Detailed information for compound 909501

Basic information

Technical information
  • TDR Targets ID: 909501
  • Name: 2,5-dichloro-N-(4-ethoxyphenyl)benzamide
  • MW: 310.175 | Formula: C15H13Cl2NO2
  • H donors: 1 H acceptors: 1 LogP: 4.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)c1cc(Cl)ccc1Cl
  • InChi: 1S/C15H13Cl2NO2/c1-2-20-12-6-4-11(5-7-12)18-15(19)13-9-10(16)3-8-14(13)17/h3-9H,2H2,1H3,(H,18,19)
  • InChiKey: PRQPWTUAFWLRJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • BIM-0011879.P001
  • STK062824
  • ZINC00434422
  • CBMicro_012001
  • Oprea1_247432

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens taste receptor, type 1, member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Metabotropic glutamate receptor precursor. taste receptor, type 1, member 1 841 aa 911 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.1067 0.1612
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0018 0.0152 0.1424
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0215 0.2012
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.001 0.002 0.0015
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0207 0.1324
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.03 0.2814
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.072 0.486
Mycobacterium ulcerans polyketide synthase 0.0029 0.0327 0.3069
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0041 0.0517 0.3678
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0028 0.03 0.2814
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0025 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0097 0.1405 1
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0171 0.0167
Schistosoma mansoni isocitrate dehydrogenase 0.0012 0.005 0.0069
Loa Loa (eye worm) nuclear factor I 0.0024 0.0245 0.024
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0013 0.0092
Echinococcus granulosus smad 0.0044 0.0553 0.1845
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0012 0.005 0.0069
Brugia malayi TAR-binding protein 0.0191 0.2887 0.2884
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0197 0.298 0.2977
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0064 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.072 0.486
Brugia malayi hypothetical protein 0.0054 0.072 0.0716
Brugia malayi MH2 domain containing protein 0.0044 0.0553 0.0549
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0553 0.1845
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0012 0.005 0.0046
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0652 0.4641
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.2887 0.2884
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.1067 0.3571
Loa Loa (eye worm) hypothetical protein 0.0168 0.2519 0.2516
Loa Loa (eye worm) RecQ helicase 0.0025 0.0255 0.0251
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0334 0.05
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0287 0.2041
Brugia malayi mothers against decapentaplegic homolog 3 0.002 0.0171 0.0167
Brugia malayi MH2 domain containing protein 0.0044 0.0553 0.0549
Schistosoma mansoni tar DNA-binding protein 0.0191 0.2887 0.4373
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1405 0.4706
Onchocerca volvulus 0.0048 0.0624 0.2266
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1405 0.4706
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0072 0.0165
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0171 0.0167
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 0.5
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0012 0.005 0.0046
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0553 0.1845
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0553 0.0549
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.03 0.2814
Brugia malayi MH1 domain containing protein 0.0024 0.0245 0.024
Brugia malayi MH1 domain containing protein 0.0044 0.0553 0.0549
Onchocerca volvulus 0.0168 0.2519 0.919
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0084 0.0568
Mycobacterium leprae Polyketide synthase Pks13 0.0041 0.0517 0.4843
Brugia malayi latrophilin 2 splice variant baaae 0.0426 0.6598 0.6596
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0046
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0271 0.0267
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0012 0.005 0.0046
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0334 0.1108
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.03 0.2814
Loa Loa (eye worm) hypothetical protein 0.0125 0.1838 0.1834
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0111 0.0793
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.011 0.0106
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.004 0.0281
Onchocerca volvulus 0.0026 0.0271 0.0977
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0247 0.0816
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0041 0.0517 0.3678
Schistosoma mansoni hypothetical protein 0.0197 0.298 0.4513
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0197 0.298 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0197 0.298 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1405 1
Echinococcus multilocularis Smad4 0.0044 0.0553 0.1845
Schistosoma mansoni DNA helicase recq5 0.001 0.0025 0.0031
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0072 0.1088
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0025 0.0068
Brugia malayi N-terminal motif family protein 0.0182 0.2741 0.2738
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0012 0.005 0.0153
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.011 0.0106
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0028 0.03 0.0296
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0097 0.1405 0.4706
Echinococcus granulosus GPCR family 3 C terminal 0.001 0.002 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0623 0.9715 0.9715
Echinococcus granulosus tar DNA binding protein 0.0191 0.2887 0.9689
Brugia malayi MH2 domain containing protein 0.002 0.0171 0.0167
Schistosoma mansoni Smad4 0.0044 0.0553 0.0833
Toxoplasma gondii hypothetical protein 0.0026 0.0277 0.1951
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0334 0.033
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0097 0.1405 0.4706
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.011 0.0106
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0025 0.002
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0327 0.3069
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0012 0.005 0.0153
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0025 0.5
Schistosoma mansoni tar DNA-binding protein 0.0191 0.2887 0.4373
Loa Loa (eye worm) MH2 domain-containing protein 0.0641 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0553 0.0549
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0215 0.2012
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0028 0.03 0.2137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0623 0.9715 0.9715
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0097 0.1405 1
Echinococcus multilocularis smad 0.0044 0.0553 0.1845
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2741 1
Schistosoma mansoni hypothetical protein 0.0197 0.298 0.4513
Brugia malayi Isocitrate dehydrogenase 0.0097 0.1405 0.1401
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.0327 0.2331
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.03 0.2814
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.072 0.4636
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0255 1
Brugia malayi RNA binding protein 0.0191 0.2887 0.2884
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.072 0.511
Echinococcus multilocularis mothers against decapentaplegic 2 0.002 0.0171 0.0561
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.072 0.5038
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0287 0.2041
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0146 0.1016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.0152 0.1424
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0012 0.005 0.0467
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0277 0.1833
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0271 0.1932
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0012 0.005 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0623 0.9715 0.9715
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0177 0.1259
Schistosoma mansoni hypothetical protein 0.0197 0.298 0.4513
Mycobacterium ulcerans polyketide synthase Pks13 0.0041 0.0517 0.4843
Schistosoma mansoni hypothetical protein 0.0197 0.298 0.4513
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0012 0.005 0.0467
Brugia malayi hypothetical protein 0.0035 0.0416 0.0412
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.0692 0.0688
Loa Loa (eye worm) Smad1 0.0044 0.0553 0.0549
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0553 0.1845
Schistosoma mansoni Smad4 0.002 0.0171 0.0253
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.002
Schistosoma mansoni unc-13 (munc13) 0.0012 0.005 0.0069
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0652 0.2177
Echinococcus multilocularis tar DNA binding protein 0.0191 0.2887 0.9689
Schistosoma mansoni hypothetical protein 0.0426 0.6598 1
Onchocerca volvulus Poor gastrulation protein homolog 0.001 0.002 0.0056
Onchocerca volvulus Mothers against decapentaplegic homolog 0.002 0.0171 0.061
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.002
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0012 0.005 0.0153
Mycobacterium ulcerans thioesterase 0.0023 0.0227 0.213
Brugia malayi Probable isocitrate dehydrogenase 0.0012 0.005 0.0046
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0024 0.0243 0.0362
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0012 0.005 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0191 0.2887 0.4373
Loa Loa (eye worm) hypothetical protein 0.0054 0.072 0.0716
Loa Loa (eye worm) hypothetical protein 0.003 0.0334 0.033
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0025 0.0068
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0277 0.1171
Brugia malayi MH1 domain containing protein 0.0044 0.0553 0.0549
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.1067 0.3571
Loa Loa (eye worm) transcription factor SMAD2 0.0641 1 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.2741 0.2738
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0294 0.029
Echinococcus granulosus Smad4 0.0044 0.0553 0.1845
Schistosoma mansoni tar DNA-binding protein 0.0191 0.2887 0.4373
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0072 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0327 0.2308
Loa Loa (eye worm) glutamate receptor 0.0024 0.0243 0.0239
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.0327 0.2331
Loa Loa (eye worm) glutamate receptor 0.0016 0.011 0.0106
Brugia malayi Probable isocitrate dehydrogenase 0.0012 0.005 0.0046
Schistosoma mansoni smad1 5 8 and 0.0044 0.0553 0.0833
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0327 0.2331
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.072 0.5038
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0174 0.1213
Echinococcus multilocularis GPCR, family 2 0.0197 0.298 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 0.5
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1405 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0097 0.1405 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.002 0.0171 0.0561
Brugia malayi Latrophilin receptor protein 2 0.0197 0.298 0.2977
Schistosoma mansoni smad1 5 8 and 0.0044 0.0553 0.0833
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0327 0.3069
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.03 0.2137
Loa Loa (eye worm) TAR-binding protein 0.0191 0.2887 0.2884
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.0651 0.2365
Loa Loa (eye worm) hypothetical protein 0.0016 0.011 0.0106
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0652 0.2177
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1405 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0145
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0172 0.0255
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0097 0.1405 0.2124
Mycobacterium ulcerans polyketide synthase 0.0028 0.03 0.2814
Echinococcus granulosus mothers against decapentaplegic 2 0.002 0.0171 0.0561
Schistosoma mansoni DNA helicase recq1 0.001 0.0025 0.0031
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0097 0.1405 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.001 0.002 0.0015
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0215 0.2012
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.001 0.002 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0125 0.0861
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0277 0.2601
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.0327 0.3069
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0652 0.4641
Loa Loa (eye worm) hypothetical protein 0.0076 0.1067 0.1063
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.1067 0.7354
Echinococcus granulosus mothers against decapentaplegic 6 0.002 0.0171 0.0561
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.0152 0.1424
Leishmania major hypothetical protein, conserved 0.0054 0.072 0.4945
Schistosoma mansoni smad 0.0044 0.0553 0.0833
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0191 0.2887 0.4373
Loa Loa (eye worm) hypothetical protein 0.0024 0.0245 0.024
Schistosoma mansoni Smad4 0.002 0.0171 0.0253
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0227 0.1618
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0553 0.0833
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0097 0.1405 1
Echinococcus granulosus bloom syndrome protein 0.0025 0.0255 0.0843
Echinococcus multilocularis isocitrate dehydrogenase 0.0097 0.1405 0.4706
Brugia malayi MH1 domain containing protein 0.0024 0.0245 0.024
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0227 0.213
Loa Loa (eye worm) RNA binding protein 0.0191 0.2887 0.2884
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1067 0.7552
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0247 0.0816
Loa Loa (eye worm) hypothetical protein 0.0623 0.9715 0.9715
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0028 0.03 0.2814
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.072 0.486
Schistosoma mansoni hypothetical protein 0.0024 0.0247 0.0368
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0197 0.298 1
Schistosoma mansoni smad 0.002 0.0171 0.0253
Brugia malayi Smad1 0.0044 0.0553 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0171 0.0167
Echinococcus multilocularis GPCR, family 3, C terminal 0.001 0.002 0.0052
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1067 0.7587
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0025 0.0068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0598 0.0594
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0012 0.005 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1405 0.4706
Schistosoma mansoni hypothetical protein 0.001 0.002 0.0023
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0255 0.0251
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.011 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0104
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0227 0.213
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0271 0.0267
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.03 0.2137
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.022 0.1569
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1067 0.7587
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.0327 0.3069
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0652 0.6111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0197 0.298 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.0327 0.3069
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0553 0.1845
Brugia malayi Probable ClpP-like protease 0.0076 0.1067 0.1063
Loa Loa (eye worm) hypothetical protein 0.0426 0.6598 0.6596
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.1067 1
Echinococcus granulosus GPCR family 2 0.0197 0.298 1
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0255 0.0843
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.2887 0.2884
Loa Loa (eye worm) hypothetical protein 0.0197 0.298 0.2977
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0334 0.1108
Brugia malayi isocitrate dehydrogenase 0.0097 0.1405 0.1401
Toxoplasma gondii isocitrate dehydrogenase 0.0097 0.1405 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0197 0.298 0.2977
Loa Loa (eye worm) isocitrate dehydrogenase 0.0097 0.1405 0.1401
Brugia malayi hypothetical protein 0.0168 0.2519 0.2516
Toxoplasma gondii isocitrate dehydrogenase 0.0097 0.1405 1
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0255 1
Schistosoma mansoni smad1 5 8 and 0.0044 0.0553 0.0833

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.08 uM Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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