Detailed information for compound 984882

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.912 | Formula: C19H28ClN5
  • H donors: 4 H acceptors: 1 LogP: 1.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](Cc1ccccc1)CN[C@@H]1CNC[C@@H]1Cc1cccc(n1)N.Cl
  • InChi: 1S/C19H27N5.ClH/c20-16(9-14-5-2-1-3-6-14)12-23-18-13-22-11-15(18)10-17-7-4-8-19(21)24-17;/h1-8,15-16,18,22-23H,9-13,20H2,(H2,21,24);1H/t15-,16+,18+;/m0./s1
  • InChiKey: GMRNYYVTWMYQDY-JTCBYWPXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Nitric-oxide synthase, brain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Trichomonas vaginalis sulfite reductase, putative 0.0027 0.0051 0.201
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0272 0.0405
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0051 0.0164
Brugia malayi Protein kinase domain containing protein 0.0048 0.0138 0.019
Brugia malayi Tubulin beta chain 0.0016 0.0008 0.001
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0273 0.1061 0.1462
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0027 0.0051 0.0164
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0058 0.0188
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.0557 0.468
Schistosoma mansoni cytochrome P450 reductase 0.0027 0.0051 0.0159
Trypanosoma cruzi p450 reductase, putative 0.0027 0.0051 0.0164
Toxoplasma gondii beta tubulin 0.0037 0.0094 0.0324
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0112
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.007 0.0588
Echinococcus multilocularis tubulin subunit beta 0.0037 0.0094 0.0133
Schistosoma mansoni lamin 0.0027 0.0051 0.0159
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0133
Brugia malayi hypothetical protein 0.0021 0.0026 0.0036
Giardia lamblia Nitric oxide synthase, inducible 0.0024 0.0039 0.0117
Schistosoma mansoni hypothetical protein 0.0068 0.022 0.077
Entamoeba histolytica hypothetical protein 0.0036 0.0087 0.1915
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0669 0.2688 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0322 0.0482
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0069 0.0226 1
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Schistosoma mansoni tubulin subunit alpha 0.0069 0.0226 0.0793
Trichomonas vaginalis tubulin alpha chain, putative 0.0021 0.0028 0.0924
Schistosoma mansoni tar DNA-binding protein 0.0063 0.02 0.07
Brugia malayi TAR-binding protein 0.0063 0.02 0.0276
Echinococcus multilocularis 0.0021 0.0026 0.0028
Schistosoma mansoni amine oxidase 0.0021 0.0026 0.0067
Loa Loa (eye worm) FAD binding domain-containing protein 0.0027 0.0051 0.0432
Trypanosoma brucei beta tubulin 0.0037 0.0094 0.0324
Entamoeba histolytica tubulin alpha-1 chain 0.0069 0.0226 0.632
Leishmania major hypothetical protein, conserved 0.0025 0.0043 0.0133
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0342 0.0512
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0027 0.0051 0.0067
Loa Loa (eye worm) hypothetical protein 0.006 0.0189 0.1583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0684 0.1036
Loa Loa (eye worm) hypothetical protein 0.0069 0.0226 0.1897
Echinococcus granulosus Tubulin beta 2C chain 0.0037 0.0094 0.0315
Plasmodium vivax tubulin beta chain, putative 0.0037 0.0094 0.0324
Brugia malayi FAD binding domain containing protein 0.0017 0.0009 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.02 0.1683
Echinococcus granulosus Tubulin beta 2C chain 0.0037 0.0094 0.0315
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0026 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.007 0.0227
Echinococcus granulosus microtubule associated protein 2 0.0687 0.2762 1
Plasmodium falciparum tubulin gamma chain 0.0037 0.0094 0.0324
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0228
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0051 0.0071
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Trypanosoma brucei epsilon tubulin 0.0037 0.0094 0.0324
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0026 0.0161
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0094 0.3974
Onchocerca volvulus 0.0027 0.0051 0.0025
Schistosoma mansoni tyrosine kinase 0.008 0.0269 0.0948
Giardia lamblia Hypothetical protein 0.0024 0.0039 0.0117
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0342 0.1213
Onchocerca volvulus 0.0273 0.1061 0.1037
Brugia malayi Muscleblind-like protein 0.0149 0.0552 0.0761
Toxoplasma gondii beta-tubulin, putative 0.0037 0.0094 0.0324
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0037 0.0284
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0027 0.0051 0.0164
Loa Loa (eye worm) RNA binding protein 0.0063 0.02 0.1683
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.0557 0.0842
Brugia malayi CHE-14 protein 0.0042 0.0113 0.0156
Echinococcus granulosus tubulin alpha 3 chain 0.0069 0.0226 0.0793
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0026 0.0067
Trichomonas vaginalis tubulin, putative 0.0037 0.0094 0.3974
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0432
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0026 0.0068
Entamoeba histolytica hypothetical protein 0.0023 0.0036 0.0279
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0058 0.0188
Trichomonas vaginalis tubulin epsilon chain, putative 0.0069 0.0226 1
Loa Loa (eye worm) tubulin alpha 2 0.0053 0.0159 0.1337
Trypanosoma brucei alpha tubulin 0.0069 0.0226 0.0814
Onchocerca volvulus 0.0027 0.0051 0.0025
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1337
Loa Loa (eye worm) tyrosinase 1 0.0273 0.1061 0.8904
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0027 0.0051 0.0159
Onchocerca volvulus 0.0273 0.1061 0.1037
Echinococcus granulosus tubulin beta 1 chain 0.0037 0.0094 0.0315
Brugia malayi FAD binding domain containing protein 0.0027 0.0051 0.0071
Schistosoma mansoni tyrosine kinase 0.0081 0.0272 0.0961
Trichomonas vaginalis tubulin epsilon chain, putative 0.0037 0.0094 0.3974
Mycobacterium ulcerans hypothetical protein 0.0023 0.0037 0.0262
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0013 0.0021
Brugia malayi tubulin alpha-2 chain 0.0069 0.0226 0.0311
Echinococcus multilocularis tubulin subunit TubB 0.0069 0.0226 0.0335
Leishmania major cytochrome P450 reductase, putative 0.0024 0.0039 0.0117
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0026 0.0028
Entamoeba histolytica tubulin family protein 0.0037 0.0094 0.2136
Onchocerca volvulus 0.0273 0.1061 0.1037
Schistosoma mansoni transient receptor potential channel 0.0063 0.0202 0.0705
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0052
Echinococcus multilocularis muscleblind protein 0.0149 0.0552 0.0834
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0272 0.0961
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Schistosoma mansoni ran 0.0021 0.0027 0.0071
Echinococcus granulosus beta tubulin 0.0037 0.0094 0.0315
Brugia malayi hypothetical protein 0.0025 0.0043 0.006
Echinococcus multilocularis tubulin alpha chain 0.0069 0.0226 0.0335
Trichomonas vaginalis tubulin gamma chain, putative 0.0037 0.0094 0.3974
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0015
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.2762 0.4221
Schistosoma mansoni tubulin subunit gamma 0.0037 0.0094 0.0315
Echinococcus granulosus tubulin alpha chain 0.0069 0.0226 0.0793
Schistosoma mansoni tar DNA-binding protein 0.0063 0.02 0.07
Loa Loa (eye worm) ShTK domain-containing protein 0.0273 0.1061 0.8904
Giardia lamblia Beta tubulin 0.0037 0.0094 0.0324
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0036 0.1299
Echinococcus multilocularis snurportin 1 0.0304 0.1191 0.1813
Echinococcus multilocularis neuropeptide s receptor 0.046 0.1831 0.2795
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0048 0.0139 0.6026
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0137 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0314
Schistosoma mansoni tyrosinase precursor 0.0273 0.1061 0.3823
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Loa Loa (eye worm) hypothetical protein 0.0273 0.1061 0.8904
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0027 0.0051 0.0067
Leishmania major telomerase reverse transcriptase, putative 0.0669 0.2688 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0112
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0026 0.0161
Echinococcus granulosus muscleblind protein 0.0149 0.0552 0.1975
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Schistosoma mansoni tubulin subunit alpha 0.0069 0.0226 0.0793
Echinococcus granulosus tubulin gamma 1 chain 0.0037 0.0094 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0684 0.2454
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0262
Brugia malayi RNA, U transporter 1 0.0081 0.0274 0.0378
Echinococcus granulosus tubulin alpha 1C chain 0.0069 0.0226 0.0793
Schistosoma mansoni tyrosine kinase 0.0048 0.0138 0.0473
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0071
Echinococcus multilocularis Tubulin alpha 1 chain 0.0069 0.0226 0.0335
Mycobacterium ulcerans dehydrogenase 0.0021 0.0026 0.0161
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0051 0.043
Echinococcus granulosus alpha tubulin 0.0069 0.0226 0.0793
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0514 0.0775
Echinococcus granulosus neuropeptide receptor A26 0.046 0.1831 0.6621
Mycobacterium ulcerans oxidoreductase 0.0021 0.0026 0.0161
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0138 0.0473
Trypanosoma cruzi epsilon tubulin, putative 0.0037 0.0094 0.0324
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0342 1
Schistosoma mansoni patched 1 0.0042 0.0113 0.0382
Echinococcus granulosus tubulin epsilon chain 0.0037 0.0094 0.0315
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0037 0.0094 0.0324
Schistosoma mansoni alpha tubulin 0.0069 0.0226 0.0793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0037 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0051 0.0164
Loa Loa (eye worm) hypothetical protein 0.0096 0.0335 0.2814
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0684 0.2454
Brugia malayi Tubulin beta chain 0.0021 0.0028 0.0038
Schistosoma mansoni tyrosine kinase 0.008 0.0269 0.0948
Toxoplasma gondii RNA-directed DNA polymerase 0.0669 0.2688 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0138 0.1158
Echinococcus multilocularis expressed conserved protein 0.0092 0.0317 0.0475
Schistosoma mansoni alpha tubulin 0.0069 0.0226 0.0793
Entamoeba histolytica hypothetical protein 0.0036 0.0087 0.1915
Echinococcus multilocularis insulin receptor 0.0048 0.0138 0.02
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Echinococcus granulosus epidermal growth factor receptor 0.015 0.0557 0.1996
Schistosoma mansoni alpha tubulin 0.0069 0.0226 0.0793
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0036 0.0106
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.1299
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0328
Trypanosoma brucei beta tubulin 0.0037 0.0094 0.0324
Trypanosoma cruzi alpha tubulin, putative 0.0069 0.0226 0.0814
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.036
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0133
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0202 0.0297
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.1831 0.2795
Schistosoma mansoni tyrosine kinase 0.0048 0.0138 0.0473
Loa Loa (eye worm) hypothetical protein 0.0098 0.0342 0.2868
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0322 0.1142
Echinococcus multilocularis tubulin alpha 3 chain 0.0069 0.0226 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0015
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Echinococcus granulosus tubulin alpha chain 0.0069 0.0226 0.0793
Plasmodium vivax tubulin epsilon chain, putative 0.0037 0.0094 0.0324
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Loa Loa (eye worm) hypothetical protein 0.0149 0.0552 0.4632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0109
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0058 0.0077
Echinococcus multilocularis Tubulin beta 2C chain 0.0037 0.0094 0.0133
Plasmodium falciparum telomerase reverse transcriptase 0.0669 0.2688 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0013 0.2322
Schistosoma mansoni ran 0.0021 0.0027 0.0071
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0294 0.1147 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0037 0.0094 0.0792
Trypanosoma brucei alpha tubulin 0.0069 0.0226 0.0814
Loa Loa (eye worm) hypothetical protein 0.0149 0.0552 0.4632
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0073
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0026 0.0068
Schistosoma mansoni tyrosine kinase 0.015 0.0557 0.1996
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0348 0.1235
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0026 0.0068
Onchocerca volvulus 0.0273 0.1061 0.1037
Trichomonas vaginalis tubulin epsilon chain, putative 0.0069 0.0226 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0053 0.0159 0.1337
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0051 0.0164
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0073
Brugia malayi Tubulin beta-1 chain 0.0037 0.0094 0.013
Echinococcus multilocularis tar DNA binding protein 0.0063 0.02 0.0296
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0328
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.007 0.0096
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Trypanosoma cruzi epsilon tubulin, putative 0.0037 0.0094 0.0324
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0026 0.6134
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0335 0.1189
Echinococcus granulosus insulin receptor 0.0048 0.0138 0.0473
Giardia lamblia Beta tubulin 0.0037 0.0094 0.0324
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.0557 0.0769
Brugia malayi ShTK domain containing protein 0.0273 0.1061 0.1462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0015
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0053 0.0159 0.6951
Schistosoma mansoni tyrosine kinase 0.008 0.0269 0.0948
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0273 0.1061 0.1462
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0202 0.0297
Trypanosoma brucei beta tubulin 0.0037 0.0094 0.0324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0314
Trichomonas vaginalis tubulin gamma chain, putative 0.0037 0.0094 0.3974
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Loa Loa (eye worm) BEN-1 protein 0.0037 0.0094 0.0792
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0335 0.1189
Echinococcus granulosus tubulin alpha chain 0.0069 0.0226 0.0793
Echinococcus granulosus beta tubulin 0.0037 0.0094 0.0315
Brugia malayi Latrophilin receptor protein 2 0.0031 0.007 0.0096
Echinococcus granulosus GPCR family 2 0.0031 0.007 0.0227
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0113 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0133
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Giardia lamblia Alpha-tubulin 0.0069 0.0226 0.0814
Plasmodium vivax flavodoxin domain containing protein 0.0024 0.0039 0.0117
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0552 0.0834
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0109
Echinococcus granulosus methionine synthase reductase 0.0017 0.0009 0.0006
Echinococcus granulosus expressed conserved protein 0.0092 0.0317 0.1125
Echinococcus granulosus lamin dm0 0.0027 0.0051 0.0159
Trichomonas vaginalis tubulin gamma chain, putative 0.0037 0.0094 0.3974
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.1273
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0413
Onchocerca volvulus 0.0021 0.0028 0.0002
Brugia malayi RNA binding protein 0.0063 0.02 0.0276
Loa Loa (eye worm) tubulin alpha chain 0.0069 0.0226 0.1897
Schistosoma mansoni amine oxidase 0.0021 0.0026 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0052
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Plasmodium falciparum nitric oxide synthase, putative 0.0027 0.0051 0.0164
Toxoplasma gondii alpha tubulin TUBA1 0.0069 0.0226 0.0814
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Trichomonas vaginalis tubulin alpha chain, putative 0.0021 0.0028 0.0924
Schistosoma mansoni lamin 0.0027 0.0051 0.0159
Echinococcus multilocularis Tubulin alpha 1 chain 0.0069 0.0226 0.0335
Plasmodium vivax tubulin gamma chain, putative 0.0037 0.0094 0.0324
Schistosoma mansoni transient receptor potential channel 0.0063 0.0202 0.0705
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0073
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0272 0.0961
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0335 0.0502
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0051 0.043
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0027 0.0051 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0109
Brugia malayi intermediate filament protein 0.0027 0.0051 0.0071
Echinococcus multilocularis tubulin alpha 1C chain 0.0069 0.0226 0.0335
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0088 0.029
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.0227
Echinococcus multilocularis musashi 0.0027 0.0051 0.0067
Brugia malayi Cell division protein ftsZ 0.0016 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0349 0.2928
Trichomonas vaginalis tubulin alpha chain, putative 0.0037 0.0094 0.3974
Entamoeba histolytica tubulin family protein 0.0037 0.0094 0.2136
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0037 0.0262
Trypanosoma brucei telomerase reverse transcriptase 0.0669 0.2688 1
Schistosoma mansoni tyrosine kinase 0.0081 0.0272 0.0961
Plasmodium vivax tubulin alpha chain, putative 0.0069 0.0226 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0684 0.2454
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0087 0.029
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0294 0.1147 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0048 0.0139 0.1168
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0037 0.0328
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0026 0.0068
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0113 0.0382
Leishmania major importin beta-1 subunit, putative 0.0023 0.0036 0.0106
Echinococcus granulosus tubulin beta 4A class IVa 0.0037 0.0094 0.0315
Plasmodium falciparum alpha tubulin 1 0.0069 0.0226 0.0814
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0109
Plasmodium falciparum alpha tubulin 2 0.0069 0.0226 0.0814
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0202 0.0705
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0487
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0027 0.0051 0.0164
Echinococcus granulosus tar DNA binding protein 0.0063 0.02 0.07
Echinococcus multilocularis tubulin epsilon chain 0.0037 0.0094 0.0133
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0024 0.0039 0.1435
Loa Loa (eye worm) BEN-1 protein 0.0037 0.0094 0.0792
Trypanosoma brucei tubulin gamma chain 0.0037 0.0094 0.0324
Leishmania major epsilon tubulin, putative 0.0037 0.0094 0.0324
Loa Loa (eye worm) tubulin alpha 2 0.0053 0.0159 0.1337
Leishmania major p450 reductase, putative 0.0027 0.0051 0.0164
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0037 1
Schistosoma mansoni importin beta-1 0.0029 0.0058 0.0183
Trichomonas vaginalis tubulin epsilon chain, putative 0.0037 0.0094 0.3974
Echinococcus granulosus tubulin alpha chain 0.0069 0.0226 0.0793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0684 0.1036
Loa Loa (eye worm) tubulin beta-2A chain 0.0037 0.0094 0.0792
Leishmania major gamma-tubulin 0.0037 0.0094 0.0324
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0027 0.0051 0.0159
Trichomonas vaginalis tubulin alpha chain, putative 0.0037 0.0094 0.3974
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0026 0.0028
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0013 0.0021
Entamoeba histolytica hypothetical protein 0.0036 0.0087 0.1915
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0043 0.0133
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0364
Echinococcus multilocularis tubulin alpha 1C chain 0.0069 0.0226 0.0335
Entamoeba histolytica hypothetical protein 0.0036 0.0087 0.1915
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0026 0.0068
Trichomonas vaginalis tubulin, putative 0.0021 0.0028 0.0924
Loa Loa (eye worm) ShTK domain-containing protein 0.0273 0.1061 0.8904
Onchocerca volvulus 0.0023 0.0037 0.0012
Echinococcus multilocularis Tubulin beta 2C chain 0.0037 0.0094 0.0133
Echinococcus granulosus Tubulin beta 2C chain 0.0037 0.0094 0.0315
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0073
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0013 0.0052
Loa Loa (eye worm) tubulin alpha-2 chain 0.0069 0.0226 0.1897
Echinococcus granulosus tubulin alpha 0.0037 0.0094 0.0315
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0625
Brugia malayi hypothetical protein 0.0016 0.0007 0.001
Echinococcus granulosus snurportin 1 0.0304 0.1191 0.4296
Echinococcus multilocularis methionine synthase reductase 0.0017 0.0009 0.0002
Trypanosoma cruzi beta tubulin, putative 0.0037 0.0094 0.0324
Brugia malayi alpha-tubulin 0.0069 0.0226 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0063 0.02 0.07
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.02 0.0276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.1299
Brugia malayi Tubulin alpha chain 0.0069 0.0226 0.0311
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.007 0.0227
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0037 0.0262
Brugia malayi Tubulin gamma chain 0.0037 0.0094 0.013
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0026 0.0068
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0026 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0087 0.0122
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.0227
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Trichomonas vaginalis tubulin alpha chain, putative 0.0021 0.0028 0.0924
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0026 0.0068
Echinococcus granulosus Tubulin beta 2C chain 0.0037 0.0094 0.0315
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Echinococcus granulosus lamin 0.0027 0.0051 0.0159
Loa Loa (eye worm) tubulin alpha 2 0.0032 0.0073 0.0609
Schistosoma mansoni tubulin subunit epsilon 0.0037 0.0094 0.0315
Echinococcus granulosus tubulin alpha 1C chain 0.0069 0.0226 0.0793
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0073
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0026 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0052
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Brugia malayi tubulin alpha chain - mouse 0.0069 0.0226 0.0311
Echinococcus multilocularis GPCR, family 2 0.0031 0.007 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0073
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0013 0.0048
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0026 0.0067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.0684 0.5739
Loa Loa (eye worm) tubulin alpha chain 0.0069 0.0226 0.1897
Giardia lamblia Beta tubulin 0.0037 0.0094 0.0324
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0028 0.0924
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0202 0.0705
Echinococcus multilocularis tubulin alpha 3 chain 0.0069 0.0226 0.0335
Giardia lamblia Alpha-tubulin 0.0069 0.0226 0.0814
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.2762 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0037 0.0262
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0043 0.0133
Toxoplasma gondii beta-1 tubulin, putative 0.0037 0.0094 0.0324
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.0684 0.0942
Echinococcus granulosus Tubulin alpha 1 chain 0.0069 0.0226 0.0793
Schistosoma mansoni tyrosinase precursor 0.0273 0.1061 0.3823
Echinococcus granulosus intermediate filament protein 0.0027 0.0051 0.0159
Loa Loa (eye worm) alpha-tubulin 0.0069 0.0226 0.1897
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.0588
Loa Loa (eye worm) alpha-tubulin 0.0069 0.0226 0.1897
Brugia malayi beta-tubulin, identical 0.0037 0.0094 0.013
Loa Loa (eye worm) TAR-binding protein 0.0063 0.02 0.1683
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0015
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0273 0.1061 0.1462
Entamoeba histolytica tubulin gamma chain 0.0037 0.0094 0.2136
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0026 0.0068
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0088 0.0121
Echinococcus multilocularis Tubulin beta 2C chain 0.0037 0.0094 0.0133
Leishmania major UDP-galactopyranose mutase 0.0021 0.0026 0.0068
Schistosoma mansoni tubulin subunit alpha 0.0069 0.0226 0.0793
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0021 0.0028 0.0924
Loa Loa (eye worm) tubulin beta-4 chain 0.0037 0.0094 0.0792
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Brugia malayi Tubulin alpha chain 0.0016 0.0008 0.001
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0026 0.0036
Echinococcus multilocularis tubulin alpha chain 0.0069 0.0226 0.0335
Toxoplasma gondii alpha-tubulin I, putative 0.0069 0.0226 0.0814
Echinococcus granulosus importin subunit beta 1 0.0029 0.0058 0.0183
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0037 0.0094 0.0133
Plasmodium falciparum tubulin epsilon chain, putative 0.0037 0.0094 0.0324
Echinococcus granulosus Tubulin alpha 1 chain 0.0069 0.0226 0.0793
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0138 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0262
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0217
Plasmodium falciparum importin beta, putative 0.0029 0.0058 0.0188
Loa Loa (eye worm) tubulin beta chain 0.0037 0.0094 0.0792
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.022 0.0303
Trypanosoma brucei alpha tubulin 0.0069 0.0226 0.0814
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0314
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1191 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0017 0.0009 0.0006
Loa Loa (eye worm) tubulin beta chain 0.0016 0.0008 0.0063
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0027 0.0051 0.0385
Echinococcus multilocularis Tubulin alpha 1 chain 0.0069 0.0226 0.0335
Brugia malayi Common central domain of tyrosinase family protein 0.0273 0.1061 0.1462
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0037 0.0262
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0027 0.0051 0.0164
Schistosoma mansoni transient receptor potential channel 0.0096 0.0335 0.1189
Echinococcus granulosus tubulin subunit beta 0.0037 0.0094 0.0315
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.007 0.0096
Giardia lamblia Telomerase catalytic subunit 0.0669 0.2688 1
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Loa Loa (eye worm) hypothetical protein 0.0099 0.0349 0.2928
Echinococcus multilocularis tubulin gamma 1 chain 0.0037 0.0094 0.0133
Trypanosoma brucei beta tubulin 0.0037 0.0094 0.0324
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0058 0.0188
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0026 0.0067
Echinococcus multilocularis beta tubulin 0.0037 0.0094 0.0133
Echinococcus multilocularis lamin dm0 0.0027 0.0051 0.0067
Brugia malayi Importin beta-1 subunit 0.0029 0.0058 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0037 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0684 0.2454
Plasmodium vivax telomerase reverse transcriptase, putative 0.0669 0.2688 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0109
Echinococcus multilocularis lamin 0.0027 0.0051 0.0067
Trypanosoma cruzi tubulin gamma chain 0.0037 0.0094 0.0324
Trypanosoma brucei beta tubulin 0.0037 0.0094 0.0324
Echinococcus multilocularis tubulin alpha chain 0.0069 0.0226 0.0335
Echinococcus multilocularis tubulin alpha 0.0037 0.0094 0.0133
Brugia malayi hypothetical protein 0.0036 0.0087 0.012
Schistosoma mansoni tar DNA-binding protein 0.0063 0.02 0.07
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Echinococcus multilocularis tubulin alpha chain 0.0069 0.0226 0.0335
Loa Loa (eye worm) hypothetical protein 0.0068 0.022 0.1845
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0113 0.0382
Trypanosoma brucei epsilon tubulin 0.0037 0.0094 0.0324
Trichomonas vaginalis tubulin beta chain, putative 0.0069 0.0226 1
Plasmodium falciparum tubulin beta chain 0.0037 0.0094 0.0324
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0514 0.1837
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.043
Echinococcus granulosus tubulin alpha chain 0.0069 0.0226 0.0793
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.036
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0669 0.2688 1
Echinococcus granulosus neuropeptide s receptor 0.046 0.1831 0.6621
Loa Loa (eye worm) hypothetical protein 0.0273 0.1061 0.8904
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0026 0.0067
Brugia malayi Tubulin alpha-2 chain 0.0069 0.0226 0.0311
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0262
Brugia malayi SWIRM domain containing protein 0.0021 0.0026 0.0036
Plasmodium vivax importin-beta 2, putative 0.0029 0.0058 0.0188
Echinococcus granulosus Tubulin beta 2C chain 0.0037 0.0094 0.0315
Echinococcus granulosus tubulin subunit TubB 0.0069 0.0226 0.0793
Plasmodium vivax tubulin alpha chain, putative 0.0069 0.0226 0.0814
Echinococcus multilocularis 0.0046 0.0132 0.019
Schistosoma mansoni intermediate filament proteins 0.0027 0.0051 0.0159
Echinococcus multilocularis protein patched 0.0042 0.0113 0.0161
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0948
Echinococcus multilocularis Tubulin beta 2C chain 0.0037 0.0094 0.0133
Echinococcus multilocularis peroxisome assembly protein 26 0.0069 0.0226 0.0335
Echinococcus granulosus peroxisome assembly protein 26 0.0069 0.0226 0.0793
Echinococcus granulosus tubulin alpha 3 chain 0.0069 0.0226 0.0793
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0349 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0684 0.2454
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0342 0.0471
Brugia malayi Tubulin alpha-2 chain 0.0069 0.0226 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0063 0.02 0.07
Echinococcus multilocularis beta tubulin 0.0037 0.0094 0.0133
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0273 0.1061 0.1462
Giardia lamblia Gamma tubulin 0.0037 0.0094 0.0324
Treponema pallidum cell division protein FtsZ 0.0016 0.0008 0.5
Loa Loa (eye worm) FAD binding domain-containing protein 0.0017 0.0009 0.0077
Echinococcus multilocularis Tubulin beta 2C chain 0.0037 0.0094 0.0133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.007 0.0096
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.1168
Trypanosoma brucei epsilon tubulin 0.0037 0.0094 0.0324
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0349 0.0481
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0735
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0026 0.0174
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0051 0.0164
Echinococcus granulosus Tubulin alpha 1 chain 0.0069 0.0226 0.0793
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0113 0.0948
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0273 0.1062 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0088 0.0123
Trypanosoma brucei alpha tubulin, putative 0.0021 0.0028 0.0075
Entamoeba histolytica tubulin alpha chain, putative 0.0069 0.0226 0.632
Trichomonas vaginalis tubulin, putative 0.0021 0.0028 0.0924
Echinococcus multilocularis tubulin alpha chain 0.0069 0.0226 0.0335
Schistosoma mansoni hypothetical protein 0.0304 0.1191 0.4296
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0087 0.029
Loa Loa (eye worm) tubulin gamma chain 0.0037 0.0094 0.0792
Trypanosoma brucei alpha tubulin 0.0069 0.0226 0.0814
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0897
Brugia malayi flavodoxin family protein 0.0027 0.0051 0.0071
Leishmania major alpha tubulin 0.0069 0.0226 0.0814
Loa Loa (eye worm) beta-tubulin 0.0037 0.0094 0.0792
Echinococcus multilocularis tubulin beta 1 chain 0.0037 0.0094 0.0133
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0016 0.0008 0.5
Echinococcus multilocularis hypothetical protein 0.0069 0.0226 0.0335
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0043 0.0133
Brugia malayi Telomerase reverse transcriptase 0.178 0.7252 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0113 0.4825
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1605 0.6534 1
Schistosoma mansoni tubulin subunit beta 0.0037 0.0094 0.0315
Leishmania major beta tubulin 0.0037 0.0094 0.0324
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0037

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.42 uM Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assay ChEMBL. 19125620
Ki (binding) = 238 uM Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assay ChEMBL. 19125620
Ki (binding) = 1450 uM Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assay ChEMBL. 19125620

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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