Detailed information for compound 926996

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 847.005 | Formula: C46H62N4O11
  • H donors: 5 H acceptors: 7 LogP: 6.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c2C4=NC5(NC4=C(C(=O)c2c(c3C)O)NC(=O)/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@H]1C)OC(=O)C)C)O)C)O)C)/C)CCN(CC5)CC(C)C
  • InChi: 1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25-,26+,27-,30-,37-,38+,41+,45-/m0/s1
  • InChiKey: ATEBXHFBFRCZMA-GKADUICLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus synaptic vesicle 2 protein 0.0033 0.0167 0.0235
Echinococcus granulosus hypothetical protein 0.0268 0.2591 0.374
Echinococcus multilocularis dro:myosuppressin receptor 0.0268 0.2591 0.374
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Onchocerca volvulus 0.0033 0.0167 0.0627
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0008
Plasmodium vivax lysine--tRNA ligase, putative 0.0052 0.0365 0.036
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0564 0.0815
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0144 0.2157
Echinococcus multilocularis geminin 0.0171 0.1598 0.2305
Echinococcus granulosus solute carrier family 22 0.0033 0.0167 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0268 0.2591 0.3744
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) sugar transporter 0.0232 0.2226 0.4082
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.016 0.0225
Brugia malayi beta-lactamase family protein 0.0036 0.02 0.0367
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0488 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0496 0.7421
Echinococcus granulosus biogenic amine 5HT receptor 0.0268 0.2591 0.374
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0231 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.016 0.0293
Echinococcus multilocularis calcium dependent protein kinase 0.0067 0.0519 0.0743
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.02 0.0367
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0071 0.0564 0.1034
Schistosoma mansoni hypothetical protein 0.0171 0.1598 0.231
Echinococcus granulosus solute carrier family 22 0.0033 0.0167 0.0235
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus granulosus dro:myosuppressin receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) TYRA-2 protein 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.007 0.0549 0.0788
Brugia malayi hypothetical protein 0.0033 0.0167 0.0307
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0291 0.1306
Echinococcus granulosus solute carrier family 22 0.0033 0.0167 0.0235
Onchocerca volvulus 0.0033 0.0167 0.0627
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0005 0.0007
Schistosoma mansoni amine GPCR 0.0268 0.2591 0.3744
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.016 0.0231
Schistosoma mansoni biogenic amine (5HT) receptor 0.0268 0.2591 0.3744
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0365 0.6953
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Onchocerca volvulus 0.0268 0.2591 1
Schistosoma mansoni sugar transporter 0.0033 0.0167 0.0242
Schistosoma mansoni hypothetical protein 0.0268 0.2591 0.3744
Schistosoma mansoni glucose transport protein 0.0232 0.2226 0.3217
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Brugia malayi RE15519p 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0365 0.0528
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0231 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Plasmodium falciparum protein kinase 7 0.0657 0.66 0.6598
Onchocerca volvulus 0.0268 0.2591 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.016 0.0293
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.007 0.0549 0.0794
Leishmania major glucose transporter, lmgt2 0.0072 0.0573 0.8581
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0001
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis solute carrier family 22 0.0033 0.0167 0.0235
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.2591 0.374
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.2591 0.374
Plasmodium vivax proline--tRNA ligase, putative 0.0081 0.0668 0.0664
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.016 0.0225
Mycobacterium leprae conserved hypothetical protein 0.0036 0.02 0.0323
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.2591 0.374
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0144 0.0218
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0095 0.0807 0.3102
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0095 0.0807 0.1161
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.2591 0.374
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0144 0.2157
Onchocerca volvulus 0.0033 0.0167 0.0627
Schistosoma mansoni amine GPCR 0.0268 0.2591 0.3744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0071 0.0564 0.0855
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.007 0.0549 0.1007
Plasmodium vivax hypothetical protein, conserved 0.0036 0.02 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0325 0.0596
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0167 0.0751
Plasmodium falciparum calcium-dependent protein kinase 2 0.0071 0.0564 0.056
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0291 0.3602
Brugia malayi Tachykinin-like peptides receptor 99D 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0005 0.0007
Onchocerca volvulus 0.0268 0.2591 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.02 0.0899
Echinococcus granulosus solute carrier family 22 0.0033 0.0167 0.0235
Onchocerca volvulus 0.0048 0.0325 0.1238
Entamoeba histolytica protein kinase, putative 0.0071 0.0564 0.6988
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.016 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.016 0.0225
Loa Loa (eye worm) ctsf protein 0.0017 0.0005 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0308 0.0444
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0071 0.0564 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Plasmodium falciparum mitogen-activated protein kinase 2 0.0376 0.3702 0.3699
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.016 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi G-protein coupled receptor 0.0268 0.2591 0.475
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0268 0.2591 0.374
Echinococcus multilocularis General substrate transporter 0.02 0.189 0.2726
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0231 0.345
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.016 0.0293
Schistosoma mansoni neuropeptide receptor 0.0268 0.2591 0.3744
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0291 0.435
Brugia malayi RNA binding protein 0.0073 0.0586 0.1075
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0071 0.0564 0.844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.016 0.0293
Echinococcus granulosus somatostatin receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0005 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0144 0.0139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.02 0.2871
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Echinococcus granulosus tachykinin peptides receptor 99D 0.0268 0.2591 0.374
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0033 0.0167 0.2503
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.016 0.0231
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Loa Loa (eye worm) cysteine protease 0.0017 0.0005 0.0009
Brugia malayi Inositol-1 0.0039 0.0231 0.0423
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.016 0.0231
Echinococcus multilocularis G-protein coupled receptor, putative 0.0268 0.2591 0.374
Schistosoma mansoni protein kinase 0.0021 0.0046 0.0066
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni biogenic amine receptor 0.0268 0.2591 0.3744
Loa Loa (eye worm) RNA binding protein 0.0073 0.0586 0.1075
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0033 0.0167 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.02 0.2997
Onchocerca volvulus 0.0268 0.2591 1
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0167 0.0307
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0308 0.0444
Plasmodium falciparum lysine--tRNA ligase 0.0052 0.0365 0.036
Brugia malayi major facilitator superfamily protein 0.0033 0.0167 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0586 0.1075
Schistosoma mansoni neuropeptide receptor 0.0268 0.2591 0.3744
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.692 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0488 0.0706
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0268 0.2591 0.374
Brugia malayi nuclear receptor NHR-88 0.0032 0.016 0.0293
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0365 0.6953
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0268 0.2591 0.3744
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0231 0.3621
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.02 0.0163
Echinococcus multilocularis solute carrier family 22 0.0033 0.0167 0.0235
Leishmania major hypothetical protein, conserved 0.0036 0.02 0.2997
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0291 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0167 0.0751
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.016 0.0293
Loa Loa (eye worm) melatonin receptor type 1A 0.0268 0.2591 0.475
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.2256 0.3256
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0167 0.0751
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0573 0.8581
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.016 0.0293
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.016 0.0225
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0668 1
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0008
Mycobacterium leprae Probable lipase LipE 0.0036 0.02 0.0323
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0291 0.1929
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.016 0.0225
Mycobacterium ulcerans integral membrane transport protein 0.0033 0.0167 0.2054
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0071 0.0564 0.0855
Treponema pallidum prolyl-tRNA synthetase 0.0025 0.0084 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.2591 0.3744
Schistosoma mansoni neuropeptide f receptor 76f 0.0268 0.2591 0.3744
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Brugia malayi hypothetical protein 0.0033 0.0167 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.016 0.0293
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.018 0.033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.2591 0.374
Leishmania major cathepsin L-like protease 0.0065 0.0496 0.7421
Toxoplasma gondii lysine-tRNA ligase 0.0052 0.0365 0.0553
Brugia malayi hypothetical protein 0.0033 0.0167 0.0307
Schistosoma mansoni opsin-like receptor 0.0268 0.2591 0.3744
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0268 0.2591 0.475
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.02 0.0899
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0237 0.354
Loa Loa (eye worm) hypothetical protein 0.0034 0.018 0.033
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Schistosoma mansoni alpha-1 adrenergic receptor 0.0268 0.2591 0.3744
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.2256 0.3256
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0268 0.2591 0.3744
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Brugia malayi steroid hormone receptor 0.0032 0.016 0.0293
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.2591 0.374
Brugia malayi putative neuropeptide receptor NPR1 0.0268 0.2591 0.475
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus granulosus g protein coupled receptor 0.0268 0.2591 0.374
Echinococcus multilocularis sex peptide receptor 0.0268 0.2591 0.374
Onchocerca volvulus 0.0033 0.0167 0.0627
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.0285 0.0579
Echinococcus multilocularis neuropeptide receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Echinococcus multilocularis neuropeptide receptor 0.0268 0.2591 0.374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0308 0.0444
Echinococcus multilocularis neuropeptide FF receptor 2 0.0268 0.2591 0.374
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0291 0.0414
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0095 0.0807 0.3626
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0076
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0071 0.0564 0.1034
Loa Loa (eye worm) sugar transporter 0.0033 0.0167 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0008
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0268 0.2591 0.3744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0308 0.0438
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Loa Loa (eye worm) hypothetical protein 0.007 0.0549 0.1007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.435
Brugia malayi Sugar transporter family protein 0.0033 0.0167 0.0307
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0063
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2194 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0144 0.2157
Loa Loa (eye worm) hypothetical protein 0.0057 0.0414 0.076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.2591 0.374
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0268 0.2591 0.374
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0231 0.1036
Loa Loa (eye worm) hypothetical protein 0.003 0.0144 0.0264
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.02 0.0283
Echinococcus multilocularis synaptic vesicle 2 protein 0.0033 0.0167 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.016 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Brugia malayi ecdysteroid receptor 0.0032 0.016 0.0293
Onchocerca volvulus 0.0268 0.2591 1
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.016 0.0599
Echinococcus multilocularis neuropeptide s receptor 0.0268 0.2591 0.374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Onchocerca volvulus 0.0033 0.0167 0.0627
Loa Loa (eye worm) hypothetical protein 0.0095 0.0807 0.148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Echinococcus granulosus equilibrative nucleoside transporter 0.0095 0.0807 0.1161
Mycobacterium ulcerans sugar transporter 0.0033 0.0167 0.2054
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0496 0.7421
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0232 0.2226 0.3213
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0291 0.0414
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.016 0.0225
Echinococcus granulosus neuropeptide s receptor 0.0268 0.2591 0.374
Echinococcus multilocularis lysyl tRNA synthetase 0.0052 0.0365 0.0522
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Schistosoma mansoni neuropeptide receptor 0.0268 0.2591 0.3744
Brugia malayi nuclear receptor RXR 0.0017 0.0005 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.016 0.0293
Onchocerca volvulus 0.0036 0.02 0.0755
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0231 0.345
Plasmodium falciparum hexose transporter 0.0232 0.2226 0.2223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0308 0.0438
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0268 0.2591 1
Schistosoma mansoni sugar transporter 0.0033 0.0167 0.0242
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0268 0.2591 0.475
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0586 0.0842
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.2591 0.374
Onchocerca volvulus 0.0268 0.2591 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0365 0.0528
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0144 0.0139
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0268 0.2591 0.475
Brugia malayi Dopamine receptor protein 2 0.0268 0.2591 0.475
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0586 0.0848
Echinococcus multilocularis allatostatin A receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis neuropeptide receptor A26 0.0268 0.2591 0.374
Brugia malayi G protein-coupled receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Echinococcus granulosus neuropeptide receptor A26 0.0268 0.2591 0.374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.016 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.016 0.0293
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.2591 0.374
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0586 0.0848
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0095 0.0807 0.3102
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0365 0.5464
Echinococcus granulosus allatostatin A receptor 0.0268 0.2591 0.374
Schistosoma mansoni inositol monophosphatase 0.0039 0.0231 0.0333
Onchocerca volvulus 0.0033 0.0167 0.0627
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.02 0.0163
Echinococcus granulosus orexin receptor type 2 0.0268 0.2591 0.374
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0008
Brugia malayi hypothetical protein 0.002 0.0033 0.006
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.016 0.0293
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0071 0.0564 0.056
Echinococcus granulosus peptide allatostatin:somatostatin 0.0268 0.2591 0.374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0488 1
Brugia malayi Nucleoside transporter family protein 0.0095 0.0807 0.148
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0052 0.0365 0.164
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0268 0.2591 0.374
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0167 0.0253
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0268 0.2591 0.3744
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0488 0.0699
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Leishmania major glucose transporter, lmgt1 0.0072 0.0573 0.8581
Onchocerca volvulus 0.0268 0.2591 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0268 0.2591 0.3744
Schistosoma mansoni sugar transporter 0.0033 0.0167 0.0242
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0573 0.8581
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0586 0.1075
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0023
Plasmodium falciparum proline--tRNA ligase 0.0081 0.0668 0.0664
Echinococcus granulosus sex peptide receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.2591 0.374
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0078 0.0638 0.0915
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0007
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0095 0.0807 0.3626
Echinococcus granulosus geminin 0.0171 0.1598 0.2305
Trichomonas vaginalis esterase, putative 0.0036 0.02 0.0899
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0167 0.2503
Brugia malayi hypothetical protein 0.0235 0.2256 0.4136
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0268 0.2591 0.374
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis fmrfamide receptor 0.0268 0.2591 0.374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.016 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.016 0.0293
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0167 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0033 0.0167 0.0235
Onchocerca volvulus 0.0268 0.2591 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.016 0.0293
Schistosoma mansoni inositol monophosphatase 0.0039 0.0231 0.0333
Echinococcus granulosus Sugar transporter ERD6 protein 0.0033 0.0167 0.0235
Brugia malayi follicle stimulating hormone receptor 0.0546 0.5455 1
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.2591 0.3744
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.435
Trypanosoma brucei glucose transporter 1E 0.0072 0.0573 0.8581
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Chlamydia trachomatis lysine--tRNA ligase 0.0052 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0496 0.7421
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni amine GPCR 0.0268 0.2591 0.3744
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0007
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Schistosoma mansoni growth hormone secretagogue receptor 0.0268 0.2591 0.3744
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0231 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Loa Loa (eye worm) inositol-1 0.0039 0.0231 0.0423
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0291 0.1306
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.2591 0.374
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0001
Brugia malayi G protein-coupled receptor F59B2.13 0.0268 0.2591 0.475
Onchocerca volvulus 0.0268 0.2591 1
Brugia malayi nuclear hormone receptor 0.0032 0.016 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.02 0.0289
Leishmania major cathepsin L-like protease 0.0065 0.0496 0.7421
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0231 0.2856
Schistosoma mansoni survival motor neuron protein 0.0048 0.0325 0.047
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.016 0.0293
Echinococcus granulosus g-protein coupled receptor 0.0268 0.2591 0.374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0268 0.2591 0.475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.016 0.0225
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0308 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0167 0.0751
Onchocerca volvulus 0.0033 0.0167 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Trypanosoma brucei sugar transporter, putative 0.0033 0.0167 0.2503
Onchocerca volvulus 0.0036 0.02 0.0755
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0291 0.0533
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0668 1
Schistosoma mansoni neuropeptide receptor 0.0268 0.2591 0.3744
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.2591 0.374
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.016 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0573 0.2576
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0546 0.5455 1
Echinococcus granulosus microtubule associated protein 2 0.0688 0.692 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.016 0.0225
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.2591 0.3744
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0268 0.2591 0.3744
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0052 0.0365 0.4897
Leishmania major hypothetical protein, conserved 0.003 0.0144 0.2157
Echinococcus multilocularis g-protein coupled receptor 0.0268 0.2591 0.374
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0586 0.0848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0668 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.016 0.0225
Brugia malayi neuropeptide F receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0438 0.6556
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Schistosoma mansoni sugar transporter 0.0033 0.0167 0.0242
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Brugia malayi major facilitator superfamily protein 0.0033 0.0167 0.0307
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Schistosoma mansoni protein kinase 0.0071 0.0564 0.0815
Echinococcus multilocularis solute carrier family 22 0.0033 0.0167 0.0235
Brugia malayi neuropeptide F receptor 0.0268 0.2591 0.475
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Echinococcus multilocularis somatostatin receptor 0.0268 0.2591 0.374
Onchocerca volvulus 0.0033 0.0167 0.0627
Brugia malayi AKH receptor 0.0268 0.2591 0.475
Brugia malayi G-protein coupled receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.005 0.0342 0.0626
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.02 0.0163
Echinococcus multilocularis g protein coupled receptor 0.0268 0.2591 0.374
Schistosoma mansoni hypothetical protein 0.0171 0.1598 0.231
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0144 0.0139
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.016 0.0225
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.016 0.0231
Echinococcus granulosus serotonin receptor 0.0268 0.2591 0.374
Brugia malayi hypothetical protein 0.003 0.0144 0.0264
Brugia malayi ORL1-like opioid receptor 0.0268 0.2591 0.475
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.016 0.0599
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0005 0.0008
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0488 0.1584
Toxoplasma gondii sugar transporter ST2 0.0033 0.0167 0.0253
Leishmania major cathepsin L-like protease 0.0065 0.0496 0.7421
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0033 0.0167 0.2054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.2226 1
Trichomonas vaginalis sugar transport protein, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.016 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0342 0.0626
Schistosoma mansoni amine GPCR 0.0268 0.2591 0.3744
Giardia lamblia Lysyl-tRNA synthetase 0.0052 0.0365 0.3093
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0167 0.0751
Echinococcus multilocularis serotonin receptor 0.0268 0.2591 0.374
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis G protein coupled receptor 139 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0095 0.0807 0.148
Echinococcus granulosus 7tm_1 domain containing protein 0.0268 0.2591 0.374
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0488 0.7306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0268 0.2591 0.374
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0339 0.3329 0.4807
Onchocerca volvulus 0.0033 0.0167 0.0627
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0081 0.0668 0.1013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.016 0.0231
Brugia malayi beta-lactamase 0.0036 0.02 0.0367
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.0285 0.2661
Onchocerca volvulus 0.0268 0.2591 1
Onchocerca volvulus 0.0032 0.016 0.0599
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.016 0.0599
Schistosoma mansoni opsin-like receptor 0.0268 0.2591 0.3744
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.016 0.0293
Schistosoma mansoni glucose transport protein 0.0232 0.2226 0.3217
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0573 0.2576
Echinococcus multilocularis serotonin receptor 0.0268 0.2591 0.374
Toxoplasma gondii sugar transporter ST1 0.0033 0.0167 0.0253
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Brugia malayi larval opioid receptor 0.0268 0.2591 0.475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0339 0.3329 0.6103
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.016 0.0225
Schistosoma mansoni hypothetical protein 0.0268 0.2591 0.3744
Loa Loa (eye worm) hypothetical protein 0.0045 0.0291 0.0533
Plasmodium vivax CDK-related protein kinase 6, putative 0.0986 1 1
Brugia malayi hypothetical protein 0.0017 0.0005 0.0008
Leishmania major myo-inositol/proton symporter (MIT) 0.0033 0.0167 0.2503
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0029 0.0125 0.023
Echinococcus granulosus lysyl tRNA synthetase 0.0052 0.0365 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0573 0.2576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0268 0.2591 0.374
Trypanosoma cruzi sugar transporter, putative 0.0033 0.0167 0.2503
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0365 0.5464
Brugia malayi GnHR receptor homolog 0.0268 0.2591 0.475
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.2591 0.374
Schistosoma mansoni hypothetical protein 0.0034 0.018 0.026
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.2591 0.475
Brugia malayi Serotonin receptor 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0291 0.1306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Echinococcus granulosus G protein coupled receptor 139 0.0268 0.2591 0.374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Schistosoma mansoni myosin xvIII 0.0268 0.2591 0.3744
Trypanosoma cruzi glucose transporter, putative 0.0033 0.0167 0.2503
Trypanosoma cruzi hexose transporter 0.0072 0.0573 0.8581
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.02 0.0163
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.2591 0.3744
Plasmodium falciparum calcium-dependent protein kinase 1 0.0071 0.0564 0.056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.016 0.0225
Schistosoma mansoni biogenic amine receptor 0.0268 0.2591 0.3744
Mycobacterium ulcerans hypothetical protein 0.0036 0.02 0.2871
Onchocerca volvulus 0.0268 0.2591 1
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.692 1
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.016 0.0231
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0071 0.0564 0.0855
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.2591 0.3744
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0291 0.435
Schistosoma mansoni histamine h1 receptor 0.0268 0.2591 0.3744
Onchocerca volvulus 0.0033 0.0167 0.0627
Schistosoma mansoni adenoreceptor 0.0268 0.2591 0.3744
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.02 0.0899
Brugia malayi sulfakinin receptor protein 0.0268 0.2591 0.475
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.2591 0.3744
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.016 0.0231
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0308 0.0564
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0488 0.0699
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0573 0.2576
Leishmania major glucose transporter, lmgt3 0.0072 0.0573 0.8581
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.02 0.0289
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Onchocerca volvulus 0.0033 0.0167 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Schistosoma mansoni hypothetical protein 0.0048 0.0325 0.047
Echinococcus multilocularis solute carrier family 22 0.0033 0.0167 0.0235
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0573 0.2576
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.016 0.0225
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0268 0.2591 0.3744
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0573 0.2576
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0308 0.0564
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0231 0.345
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0488 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi lysyl-tRNA synthetase 0.0052 0.0365 0.0669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Leishmania major glucose transporter/membrane transporter D2, putative 0.0072 0.0573 0.8581
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0033 0.0167 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0167 0.0751
Leishmania major hypothetical protein, conserved 0.0033 0.0167 0.2503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0008
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0071 0.0564 0.1034
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.02 0.0367
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Giardia lamblia Hypothetical protein 0.0095 0.0807 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.02 0.0163
Loa Loa (eye worm) hypothetical protein 0.007 0.0549 0.1007
Brugia malayi Cam kinase protein 1 0.0071 0.0564 0.1034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0231 0.1036
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0071 0.0564 0.056
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0189 0.0105
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0268 0.2591 0.374
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0095 0.0807 0.1161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.2591 0.374
Plasmodium falciparum calcium-dependent protein kinase 5 0.0071 0.0564 0.056
Echinococcus granulosus neuropeptide FF receptor 2 0.0268 0.2591 0.374
Brugia malayi hypothetical protein 0.0017 0.0005 0.0008
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0376 0.3702 0.5609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Onchocerca volvulus 0.0033 0.0167 0.0627
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Echinococcus granulosus g protein coupled receptor 0.0268 0.2591 0.374
Onchocerca volvulus 0.0268 0.2591 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.016 0.0293
Toxoplasma gondii protein kinase, putative 0.0657 0.66 1
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0095 0.0807 0.1161
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Schistosoma mansoni biogenic amine receptor 0.0268 0.2591 0.3744
Giardia lamblia Prolyl-tRNA synthetase 0.007 0.0549 0.5968
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0586 0.0848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0291 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Loa Loa (eye worm) beta-lactamase 0.0036 0.02 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Onchocerca volvulus 0.0033 0.0167 0.0627
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0564 0.2533
Toxoplasma gondii sugar transporter ST3 0.0033 0.0167 0.0253
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0299 0.1344
Echinococcus multilocularis g protein coupled receptor 0.0268 0.2591 0.374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0669
Onchocerca volvulus 0.0268 0.2591 1
Schistosoma mansoni opsin-like receptor 0.0268 0.2591 0.3744
Schistosoma mansoni hypothetical protein 0.0268 0.2591 0.3744
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.016 0.0293
Schistosoma mansoni nuclear hormone receptor 0.0032 0.016 0.0231
Loa Loa (eye worm) hypothetical protein 0.0095 0.0807 0.148
Echinococcus granulosus neuropeptide receptor 0.0268 0.2591 0.374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.016 0.0225
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.02 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.02 0.0899
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.02 0.0899
Onchocerca volvulus Neuropeptide F receptor homolog 0.0268 0.2591 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0167 0.0307
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0231 0.0349
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0076
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.016 0.0293
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0044 0.0285 0.0579
Echinococcus granulosus biogenic amine 5HT receptor 0.0268 0.2591 0.374
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0268 0.2591 0.3744
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0071 0.0564 0.056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.02 0.0283
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0268 0.2591 0.374
Onchocerca volvulus 0.0033 0.0167 0.0627
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.007 0.0549 0.1007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0268 0.2591 0.374
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0268 0.2591 0.374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Entamoeba histolytica protein kinase, putative 0.0071 0.0564 0.6988
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.02 0.0163
Echinococcus granulosus tar DNA binding protein 0.0073 0.0586 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0496 0.7421
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0001
Schistosoma mansoni coup transcription factor 0.0032 0.016 0.0231
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.2591 0.3744
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0353 0.5289
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.007 0.0549 0.2467
Entamoeba histolytica nucleoside transporter, putative 0.0095 0.0807 1
Onchocerca volvulus 0.0268 0.2591 1
Schistosoma mansoni glucose transport protein 0.0232 0.2226 0.3217
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.016 0.0293
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0231 0.345
Onchocerca volvulus 0.0033 0.0167 0.0627
Trichomonas vaginalis myo-inositol transporter, putative 0.0033 0.0167 0.0751
Onchocerca volvulus Putative transporter 0.0033 0.0167 0.0627
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.2591 0.374
Onchocerca volvulus 0.0268 0.2591 1
Echinococcus granulosus neuropeptide receptor 0.0268 0.2591 0.374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0308 0.0438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0342 0.0626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.016 0.0293
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.2591 0.374
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Brugia malayi hypothetical protein 0.0095 0.0807 0.148
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.016 0.0231
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Schistosoma mansoni hypothetical protein 0.0268 0.2591 0.3744
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.02 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0291 0.0414
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0307
Schistosoma mansoni protein kinase 0.0071 0.0564 0.0815
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0488 0.0706
Mycobacterium tuberculosis Conserved protein 0.0036 0.02 0.0163
Echinococcus granulosus alpha 1A adrenergic receptor 0.0268 0.2591 0.374
Brugia malayi putative neuropeptide receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.016 0.0293
Loa Loa (eye worm) hypothetical protein 0.0235 0.2256 0.4136
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0167 0.0307
Echinococcus granulosus General substrate transporter 0.02 0.189 0.2726
Plasmodium falciparum calcium-dependent protein kinase 4 0.0071 0.0564 0.056
Loa Loa (eye worm) fibroinase 0.0017 0.0005 0.0009
Echinococcus multilocularis orexin receptor type 2 0.0268 0.2591 0.374
Onchocerca volvulus 0.0268 0.2591 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0291 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.02 0.2997
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0033 0.0167 0.2054
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.02 0.2871
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0268 0.2591 0.374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0005 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0231 0.1036
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0291 0.0414
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Echinococcus granulosus FTZ F1 alpha 0.0032 0.016 0.0225
Schistosoma mansoni hypothetical protein 0.0232 0.2226 0.3217
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0268 0.2591 0.374
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Mycobacterium ulcerans beta-lactamase 0.0036 0.02 0.2871
Echinococcus granulosus calcium dependent protein kinase 0.0067 0.0519 0.0743
Brugia malayi Dopamine receptor protein 1 0.0268 0.2591 0.475
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0573 0.8581
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.007 0.0549 1
Brugia malayi Sugar transporter family protein 0.0033 0.0167 0.0307
Schistosoma mansoni glucose transporter 0.0033 0.0167 0.0242
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Toxoplasma gondii facilitative glucose transporter GT1 0.0232 0.2226 0.3373
Schistosoma mansoni amine GPCR 0.0268 0.2591 0.3744
Plasmodium falciparum calcium-dependent protein kinase 3 0.0071 0.0564 0.056
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0167 0.0307
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0564 0.0809
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0586 0.1075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Echinococcus granulosus g protein coupled receptor 0.0268 0.2591 0.374
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.016 0.0293
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0232 0.2226 0.3213
Onchocerca volvulus 0.0033 0.0167 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.007 0.0549 0.0788
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0008
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.02 0.2997
Echinococcus granulosus fmrfamide receptor 0.0268 0.2591 0.374
Loa Loa (eye worm) hypothetical protein 0.0036 0.02 0.0367
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0586 0.0848
Brugia malayi Melatonin receptor type 1A 0.0268 0.2591 0.475
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0339 0.3329 0.4807
Plasmodium vivax sugar transporter, putative 0.0033 0.0167 0.0162
Onchocerca volvulus 0.0268 0.2591 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.2591 0.374
Plasmodium vivax hexose transporter 0.0232 0.2226 0.2223
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Mycobacterium tuberculosis Conserved protein 0.0036 0.02 0.0163
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.007 0.0549 0.6804
Schistosoma mansoni protein kinase 0.0071 0.0564 0.0815
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0339 0.3329 0.6103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Leishmania major protein kinase, putative 0.0071 0.0564 0.844
Echinococcus multilocularis fmrfamide receptor 0.0268 0.2591 0.374
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.007 0.0549 0.0794
Brugia malayi beta-lactamase family protein 0.0036 0.02 0.0367
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0071 0.0564 0.0809
Brugia malayi Serotonin receptor 0.0268 0.2591 0.475
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.2591 0.374
Mycobacterium ulcerans lipase LipD 0.0036 0.02 0.2871
Trypanosoma brucei glucose transporter, putative 0.0072 0.0573 0.8581
Schistosoma mansoni thyroid hormone receptor 0.0032 0.016 0.0231
Onchocerca volvulus 0.0036 0.02 0.0755
Schistosoma mansoni thyroid hormone receptor 0.0032 0.016 0.0231
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0339 0.3329 0.481
Plasmodium vivax calcium-dependent protein kinase, putative 0.0071 0.0564 0.056
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Toxoplasma gondii ABC1 family protein 0.0036 0.02 0.0303
Entamoeba histolytica hypothetical protein 0.0052 0.0365 0.4524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.2591 0.3744
Trypanosoma brucei glucose transporter 2A 0.0072 0.0573 0.8581
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Echinococcus multilocularis g protein coupled receptor 0.0268 0.2591 0.374
Brugia malayi Sugar transporter family protein 0.0232 0.2226 0.4082
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0291 0.042
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0167 0.0751
Brugia malayi Dopamine receptor 0.0268 0.2591 0.475
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0488 0.074
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Loa Loa (eye worm) hypothetical protein 0.0268 0.2591 0.475
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0095 0.0807 0.3626
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.2591 0.475
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0376 0.3702 0.3699
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0095 0.0807 0.3626
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0342 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0573 0.2576
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0365 0.5464
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0496 0.7421
Brugia malayi TAR-binding protein 0.0073 0.0586 0.1075
Brugia malayi hypothetical protein 0.0268 0.2591 0.475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0063

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.59 uM DNDI: Malaria in Vitro, 72 hour ChEMBL. No reference
IC50 (functional) = 12.61 uM DNDI: HAT in Vitro, 72 hour ChEMBL. No reference
IC50 (functional) = 27.51 uM DNDI: Chagas in Vitro, 96 hour ChEMBL. No reference
IC50 (functional) > 35.42 uM DNDI: Leish (macro) in Vitro, 96 hour ChEMBL. No reference
IC50 (functional) = 56.43 uM DNDI: Leish (axenic) in Vitro, 72 hour ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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