TDR Targets

Basic information

Technical information

TDR Targets ID: 903209
Name: N-(2-methylphenyl)-1-oxoisochroman-3-carboxam ide
MW: 281.306 | Formula: C17H15NO3
H donors: 1 H acceptors: 2 LogP: 3.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1OC(=O)c2c(C1)cccc2)Nc1ccccc1C
InChi: 1S/C17H15NO3/c1-11-6-2-5-9-14(11)18-16(19)15-10-12-7-3-4-8-13(12)17(20)21-15/h2-9,15H,10H2,1H3,(H,18,19)
InChiKey: AYSCVFYEHCMWKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methylphenyl)-1-oxo-isochroman-3-carboxamide
N-(2-methylphenyl)-1-oxo-3-isochromancarboxamide
1-keto-N-(2-methylphenyl)isochroman-3-carboxamide
MLS000049648
N-(2-methylphenyl)-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
SMR000076243
1-Oxo-isochroman-3-carboxylic acid o-tolylamide
BAS 07776984
STOCK4S-68798
ChemDiv2_004714
IDI1_003429

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	glycogenphosphorylase, putative	0.0047	0.0574	0.178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2981	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.035	0.5962	0.5962
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.053	0.0905
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0742	0.2383
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Echinococcus multilocularis	hypothetical protein	0.0017	0.0052	0.0075
Brugia malayi	carbohydrate phosphorylase	0.0108	0.1662	0.1662
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0017	0.0052	0.0052
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Onchocerca volvulus		0.0017	0.0052	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0052	0.0075
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Entamoeba histolytica	glycogen phosphorylase, putative	0.0108	0.1662	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0182	0.2981	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0017	0.0042	0.006
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0837	0.1198
Plasmodium falciparum	plasmepsin X	0.0017	0.0042	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0837	0.2681
Onchocerca volvulus		0.0017	0.0052	0.0035
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0108	0.1662	0.2377
Brugia malayi	Pepsin A precursor	0.0017	0.0042	0.0042
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0837	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2981	1
Onchocerca volvulus		0.0017	0.0052	0.0035
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0017	0.0052	0.005
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0052
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Brugia malayi	hypothetical protein	0.0017	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0052	0.0062
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0574	0.178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.035	0.5962	0.8529
Entamoeba histolytica	glycogen phosphorylase, putative	0.0108	0.1662	0.5495
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0017	0.0052	0.0075
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Onchocerca volvulus		0.0182	0.2981	1
Echinococcus multilocularis		0.0017	0.0052	0.0075
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0017	0.0052	0.0052
Onchocerca volvulus		0.0017	0.0052	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Onchocerca volvulus		0.006	0.0805	0.2597
Loa Loa (eye worm)	hypothetical protein	0.0578	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus granulosus	glycogen phosphorylase	0.0108	0.1662	0.2377
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Schistosoma mansoni	glycogen phosphorylase	0.0108	0.1662	0.1983
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.2981	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0052	0.0075
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0052	0.0052
Plasmodium falciparum	plasmepsin VII	0.0017	0.0042	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Onchocerca volvulus		0.0017	0.0052	0.0035
Onchocerca volvulus		0.0017	0.0052	0.0035
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0017	0.0052	0.005
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.053	0.0905
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0574	0.178
Onchocerca volvulus		0.0017	0.0052	0.0035
Onchocerca volvulus		0.0017	0.0052	0.0035
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0837	0.2707
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Giardia lamblia	Glycogen phosphorylase	0.0108	0.1662	0.5495
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.035	0.5962	0.8529
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.2387	0.2804
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0042	0.5
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0837	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0042	0.5
Plasmodium falciparum	plasmepsin VI	0.0017	0.0042	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0052	0.0062
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.053	0.0574
Plasmodium falciparum	plasmepsin IX	0.0017	0.0042	0.5
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0017	0.0052	0.0062
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0108	0.1662	0.5511
Schistosoma mansoni	glycogen phosphorylase	0.0108	0.1662	0.1983
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Plasmodium falciparum	plasmepsin V	0.0017	0.0042	0.5
Trypanosoma brucei	RNA helicase, putative	0.0486	0.8379	1
Plasmodium vivax	plasmepsin V, putative	0.0017	0.0042	0.5
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.2387	0.4426
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0052	0.0062
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0837	0.0943
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0017	0.0052	0.0062
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0052	0.0062
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2981	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0837	0.2707
Brugia malayi	MAP kinase sur-1	0.0062	0.0837	0.0837
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0017	0.0042	0.004
Onchocerca volvulus		0.0017	0.0052	0.0035
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	0.5328	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0052	0.0075
Loa Loa (eye worm)	glycogen phosphorylase	0.0108	0.1662	0.166
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0042	0.004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0052	0.0075
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0837	0.1198
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0052	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0017	0.0052	0.0062
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0052	0.0062
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0837	0.0999
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0837	0.1488
Schistosoma mansoni	hypothetical protein	0.0486	0.8379	1
Chlamydia trachomatis	glycogen phosphorylase	0.0108	0.1662	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.035	0.5962	0.5961
Brugia malayi	aspartic protease BmAsp-2, identical	0.0017	0.0042	0.0042
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.053	0.0905
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0017	0.0052	0.0062
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	0.5328	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Plasmodium falciparum	plasmepsin VIII, putative	0.0017	0.0042	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0052	0.0062
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0837	1
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0108	0.1662	0.5511
Onchocerca volvulus	4.1 G protein, putative homolog	0.0017	0.0052	0.0035
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Onchocerca volvulus		0.0017	0.0052	0.0035
Mycobacterium ulcerans	hypothetical protein	0.0166	0.2686	0.8773
Echinococcus multilocularis	glycogen phosphorylase	0.0108	0.1662	0.2377
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Plasmodium falciparum	plasmepsin I	0.0017	0.0042	0.5
Onchocerca volvulus		0.0017	0.0052	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0837	0.1488
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0017	0.0042	0.0042
Schistosoma mansoni	glycogen phosphorylase	0.0047	0.0574	0.0685
Onchocerca volvulus		0.0017	0.0052	0.0035
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0742	0.1308
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2981	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Plasmodium vivax	aspartyl proteinase, putative	0.0017	0.0042	0.5
Schistosoma mansoni	cathepsin D (A01 family)	0.0017	0.0042	0.005
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0052	0.0062
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0182	0.2981	0.2981
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0182	0.2981	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0052	0.0062
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0837	0.1198
Onchocerca volvulus		0.0017	0.0052	0.0035
Onchocerca volvulus		0.0017	0.0052	0.0035
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0837	0.1488
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0017	0.0042	0.004
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.2981	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0837	0.2707
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0017	0.0052	0.0075
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0182	0.2981	0.2979
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0052	0.0075
Onchocerca volvulus		0.0017	0.0052	0.0035
Plasmodium vivax	plasmepsin IV, putative	0.0017	0.0042	0.5
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0042	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.2981	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0837	0.1488
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0017	0.0052	0.0062
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Echinococcus granulosus	glycogen phosphorylase	0.0108	0.1662	0.2377
Onchocerca volvulus		0.0017	0.0052	0.0035
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.035	0.5962	0.7116
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Schistosoma mansoni	memapsin-2 (A01 family)	0.0417	0.7145	0.8527
Plasmodium falciparum	plasmepsin III	0.0017	0.0042	0.5
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0002	0.0003
Plasmodium falciparum	plasmepsin II	0.0017	0.0042	0.5
Echinococcus granulosus	tumor protein p63	0.0408	0.6991	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0126	0.1983	0.6675
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0052	0.0062
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0017	0.0052	0.0075
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0017	0.0052	0.005
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0837	0.1198
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0837	0.2707
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0017	0.0052	0.005
Trypanosoma brucei	protein kinase, putative	0.0062	0.0837	0.0943
Onchocerca volvulus		0.0017	0.0052	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Onchocerca volvulus		0.0017	0.0052	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0166	0.2686	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Loa Loa (eye worm)	aspartyl protease 6	0.0017	0.0042	0.004
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0052	0.0075
Schistosoma mansoni	cathepsin D (A01 family)	0.0017	0.0042	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.2387	0.4426
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0052	0.0075
Trichomonas vaginalis	pten, drome, putative	0.0017	0.0052	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus multilocularis	tumor protein p63	0.0408	0.6991	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0742	0.2383
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Plasmodium vivax	aspartyl proteinase, putative	0.0017	0.0042	0.5
Leishmania major	mitochondrial DNA polymerase beta	0.0314	0.5328	1
Onchocerca volvulus		0.0017	0.0052	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0017	0.0052	0.0075
Brugia malayi	Protein kinase domain containing protein	0.0015	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0042	0.004
Onchocerca volvulus		0.0017	0.0052	0.0035
Schistosoma mansoni	pcd6 interacting protein-related	0.0017	0.0052	0.0062
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0052	0.005
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0742	0.1308
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Brugia malayi	hypothetical protein	0.0017	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase 1	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0042	0.004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0052	0.0075
Onchocerca volvulus		0.0017	0.0052	0.0035
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0108	0.1662	0.5511
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.1052	0.1505
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0314	0.5328	0.6336
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0017	0.0052	0.0062
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0805	0.0961
Loa Loa (eye worm)	hypothetical protein	0.006	0.0805	0.0803
Plasmodium falciparum	plasmepsin IV	0.0017	0.0042	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0837	0.0835
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0017	0.0052	0.005
Echinococcus granulosus	Glycosyl transferase family 35	0.0108	0.1662	0.2377
Onchocerca volvulus		0.0017	0.0052	0.0035
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.2981	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.0742	0.0829
Brugia malayi	aspartic protease BmAsp-1, identical	0.0017	0.0042	0.0042
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0017	0.0052	0.0062
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0042	0.005
Echinococcus multilocularis	glycogen phosphorylase	0.0108	0.1662	0.2377
Leishmania major	hypothetical protein, conserved	0.0056	0.0742	0.1308
Echinococcus granulosus	Ankyrin	0.0014	0.0002	0.0003
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0702	0.1231
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.1052	0.1505
Echinococcus multilocularis	Ankyrin	0.0014	0.0002	0.0003
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.005
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0052	0.0075
Onchocerca volvulus		0.0017	0.0052	0.0035
Toxoplasma gondii	hypothetical protein	0.0051	0.0645	0.7584
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0017	0.0042	0.006

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0032 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.6573 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1577603
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 903209