TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.354 | Formula: C14H15F3N4O3S
H donors: 1 H acceptors: 4 LogP: 1.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(S(=O)(=O)c1ccc(cc1)NC(=O)c1cc(nn1C)C(F)(F)F)C
InChi: 1S/C14H15F3N4O3S/c1-20(2)25(23,24)10-6-4-9(5-7-10)18-13(22)11-8-12(14(15,16)17)19-21(11)3/h4-8H,1-3H3,(H,18,22)
InChiKey: OOVZALCWNSMNPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0122	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0034	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0035	0.007	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0932	0.0932
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0306	0.1019	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0072	0.0385
Giardia lamblia	Histone deacetylase	0.0041	0.0092	0.0786
Echinococcus multilocularis	lamin dm0	0.0028	0.0046	0.0073
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0103	0.0713
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0026	0.0037
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Echinococcus granulosus	Solute carrier family 22 5	0.1082	0.3743	1
Brugia malayi	hypothetical protein	0.005	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Schistosoma mansoni	integrin alpha-ps	0.0038	0.008	0.0432
Echinococcus granulosus	integrin alpha ps	0.0035	0.007	0.0173
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0087	0.022
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0219	0.0716	0.0716
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0096	0.0282	0.159
Echinococcus granulosus	integrin alpha 3	0.0125	0.0384	0.1015
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0189	0.6545
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0147	0.0464	0.1227
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0491
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.005	0.0121	0.0311
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0192	0.062	0.3528
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0034	0.0034
Onchocerca volvulus	Phospholipase A2 homolog	0.0282	0.0935	0.3785
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0034	0.0034
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0477	0.1621	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.005	0.0121	0.0311
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0034	0.0034
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0192	0.062	0.3528
Schistosoma mansoni	hypothetical protein	0.0035	0.0071	0.0382
Leishmania major	histone deacetylase, putative	0.0041	0.0092	0.2939
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.0604	0.344
Loa Loa (eye worm)	hypothetical protein	0.0038	0.008	0.008
Brugia malayi	Peptidase family M1 containing protein	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.0604	0.1062
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1627	0.5652	1
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0932	0.0932
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0034	0.0209
Schistosoma mansoni	hypothetical protein	0.0514	0.1748	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0013	0.0046
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0103	0.0263
Echinococcus multilocularis	integrin alpha 3	0.0125	0.0384	0.0672
Brugia malayi	ephrin receptor 1 precursor	0.0032	0.0058	0.0058
Mycobacterium leprae	probable zinc metalloprotease	0.038	0.128	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0103	0.8289
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.005	0.0121	0.4026
Entamoeba histolytica	hypothetical protein	0.0035	0.0071	0.0581
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0122	0.0862
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0046	0.0108	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Onchocerca volvulus		0.0096	0.0282	0.1042
Loa Loa (eye worm)	hypothetical protein	0.038	0.128	0.128
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0742
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0265	0.0875	0.154
Echinococcus granulosus	aminopeptidase N	0.0265	0.0877	0.2332
Plasmodium vivax	histone deacetylase 1, putative	0.0041	0.0092	0.7265
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0093	0.0272	0.1531
Toxoplasma gondii	peptidase family M13 protein	0.038	0.128	1
Onchocerca volvulus		0.0028	0.0046	0.005
Schistosoma mansoni	neprilysin	0.0099	0.0295	0.1665
Echinococcus multilocularis	histone deacetylase 1	0.0041	0.0092	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0932	0.0932
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0096	0.0282	0.2676
Brugia malayi	Peptidase family M1 containing protein	0.0096	0.0282	0.0282
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Brugia malayi	hypothetical protein	0.0215	0.07	0.07
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0034	0.0781
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.013	0.013
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0071	0.0118
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0005	0.0005
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0026	0.0055
Mycobacterium ulcerans	aminopeptidase N PepN	0.005	0.0121	0.0679
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0013	0.0006
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0052	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Leishmania major	hypothetical protein, conserved	0.005	0.0122	0.4059
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0491
Echinococcus granulosus	histone deacetylase 3	0.0041	0.0092	0.0233
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.0604	0.344
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956
Loa Loa (eye worm)	hypothetical protein	0.009	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Loa Loa (eye worm)	histone deacetylase 1	0.0041	0.0092	0.0092
Schistosoma mansoni	solute carrier family 12 electroneutral k-cl cotransporter	0.005	0.0121	0.0664
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0005	0.0005
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0192	0.062	0.3528
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0122	1
Echinococcus multilocularis	endothelin converting enzyme 1	0.038	0.128	0.2259
Schistosoma mansoni	lamin	0.0028	0.0046	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0379	0.0379
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0069	0.0189	0.1751
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0122	0.4059
Trypanosoma cruzi	histone deacetylase 1, putative	0.0041	0.0092	0.2939
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0034	0.0034
Brugia malayi	Peptidase family M13 containing protein	0.038	0.128	0.128
Echinococcus multilocularis	geminin	0.0514	0.1748	0.3086
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.0471	0.285
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0123	0.0379	0.0379
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0122	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Trypanosoma cruzi	aminopeptidase, putative	0.005	0.0121	0.4026
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.0604	0.1062
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.005	0.0121	0.9919
Loa Loa (eye worm)	hypothetical protein	0.0035	0.007	0.007
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0034	0.0137
Entamoeba histolytica	hypothetical protein	0.0035	0.0071	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.005	0.0121	0.4026
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Toxoplasma gondii	aminopeptidase N, putative	0.005	0.0121	0.0855
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.005	0.0121	0.1077
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0096	0.0282	0.0491
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0034	0.0034
Schistosoma mansoni	endothelin-converting enzyme-related	0.0093	0.0272	0.1531
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.038	0.128	0.7888
Trypanosoma cruzi	aminopeptidase, putative	0.0096	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0122	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0096	0.0282	0.2676
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.005	0.0121	0.4026
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0096	0.0282	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0187	0.0604	0.0604
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0067	0.0181	0.0311
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.005	0.0121	0.4026
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.2867	1	1
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0281	0.0932	0.0932
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0012	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0932	0.0932
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0041	0.0092	0.0786
Loa Loa (eye worm)	aminopeptidase N	0.0096	0.0282	0.0282
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.038	0.128	0.7318
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0099	0.0295	0.1665
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0491
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0072	0.0072
Plasmodium falciparum	histone deacetylase 1	0.0041	0.0092	0.7265
Loa Loa (eye worm)	hypothetical protein	0.005	0.0122	0.0122
Echinococcus granulosus	intermediate filament protein	0.0028	0.0046	0.011
Brugia malayi	peptidase family M13 containing protein	0.0093	0.0272	0.0272
Entamoeba histolytica	histone deacetylase, putative	0.0041	0.0092	0.0786
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0103	0.0899
Echinococcus multilocularis	histone deacetylase 3	0.0041	0.0092	0.0154
Schistosoma mansoni	integrin alpha-ps	0.0073	0.0203	0.1136
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.005	0.0121	0.0668
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0013	0.0022
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0096	0.0282	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0122	0.4059
Entamoeba histolytica	aminopeptidase, putative	0.0096	0.0282	0.2676
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0071	0.0178
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.009	0.0769
Brugia malayi	hypothetical protein	0.005	0.0121	0.0121
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0034	0.0112
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0087	0.0146
Loa Loa (eye worm)	histone deacetylase 3	0.0041	0.0092	0.0092
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Brugia malayi	Amino acid permease family protein	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0034	0.0034
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.0471	0.2866
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956
Echinococcus granulosus	geminin	0.0514	0.1748	0.4663
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0034	0.0158
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0093	0.0272	0.0272
Treponema pallidum	fructose-bisphosphate aldolase	0.0306	0.1019	1
Echinococcus multilocularis	musashi	0.0028	0.0046	0.0073
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.013	0.013
Onchocerca volvulus		0.0066	0.0178	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0096	0.0282	1
Toxoplasma gondii	histone deacetylase HDAC2	0.0041	0.0092	0.0624
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Trypanosoma brucei	aminopeptidase, putative	0.005	0.0121	0.4026
Schistosoma mansoni	hypothetical protein	0.0022	0.0026	0.0119
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0034	0.0137
Schistosoma mansoni	integrin alpha	0.0163	0.0518	0.2941
Brugia malayi	Phospholipase A2 family protein	0.0704	0.2414	0.2414
Echinococcus multilocularis	solute carrier family 12	0.005	0.0121	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0092
Brugia malayi	Hypothetical 112.3 kDa protein K02A2.3 in chromosome II	0.005	0.0121	0.0121
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0034	0.0137
Echinococcus granulosus	lamin	0.0028	0.0046	0.011
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.038	0.128	0.128
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0093	0.0272	0.1531
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0013	0.0013
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0034	0.0112
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0702	0.0702
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Echinococcus multilocularis	integrin alpha ps	0.0073	0.0203	0.035
Onchocerca volvulus		0.0265	0.0877	0.3539
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0034	0.0137
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0189	0.6545
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0096	0.0282	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0034	0.0209
Loa Loa (eye worm)	amino acid permease	0.005	0.0121	0.0121
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0374	0.0374
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0005	0.0005
Echinococcus multilocularis	integrin alpha ps	0.0035	0.007	0.0115
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.0189	0.0326
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.005	0.0121	0.4026
Toxoplasma gondii	aminopeptidase n, putative	0.005	0.0121	0.0855
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0265	0.0875	0.2327
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0477	0.1621	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.002	0.0049
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.009	0.0769
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0491
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0187	0.0604	0.0604
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0013	0.0013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.0604	0.1604
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0046	0.0235
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0491
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0103	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.0604	0.1604
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Loa Loa (eye worm)	acetyltransferase	0.0152	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0096	0.0282	0.0282
Echinococcus granulosus	endothelin converting enzyme 1	0.038	0.128	0.3412
Entamoeba histolytica	hypothetical protein	0.0035	0.0071	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Schistosoma mansoni	lamin	0.0028	0.0046	0.0235
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.0478	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0282	0.0935	0.0935
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Onchocerca volvulus		0.005	0.0121	0.0367
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0034	0.0209
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0096	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0044	0.0044
Brugia malayi	Peptidase family M1 containing protein	0.0265	0.0877	0.0877
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0742
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0034	0.0158
Schistosoma mansoni	histone deacetylase	0.0041	0.0092	0.05
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0122	0.4059
Echinococcus granulosus	histone deacetylase 1	0.0041	0.0092	0.0233
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.0189	0.0189
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.0478	0.0839
Echinococcus multilocularis	lamin	0.0028	0.0046	0.0073
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.005	0.0121	0.9919
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Schistosoma mansoni	ephrin receptor	0.0067	0.0181	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Mycobacterium ulcerans	aminopeptidase N PepN	0.0096	0.0282	0.1679
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0046	0.0046
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0096	0.0282	0.159
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0034	0.0781
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Brugia malayi	histone deacetylase 3 (HD3)	0.0041	0.0092	0.0092
Brugia malayi	Integrin alpha pat-2 precursor	0.0163	0.0518	0.0518
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.005	0.0121	0.4026
Toxoplasma gondii	aminopeptidase N protein	0.005	0.0121	0.0855
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Schistosoma mansoni	histone deacetylase	0.0041	0.0092	0.05
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.005	0.0121	0.9919
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0034	0.0137
Trichomonas vaginalis	histone deacetylase, putative	0.0041	0.0092	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.017	0.0541	0.0541
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.0189	0.1057
Loa Loa (eye worm)	hypothetical protein	0.038	0.128	0.128
Schistosoma mansoni	aminopeptidase A (M01 family)	0.005	0.0121	0.0668
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.009	0.7107
Brugia malayi	hypothetical protein	0.0035	0.0071	0.0071
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0071	0.0581
Brugia malayi	histone deacetylase 1 (HD1)	0.0041	0.0092	0.0092
Trypanosoma brucei	histone deacetylase 1	0.0041	0.0092	0.2939
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0306	0.1019	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.0604	0.344
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0189	0.6545
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0093	0.0272	0.1531
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0192	0.062	0.3528
Echinococcus multilocularis	aminopeptidase N	0.0265	0.0877	0.1544
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.0189	0.0189
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0041	0.0092	0.0786
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0265	0.0875	0.4991
Loa Loa (eye worm)	TK/EPH protein kinase	0.0085	0.0244	0.0244
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0281	0.0932	0.0932
Brugia malayi	intermediate filament protein	0.0028	0.0046	0.0046
Leishmania major	histone deacetylase, putative	0.0041	0.0092	0.2939
Trypanosoma cruzi	histone deacetylase 1, putative	0.0041	0.0092	0.2939
Echinococcus granulosus	integrin alpha ps	0.0073	0.0203	0.053
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0103	0.0899
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0041	0.0092	0.0786
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Onchocerca volvulus		0.0188	0.0608	0.241
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0034	0.0137
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0013	0.0028
Brugia malayi	TATA binding protein associated factor	0.005	0.0121	0.0121
Echinococcus granulosus	ephrin type A receptor 4 A	0.0067	0.0181	0.047
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0149	0.0471	0.3575
Echinococcus multilocularis	integrin alpha ps	0.0073	0.0203	0.035
Schistosoma mansoni	hypothetical protein	0.0514	0.1748	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0013	0.5
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0034	0.0137
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0093	0.0272	0.1531
Trypanosoma brucei	Aminopeptidase M1, putative	0.0096	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0704	0.2414	0.2414
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0046	0.0108	0.3525
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0013	0.0014
Onchocerca volvulus	Phospholipase A2 homolog	0.0704	0.2414	1
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0046	0.0108	0.0591
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0046	0.0046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0306	0.1019	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0069	0.0189	0.6545
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0072	0.0072
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0096	0.0282	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0034	0.0137
Schistosoma mansoni	ap endonuclease	0.0019	0.0013	0.0046
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0265	0.0875	0.0875
Brugia malayi	hypothetical protein	0.0032	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0099	0.0295	0.1665
Loa Loa (eye worm)	hypothetical protein	0.038	0.128	0.128
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0013	0.0087
Loa Loa (eye worm)	integrin alpha pat-2	0.0251	0.0826	0.0826
Brugia malayi	Histone deacetylase 1	0.0041	0.0092	0.0092
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.005	0.0121	0.9919
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0093	0.0272	0.1531
Giardia lamblia	Fructose-bisphosphate aldolase	0.0306	0.1019	1
Echinococcus granulosus	solute carrier family 12	0.005	0.0121	0.031
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0071	0.0382
Mycobacterium ulcerans	zinc metalloprotease	0.038	0.128	0.7884
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0742
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0096	0.0282	0.0742
Loa Loa (eye worm)	hypothetical protein	0.005	0.0121	0.0121
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0192	0.062	0.3528
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0046	0.0046
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0012	0.5
Toxoplasma gondii	histone deacetylase HDAC3	0.0041	0.0092	0.0624
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0021	0.002	0.0071
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.0189	0.0493
Loa Loa (eye worm)	TATA binding protein associated factor	0.005	0.0121	0.0121
Echinococcus granulosus	lamin dm0	0.0028	0.0046	0.011
Onchocerca volvulus		0.0028	0.0046	0.005
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0013	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0956	0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL458137

Bibliographic References

No literature references available for this target.

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Detailed information for compound 957672