TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 481.561 | Formula: C26H27NO6S
H donors: 1 H acceptors: 4 LogP: 4.67 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CN(S(=O)(=O)c1ccc2c(c1)CCC(O2)(C)C)Cc1ccccc1Oc1ccccc1
InChi: 1S/C26H27NO6S/c1-26(2)15-14-19-16-22(12-13-24(19)33-26)34(30,31)27(18-25(28)29)17-20-8-6-7-11-23(20)32-21-9-4-3-5-10-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
InChiKey: WYVZGAPIWQJOPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol lipase, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	lipase containing protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Loa Loa (eye worm)	lipase	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Trichomonas vaginalis	lipase containing protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Onchocerca volvulus		Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma brucei	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	Get druggable targets OG5_129115	All targets in OG5_129115
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma congolense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania donovani	Lipase (class 3), putative	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma brucei gambiense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma congolense	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115
Brugia malayi	Lipase family protein	Get druggable targets OG5_129115	All targets in OG5_129115
Trypanosoma brucei	lipase domain protein, putative	Get druggable targets OG5_129115	All targets in OG5_129115

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0038	0.0453	0.0453
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Loa Loa (eye worm)	SH2 domain-containing protein	0.0019	0.0048	0.0048
Onchocerca volvulus		0.0019	0.0048	0.0031
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0108	0.1997	0.1997
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0019	0.0038	0.0038
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0867	0.147
Onchocerca volvulus		0.0026	0.0207	0.0501
Schistosoma mansoni	tyrosine kinase	0.0026	0.0207	0.0177
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0027	0.0225	0.0554
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0089	0.1591	0.1591
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.3414	1
Schistosoma mansoni	adapter molecule crk	0.0038	0.0453	0.0436
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0039	0.0486	0.0486
Schistosoma mansoni	vav2	0.0021	0.0099	0.0065
Brugia malayi	Tensin	0.0019	0.0048	0.0018
Echinococcus granulosus	SH2 domain containing protein 7	0.0019	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0109	0.2026	0.2026
Echinococcus granulosus	Glutaredoxin protein 5	0.0023	0.0145	0.0145
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0019	0.0048	0.0018
Echinococcus multilocularis	NCK adaptor protein	0.0038	0.0453	0.0453
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0048	0.0048
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0019	0.0038	0.0038
Loa Loa (eye worm)	thyroid receptor interactor	0.0019	0.0038	0.0038
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.0173	0.0402
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0019	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3536	0.3536
Brugia malayi	p70 ribosomal S6 kinase beta	0.0037	0.0435	0.0704
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.0173	0.0173
Schistosoma mansoni	tensin	0.0019	0.0048	0.0011
Schistosoma mansoni	tyrosine kinase	0.0061	0.0961	0.0968
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0019	0.0048	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Schistosoma mansoni	tyrosine kinase	0.0091	0.1614	0.1652
Echinococcus granulosus	tyrosine protein kinase HCK	0.007	0.1176	0.1176
Schistosoma mansoni	tyrosine kinase	0.0108	0.1997	0.2052
Echinococcus multilocularis	insulin receptor	0.0061	0.0961	0.0961
Schistosoma mansoni	tyrosine kinase	0.0091	0.1614	0.1652
Brugia malayi	RhoGAP domain containing protein	0.0019	0.0048	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0197	0.0167
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0021	0.0089	0.0451
Schistosoma mansoni	suppressor of cytokine signaling	0.0019	0.0048	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0038	0.0453	0.0453
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Schistosoma mansoni	suppressor of cytokine signaling	0.0019	0.0048	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Onchocerca volvulus		0.0019	0.0048	0.0031
Echinococcus granulosus	tyrosine kinase	0.0026	0.0207	0.0207
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0019	0.0048	0.0011
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0056	0.0867	0.147
Echinococcus granulosus	expressed conserved protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	SH2 domain-containing protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Echinococcus granulosus	insulin receptor	0.0061	0.0961	0.0961
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0019	0.0048	0.0048
Schistosoma mansoni	tyrosine kinase	0.0026	0.0207	0.0177
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0108	0.1997	0.1997
Echinococcus multilocularis	tyrosine kinase	0.0026	0.0207	0.0207
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0207	0.03
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Onchocerca volvulus		0.0019	0.0048	0.0031
Trypanosoma brucei	lipase domain protein, putative	0.0173	0.3414	1
Onchocerca volvulus		0.0019	0.0048	0.0031
Schistosoma mansoni	tensin	0.0019	0.0048	0.0011
Brugia malayi	Tyrosine-protein kinase abl-1	0.0276	0.5681	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0023	0.0145	0.0145
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0048	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0039	0.0486	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0453	0.0453
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.0173	0.1194
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase shark	0.0026	0.0207	0.0207
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0019	0.0048	0.0048
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0177	0.3499	0.3499
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Echinococcus multilocularis	expressed protein	0.0019	0.0038	0.0038
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0025	0.0173	0.5
Echinococcus multilocularis	transfer RNA-Ala	0.0019	0.0038	0.0038
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0056	0.0867	0.0867
Echinococcus granulosus	N chimaerin	0.0019	0.0048	0.0048
Onchocerca volvulus		0.0026	0.0207	0.0501
Echinococcus granulosus	c src tyrosine kinase	0.0045	0.0612	0.0612
Echinococcus granulosus	tyrosine kinase	0.0089	0.1591	0.1591
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0019	0.0048	0.0048
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0019	0.0048	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0207	0.03
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.1591	0.1591
Entamoeba histolytica	SH2 domain containing protein	0.0019	0.0048	0.0091
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0061	0.0961	0.0961
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0173	0.3414	0.3414
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0019	0.0048	0.0048
Echinococcus granulosus	epidermal growth factor receptor	0.0177	0.3499	0.3499
Echinococcus multilocularis	tyrosine protein kinase HCK	0.007	0.1176	0.1176
Echinococcus granulosus	tyrosine protein kinase Blk	0.0089	0.1591	0.1591
Echinococcus granulosus	SH2 motif	0.0019	0.0048	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0019	0.0048	0.0048
Brugia malayi	Furin-like cysteine rich region family protein	0.0177	0.3499	0.6133
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0207	0.03
Schistosoma mansoni	tyrosine kinase	0.0045	0.0612	0.0602
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0019	0.0048	0.0048
Echinococcus granulosus	serine/threonine protein kinase	0.0027	0.0225	0.0225
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.3414	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0038	0.0453	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Onchocerca volvulus	Tyrosine kinase homolog	0.0168	0.3301	0.9665
Brugia malayi	SH2 domain containing protein	0.0026	0.0207	0.03
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0048	0.0048
Echinococcus multilocularis		0.0019	0.0048	0.0048
Trichomonas vaginalis	lipase containing protein, putative	0.0173	0.3414	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0098	0.1773	0.1773
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0027	0.0225	0.1644
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0045	0.0612	0.0612
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0099	0.0099
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0056	0.0867	0.0867
Loa Loa (eye worm)	TK protein kinase	0.007	0.1176	0.1176
Echinococcus multilocularis	rac serine:threonine kinase	0.0027	0.0225	0.0225
Loa Loa (eye worm)	lipase	0.0173	0.3414	0.3414
Echinococcus granulosus	signal transduction protein lnk realted	0.0019	0.0048	0.0048
Echinococcus multilocularis	SH2 motif	0.0019	0.0048	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Trypanosoma cruzi	Protein kinase B	0.0027	0.0225	0.0554
Schistosoma mansoni	GTPase activating protein	0.0019	0.0048	0.0011
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0038	0.0453	0.0453
Echinococcus multilocularis	N chimaerin	0.0019	0.0048	0.0048
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.002	0.0077	0.0344
Echinococcus multilocularis	c src tyrosine kinase	0.0045	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Entamoeba histolytica	protein kinase, putative	0.007	0.1176	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0089	0.1591	0.1591
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0019	0.0048	0.0048
Echinococcus granulosus	src region	0.0019	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase shark	0.0026	0.0207	0.0207
Schistosoma mansoni	tensin-related	0.0019	0.0048	0.0011
Schistosoma mansoni	tyrosine kinase	0.0177	0.3499	0.3625
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0089	0.1591	0.1591
Echinococcus granulosus	hypothetical protein	0.0019	0.0048	0.0048
Echinococcus granulosus	nostrin	0.0019	0.0038	0.0038
Loa Loa (eye worm)	TK/INSR protein kinase	0.0061	0.0961	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0867	0.2457
Loa Loa (eye worm)	protein-tyrosine kinase	0.0019	0.0038	0.0038
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0021	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Schistosoma mansoni	tyrosine kinase	0.0455	0.9584	1
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0019	0.0038	0.0038
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0019	0.0048	0.0011
Echinococcus multilocularis	intersectin 2	0.0019	0.0038	0.0038
Schistosoma mansoni	SH2A	0.0019	0.0048	0.0011
Leishmania major	hypothetical protein, conserved	0.0173	0.3414	1
Echinococcus granulosus	expressed protein	0.0019	0.0038	0.0038
Echinococcus multilocularis	epidermal growth factor receptor	0.0177	0.3499	0.3499
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0867	0.2457
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Loa Loa (eye worm)	SH2 domain-containing protein	0.0019	0.0048	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Loa Loa (eye worm)	TK protein kinase	0.0089	0.1591	0.1591
Echinococcus multilocularis	endophilin A3	0.0019	0.0038	0.0038
Echinococcus multilocularis	nervana 2	0.0023	0.0145	0.0145
Onchocerca volvulus		0.0026	0.0207	0.0501
Entamoeba histolytica	protein kinase, putative	0.0039	0.0486	0.3942
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0019	0.0038	0.0038
Onchocerca volvulus		0.0158	0.3083	0.9018
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0019	0.0048	0.0048
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0048	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0207	0.03
Brugia malayi	SH2 domain containing protein	0.0026	0.0207	0.03
Brugia malayi	Tyrosine-protein kinase abl-1	0.0216	0.4357	0.7654
Loa Loa (eye worm)	SRC-1	0.0108	0.1997	0.1997
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0021	0.0089	0.0089
Schistosoma mansoni	tyrosine kinase	0.0098	0.1773	0.1818
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0019	0.0038	0.0038
Onchocerca volvulus		0.0026	0.0207	0.0501
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0048	0.0018
Brugia malayi	hypothetical protein	0.0019	0.0048	0.0018
Brugia malayi	Sex muscle abnormal protein 5	0.0038	0.0453	0.0737
Echinococcus multilocularis	epidermal growth factor receptor	0.0098	0.1773	0.1773
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Echinococcus granulosus	NCK adaptor protein	0.0038	0.0453	0.0453
Onchocerca volvulus		0.0019	0.0048	0.0031
Loa Loa (eye worm)	TK/ABL protein kinase	0.0474	1	1
Echinococcus multilocularis	tensin	0.0019	0.0048	0.0048
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0045	0.0612	0.0612
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0025	0.0173	0.5
Echinococcus multilocularis	Glutaredoxin protein 5	0.0023	0.0145	0.0145
Trichomonas vaginalis	lipase containing protein, putative	0.0173	0.3414	1
Brugia malayi	Variant SH3 domain containing protein	0.0038	0.0453	0.0737
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0108	0.1997	0.1997
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0099	0.0109
Brugia malayi	protein-tyrosine kinase	0.0089	0.1591	0.2753
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0011
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0179	0.355	0.355
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0019	0.0048	0.0048
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0021	0.0099	0.0099
Schistosoma mansoni	signal transduction protein lnk-related	0.0019	0.0048	0.0011
Entamoeba histolytica	protein kinase, putative	0.0037	0.0435	0.3491
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0019	0.0048	0.0048
Echinococcus granulosus	growth factor receptor bound protein 2	0.0038	0.0453	0.0453
Schistosoma mansoni	tyrosine kinase	0.0098	0.1773	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Echinococcus multilocularis	signal transduction protein lnk realted	0.0019	0.0048	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0867	0.0869
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0019	0.0048	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0867	0.2457
Echinococcus granulosus	Spectrin alpha actinin	0.0019	0.0038	0.0038
Echinococcus multilocularis	nostrin	0.0019	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0082	0.1432	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Onchocerca volvulus		0.0019	0.0048	0.0031
Onchocerca volvulus		0.0026	0.0207	0.0501
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0019	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0108	0.1997	0.1997
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0039	0.0486	0.1328
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0108	0.1997	0.1997
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0037	0.0435	0.0435
Schistosoma mansoni	tyrosine kinase	0.0108	0.1997	0.2052
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0108	0.1997	0.1997
Echinococcus multilocularis		0.0053	0.0786	0.0786
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0026	0.0207	0.1488
Echinococcus granulosus	tensin	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0026	0.0207	0.0207
Schistosoma mansoni	serine/threonine-protein kinase	0.0027	0.0225	0.0196
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Echinococcus multilocularis	nervana 2	0.0023	0.0145	0.0145
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0019	0.0038	0.0038
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Trypanosoma brucei	lipase domain protein, putative	0.0173	0.3414	1
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0019	0.0038	0.0038
Brugia malayi	SRC-1	0.0108	0.1997	0.3472
Loa Loa (eye worm)	guanylate kinase	0.0019	0.0038	0.0038
Echinococcus granulosus	nervana 2	0.0023	0.0145	0.0145
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0061	0.0961	0.0961
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0108	0.1997	0.1997
Echinococcus multilocularis	SH2 domain containing protein 7	0.0019	0.0048	0.0048
Loa Loa (eye worm)	p53BP2	0.0019	0.0038	0.0038
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0019	0.0048	0.0011
Schistosoma mansoni	tyrosine kinase	0.0045	0.0612	0.0602
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0019	0.0038	0.0038
Toxoplasma gondii	AGC kinase	0.0037	0.0435	0.5
Entamoeba histolytica	protein kinase, putative	0.002	0.0077	0.0344
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0045	0.0612	0.0602
Echinococcus multilocularis	SH2 motif	0.0019	0.0048	0.0048
Echinococcus granulosus	epidermal growth factor receptor	0.0098	0.1773	0.1773
Echinococcus granulosus	tyrosine protein kinase Srms	0.0026	0.0207	0.0207
Entamoeba histolytica	protein kinase, putative	0.0039	0.0486	0.3942
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0019	0.0048	0.0011
Schistosoma mansoni	nck2/grb4	0.0038	0.0453	0.0436
Onchocerca volvulus		0.0173	0.3414	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0108	0.1997	0.1997
Echinococcus granulosus	intersectin 2	0.0019	0.0038	0.0038
Echinococcus granulosus	nervana 2	0.0023	0.0145	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0474	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Brugia malayi	Variant SH3 domain containing protein	0.0019	0.0048	0.0018
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0019	0.0038	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Loa Loa (eye worm)	STAT protein	0.0019	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0026	0.0207	0.0207
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0019	0.0038	0.0038
Echinococcus multilocularis	SH2 motif	0.0019	0.0048	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0207	0.03
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0082	0.1432	0.1432
Echinococcus granulosus	endophilin A3	0.0019	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0026	0.0207	0.03
Schistosoma mansoni	tensin-related	0.0019	0.0048	0.0011
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0108	0.1997	0.1997
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0056	0.0867	0.0867
Schistosoma mansoni	tyrosine kinase	0.0061	0.0961	0.0968
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0108	0.1997	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Schistosoma mansoni	growth factor receptor-bound protein	0.0038	0.0453	0.0436
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0056	0.0867	0.0867
Entamoeba histolytica	protein kinase, putative	0.0056	0.0867	0.7291
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0027	0.0225	0.1644
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0019	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0108	0.1997	0.1997
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.0173	0.0173
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0019	0.0048	0.0018
Echinococcus granulosus	SHC transforming protein 3	0.0019	0.0048	0.0048
Onchocerca volvulus		0.0026	0.0207	0.0501
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0019	0.0048	0.0031
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0179	0.355	0.6225
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0173	0.3414	0.3414
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0019	0.0038	0.0038
Schistosoma mansoni	shc transforming protein	0.0019	0.0048	0.0011
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0207	0.0207
Echinococcus multilocularis	Spectrin alpha actinin	0.0019	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0216	0.4357	0.4357
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0019	0.0048	0.0018
Schistosoma mansoni	tyrosine kinase	0.0091	0.1614	0.1652
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0961	0.1637
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0019	0.0038	0.0038
Giardia lamblia	Kinase, AGC PKA	0.0025	0.0173	0.5
Echinococcus multilocularis	tensin	0.0019	0.0048	0.0048
Schistosoma mansoni	serine/threonine-protein kinase	0.0027	0.0225	0.0196
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0019	0.0048	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0038	0.0453	0.0737
Onchocerca volvulus		0.002	0.0066	0.0085
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0021	0.0089	0.0054
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0038	0.0453	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Echinococcus granulosus	SH2 motif	0.0019	0.0048	0.0048
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0023	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0048
Brugia malayi	Lipase family protein	0.0173	0.3414	0.5984
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0038
Echinococcus multilocularis	SHC transforming protein 3	0.0019	0.0048	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0486	0.1328
Schistosoma mansoni	tensin	0.0019	0.0048	0.0011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 185 nM	Inhibition of human DAGLalpha expressed in HEK293T cell membranes	ChEMBL.	24988361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3319618

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 922418