Detailed information for compound 909098

Basic information

Technical information
  • TDR Targets ID: 909098
  • Name: N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-3 -nitrobenzamide
  • MW: 394.232 | Formula: C16H9Cl2N3O3S
  • H donors: 1 H acceptors: 4 LogP: 4.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1scc(n1)c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C16H9Cl2N3O3S/c17-12-5-4-9(7-13(12)18)14-8-25-16(19-14)20-15(22)10-2-1-3-11(6-10)21(23)24/h1-8H,(H,19,20,22)
  • InChiKey: CSAKNYVJHABGCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(3,4-dichlorophenyl)thiazol-2-yl]-3-nitro-benzamide
  • N-[4-(3,4-dichlorophenyl)-2-thiazolyl]-3-nitrobenzamide
  • N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-3-nitro-benzamide
  • Oprea1_609328
  • CBMicro_029539
  • Oprea1_110517
  • ZINC01194430
  • BIM-0029491.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0084 0.0354 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0319 0.1793 1
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0274 0.1526
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Brugia malayi hypothetical protein 0.0084 0.0354 0.0518
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0319 0.1793 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0266 0.0095
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.0274 0.0528
Loa Loa (eye worm) hypothetical protein 0.0084 0.0354 0.0518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Leishmania major endonuclease G, putative 0.0319 0.1793 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0799 0.1168
Schistosoma mansoni hypothetical protein 0.0084 0.0354 0.0228
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.5436
Echinococcus multilocularis geminin 0.019 0.1001 0.0814
Toxoplasma gondii melibiase subfamily protein 0.0104 0.0477 0.266
Echinococcus granulosus transferase 0.0084 0.0354 0.0448
Loa Loa (eye worm) hypothetical protein 0.0532 0.3087 0.451
Loa Loa (eye worm) ICD-1 protein 0.007 0.0274 0.04
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0274 0.0469
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0532 0.3087 0.4343
Loa Loa (eye worm) hypothetical protein 0.0532 0.3087 0.451
Entamoeba histolytica hypothetical protein 0.007 0.0274 0.0528
Onchocerca volvulus 0.0157 0.0799 0.0685
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0532 0.3087 0.4343
Echinococcus multilocularis Endonuclease G 0.0319 0.1793 0.1623
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.5436
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0084 0.0354 0.0518
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0718 0.1113
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.0354 0.0448
Echinococcus granulosus transcription factor btf3 0.007 0.0274 0.0301
Echinococcus granulosus geminin 0.019 0.1001 0.1628
Loa Loa (eye worm) hypothetical protein 0.0084 0.0354 0.0518
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0744 0.0814
Schistosoma mansoni hypothetical protein 0.0084 0.0354 0.0228
Echinococcus granulosus ectonucleotide 0.0448 0.2577 0.4505
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0203 0.0172
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.0354 0.0155
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0203 0.0172
Schistosoma mansoni transcription factor btf3 0.007 0.0274 0.0106
Treponema pallidum fructose-bisphosphate aldolase 0.0619 0.3622 0.5
Echinococcus multilocularis ectonucleotide 0.0448 0.2577 0.2424
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0084 0.0354 0.0155
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.0274 0.7718
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0303 0.169 1
Onchocerca volvulus 0.0532 0.3087 0.4211
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0532 0.3087 0.451
Trypanosoma cruzi endonuclease G, putative 0.0319 0.1793 1
Echinococcus multilocularis transferase 0.0084 0.0354 0.0155
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0477 0.0412
Brugia malayi hypothetical protein 0.0084 0.0354 0.0518
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0084 0.0354 0.0518
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1148 0.6845 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0203 0.0297
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.0477 0.0279
Schistosoma mansoni hypothetical protein 0.1148 0.6845 1
Loa Loa (eye worm) hypothetical protein 0.0532 0.3087 0.451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0274 0.0469
Echinococcus multilocularis transcription factor btf3 0.007 0.0274 0.0072
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Toxoplasma gondii NAC domain-containing protein 0.007 0.0274 0.1526
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.5436
Brugia malayi jmjC domain containing protein 0.0059 0.0203 0.0297
Loa Loa (eye worm) hypothetical protein 0.0084 0.0354 0.0518
Loa Loa (eye worm) hypothetical protein 0.0448 0.2577 0.3765
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0109 0.3978
Leishmania major ethanolamine phosphotransferase, putative 0.0084 0.0354 0.1977
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0619 0.3622 1
Onchocerca volvulus 0.1148 0.6845 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0215 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0942 0.5588 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0215 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0274 0.0469
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0303 0.169 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.5436
Brugia malayi beta-NAC-like protein 0.007 0.0274 0.04
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0532 0.3087 0.4343
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.0274 1
Schistosoma mansoni hypothetical protein 0.0084 0.0354 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0319 0.1793 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0084 0.0354 0.0228
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0448 0.2577 0.2424
Trypanosoma brucei endonuclease G, putative 0.0319 0.1793 1
Mycobacterium ulcerans hypothetical protein 0.0084 0.0354 0.0948
Echinococcus granulosus Endonuclease G 0.0319 0.1793 0.3073
Brugia malayi AEL166Cp 0.0084 0.0354 0.0518
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.0477 0.0672
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0084 0.0354 1
Schistosoma mansoni hypothetical protein 0.019 0.1001 0.1201
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0532 0.3087 0.4343
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0087 0.2449
Giardia lamblia Fructose-bisphosphate aldolase 0.0619 0.3622 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0215 0.0018
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0084 0.0354 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0477 0.0412
Schistosoma mansoni endonuclease related 0.0319 0.1793 0.2393
Leishmania major basic transcription factor 3a, putative 0.007 0.0274 0.1526
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Brugia malayi Melibiase family protein 0.0069 0.0266 0.0389
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0084 0.0354 0.0757
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0215 0.1198
Loa Loa (eye worm) acetyltransferase 0.0147 0.0744 0.1086
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0266 0.0448
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0477 0.0412
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.0274 0.1526
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0084 0.0354 0.0757
Brugia malayi hypothetical protein 0.0157 0.0799 0.1168
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0319 0.1793 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0744 0.0552
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0477 0.0412
Trypanosoma cruzi endonuclease G, putative 0.0319 0.1793 1
Schistosoma mansoni hypothetical protein 0.019 0.1001 0.1201
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0084 0.0354 0.0757
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0215 0.0018
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.0354 0.0155
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0744 0.1086
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0448 0.2577 0.4505
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0215 0.0193
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0619 0.3622 1
Brugia malayi endonuclease G, mitochondrial precursor 0.0319 0.1793 0.2619
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.0477 0.0279
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0084 0.0354 0.1977
Echinococcus multilocularis neuropeptide s receptor 0.0942 0.5588 0.5497
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0109 0.0607
Onchocerca volvulus 0.0532 0.3087 0.4211
Loa Loa (eye worm) hypothetical protein 0.0084 0.0354 0.0518
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0109 0.0607
Trypanosoma brucei endonuclease G, putative 0.0319 0.1793 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0266 0.0095
Echinococcus granulosus neuropeptide receptor A26 0.0942 0.5588 1
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0274 0.1526
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.5436
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0532 0.3087 0.2944
Brugia malayi jmjC domain containing protein 0.0059 0.0203 0.0297
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0303 0.169 1
Trypanosoma brucei endonuclease G, putative 0.0319 0.1793 1
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0084 0.0354 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.3622 1
Echinococcus multilocularis neuropeptide receptor A26 0.0942 0.5588 0.5497
Loa Loa (eye worm) hypothetical protein 0.0069 0.0266 0.0389
Schistosoma mansoni hypothetical protein 0.0084 0.0354 0.0228
Brugia malayi Thrombospondin type 1 domain containing protein 0.1148 0.6845 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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