Detailed information for compound 923383

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.39 | Formula: C22H18N2O3
  • H donors: 3 H acceptors: 3 LogP: 4.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(NC(=O)c1ccc2c(c1)cccc2)Cc1cc2c([nH]1)cccc2
  • InChi: 1S/C22H18N2O3/c25-21(17-10-9-14-5-1-2-6-15(14)11-17)24-20(22(26)27)13-18-12-16-7-3-4-8-19(16)23-18/h1-12,20,23H,13H2,(H,24,25)(H,26,27)
  • InChiKey: JRJZXYIYEXKPQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.137 0.137
Entamoeba histolytica protein kinase, putative 0.0015 0.0397 0.0074
Entamoeba histolytica PH domain containing protein kinase, putative 0.0015 0.0397 0.0074
Leishmania major protein kinase, putative 0.0015 0.0397 0.094
Trypanosoma cruzi Protein kinase B 0.0081 0.368 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Onchocerca volvulus outspread protein homolog 0.0014 0.0361 0.5
Echinococcus granulosus oxysterol binding protein 3 0.0014 0.0361 0.0361
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0067 0.2979 0.2979
Echinococcus multilocularis nervana 2 0.0066 0.2942 0.2678
Trypanosoma cruzi NIMA-related kinase, putative 0.0015 0.0397 0.0373
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1623 0.2528
Echinococcus granulosus NDR protein kinase 0.0034 0.137 0.137
Toxoplasma gondii hypothetical protein 0.0014 0.0361 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.1623 0.3967
Entamoeba histolytica protein kinase, putative 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Loa Loa (eye worm) hypothetical protein 0.0034 0.137 0.1047
Echinococcus granulosus Protein kinase C brain isozyme 0.0034 0.137 0.137
Schistosoma mansoni vav2 0.0017 0.0495 0.014
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.1623 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0015 0.0397 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Onchocerca volvulus 0.0014 0.0361 0.5
Echinococcus granulosus cytohesin 1 0.0207 1 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0067 0.2979 1
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0014 0.0361 0.0361
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0361 0.0264
Entamoeba histolytica protein kinase 2, putative 0.0067 0.2979 0.5242
Echinococcus multilocularis expressed protein 0.004 0.167 0.1359
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0014 0.0361 0.0361
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0014 0.0361 0.5
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.137 0.137
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0149 0.7097 0.7097
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0034 0.137 0.2022
Trypanosoma brucei PH domain containing protein, putative 0.0014 0.0361 0.0177
Onchocerca volvulus Protein melted homolog 0.0014 0.0361 0.5
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Schistosoma mansoni serine/threonine-protein kinase 0.0081 0.368 0.3444
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0015 0.0397 0.0141
Entamoeba histolytica protein kinase, putative 0.0015 0.0397 0.0074
Entamoeba histolytica hypothetical protein 0.0015 0.0397 0.0074
Onchocerca volvulus 0.0014 0.0361 0.5
Brugia malayi Hr1 repeat family protein 0.0034 0.137 0.1047
Echinococcus granulosus oxysterol binding protein 1 0.0014 0.0361 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0034 0.137 0.2022
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0015 0.0397 0.029
Entamoeba histolytica protein kinase, putative 0.0015 0.0397 0.0074
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.1623 0.266
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0017 0.0492 0.0492
Brugia malayi Protein kinase domain containing protein 0.0034 0.137 0.1047
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0015 0.0397 0.0074
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0015 0.0397 0.025
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0015 0.0397 0.025
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0014 0.0361 0.0264
Echinococcus granulosus oxysterol binding protein 9 0.0014 0.0361 0.0361
Echinococcus granulosus nervana 2 0.0066 0.2942 0.2942
Brugia malayi protein kinase C II. 0.0034 0.137 0.1047
Entamoeba histolytica protein kinase, putative 0.0114 0.5355 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0015 0.0397 0.0373
Schistosoma mansoni rotamase 0.004 0.167 0.1359
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.1623 0.3086
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0014 0.0361 0.0361
Entamoeba histolytica p21-activated kinase 0.0015 0.0397 0.0074
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0016 0.0476 0.0232
Echinococcus granulosus pleckstrin y domain containing family A 0.0014 0.0361 0.0361
Entamoeba histolytica protein kinase, putative 0.0114 0.5355 1
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0014 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0017 0.0495 0.014
Echinococcus granulosus dynamin 1 0.0014 0.0361 0.0361
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.137 0.1047
Echinococcus granulosus myotubularin protein 13 0.0014 0.0361 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Entamoeba histolytica protein kinase, putative 0.0015 0.0397 0.0074
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0014 0.0361 0.0264
Entamoeba histolytica PH domain containing protein kinase, putative 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.167 0.1359
Echinococcus granulosus protein kinase C gamma type 0.0034 0.137 0.137
Echinococcus granulosus Pleckstrin y 0.0014 0.0361 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Onchocerca volvulus 0.0014 0.0361 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0034 0.137 0.1047
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0066 0.2942 0.2678
Entamoeba histolytica protein kinase, putative 0.0034 0.137 0.2022
Schistosoma mansoni tyrosine kinase 0.0146 0.6965 0.6852
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.027 0.5
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.167 0.1359
Plasmodium falciparum calcium-dependent protein kinase 7 0.0015 0.0397 0.0141
Brugia malayi p70 ribosomal S6 kinase beta 0.01 0.4653 0.4453
Echinococcus multilocularis cytohesin 1 0.0207 1 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.137 0.1047
Echinococcus multilocularis protein kinase c iota type 0.0034 0.137 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0067 0.2979 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.137 0.1047
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Trichomonas vaginalis protein transport protein sec7, putative 0.0016 0.0476 0.0232
Echinococcus granulosus beta 1 syntrophin 0.0014 0.0361 0.0361
Onchocerca volvulus 0.0014 0.0361 0.5
Echinococcus granulosus protein kinase c iota type 0.0034 0.137 0.137
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.137 0.1047
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0067 0.2979 0.7942
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Echinococcus granulosus expressed protein 0.004 0.167 0.167
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0067 0.2979 0.2716
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.01 0.4653 0.4453
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0015 0.0397 0.0373
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0495 0.014
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trypanosoma brucei protein kinase, putative 0.0015 0.0397 0.025
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Echinococcus multilocularis protein kinase c epsilon type 0.0034 0.137 0.1047
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0014 0.0361 0.0361
Onchocerca volvulus 0.0014 0.0361 0.5
Trypanosoma cruzi PH domain containing protein, putative 0.0014 0.0361 0.0264
Echinococcus granulosus Oxysterol binding protein 11 0.0014 0.0361 0.0361
Toxoplasma gondii Oxysterol-binding protein 0.0014 0.0361 0.0206
Leishmania major folate/biopterin transporter, putative 0.0015 0.0397 0.094
Echinococcus granulosus Rho GTPase activating protein 24 0.0014 0.0361 0.0361
Echinococcus granulosus Glutaredoxin protein 5 0.0066 0.2942 0.2942
Echinococcus granulosus calcium dependent secretion activator 1 0.0014 0.0361 0.0361
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Schistosoma mansoni atypical protein kinase C 0.0034 0.137 0.1047
Entamoeba histolytica PH domain containing protein kinase, putative 0.0015 0.0397 0.0074
Onchocerca volvulus 0.0014 0.0361 0.5
Echinococcus multilocularis Glutaredoxin protein 5 0.0066 0.2942 0.2678
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0015 0.0397 0.0373
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.368 0.6647
Trichomonas vaginalis rotamase, putative 0.004 0.167 0.2623
Schistosoma mansoni serine/threonine kinase 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.004 0.167 0.2623
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.137 0.1047
Brugia malayi Protein kinase domain containing protein 0.0114 0.5355 0.5181
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0034 0.137 0.1047
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0015 0.0397 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0015 0.0397 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Entamoeba histolytica protein kinase, putative 0.01 0.4653 0.8595
Echinococcus granulosus GRB2 associated binding protein 3 0.0014 0.0361 0.0361
Leishmania major hypothetical protein, conserved 0.0014 0.0361 0.0667
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.137 0.137
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0015 0.0397 0.0373
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0081 0.368 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.137 0.1047
Echinococcus multilocularis nervana 2 0.0066 0.2942 0.2678
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.368 0.6647
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.137 0.137
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0017 0.0492 0.0137
Trypanosoma cruzi PH domain containing protein, putative 0.0014 0.0361 0.0264
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0014 0.0361 0.0361
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0015 0.0397 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Toxoplasma gondii phosphatidylinositol transfer protein 0.0014 0.0361 0.0206
Entamoeba histolytica PH domain containing protein kinase, putative 0.0015 0.0397 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0034 0.137 0.2022
Toxoplasma gondii protein kinase domain-containing protein 0.0015 0.0397 0.029
Giardia lamblia Kinase, AGC PKA 0.0067 0.2979 0.5
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Echinococcus granulosus serine/threonine protein kinase 0.0081 0.368 0.368
Leishmania major hypothetical protein, conserved 0.0014 0.0361 0.0667
Leishmania major serine/threonine-protein kinase a, putative 0.0015 0.0397 0.094
Loa Loa (eye worm) AGC/AKT protein kinase 0.0114 0.5355 0.5181
Echinococcus granulosus nervana 2 0.0066 0.2942 0.2942
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.137 0.1047
Toxoplasma gondii AtPH1 family protein 0.0014 0.0361 0.0206
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0034 0.1333 0.1948
Echinococcus granulosus DCC interacting protein 13 beta 0.0014 0.0361 0.0361
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0495 0.014
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0017 0.0492 0.0137
Toxoplasma gondii AGC kinase 0.01 0.4653 1
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0014 0.0361 0.5
Trypanosoma cruzi PH domain containing protein, putative 0.0014 0.0361 0.0264
Echinococcus multilocularis rac serine:threonine kinase 0.0081 0.368 0.3444
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.137 0.1047
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0015 0.0397 0.094
Onchocerca volvulus 0.0014 0.0361 0.5
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trichomonas vaginalis rotamase, putative 0.0039 0.1623 0.2528
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Trypanosoma brucei rac serine-threonine kinase, putative 0.0114 0.5355 1
Echinococcus granulosus protein kinase c epsilon type 0.0034 0.137 0.137
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0015 0.0397 0.0373
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.1623 0.3967
Echinococcus granulosus Pleckstrin y 0.0014 0.0361 0.0361
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0015 0.0397 0.094
Trichomonas vaginalis protein transport protein sec7, putative 0.0016 0.0476 0.0232
Leishmania major protein kinase, putative 0.0015 0.0397 0.094
Onchocerca volvulus Putative zinc finger protein 0.0014 0.0361 0.5
Echinococcus granulosus serine threonine protein kinase nrc 0.0067 0.2979 0.2979
Entamoeba histolytica hypothetical protein 0.0017 0.0492 0.0263
Brugia malayi Protein kinase domain containing protein 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Schistosoma mansoni serine/threonine-protein kinase 0.0081 0.368 0.3444
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0066 0.2942 0.2942
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0149 0.7097 0.6988
Trypanosoma cruzi hypothetical protein 0.0014 0.0361 0.0264
Toxoplasma gondii hypothetical protein 0.0014 0.0361 0.0206
Loa Loa (eye worm) cytohesin 3 0.0207 1 1
Echinococcus granulosus pdz domain containing protein 0.0014 0.0361 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0048 0.2072 0.3427
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0207 1 1
Trypanosoma cruzi PH domain containing protein, putative 0.0014 0.0361 0.0264
Entamoeba histolytica hypothetical protein 0.0015 0.0397 0.0074
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0015 0.0397 0.025
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.137 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0015 0.0397 0.025
Trichomonas vaginalis AGC family protein kinase 0.0114 0.5355 1
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0014 0.0361 0.0361
Echinococcus granulosus Pleckstrin y 0.0014 0.0361 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0397 0.0074

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.9 uM Inhibition of Pin1 (unknown origin) ChEMBL. 25091930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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