Detailed information for compound 947721

Basic information

Technical information
  • TDR Targets ID: 947721
  • Name: 4-phenyl-1-(6,7,8,9-tetrahydro-5H-benzo[7]ann ulen-7-yl)piperidine
  • MW: 305.456 | Formula: C22H27N
  • H donors: 0 H acceptors: 0 LogP: 5.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C1CCN(CC1)C1CCc2c(CC1)cccc2
  • InChi: 1S/C22H27N/c1-2-6-18(7-3-1)21-14-16-23(17-15-21)22-12-10-19-8-4-5-9-20(19)11-13-22/h1-9,21-22H,10-17H2
  • InChiKey: DHMDOIVYRXIWRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B Starlite/ChEMBL References
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0338 0.0318
Leishmania major fatty acid transporter protein-like protein 0.0189 0.4184 0.4172
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0076 0.0056
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0534 0.126
Echinococcus multilocularis glutamate receptor 2 0.0024 0.043 0.1013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0076 0.0076
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0192 0.4241 0.4229
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0009 0.0076 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.3194 0.753
Schistosoma mansoni glutamate receptor kainate 0.0024 0.043 0.1013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0968 0.0968
Schistosoma mansoni dishevelled 0.0009 0.009 0.0211
Schistosoma mansoni glutamate receptor NMDA 0.0091 0.1947 0.4591
Loa Loa (eye worm) hypothetical protein 0.0009 0.009 0.009
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.009 0.0211
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1312 0.3093
Loa Loa (eye worm) acetyltransferase 0.015 0.3289 0.3289
Echinococcus multilocularis glutamate receptor 2 0.002 0.033 0.0778
Brugia malayi hypothetical protein 0.0009 0.009 0.009
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.043 0.043
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.009 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0338 0.0318
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.009 0.0211
Giardia lamblia DINP protein human, muc B family 0.002 0.0338 0.4083
Echinococcus granulosus dna polymerase eta 0.002 0.0338 0.0797
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0076 0.0137
Trypanosoma cruzi hypothetical protein 0.0007 0.0029 0.0008
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0338 0.0797
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Brugia malayi N-terminal motif family protein 0.0007 0.0029 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0798 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0881 0.7045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0338 0.0765
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0087 0.0205
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0968 0.2283
Loa Loa (eye worm) hypothetical protein 0.0009 0.009 0.009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0534 0.126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Echinococcus granulosus cpg binding protein 0.0031 0.0592 0.1397
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0009 0.0076 0.0076
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0076 0.0179
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0009 0.0076 0.0127
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0009 0.0076 0.0127
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0087 0.0087
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0009 0.0076 0.0056
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0009 0.0076 0.0137
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0029 0.0068
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.043 0.1013
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0881 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0338 0.0338
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0338 0.3626
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Schistosoma mansoni cpg binding protein 0.0031 0.0592 0.1397
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0338 0.0318
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.009 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0195 0.0175
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0029 0.0068
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0338 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0338 0.0765
Echinococcus multilocularis dna polymerase kappa 0.002 0.0338 0.0797
Loa Loa (eye worm) hypothetical protein 0.0227 0.5051 0.5051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0554 0.0554
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0009 0.0076 0.0127
Onchocerca volvulus 0.003 0.0554 0.1265
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0009 0.0076 0.0137
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0009 0.0082 0.0193
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0076 0.0127
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0076 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0338 0.0318
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0881 0.7045
Brugia malayi RasGEF domain containing protein 0.0007 0.0029 0.0029
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0189 0.4184 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0881 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0198 0.4382 0.4382
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0009 0.0076 0.0127
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0009 0.0076 0.0127
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0076 0.0056
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0009 0.0082 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.009 0.009
Loa Loa (eye worm) oxidoreductase 0.0009 0.0076 0.0076
Echinococcus granulosus glutamate receptor 2 0.0029 0.0534 0.126
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0029 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1242 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0076 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 1 1
Echinococcus granulosus long chain fatty acid transport protein 4 0.0192 0.4241 1
Echinococcus multilocularis son of sevenless 1 0.0007 0.0029 0.0068
Onchocerca volvulus 0.0009 0.0076 0.0114
Brugia malayi RasGEF domain containing protein 0.0007 0.0029 0.0029
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0009 0.0076 0.0137
Trypanosoma brucei unspecified product 0.0014 0.0195 0.0175
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0009 0.0076 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0192 0.4241 0.4229
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0009 0.0082 0.0193
Onchocerca volvulus 0.0009 0.0076 0.0114
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0881 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0009 0.0076 0.0615
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0029 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0195 0.0175
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.009 0.0211
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0009 0.0076 0.0714
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.009 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0338 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Trichomonas vaginalis helicase, putative 0.0007 0.0031 0.0026
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.3289 0.7756
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0021
Toxoplasma gondii propionate-CoA ligase 0.0009 0.0076 0.0454
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0029 0.0068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0029
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0009 0.0076 0.0137
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0009 0.0082 0.0193
Mycobacterium ulcerans hypothetical protein 0.0009 0.0076 0.0127
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0009 0.0076 0.0137
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.009 0.0211
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0009 0.0076 0.0127
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0076 0.0127
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0534 0.126
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0076 0.0137
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0534 0.126
Trypanosoma cruzi hypothetical protein 0.0007 0.0029 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Echinococcus granulosus son of sevenless 1 0.0007 0.0029 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0968 0.2283
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0009 0.0082 0.0193
Brugia malayi N-terminal motif family protein 0.0189 0.4181 0.4181
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.009 0.0211
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0029 0.0068
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0029 0.0029
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0009 0.0076 0.0137
Brugia malayi RasGEF domain containing protein 0.0007 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0189 0.4184 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0076 0.0056
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0029 0.0068
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0076 0.0056
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0798 1
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.043 0.043
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.043 0.043
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0338 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0076 0.0615
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.009 0.009
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0076 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0968 0.0968
Echinococcus granulosus nmda type glutamate receptor 0.0009 0.0082 0.0193
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0026
Leishmania major C-8 sterol isomerase-like protein 0.0445 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0968 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0076 0.0056
Onchocerca volvulus 0.0009 0.0076 0.0114
Schistosoma mansoni regulator of G protein signaling 0.0009 0.009 0.0211
Schistosoma mansoni cpg binding protein 0.0031 0.0592 0.1397
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0076
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0076
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0029 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0338 0.3626
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0534 0.126
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0009 0.0082 0.0193
Echinococcus multilocularis cpg binding protein 0.0031 0.0592 0.1397
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0076 0.0554
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0076 0.0179
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0009 0.0082 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0338 0.0318
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0029 0.0029
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.009 0.0211
Onchocerca volvulus 0.0009 0.0076 0.0114
Brugia malayi N-terminal motif family protein 0.0007 0.0029 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0091 0.1947 0.4591
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0076 0.0056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0338 0.0797
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0076 0.0056
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.009 0.0146
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.009 0.0211
Echinococcus multilocularis dna polymerase eta 0.002 0.0338 0.0797
Schistosoma mansoni hypothetical protein 0.0009 0.0082 0.0193
Brugia malayi CXXC zinc finger family protein 0.003 0.0554 0.0554
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0338 0.0318
Echinococcus multilocularis nmda type glutamate receptor 0.0009 0.0082 0.0193
Trypanosoma brucei unspecified product 0.0014 0.0195 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0968 0.2283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0968 0.2283
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0076
Onchocerca volvulus 0.0009 0.009 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0968 0.2283
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0029 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0046 0.0108
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0009 0.0076 0.0137
Schistosoma mansoni FFA transport protein 0.0192 0.4241 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0087 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Brugia malayi hypothetical protein 0.0009 0.009 0.009
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0009 0.0076 0.0127
Schistosoma mansoni glutamate receptor kainate 0.0024 0.043 0.1013
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0534 0.126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0076 0.0615
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0046 0.0108
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0029 0.0008
Schistosoma mansoni DNA polymerase eta 0.002 0.0338 0.0797
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0338 0.402
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0029 0.0068
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0021 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0338 0.0338
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0534 0.126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0338 0.0318
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.009 0.009
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0076 0.0179
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0338 0.0318
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.009 0.009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0534 0.126
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0076
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0076 0.0056
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0192 0.4241 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0338
Brugia malayi DIX domain containing protein 0.0009 0.009 0.009
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.4181 1
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.043 0.1013
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.043 0.1013
Echinococcus granulosus Protein son of sevenless 0.0007 0.0029 0.0068
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0009 0.0076 0.0454
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0338 0.0338
Echinococcus multilocularis NMDA receptor 0.0009 0.0082 0.0193
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0046 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0534 0.126
Loa Loa (eye worm) hypothetical protein 0.0445 1 1
Brugia malayi polk-prov protein 0.0006 0.0021 0.0021
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.3289 0.3289
Toxoplasma gondii hypothetical protein 0.0009 0.009 0.0565
Plasmodium vivax acetyl-CoA synthetase, putative 0.0009 0.0076 0.0644
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0009 0.0076 0.0127
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0076 0.0554
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0338 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0195 0.0175
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.1306
Trypanosoma brucei unspecified product 0.002 0.0338 0.0318
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0076 0.0056
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0198 0.4382 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0009 0.0082 0.0193
Loa Loa (eye worm) hypothetical protein 0.0189 0.4181 0.4181
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0798 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0338 0.0797
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Echinococcus granulosus glutamate NMDA receptor subunit 0.0091 0.1947 0.4591
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0338 0.0727
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.009 0.0211
Leishmania major DNA polymerase kappa, putative 0.002 0.0338 0.0318
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.3289 0.7756
Echinococcus granulosus glutamate receptor 2 0.002 0.033 0.0778
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0046 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0076 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0076 0.0137
Schistosoma mansoni dishevelled 0.0009 0.009 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0968 0.2283
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0534 0.126
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0009 0.0076 0.0615
Mycobacterium ulcerans acetyl-CoA synthetase 0.0009 0.0076 0.0127
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.009 0.009
Schistosoma mansoni glutamate receptor kainate 0.0024 0.043 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0026
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0029 0.0068
Onchocerca volvulus 0.0009 0.0076 0.0114
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0009 0.0076 0.0137
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0338 0.0727
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0084 0.0084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0881 0.2078
Leishmania major DNA polymerase eta, putative 0.002 0.0338 0.0318
Schistosoma mansoni dep domain containing protein 0.0009 0.009 0.0211
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.043 0.043
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.009 0.0211
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0029 0.0068
Echinococcus granulosus dna polymerase kappa 0.002 0.0338 0.0797
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0076 0.0127
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0076 0.0137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0198 0.4382 0.4382
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0046 0.0108

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6.9 nM Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method ChEMBL. 25458498
Ki (binding) = 22 nM Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method ChEMBL. 25458498

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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