Detailed information for compound 977228

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 264.734 | Formula: C11H9ClN4S
  • H donors: 1 H acceptors: 2 LogP: 2.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(NCc2cccs2)n2c(n1)ccn2
  • InChi: 1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
  • InChiKey: CYMQFMRIPVOICF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Starlite/ChEMBL References
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Starlite/ChEMBL References
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR011996,SK channel region,domain-containing Get druggable targets OG5_130097 All targets in OG5_130097
Echinococcus granulosus small conductance calcium activated potassium Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum expressed protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum Small conductance calcium-activated potassium channel protein, putative Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma mansoni calcium-activated potassium channel Get druggable targets OG5_130097 All targets in OG5_130097
Echinococcus multilocularis small conductance calcium activated potassium Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum Small conductance calcium-activated potassium channel protein, putative Get druggable targets OG5_130097 All targets in OG5_130097
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
Schistosoma japonicum ko:K01047 phospholipase A2 [EC3.1.1.4], putative Get druggable targets OG5_130097 All targets in OG5_130097
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130097 All targets in OG5_130097
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax hypothetical protein, conserved potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 231 aa 188 aa 21.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0009 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0009 0.0014 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0726 0.4379
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.001 0.0022 0.5
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.0031 0.0376 0.0367
Schistosoma mansoni polycystin 1-related 0.0019 0.0173 0.0164
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.163 0.1622
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.163 0.5194
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0009 0.0009
Echinococcus granulosus potassium channel subfamily K 0.0023 0.024 0.024
Brugia malayi ABC transporter family protein 0.001 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.0031 0.0376 0.0367
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0009 0.0009
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Onchocerca volvulus 0.0023 0.024 0.3628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0019
Plasmodium falciparum multidrug resistance-associated protein 2 0.001 0.0022 0.0004
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0376 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0009 0.0009
Toxoplasma gondii exonuclease III APE 0.0018 0.0158 0.0853
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0009 0.0009
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0395 0.6378 0.6375
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis potassium channel subfamily K 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0033 0.0402 0.0393
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.022 0.5696
Schistosoma mansoni nuclear hormone receptor 0.001 0.0019 0.001
Plasmodium vivax ABC transporter B family member 5, putative 0.001 0.0022 0.0018
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0022 0.0356
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0019 0.0163
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0158 0.6376
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Plasmodium falciparum ABC transporter B family member 3, putative 0.001 0.0022 0.0004
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0158 0.0158
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.001 0.0022 0.0002
Echinococcus multilocularis G protein coupled receptor 139 0.0245 0.3898 0.3898
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0653 0.2063
Echinococcus granulosus fmrfamide receptor 0.0009 0.0009 0.0009
Brugia malayi steroid hormone receptor 0.001 0.0019 0.0033
Schistosoma mansoni cpg binding protein 0.0028 0.0316 0.0307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0829 0.0821
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0615 1 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1974 0.1974
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Plasmodium vivax potassium channel, putative 0.0023 0.024 0.6184
Schistosoma mansoni loxhd1 0.0019 0.0173 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0023 0.024 0.0741
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1738 0.1738
Plasmodium falciparum carbonic anhydrase 0.0107 0.163 1
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Plasmodium falciparum multidrug resistance protein 2 0.001 0.0022 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0158 0.6253
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0023 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0015 0.011 0.0101
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0009 0.0009
Plasmodium vivax multidrug resistance protein 2, putative 0.001 0.0022 0.0018
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.001 0.0022 0.5
Echinococcus granulosus ATP binding cassette sub family B 0.0009 0.0014 0.0014
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0022 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0033
Trypanosoma cruzi multidrug resistance protein E, putative 0.001 0.0022 0.0002
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0376 1
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0376 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0173 0.0173
Entamoeba histolytica ABC transporter, putative 0.001 0.0021 0.0189
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0009 0.0009
Brugia malayi hypothetical protein 0.0016 0.0118 0.0348
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.163 0.5194
Leishmania major ion transport protein-like protein 0.0023 0.024 0.0706
Echinococcus granulosus neuropeptide receptor 0.0009 0.0009 0.0009
Leishmania major p-glycoprotein e 0.001 0.0022 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0158 0.3867
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0376 0.0376
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0023 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus granulosus multidrug resistance associated protein 7 0.001 0.0022 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0023 0.024 0.0232
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0019 0.001
Leishmania major potassium channel subunit-like protein 0.0023 0.024 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis serotonin receptor 0.0009 0.0009 0.0009
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0019 0.0033
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0376 0.0376
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus g protein coupled receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0107 0.163 0.163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Trichomonas vaginalis abcb9, putative 0.0031 0.0376 1
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0023 0.024 0.024
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0376 0.0376
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.001 0.0022 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0019
Brugia malayi nuclear receptor NHR-88 0.001 0.0019 0.0033
Plasmodium vivax ABC transporter B family member 7, putative 0.001 0.0022 0.0018
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0022 0.0206
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0198 0.313 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.001 0.0022 0.0004
Echinococcus multilocularis twik family of potassium channels 0.0023 0.024 0.024
Onchocerca volvulus 0.0023 0.024 0.3628
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0158 0.0441
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0009 0.0009
Giardia lamblia Multidrug resistance-associated protein 1 0.0009 0.0014 0.0028
Echinococcus multilocularis multidrug resistance associated protein 1 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Echinococcus granulosus sex peptide receptor 0.0009 0.0009 0.0009
Onchocerca volvulus 0.0023 0.024 0.3628
Trichomonas vaginalis abcb9, putative 0.0031 0.0376 1
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.001 0.0022 0.0206
Loa Loa (eye worm) TWK-7 protein 0.0023 0.024 0.024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0009 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0158 0.0853
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0023 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0019 0.0019
Echinococcus multilocularis twik family of potassium channels 0.0023 0.024 0.024
Toxoplasma gondii ABC transporter family protein 0.001 0.0022 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis carbonic anhydrase II 0.0198 0.313 0.313
Brugia malayi ABC transporter 0.001 0.0022 0.004
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0033 0.0402 0.0402
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Plasmodium vivax ABC transporter B family member 6, putative 0.001 0.0022 0.0018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0019 0.0163
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0009 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0019
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.024 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0022 0.0356
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.024 0.024
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.001 0.0022 0.0002
Trypanosoma cruzi ion transport protein, putative 0.0023 0.024 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0158 0.0478
Brugia malayi hypothetical protein 0.0024 0.026 0.0805
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0019 0.0019
Toxoplasma gondii ABC transporter, putative 0.001 0.0022 0.0004
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.001 0.0022 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.011 0.011
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.024 0.0706
Leishmania major ABC-thiol transporter 0.001 0.0022 0.0002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0023 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0019
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0173 0.0173
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0022 0.0206
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0009 0.0009
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0023 0.024 0.0741
Echinococcus multilocularis carbonic anhydrase 0.0107 0.163 0.163
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0158 1
Giardia lamblia ABC transporter, putative 0.001 0.0022 0.0356
Trypanosoma brucei multidrug resistance protein E 0.001 0.0022 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0019 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.022 0.022
Onchocerca volvulus 0.0019 0.0173 0.2565
Entamoeba histolytica ABC transporter, putative 0.001 0.0022 0.0206
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0376 1
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Onchocerca volvulus 0.0031 0.0376 0.5752
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0376 0.2206
Schistosoma mansoni hypothetical protein 0.0107 0.163 0.1622
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0009 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.001 0.0022 0.0022
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0376 0.0376
Echinococcus multilocularis carbonic anhydrase 0.0107 0.163 0.163
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1738 0.1738
Plasmodium vivax ABC transporter B family member 4, putative 0.001 0.0022 0.0018
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0023 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0009 0.0014 0.0005
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.001 0.0022 0.0002
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.022 0.022
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.026 0.674
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0164 0.2559 0.2553
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.024 0.6256
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0158 0.0158
Onchocerca volvulus 0.001 0.0019 0.0163
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0376 1
Schistosoma mansoni multidrug resistance protein 0.0009 0.0014 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0021 0.0021
Brugia malayi ABC transporter family protein 0.001 0.0022 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0022 0.0022
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.001 0.0022 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0158 0.3982
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0173 0.0173
Echinococcus granulosus g protein coupled receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0022 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0158 0.0158
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.024 0.0706
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.024 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0015 0.011 0.0101
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0023 0.024 0.024
Plasmodium falciparum ABC transporter B family member 6, putative 0.001 0.0022 0.0004
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0376 0.2206
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0023 0.024 0.0741
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0158 0.3982
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0164 0.2559 0.2553
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.026 0.1487
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0023 0.024 0.6256
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0015 0.011 0.0323
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.163 0.1622
Echinococcus multilocularis RUN 0.0019 0.0173 0.0173
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0015 0.011 0.0101
Leishmania major hypothetical protein, conserved 0.0023 0.024 0.0706
Onchocerca volvulus 0.0023 0.024 0.3628
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.026 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0033
Echinococcus granulosus RUN 0.0019 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0376 0.0376
Echinococcus granulosus serotonin receptor 0.0009 0.0009 0.0009
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.001 0.0022 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0009 0.0009
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0023 0.024 0.0741
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.313 0.3124
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0023 0.024 0.0741
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.026 0.1487
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Loa Loa (eye worm) ABC transporter 0.001 0.0022 0.0022
Schistosoma mansoni rab6-interacting 0.0019 0.0173 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus GPCR family 2 0.0015 0.011 0.011
Giardia lamblia Hypothetical protein 0.0009 0.0014 0.0028
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0009 0.0009
Schistosoma mansoni coup transcription factor 0.001 0.0019 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0019 0.0163
Echinococcus granulosus FTZ F1 alpha 0.001 0.0019 0.0019
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0376 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.011 0.011
Schistosoma mansoni ap endonuclease 0.0018 0.0158 0.0149
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0009 0.0009
Echinococcus multilocularis tumor protein p63 0.0326 0.5244 0.5244
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.001 0.0022 0.0002
Echinococcus multilocularis cpg binding protein 0.0029 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0022 0.0022
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.024 0.0706
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis somatostatin receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0653 0.0653
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.024 0.6256
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.024 0.0232
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0009 0.0009
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.001 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0368 0.0368
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0019 0.001
Brugia malayi hypothetical protein 0.0019 0.0173 0.0524
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.163 0.5194
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.001 0.0022 0.0018
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0107 0.163 0.163
Brugia malayi CXXC zinc finger family protein 0.0028 0.0316 0.0984
Leishmania major hypothetical protein, conserved 0.0023 0.024 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0653 0.0653
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.001 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0376 0.0376
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0023 0.024 0.0741
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0023 0.024 0.0741
Echinococcus granulosus carbonic anhydrase II 0.0198 0.313 0.313
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0023 0.024 0.0741
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0022 0.0206
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.026 0.0769
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0033
Schistosoma mansoni hypothetical protein 0.0015 0.011 0.0101
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.022 0.022
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0158 0.3982
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0368 0.0368
Echinococcus granulosus allatostatin A receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0376 0.0376
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.163 0.5194
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0023 0.024 0.0741
Schistosoma mansoni smdr1 0.001 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0238 0.3787 0.3787
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0033
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.001
Toxoplasma gondii ion channel protein 0.0023 0.024 0.1364
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.313 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus neuropeptide receptor 0.0245 0.3898 0.3898
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0039 0.0039
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0023 0.024 0.024
Onchocerca volvulus 0.0023 0.024 0.3628
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0009 0.0009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0022 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0009 0.0009
Echinococcus granulosus hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0615 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase 0.0107 0.163 0.1622
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus granulosus multidrug resistance associated protein 1 0.001 0.0022 0.0022
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0022 0.0029
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0023 0.024 0.0706
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0021 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0647 0.0638
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0009 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0009 0.0009
Brugia malayi P-glycoprotein-like protein 0.001 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0009 0.0009
Brugia malayi ABC transporter family protein 0.001 0.0022 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0107 0.163 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0158 0.0441
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0022 0.0022
Echinococcus multilocularis geminin 0.0164 0.2559 0.2559
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0019 0.001
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) TWK-28 protein 0.0023 0.024 0.024
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0376 0.0376
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0376 0.2206
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0376 0.0376
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.001 0.0022 0.004
Plasmodium falciparum potassium channel 0.0023 0.024 0.1364
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0023 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.0015 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0011 0.0039 0.003
Plasmodium falciparum ABC transporter B family member 5, putative 0.001 0.0022 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0009 0.0009
Brugia malayi nuclear hormone receptor 0.001 0.0019 0.0033
Trypanosoma brucei calcium-activated potassium channel, putative 0.0023 0.024 0.0706
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0019 0.0033
Echinococcus multilocularis sex peptide receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0009 0.0009
Echinococcus granulosus g protein coupled receptor 0.0009 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.001 0.0022 0.0012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Onchocerca volvulus 0.0019 0.0173 0.2565
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trypanosoma brucei carbonic anhydrase-like protein 0.0198 0.313 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Schistosoma mansoni calcium-activated potassium channel 0.0366 0.5902 0.5898
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0009 0.0009
Plasmodium vivax potassium channel, putative 0.0023 0.024 0.6184
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.024 0.0706
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.024 0.0232
Echinococcus multilocularis calcium activated potassium channel variant 0.0023 0.024 0.024
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0019 0.001
Trichomonas vaginalis taga, putative 0.0031 0.0376 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0009 0.0009
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0033
Schistosoma mansoni cpg binding protein 0.0029 0.0342 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0173 0.0173
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0023 0.024 0.0741
Brugia malayi hypothetical protein 0.0023 0.024 0.0741
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0376 0.0376
Leishmania major carbonic anhydrase-like protein 0.0198 0.313 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0009 0.0009
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.163 0.5194
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0019 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0009 0.0009
Echinococcus granulosus somatostatin receptor 0.0009 0.0009 0.0009
Schistosoma mansoni calcium-activated potassium channel 0.0615 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0009 0.0009
Trypanosoma brucei p-glycoprotein 0.001 0.0022 0.0002
Plasmodium falciparum ABC transporter B family member 4, putative 0.001 0.0022 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0009 0.0009
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0023 0.024 0.6177
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Schistosoma mansoni multidrug resistance protein 0.001 0.0022 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0376 0.0376
Echinococcus granulosus carbonic anhydrase 0.0107 0.163 0.163
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0376 0.1142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0158 0.3856
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Leishmania major p-glycoprotein 0.0031 0.0376 0.1142
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0022 0.0206
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Onchocerca volvulus 0.0023 0.024 0.3628
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0019 0.0173 0.0164
Loa Loa (eye worm) hypothetical protein 0.0107 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0009 0.0009
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0376 1
Loa Loa (eye worm) uncoordinated protein 58 0.0023 0.024 0.024
Plasmodium vivax ABC transporter B family member 3, putative 0.001 0.0022 0.0018
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Echinococcus granulosus tumor protein p63 0.0326 0.5244 0.5244
Loa Loa (eye worm) carbonic anhydrase 3 0.0198 0.313 0.313
Brugia malayi ABC transporter family protein 0.0031 0.0376 0.1175
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0009 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0316 0.0316
Brugia malayi Doublecortin family protein 0.0019 0.0173 0.0524
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Toxoplasma gondii ion channel protein 0.0023 0.024 0.1364
Loa Loa (eye worm) hypothetical protein 0.0048 0.0647 0.0647
Echinococcus granulosus carbonic anhydrase 0.0107 0.163 0.163
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0376 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0019 0.001
Onchocerca volvulus 0.0023 0.024 0.3628
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0376 0.0376
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0023 0.024 0.0741
Mycobacterium ulcerans transmembrane cation transporter 0.0023 0.024 1
Schistosoma mansoni multidrug resistance protein 0.001 0.0022 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0019
Leishmania major calcium/potassium channel (CAKC), putative 0.0023 0.024 0.0706
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0376 0.0376
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0009 0.0009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0173 0.0173
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0376 1
Echinococcus granulosus orexin receptor type 2 0.0009 0.0009 0.0009
Schistosoma mansoni ap endonuclease 0.0018 0.0158 0.0149
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0368 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0033
Giardia lamblia Hypothetical protein 0.0023 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Onchocerca volvulus 0.0023 0.024 0.3628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0173 0.0173
Leishmania major hypothetical protein, conserved 0.0024 0.026 0.0769
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0009 0.0009
Echinococcus granulosus twik family of potassium channels 0.0023 0.024 0.024
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.001 0.0022 0.0029
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0023 0.024 0.024
Schistosoma mansoni cpg binding protein 0.0029 0.0342 0.0333
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0376 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0173 0.4275
Trypanosoma cruzi ion transport protein, putative 0.0023 0.024 0.0706
Schistosoma mansoni multidrug resistance protein 0.0031 0.0376 0.0367
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0158 0.5
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0022 0.004
Echinococcus granulosus calcium activated potassium channel variant 0.0023 0.024 0.024
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0376 1
Trichomonas vaginalis abcb9, putative 0.0031 0.0376 1
Echinococcus granulosus carbonic anhydrase 0.0107 0.163 0.163
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.313 1
Brugia malayi multidrug resistance protein 3 0.0031 0.0376 0.1175
Brugia malayi hypothetical protein 0.0019 0.0173 0.0524
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0376 0.0376
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0376 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.011 0.011
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0023 0.024 0.0741
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.011 0.0323
Echinococcus multilocularis neuropeptide receptor 0.0245 0.3898 0.3898
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Loa Loa (eye worm) ABC transporter 0.001 0.0022 0.0022
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0009 0.0009
Plasmodium falciparum multidrug resistance-associated protein 1 0.001 0.0022 0.0004
Loa Loa (eye worm) ABC transporter 0.001 0.0022 0.0022
Trypanosoma brucei multidrug resistance-associated protein, putative 0.001 0.0022 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0173 0.0173
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.026 0.1487
Echinococcus multilocularis carbonic anhydrase 0.0107 0.163 0.163
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0376 1
Onchocerca volvulus 0.0048 0.0647 1
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0009 0.0009
Mycobacterium ulcerans ion transport protein 0.0023 0.024 1
Brugia malayi hypothetical protein 0.001 0.0022 0.004
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.001 0.0022 0.0002
Schistosoma mansoni neuropeptide receptor 0.0245 0.3898 0.3892
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0376 1
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0021 0.0021
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.001 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0009 0.0009
Brugia malayi multidrug resistance related protein 1 0.001 0.0022 0.004
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.024 0.0706
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.6378 0.6378
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0022 0.0029
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0376 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.001 0.0022 0.0002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0009 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0019 0.0033
Echinococcus multilocularis serotonin receptor 0.0009 0.0009 0.0009
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.001 0.0022 0.0002
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0023 0.024 0.024
Schistosoma mansoni rab6-interacting 0.0019 0.0173 0.0164
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.001 0.0022 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0033
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0009 0.0009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0039 0.0039
Brugia malayi ABC transporter transmembrane region family protein 0.0009 0.0014 0.0016
Echinococcus multilocularis GPCR, family 2 0.0015 0.011 0.011
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0376 0.0376
Plasmodium falciparum potassium channel 0.0023 0.024 0.1364
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0198 0.313 0.313
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0653 0.2063
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.001 0.0022 0.0002
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.313 0.3124
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.024
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0009 0.0009
Entamoeba histolytica multidrug resistance protein, putative 0.001 0.0022 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0033
Schistosoma mansoni lipoxygenase 0.008 0.1173 0.1165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0019
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0173 0.0943
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0158 0.0441
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0376 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.001 0.0022 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0019 0.0019
Brugia malayi ecdysteroid receptor 0.001 0.0019 0.0033
Schistosoma mansoni lipoxygenase 0.0114 0.1738 0.1731
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0009 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0019 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus granulosus dnaJ subfamily B 0.0395 0.6378 0.6378
Schistosoma mansoni multidrug resistance protein 0.001 0.0022 0.0012
Leishmania major pentamidine resistance protein 1 0.001 0.0022 0.0002
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0023 0.024 0.024
Echinococcus multilocularis small conductance calcium activated potassium 0.0615 1 1
Schistosoma mansoni smdr2 0.0031 0.0376 0.0367
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0376 1
Giardia lamblia MRP-like ABC transporter 0.001 0.0022 0.0356
Trypanosoma brucei multidrug resistance-associated protein, putative 0.001 0.0022 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.026 0.0769
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.024 0.6256
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0158 0.0441
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.001 0.0022 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.024 0.6256
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0009 0.0009
Echinococcus granulosus twik family of potassium channels 0.0023 0.024 0.024
Echinococcus granulosus cpg binding protein 0.0029 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.001 0.0022 0.0029
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0009 0.0009
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0022 0.0004
Echinococcus granulosus geminin 0.0164 0.2559 0.2559
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0009 0.0009
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.024 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0033
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.163 0.1622
Echinococcus multilocularis 0.001 0.0022 0.0022
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Brugia malayi ABC transporter 0.0009 0.0014 0.0016
Onchocerca volvulus 0.0028 0.0316 0.4816
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0198 0.313 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0402 0.1258
Brugia malayi hypothetical protein 0.0023 0.024 0.0741
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.024 0.0232
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0019 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.024 0.6256
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0022 0.0206
Loa Loa (eye worm) hypothetical protein 0.0225 0.3574 0.3574
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0009 0.0009
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0009 0.0009

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.3 uM Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay ChEMBL. 18824351
IC50 (binding) = 0.35 uM Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay ChEMBL. 18824351
IC50 (binding) = 0.53 uM Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay ChEMBL. 18824351
IC50 (binding) = 0.58 uM Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay ChEMBL. 18824351
Inhibition (binding) = 105 % Inhibition of Kca2.3 channel expressed in HEK293 cells at 30 uM by thallium flux assay ChEMBL. 18824351

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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