0042	0.0432	0.149
Echinococcus multilocularis	prolyl tRNA synthetase, mitochondrial	0.0613	0.8389	0.8558
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Schistosoma mansoni	seryl-tRNA synthetase	0.0077	0.0917	0.1067
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0192	0.2528	0.251
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.004	0.0408	0.0384
Schistosoma mansoni	6-phosphofructokinase	0.0096	0.118	0.1381
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0192	0.2528	0.2993
Echinococcus multilocularis	polycomb protein SCMH1	0.0042	0.0432	0.0416
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0183	0.24	0.2382
Brugia malayi	seryl-tRNA synthetase, mitochondrial precursor, putative	0.0077	0.0917	0.0895
Plasmodium vivax	proline--tRNA ligase, putative	0.0613	0.8389	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0276	0.0377
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0192	0.2528	0.251
Entamoeba histolytica	phosphofructokinase, putative	0.0096	0.118	0.4221
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0048	0.0513	0.0489
Brugia malayi	beta-NAC-like protein	0.0031	0.0275	0.0251
Schistosoma mansoni	histidyl-tRNA synthetase	0.0116	0.1457	0.1712
Entamoeba histolytica	phosphofructokinase, putative	0.0096	0.118	0.4221
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0455	0.0622
Echinococcus granulosus	seryl tRNA synthetase mitochondrial	0.0077	0.0917	0.1067
Echinococcus multilocularis	neuropeptide receptor A26	0.0407	0.5522	0.5624
Entamoeba histolytica	phosphofructokinase, putative	0.0096	0.118	0.4221
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0014	0.004	0.0016
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0455	0.0431
Giardia lamblia	Seryl-tRNA synthetase	0.0077	0.0917	0.2782
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0013	0.0025	0.0034
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Brugia malayi	Pre-SET motif family protein	0.0183	0.24	0.2382
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0165	0.2153	0.2545
Treponema pallidum	prolyl-tRNA synthetase	0.0728	1	1
Toxoplasma gondii	histidyl-tRNA synthetase (HisRS), putative	0.0116	0.1457	0.5233
Plasmodium falciparum	glycine--tRNA ligase	0.0116	0.1457	0.1712
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0209	0.2762	1
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Echinococcus multilocularis	geminin	0.0149	0.1926	0.1945
Brugia malayi	Met-10+ like-protein	0.0536	0.7318	0.7311
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0276	0.0377
Echinococcus multilocularis	glycyl tRNA synthetase	0.0219	0.2904	0.2946
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0048	0.0513	0.0499
Plasmodium vivax	histidine--tRNA ligase, putative	0.0116	0.1457	0.1712
Chlamydia trachomatis	proline--tRNA ligase	0.0728	1	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0209	0.2762	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.04	0.0376
Plasmodium vivax	serine--tRNA ligase, putative	0.0077	0.0917	0.1067
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0207	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0277
Echinococcus granulosus	transcription factor btf3	0.0031	0.0275	0.0299
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0209	0.2762	0.2744
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0014	0.004	0.0055
Entamoeba histolytica	transcription factor BTF3, putative	0.0031	0.0275	0.0915
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0013	0.0025	0.0034
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.004	0.0408	0.0384
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0455	0.0431
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0014	0.004	0.0015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0025	0.0034
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0116	0.1457	0.5233
Plasmodium falciparum	acyl-CoA synthetase	0.0033	0.0301	0.033
Leishmania major	ATP-dependent phosphofructokinase	0.0096	0.118	0.4221
Wolbachia endosymbiont of Brugia malayi	histidyl-tRNA synthetase	0.0116	0.1457	0.0594
Trichomonas vaginalis	phosphofructokinase, putative	0.0096	0.118	0.4221
Echinococcus multilocularis	6 phosphofructokinase	0.0096	0.118	0.1182
Brugia malayi	Sars1 protein	0.0077	0.0917	0.0895
Echinococcus granulosus	6 phosphofructokinase	0.0096	0.118	0.1381
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0014	0.004	0.0016
Onchocerca volvulus		0.0044	0.0455	0.1576
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0455	0.0431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0408	0.0457
Schistosoma mansoni	sex comb on midleg homolog	0.0042	0.0432	0.0486
Mycobacterium ulcerans	6-phosphofructokinase	0.0096	0.118	0.1158
Mycobacterium tuberculosis	Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase)	0.0536	0.7318	1
Schistosoma mansoni	glycyl-tRNA synthetase	0.0219	0.2904	0.3442
Leishmania major	glycyl tRNA synthetase, putative	0.0116	0.1457	0.5233
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0014	0.004	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0209	0.2762	0.2744
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0212	0.0224
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.004	0.0408	0.0457
Toxoplasma gondii	isocitrate dehydrogenase	0.0014	0.004	0.0055
Echinococcus multilocularis	neuropeptide s receptor	0.0407	0.5522	0.5624
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0408	0.0457
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0096	0.118	0.4221
Treponema pallidum	threonyl-tRNA synthetase	0.0192	0.2528	0.2371
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.004	0.0408	0.0457
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.024	0.3198	0.3181
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0025	0.0034
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0212	0.0224
Chlamydia trachomatis	serine--tRNA ligase	0.0077	0.0917	0.0726
Mycobacterium ulcerans	seryl-tRNA synthetase	0.0077	0.0917	0.0895
Plasmodium falciparum	basic transcription factor 3b, putative	0.0031	0.0275	0.0299
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0408	0.0457
Echinococcus granulosus	glycyl tRNA synthetase	0.0219	0.2904	0.3442
Entamoeba histolytica	histidyl-tRNA synthetase, putative	0.0116	0.1457	0.5233
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0025	0.0199	0.0208
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0042	0.0432	0.0416
Trypanosoma cruzi	transcription factor btf3, putative	0.0031	0.0275	0.0915
Entamoeba histolytica	hypothetical protein	0.0032	0.0288	0.096
Entamoeba histolytica	hypothetical protein	0.0032	0.0288	0.096
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0209	0.2762	1
Entamoeba histolytica	hypothetical protein	0.0032	0.0288	0.096
Loa Loa (eye worm)	MBCTL1	0.0048	0.0513	0.0489
Echinococcus granulosus	SAM and MBT domain containing protein	0.0042	0.0432	0.0486
Toxoplasma gondii	glycyl-tRNA synthetase	0.0192	0.2528	0.9146
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0455	0.0431
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0044	0.0455	0.0431
Leishmania major	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Brugia malayi	hypothetical protein	0.0032	0.0288	0.0263
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0032	0.0288	0.0269
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0044	0.0455	0.1571
Trypanosoma cruzi	transcription factor btf3, putative	0.0031	0.0275	0.0915
Echinococcus granulosus	prolyl tRNA synthetase mitochondrial	0.0613	0.8389	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0165	0.2153	0.2178
Schistosoma mansoni	threonyl-tRNA synthetase	0.0116	0.1457	0.1712
Echinococcus multilocularis	seryl tRNA synthetase, mitochondrial	0.0077	0.0917	0.0913
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0207	0.0217
Echinococcus granulosus	neuropeptide receptor A26	0.0407	0.5522	0.6572
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0192	0.2528	0.9146
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0714	0.9799	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0033	0.0301	0.0411
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0207	0.0217
Trichomonas vaginalis	phosphofructokinase, putative	0.0096	0.118	0.4221
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0096	0.118	0.4221
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0192	0.2528	0.251
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0209	0.2762	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0096	0.118	0.1158
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0455	0.0431
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0219	0.2904	0.2886
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0013	0.0025	0.0034
Loa Loa (eye worm)	ICD-1 protein	0.0031	0.0275	0.0251
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0014	0.004	0.0055
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0276	0.0377
Echinococcus granulosus	histone acetyltransferase MYST2	0.0048	0.0513	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0277
Toxoplasma gondii	seryl-tRNA synthetase, cytoplasmic, putative	0.0077	0.0917	0.3261
Brugia malayi	6-phosphofructokinase	0.0096	0.118	0.1158
Loa Loa (eye worm)	Sars1 protein	0.0077	0.0917	0.0895
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0013	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0513	0.0489
Loa Loa (eye worm)	phosphofructokinase	0.0096	0.118	0.1158
Plasmodium falciparum	proline--tRNA ligase, putative	0.0613	0.8389	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0026	0.0207	0.0664
Toxoplasma gondii	6-phosphofructokinase	0.0026	0.0207	0.0664
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0096	0.118	0.1613
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0044	0.0455	0.1571
Plasmodium vivax	SET domain protein, putative	0.0026	0.0212	0.0224
Brugia malayi	Isocitrate dehydrogenase	0.0014	0.004	0.0015
Schistosoma mansoni	hypothetical protein	0.0149	0.1926	0.2273
Leishmania major	basic transcription factor 3a, putative	0.0031	0.0275	0.0915
Entamoeba histolytica	seryl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Chlamydia trachomatis	histidine--tRNA ligase	0.0116	0.1457	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0055
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0192	0.2528	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0275	0.0915
Plasmodium vivax	proline--tRNA ligase, putative	0.0209	0.2762	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0455	0.0431
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0014	0.004	0.0018
Brugia malayi	Pre-SET motif family protein	0.0026	0.0212	0.0188
Echinococcus granulosus	histidyl tRNA synthetase	0.0116	0.1457	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0728	1	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0013	0.0025	0.0034
Giardia lamblia	Threonyl-tRNA synthetase	0.0192	0.2528	0.9086
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0728	1	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0048	0.0513	0.0583
Chlamydia trachomatis	threonine--tRNA ligase	0.0192	0.2528	0.2371
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0032	0.0288	0.0314
Loa Loa (eye worm)	6-phosphofructokinase	0.0096	0.118	0.1158
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0212	0.0224
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0728	1	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0033	0.0301	0.033
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0192	0.2528	0.251
Plasmodium vivax	serine--tRNA ligase, putative	0.0077	0.0917	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0455	0.0431
Mycobacterium ulcerans	histidyl-tRNA synthetase	0.0116	0.1457	0.1436
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0044	0.0455	0.1571
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0014	0.004	0.0055
Loa Loa (eye worm)	mbt repeat family protein	0.0042	0.0432	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0455	0.0431
Echinococcus granulosus	Seryl tRNA Synthetase	0.0077	0.0917	0.1067
Giardia lamblia	Prolyl-tRNA synthetase	0.0209	0.2762	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0209	0.2762	1
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0033	0.0301	0.0277
Echinococcus granulosus	polycomb protein SCMH1	0.0042	0.0432	0.0486
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0044	0.0455	0.0431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.004	0.0408	0.0392
Leishmania major	seryl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0044	0.0455	0.0431
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0014	0.004	0.0018
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0025	0.0034
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0026	0.0212	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0209	0.2762	0.2744
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0212	0.0224
Trichomonas vaginalis	set domain proteins, putative	0.0208	0.2753	0.9969
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0207	0.0217
Trypanosoma brucei	histidyl-tRNA synthetase	0.0116	0.1457	0.5233
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0048	0.0513	0.0583
Schistosoma mansoni	transcription factor LCR-F1	0.0032	0.0288	0.0314
Plasmodium falciparum	threonine--tRNA ligase	0.0192	0.2528	0.2993
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0014	0.004	0.0055
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0209	0.2762	1
Schistosoma mansoni	histidyl-tRNA synthetase	0.0116	0.1457	0.1712
Plasmodium falciparum	serine--tRNA ligase, putative	0.0077	0.0917	0.1067
Brugia malayi	6-phosphofructokinase	0.0096	0.118	0.1158
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0042	0.0432	0.149
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0044	0.0455	0.1571
Toxoplasma gondii	serine--tRNA ligase	0.0077	0.0917	0.3261
Plasmodium falciparum	histidine--tRNA ligase, putative	0.0116	0.1457	0.1712
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0192	0.2528	0.1774
Toxoplasma gondii	NAC domain-containing protein	0.0031	0.0275	0.0915
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0014	0.004	0.0055
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Trypanosoma brucei	seryl-tRNA synthetase	0.0077	0.0917	0.3261
Schistosoma mansoni	threonyl-tRNA synthetase	0.0077	0.0917	0.1067
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0275	0.0915
Brugia malayi	isocitrate dehydrogenase	0.0014	0.004	0.0015
Trypanosoma brucei	transcription factor BTF3, putative	0.0031	0.0275	0.0915
Loa Loa (eye worm)	histidyl-tRNA synthetase	0.0116	0.1457	0.1436
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0116	0.1457	0.5233
Loa Loa (eye worm)	seryl-tRNA synthetase	0.0077	0.0917	0.0895
Trypanosoma cruzi	histidyl-tRNA synthetase	0.0116	0.1457	0.5233
Trichomonas vaginalis	interferon-induced, double-stranded RNA-activated protein kinase, putative	0.0116	0.1457	0.5233
Brugia malayi	phosphofructokinase	0.0096	0.118	0.1158
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0455	0.0431
Brugia malayi	mbt repeat family protein	0.0042	0.0432	0.0408
Toxoplasma gondii	isocitrate dehydrogenase	0.0014	0.004	0.0055
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0116	0.1457	0.5233
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0025	0.0034
Echinococcus granulosus	neuropeptide s receptor	0.0407	0.5522	0.6572
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0209	0.2762	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.0212	0.0224
Echinococcus multilocularis	transcription factor btf3	0.0031	0.0275	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0277
Entamoeba histolytica	hypothetical protein	0.0031	0.0275	0.0915
Schistosoma mansoni	hypothetical protein	0.0149	0.1926	0.2273
Plasmodium falciparum	proline--tRNA ligase	0.0209	0.2762	0.3272
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0014	0.004	0.0055
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0192	0.2528	0.2561
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Toxoplasma gondii	tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein	0.0077	0.0917	0.3261
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0026	0.0207	0.0664
Toxoplasma gondii	phosphofructokinase PFKII	0.0026	0.0207	0.0664
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.004	0.0408	0.0392
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0014	0.004	0.0018
Trichomonas vaginalis	seryl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0013	0.0025	0.0034
Trichomonas vaginalis	phosphofructokinase, putative	0.0096	0.118	0.4221
Onchocerca volvulus		0.0208	0.2753	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0048	0.0513	0.0499
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0455	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0432	0.0408
Treponema pallidum	seryl-tRNA synthetase	0.0077	0.0917	0.0726
Schistosoma mansoni	hypothetical protein	0.0255	0.3405	0.4041
Trichomonas vaginalis	phosphofructokinase, putative	0.0096	0.118	0.4221
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0014	0.004	0.0016
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0213	0.2822	0.2862
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0275	0.0915
Trichomonas vaginalis	seryl-tRNA synthetase, putative	0.0077	0.0917	0.3261
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0192	0.2528	0.9146
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0277
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0096	0.118	0.0994
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0192	0.2528	0.9146
Echinococcus multilocularis	histidyl tRNA synthetase	0.0116	0.1457	0.1465
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0044	0.0455	0.0431
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0455	0.1571
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0033	0.0301	0.0096
Trypanosoma cruzi	seryl-tRNA synthetase	0.0077	0.0917	0.3261
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0207	0.0664
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0026	0.0212	0.0192
Plasmodium falciparum	serine--tRNA ligase, putative	0.0077	0.0917	0.1067
Onchocerca volvulus		0.0026	0.0212	0.0688
Schistosoma mansoni	seryl-tRNA synthetase	0.0077	0.0917	0.1067
Entamoeba histolytica	acyl-coA synthetase, putative	0.0044	0.0455	0.1571
Echinococcus granulosus	geminin	0.0149	0.1926	0.2273
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0209	0.2762	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0026	0.0212	0.0685
Schistosoma mansoni	transcription factor btf3	0.0031	0.0275	0.0299
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0044	0.0455	0.0622

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 895854